Mechanisms of cytochrome P450 regulation by inflammatory mediators

Toxicology

Volumn 181, Issue 182, 2002, Pages 207-210

  Morgan, Edward T ^a   Li Masters, Tong ^a   Cheng, Po Yung ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytochrome P450; Gene regulation; Inflammation; Nitric oxide

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYTOCHROME P450; CYTOCHROME P450 2B1; CYTOCHROME P450 2C; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NITRIC OXIDE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DISEASE MODEL; DOWN REGULATION; ENZYME REPRESSION; GENETIC TRANSCRIPTION; INFECTION; INFLAMMATION; LIVER CELL; LIVER LEVEL; MEDIATOR; MOLECULAR MECHANICS; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROCESSING; REGULATORY MECHANISM; REPORTER GENE; TRANSCRIPTION REGULATION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DOWN-REGULATION; HUMANS; INFLAMMATION MEDIATORS; MICE; NITRIC OXIDE; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS);

EID: 0037184799     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00283-4     Document Type: Article

References (11)

1. Delaporte E., Renton K.W. Cytochrome P4501A1 and cytochrome P4501A2 are downregulated at both transcriptional and post-transcriptional levels by conditions resulting in interferon-α/β induction. Life Sci. 60:1997;787-796.
2. Ferrari L., Peng N., Halpert J.R., Morgan E.T. Role of nitric oxide in down-regulation of CYP2B1 protein, but not RNA, in primary cultures of rat hepatocytes. Mol. Pharmacol. 60:2001;209-216.
3. Iber H., Chen Q., Morgan E.T. Suppression of CYP2C11 gene transcription by interleukin-1 mediated by NF-κB binding at the transcription start site. Arch. Biochem. Biophys. 377:2000;187-194.
4. Liaudet L., Soriano F.G., Szabo C. Biology of nitric oxide signaling. Crit. Care Med. 28:2000;N37-N52.
5. Morgan E.T. Suppression of constitutive cytochrome P-450 gene expression in livers of rats undergoing an acute phase response to endotoxin. Mol. Pharmacol. 36:1989;699-707.
6. Morgan E.T. Regulation of cytochromes P450 during inflammation and infection. Drug Metab. Rev. 29:1997;1129-1188.
7. Morgan E.T. Regulation of cytochrome P450 by inflammatory mediators: why and how? Drug Metab. Dispos. 29:2001;207-212.
8. Pascussi J.M., Gerbal-Chaloin S., Pichard-Garcia L., Daujat M., Fabre J.M., Maurel P., Vilarem M.J. Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. Biochem. Biophys. Res. Commun. 274:2000;707-713.
9. Roberts E.S., Lin H.L., Crowley J.R., Vuletich J.L., Osawa Y., Hollenberg P.F. Peroxynitrite-mediated nitration of tyrosine and inactivation of the catalytic activity of cytochrome P450 2B1. Chem. Res. Toxicol. 11:1998;1067-1074.
10. Wink D.A., Osawa Y., Darbyshire J.F., Jones C.R., Eshenaur S.C., Nims R.W. Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent. Arch. Biochem. Biophys. 300:1993;115-123.
11. Wright K., Morgan E.T. Transcriptional and post-transcriptional suppression of P450IIC11 and P450IIC12 by inflammation. FEBS Lett. 271:1990;59-61.