Phospholipase Cγ2 dosage is critical for B cell development in the absence of adaptor protein BLNK

Journal of Immunology

Volumn 176, Issue 8, 2006, Pages 4690-4698

  Xu, Shengli ^a   Huo, Jianxin ^a   Chew, Weng Keong ^a   Hikida, Masaki ^b   Kurosaki, Tomohiro ^b   Lam, Kong Peng ^a  

^a AGENCY FOR SCIENCE   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN BLNK; B LYMPHOCYTE RECEPTOR; CALCIUM; GENOMIC DNA; IMMUNOGLOBULIN HEAVY CHAIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C GAMMA2; UNCLASSIFIED DRUG; B CELL LINKER PROTEIN; CARRIER PROTEIN; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BONE MARROW CELL; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE DOSAGE; LYMPHOPOIESIS; MACROMOLECULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; SPLEEN CELL; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; ENZYMOLOGY; GENE REARRANGEMENT; GENETICS; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; MOUSE MUTANT; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; B-LYMPHOCYTES; CALCIUM SIGNALING; CARRIER PROTEINS; CELL DIFFERENTIATION; ENZYME ACTIVATION; GENE DOSAGE; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; LYMPHOPOIESIS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEINS;

EID: 33645756083     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.8.4690     Document Type: Article

References (42)

