ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation

EMBO Journal

Volumn 20, Issue 22, 2001, Pages 6327-6336

  Ong, Siew Hwa ^a,b   Dilworth, Stephen ^c   Hauck Schmalenberger, Ingrid ^d   Pawson, Tony ^a,b   Kiefer, Friedemann ^d  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

Gab l; Hemangioma; Phosphatidylinositol 3 kinase; Phosphorylation; Polyomavirus middle T; ShcA

Indexed keywords

ADAPTOR PROTEIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; POLYPEPTIDE; PROTEIN GAB 1; PROTEIN SHCA; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VIRUS MIDDLE T ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CELL TRANSFORMATION; COMPLEX FORMATION; CONTROLLED STUDY; ENDOTHELIUM; ENZYME ACTIVATION; HEMANGIOMA; MOUSE; NEWBORN; NONHUMAN; POLYOMA VIRUS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, POLYOMAVIRUS TRANSFORMING; BINDING SITES; CELL LINE; DNA; ENDOTHELIUM; FIBROBLASTS; GRB2 ADAPTOR PROTEIN; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; PHOSPHOPROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; PROTEINS; RATS; RATS, INBRED F344; RECEPTOR PROTEIN-TYROSINE KINASES; RETROVIRIDAE; SIGNAL TRANSDUCTION; SOS1 PROTEIN; TIME FACTORS; TRANSFECTION; TYROSINE;

ANIMALIA; DNA VIRUSES; POLYOMAVIRUS;

EID: 0035890056     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.22.6327     Document Type: Article

References (60)

1. Sympathetic hyperplasia and neuroblastomas in transgenic mice expressing polyoma middle T antigen
2. The role of the Shc phosphotyrosine interaction/phosphotyrosine binding domain and tyrosine phosphorylation sites in polyoma middle T antigen-mediated cell transformation
3. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling
4. pp60c-src binding to polyomavirus middle T-antigen (MT) requires residues 185 to 210 of the MT sequence
5. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
6. Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen
7. Mechanisms of angiogenesis and arteriogenesis
8. Transformation by polyoma virus is drastically reduced by substitution of phenylalanine for tyrosine at residue 315 of middle-sized tumor antigen
9. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
10. Human Sosl: A guanine nucleotide exchange factor for Ras that binds to GRB2
11. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation
12. An 81 kd protein complexed with middle T antigen and pp60c-src: A possible phosphatidylinositol kinase
13. Polyoma virus transforming protein associates with the product of the c-src cellular gene
14. Polyoma virus middle T antigen: Meddler or mimic?
15. Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc
16. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins and ephrins in vascular development
17. Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/ mitogen-activated protein kinase activation
18. New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
19. Induction of mammary tumours by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease
20. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein
21. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
22. Sck interacts with KDR and Flt-I via its SH2 domain
23. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
24. Phosphatidylinositol metabolism and polyoma-mediated transformation
25. Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
26. Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis
27. Endothelial cell transformation by polyomavirus middle T antigen in mice lacking Src-related kinases
28. Oncogenic properties of the middle T antigens of polyomaviruses
29. Association of the polyomavirus middle-T antigen with c-yes protein
30. Identification and characterization of p59fyn (a src-like protein tyrosine kinase) in normal and polyoma virus transformed cells
31. The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo
32. Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gabl to receptor tyrosine kinases
33. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
34. Site-directed mutagenesis of polyomavirus middle-T antigen sequences encoding tyrosine 315 and tyrosine 250
35. Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries
36. Formation of transformed endothelial cells in the absence of VEGFR-2/Flk-1 by polyoma middle T oncogene
37. Interaction of Shc with adaptor protein adaptins
38. A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange
39. Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
40. Transforming activity of polyoma virus middle-T antigen probed by site-directed mutagenesis
41. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A
42. Association of polyomavirus middle tumor antigen with 14-13-3 proteins
43. Signaling through scaffold, anchoring and adaptor proteins
44. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
45. A family of Shc related proteins with conserved PTB, CH1 and SH2 regions
46. Biochemical and genetic analysis of the Drk SH2/ SH3 adaptor protein of Drosophila
47. A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family
48. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSosl
49. Coupling of Gabl to c-Met, Grb2 and Shp2 mediates biological responses
50. An SH3-SH2-SH3 protein is required for p21Rasl activation and binds to sevenless and Sos proteins in vitro
51. Association of polyomavirus middle tumor antigen with phospholipase C-τl
52. Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase
53. The PTB domain: A new protein module implicated in signal transduction
54. The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions
55. Association of protein phosphatase 2A with polyoma virus medium tumor antigen
56. The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells
57. Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis
58. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
59. Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene
60. Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis