Imatinib mesylate inhibits proliferation of rheumatoid synovial fibroblast-like cells and phosphorylation of Gab adapter proteins activated by platelet-derived growth factor

Clinical and Experimental Immunology

Volumn 144, Issue 2, 2006, Pages 335-341

  Kameda, H ^a   Ishigami, H ^a   Suzuki, M ^a   Abe, T ^a   Takeuchi, T ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Adapter proteins; Arthritis; Growth factors; Signal transduction

Indexed keywords

ADAPTER PROTEIN; AGAR; EPIDERMAL GROWTH FACTOR; GAB PROTEIN; GAB1 PROTEIN; GAB2 PROTEIN; IMATINIB; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN DERIVATIVE; PROTEIN TYROSINE KINASE; TETRAZOLIUM; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; ASSAY; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL STIMULATION; COLONY FORMATION; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIAL FIBROBLAST LIKE CELL; SYNOVIOCYTE; TARGET CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ARTHRITIS; ARTHRITIS, RHEUMATOID; CELL DIVISION; CELLS, CULTURED; FIBROBLASTS; HUMANS; OSTEOARTHRITIS; PHOSPHORYLATION; PIPERAZINES; PLATELET-DERIVED GROWTH FACTOR; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; TYROSINE;

EID: 33645875870     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2006.03067.x     Document Type: Article

References (41)