1. Kurosaki, T. 2002. Regulation of B cell fates by BCR signaling components. Curr. Opin. Immunol. 14: 341-347.
2. Niiro, H., and E. A. Clark. 2002. Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2: 945-956.
3. Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature 381: 751-758.
4. Reth, M., and J. Wienands. 1997. Initiation and processing of signals from the B cell antigen receptor. Annu. Rev. Immunol. 15: 453-479.
5. Campbell, K. S. 1999. Signal transduction from the B cell antigen-receptor. Curr. Opin. Immunol. 11: 256-264.
6. Kurosaki, T., and S. Tsukada. 2000. BLNK: connecting Syk and Btk to calcium signals. Immunity 12: 1-5.
7. Fruman, D. A., A. B. Satterthwaite, and O. N. Witte. 2000. Xid-like phenotypes: a B cell signalosome takes shape. Immunity 13: 1-3.
8. Kerner, J. D., M. W. Appleby, R. N. Mohr, S. Chien, D. J. Rawlings, C. R. Maliszewski, O. N. Witte, and R. M. Perlmutter. 1995. Impaired expansion of mouse B cell progenitors lacking Btk. Immunity 3: 301-312.
9. Khan, W. N., F. W. Alt, R. M. Gerstein, B. A. Malynn, I. Larsson, G. Rathbun, L. Davidson, S. Muller, A. B. Kantor, L. A. Herzenberg, et al. 1995. Defective B cell development and function in Btk-deficient mice. Immunity 3: 283-299.
10. Jumaa, H., B. Wollscheid, M. Mitterer, J. Wienands, M. Reth, and P. J. Nielsen. 1999. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity 11: 547-554.
11. Pappu, R., A. M. Cheng, B. Li, Q. Gong, C. Chiu, N. Griffin, M. White, B. P. Sleckman, and A. C. Chan. 1999. Requirement for B cell linker protein (BLNK) in B cell development. Science 286: 1949-1954.
12. Hayashi, K., R. Nittono, N. Okamoto, S. Tsuji, Y. Hara, R. Goitsuka, and D. Kitamura. 2000. The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells. Proc. Natl. Acad. Sci. USA 97: 2755-2760.
13. Xu, S., J. E. Tan, E. P. Wong, A. Manickam, S. Ponniah, and K. P. Lam. 2000. B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice. Int. Immunol 12: 397-404.
14. Wang, D., J. Feng, R. Wen, J. C. Marine, M. Y. Sangster, E. Parganas, A. Hoffmeyer, C. W. Jackson, J. L. Cleveland, P. J. Murray, and J. N. Ihle. 2000. Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors. Immunity 13: 25-35.
15. Hashimoto, A., K. Takeda, M. Inaba, M. Sekimata, T. Kaisho, S. Ikehara, Y. Homma, S. Akira, and T. Kurosaki. 2000. Cutting edge: essential role of phospholipase C-γ2 in B cell development and function. J. Immunol. 165: 1738-1742.
16. Rigley, K. P., M. M. Harnett, R. J. Phillips, and G. G. Klaus. 1989. Analysis of signaling via surface immunoglobulin receptors on B cells from CBA/N mice. Eur. J. Immunol. 19: 2081-2086.
17. Bajpai, U. D., K. Zhang, M. Teutsch, R. Sen, and H. H. Wortis. 2000. Bruton's tyrosine kinase links the B cell receptor to nuclear factor κB activation. J. Exp. Med. 191: 1735-1744.
18. Petro, J. B., S. M. Rahman, D. W. Ballard, and W. N. Khan. 2000. Bruton's tyrosine kinase is required for activation of IκB kinase and nuclear factor κB in response to B cell receptor engagement. J. Exp. Med. 191: 1745-1754.
19. Tan, J. E., S. C. Wong, S. K. Gan, S. Xu, and K. P. Lam. 2001. The adaptor protein BLNK is required for B cell antigen receptor-induced activation of nuclear factor-κB and cell cycle entry and survival of B lymphocytes. J. Biol. Chem. 276: 20055-20063.
20. Hikida, M., S. Johmura, A. Hashimoto, M. Takezaki, and T. Kurosaki. 2003. Coupling between B cell receptor and phospholipase C-γ2 is essential for mature B cell development. J. Exp. Med. 198: 581-589.
21. Jumaa, H., M. Mitterer, M. Reth, and P. J. Nielsen. 2001. The absence of SLP65 and Btk blocks B cell development at the preB cell receptor-positive stage. Eur. J. Immunol. 31: 2164-2169.
22. Lam, K. P., R. Kuhn, and K. Rajewsky. 1997. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90: 1073-1083.
23. Hara, H., C. Bakal, T. Wada, D. Bouchard, R. Rottapel, T. Saito, and J. M. Penninger. 2004. The molecular adapter Carma1 controls entry of IκB kinase into the central immune synapse. J. Exp. Med. 200: 1167-1177.
24. + B cells. J. Immunol. 165: 4153-4157.
25. 2+ influx and membrane depolarization. J. Biol. Chem. 266: 3449-3457.
26. Hardy, R. R., and K. Hayakawa. 2001. B cell development pathways. Annu. Rev. Immunol. 19: 595-621.
27. Coggeshall, K. M., J. C. McHugh, and A. Altman. 1992. Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-γ2 in B lymphocytes. Proc. Natl. Acad. Sci. USA 89: 5660-5664.
28. Roifman, C. M., and G. Wang. 1992. Phospholipase C-γ1 and phospholipase C-γ2 are substrates of the B cell antigen receptor associated protein tyrosine kinase. Biochem. Biophys. Res. Commun. 183: 411-416.
29. Kim, H. K., J. W. Kim, A. Zilberstein, B. Margolis, J. G. Kim, J. Schlessinger, and S. G. Rhee. 1991. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254. Cell 65: 435-441.
30. Finco, T. S., T. Kadlecek, W. Zhang, L. E. Samelson, and A. Weiss. 1998. LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway. Immunity 9: 617-626.
31. Su, Y. W., and H. Jumaa. 2003. LAT links the pre-BCR to calcium signaling. Immunity 19: 295-305.
32. Humphries, L. A., C. Dangelmaier, K. Sommer, K. Kipp, R. M. Kato, N. Griffith, I. Bakman, C. W. Turk, J. L. Daniel, and D. J. Rawlings. 2004. Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cγ Src homology 2-Src homology 3 linker. J. Biol. Chem. 279: 37651-37661.
33. Schweighoffer, E., L. Vanes, A. Mathiot, T. Nakamura, and V. L. Tybulewicz. 2003. Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion. Immunity 18: 523-533.
34. Wen, R., Y. Chen, L. Xue, J. Schuman, S. Yang, S. W. Morris, and D. Wang. 2003. Phospholipase Cγ2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells. J. Biol. Chem. 278: 43654-43662.
35. Fu, C., C. W. Turck, T. Kurosaki, and A. C. Chan. 1998. BLNK: a central linker protein in B cell activation. Immunity 9: 93-103.
36. Johmura, S., M. Oh-hora, K. Inabe, Y. Nishikawa, K. Hayashi, E. Vigorito, D. Kitamura, M. Turner, K. Shingu, M. Hikida, and T. Kurosaki. 2003. Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNK. Immunity 18: 777-787.
37. Thompson, J. S., S. A. Bixler, F. Qian, K. Vora, M. L. Scott, T. G. Cachero, C. Hession, P. Schneider, I. D. Sizing, C. Mullen, et al. 2001. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293: 2108-2111.
38. Wen, R., Y. Chen, J. Schuman, G. Fu, S. Yang, W. Zhang, D. K. Newman, and D. Wang. 2004. An important role of phospholipase Cγ1 in pre-B-cell development and allelic exclusion. EMBO J. 23: 4007-4017.
39. Chiu, C. W., M. Dalton, M. Ishiai, T. Kurosaki, and A. C. Chan. 2002. BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins. EMBO J. 21: 6461-6472.
40. Hashimoto, S., A. Iwamatsu, M. Ishiai, K. Okawa, T. Yamadori, M. Matsushita, Y. Baba, T. Kishimoto, T. Kurosaki, and S. Tsukada. 1999. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK-functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling. Blood 94: 2357-2364.
41. Su, Y. W., Y. Zhang, J. Schweikert, G. A. Koretzky, M. Reth, and J. Wienands. 1999. Interaction of SLP adaptors with the SH2 domain of Tec family kinases. Eur. J. Immunol 29: 3702-3711.
42. Whyburn, L. R., K. E. Halcomb, C. M. Contreras, R. Pappu, O. N. Witte, A. C. Chan, and A. B. Satterthwaite. 2003. Haploinsufficiency of B cell linker protein enhances B cell signaling defects in mice expressing a limiting dosage of Bruton's tyrosine kinase. Int. Immunol. 15: 383-392.