1. Choy EHS Panayi GS Cytokine pathways and joint inflammation in rheumatoid arthritis N Eng J Med 2001 344 907 16
2. Firestein GS Zvaifler NJ How important are T cells in chronic rheumatoid synovitis? II. T cell-independent mechanisms from beginning to end Arthritis Rheum 2002 46 298 308
3. Müller-Ladner U Gay RE Gay S Activation of synoviocytes Curr Opin Rheumatol 2000 12 186 94
4. Yamanishi Y Firestein GS Pathogenesis of rheumatoid arthritis: the role of synoviocytes Rheum Dis Clin North Am 2001 27 355 71
5. Lafyatis R Remmers EF Roberts AB Yocum DE Sporn MB Wilder RL Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids J Clin Invest 1989 83 1267 76
6. Müller-Ladner U Kriegsmann J Gay RE Gay S Oncogenes in rheumatoid arthritis Rheum Dis Clin North Am 1995 21 675 90
7. Imamura F Aono H Hasunuma T et al. Monoclonal expansion of synoviocytes in rheumatoid arthritis Arthritis Rheum 1998 41 1979 86
8. Müller-Ladner U Kriegsmann J Franklin BN et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice Am J Pathol 1996 149 1607 15
9. Heldin C-H Westermark B Mechanism of action and in vivo role of platelet-derived growth factor Physiol Rev 1999 79 1283 316
10. Östman A Heldin C-H Involvement of platelet-derived growth factor in disease: development of specific antagonists Adv Cancer Res 2001 80 1 38
11. George D Platelet-derived growth factor receptors: a therapeutic target in solid tumors Semin Oncol 2001 28 27 33
12. Pietras K Sjöblom T Rubin K Heldin C-H Östman A PDGF receptors as cancer drug targets Cancer Cell 2003 3 439 43
13. Apperley JF Gardembas M Melo JV et al. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta N Engl J Med 2002 347 481 7
14. Carroll M Ohno-Jones S Tamura S et al. CGP57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins Blood 1997 90 4947 52
15. Druker BJ Tamura S Buchdunger E et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells Nat Med 1996 2 561 6
16. Druker BJ Talpaz M Resta DJ et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia N Engl J Med 2001 344 1031 7
17. Druker BJ Sawyers CL Kantarjian H et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome N Engl J Med 2001 344 1038 42
18. Rubin K Terracio L Ronnstrand L Heldin C-H Klareskog L Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial inflammation Scand J Immunol 1988 27 285 94
19. Kumkumian GK Lafyatis R Remmers EF Case JP Kim S-J Wilder RL Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis. Regulation of synovial proliferation, prostaglandin production, and collagenase transcription J Immunol 1989 143 833 7
20. Butler DM Leizer T Hamilton JA Stimulation of human synovial fibroblast DNA synthesis by platelet-derived growth factor and fibroblast growth factor. Differences to the activation by IL-1 J Immunol 1989 142 3098 103
21. Reuterdahl C Tingström A Terracio L Funa K Heldin C-H Rubin K Characterization of platelet-derived growth factor beta-receptor expressing cells in the vasculature of human rheumatoid synovium Lab Invest 1991 64 321 9
22. Remmers EF Sano H Lafyatis R et al. Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1 J Rheumatol 1991 18 7 13
23. Remmers EF Sano H Wilder RL Platelet-derived growth factors and heparin-binding (fibroblast) growth factors in the synovial tissue pathology of rheumatoid arthritis Semin Arthritis Rheum 1991 21 191 9
24. Sano H Engleka K Mathern P et al. Coexpression of phosphotyrosine-containing proteins, platelet-derived growth factor-B, and fibroblast growth factor-1 in situ in synovial tissues of patients with rheumatoid arthritis and Lewis rats with adjuvant or streptococcal cell wall arthritis J Clin Invest 1993 91 553 65
25. Watanabe N Ando K Yoshida S et al. Gene expression profile analysis of rheumatoid synovial fibroblast cultures revealing the overexpression of genes responsible for tumor-like growth of rheumatoid synovium Biochem Biophys Res Commun 2002 294 1121 9
26. Thornton SC Por SB Penny R Richter M Shelley L Breit SN Identification of the major fibroblast growth factors released spontaneously in inflammatory arthritis as platelet derived growth factor and tumour necrosis factor-alpha Clin Exp Immunol 1991 86 79 86
27. Ohba T Takase Y Ohhara M Kasukawa R Thrombin in the synovial fluid of patients with rheumatoid arthritis mediates proliferation of synovial fibroblast-like cells by induction of platelet derived growth factor J Rheumatol 1996 23 1505 11
28. Nishida K Yoshida Y Itoh M et al. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors Blood 1999 93 1809 16
29. Itoh M Yoshida Y Nishida K Narimatsu M Hibi M Hirano T Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation Mol Cell Biol 2000 20 3695 704
30. Kallin A Demoulin J-B Nishida K Hirano T Ronnstrand L Heldin C-H Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor J Biol Chem 2004 279 17897 904
31. Kameda H Risinger JI Han B-B et al. Identification of epidermal growth factor receptor-Grb2-associated binder-1-SHP-2 complex formation and its functional loss during neoplastic cell progression Cell Growth Diff 2001 12 307 18
32. Kameda H Risinger JI Han B-B et al. Expression of Gab1 lacking the preckstrin homology domain is associated with neoplastic progression Mol Cell Biol 2001 21 6895 905
33. Koi M Afshari CA Annab LA Barrett JC Role of a tumor-suppressor gene in the negative control of anchorage-independent growth of Syrian hamster cells Proc Natl Acad Sci USA 1989 86 8773 7
34. Holgado-Madruga M Emlet DR Moscatello DK Godwin AK Wong AJ A Grb2-associated docking protein in EGF- and insulin-receptor signaling Nature 1996 379 560 4
35. Fixman ED Holgado-Madruga M Nguyen L et al. Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1 J Biol Chem 1997 272 20167 72
36. Ong SH Dilworth S Hauck-Schmalenberger I Pawson T Kiefer F Shc A and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation EMBO J 2001 20 6327 36
37. Sattler M Mohi MG Pride YB et al. Critical role for Gab2 in transformation by BCR/ABL Cancer Cell 2002 1 479 92
38. Podar K Mostoslavsky G Sattler M et al. Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells J Biol Chem 2004 279 21658 65
39. Miyashita T Kawakami A Tamai M et al. Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells Biochem Biophys Res Commun 2003 312 397 404
40. Eklund KK Joensuu H Treatment of rheumatoid arthritis with imatinib mesylate: clinical improvement in three refractory cases Ann Med 2003 35 362 7
41. Miyachi K Ihara A Hankins RW Murai R Maehiro S Miyashita H Efficacy of imatinib mesylate (STI571) treatment for a patient with rheumatoid arthritis developing chronic myelogenous leukemia Clin Rheumatol 2003 22 329 32