Mineral changes in osteoporosis: A review

Clinical Orthopaedics and Related Research

Volumn 443, Issue , 2006, Pages 28-38

  Faibish, Dan ^a   Ott, Susan M ^b   Boskey, Adele L ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CALCITONIN; CALCIUM; ESTROGEN; ETIDRONIC ACID; FLUORIDE; GROWTH FACTOR; IBANDRONIC ACID; ISOFLAVONE DERIVATIVE; MINERAL; NANDROLONE DECANOATE; PAMIDRONIC ACID; PARATHYROID HORMONE; PHYTOESTROGEN; PROGESTERONE; RALOXIFENE; RISEDRONIC ACID; SOMATOMEDIN C; TILUDRONIC ACID; VITAMIN D; ZOLEDRONIC ACID;

BIOPSY; BONE MINERALIZATION; BONE STRENGTH; CONFERENCE PAPER; FRACTURE; HIP FRACTURE; HORMONE SUBSTITUTION; HUMAN; INFRARED RADIATION; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; SPECTROSCOPY; ANIMAL; BONE; BONE DENSITY; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; BIOPSY; BONE AND BONES; BONE DENSITY; HUMANS; MINERALS; OSTEOPOROSIS; SPECTRUM ANALYSIS;

EID: 33645301619     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/01.blo.0000200241.14684.4e     Document Type: Conference Paper

References (130)

1. Akkus O, Adar F, Schaffler MB. Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone. Bone. 2004;34:443-453.
2. Aparicio S, Doty SB, Camacho NP, Paschalis EP, Spevak L, Mendelsohn R, Boskey AL. Optimal methods for processing mineralized tissues for Fourier transform infrared microspectroscopy. Calcif Tissue Int. 2002;70:422-429.
3. Atti E, Boskey AL, Canalis E. Over-expression of IGF-binding protein 5 alters mineral and matrix properties in mouse tibia: An infrared imaging study. Calcif Tissue Int. 2004;76:187-193.
4. Bagi CM, Ammann P, Rizzoli R, Miller SC. Effect of estrogen deficiency on cancellous and cortical bone structure and strength of the femoral neck in rats. Calcif Tissue Int. 1997;61:336-344.
5. Bailey AJ, Wotton SF, Sims TJ, Thompson PW. Biochemical changes in the collagen of human osteoporotic bone matrix. Connect Tissue Res. 1993;29:119-132.
6. Baud CA, Very JM, Courvoisier B. Biophysical study of bone mineral in biopsies of osteoporotic patients before and after long-term treatment with fluoride. Bone. 1988;93:61-65.
7. Blank RD, Baldini TH, Kaufman M, Bailey S, Gupta R, Yershov Y, Boskey AL, Coppersmith SN, Demant P, Paschalis EP. Spectroscopically determined collagen Pyr/deH-DHLNL cross-link ratio and crystallinity indices differ markedly in recombinant congenic mice with divergent calculated bone tissue strength. Connect Tissue Res. 2003;44:134-142.
8. Bloebaum RD, Skedros JG, Vajda EG, Bachus KN, Constantz BR. Determining mineral content variations in bone using backscattered electron imaging. Bone. 1997;20:485-490.
9. Bohic S, Rey C, Legrand A, Sfihi H, Rohanizadeh R, Martel C, Barbier A, Daculsi G. Characterization of the trabecular rat bone mineral: effect of ovariectomy and bisphosphonate treatment. Bone. 2000;26:341-348.
10. Boivin GY, Chavassieux PM, Santora AC, Yates J, Meunier PJ. Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women. Bone. 2000;27:687-694.
11. Boivin G, Deloffre P, Perrat B, Panczer G, Boudeulle M, Mauras Y, Allain P, Tsouderos Y, Meunier PJ. Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration. J Bone Miner Res. 1996;11:1302-1311.
12. Boivin G, Lips P, Ott SM, Harper KD, Sarkar S, Pinette KV, Meunier PJ. Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women. J Clin Endocrinol Metab. 2003;884:199-205.
13. Boivin G, Meunier PJ. The mineralization of bone tissue: a forgotten dimension in osteoporosis research. Osteoporos Int. 2003;14:S19-S24.
14. Boskey AL. Bone Mineralization. In: Cowin SC, ed. Bone Biomechanics. Ed 3. Boca Raton: CRC Press; 2001:5.1-5.34.
15. Boskey A, DiCarlo E, Paschalis E, West P, Mendelsohn R. Comparison of mineral quality and quantity in iliac crest biopsies from high-turnover and low-turnover osteoporosis: an ft-ir microspectroscopic investigation. Osteoporos Int. 2005 Aug 9; [Epub ahead of print].
16. Boskey AL, Mendelsohn R. Infrared Analysis of Bone in Health and Disease. J Biomed Opt. 2004. In press.
17. Boskey AL, Moore DJ, Amling M, Canalis E, Delaney AM. Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls. J Bone Miner Res. 2003;18:1005-1011.
18. Boyde A, Kingsmill VJ. Age changes in bone. Gerodontology. 1998;15:25-34.
19. Branca F. Dietary phyto-oestrogens and bone health. Proc Nutr Soc. 2003;62:877-887.
20. Brown CE, Srinivasan R, Sigmann P, Myklebust JB, Battocletti JH. Comparison of the compression strength of human vertebral bodies with the mass and density of apatite: A study by 31P NMR spectroscopy. Clin Chem. 1988;34:2114-2117.
21. Broulik PD, Rosenkrancova J, Ruzicka P, Sedlacek R. Effects of triiodothyronine and estrogen administration on bone mass, mineral content and bone strength in male rats. Horm Metab Res. 2003;35:527-531.
22. Burnell JM, Baylink DJ, Chestnut CH III, Mathews MW, Teubner EJ. Bone matrix and mineral abnormalities in postmenopausal osteoporosis. Metabolism. 1982;31:1113-1120.
23. Burr DB, Miller L, Grynpas M, Li J, Boyde A, Mashiba T, Hirano T, Johnston CC. Tissue mineralization is increased following 1-year treatment with high doses of bisphosphonates in dogs. Bone. 2003;33:960-969.
24. Carden A, Morris MD. Application of vibrational spectroscopy to the study of mineralized tissues (review). J Biomed Opt. 2000;5:259-268.
25. Cefalu CA. Is bone mineral density predictive of fracture risk reduction? Curr Med Res Opin. 2004;20:341-349.
26. Chachra D, Turner CH, Dunipace AJ, Grynpas MD. The effect of fluoride treatment on bone mineral in rabbits. Calcif Tissue Int. 1999;4:345-351.
27. Chatterji S, Wall JC, Jeffery JW. Age-related changes in the orientation and particle size of the mineral phase in human femoral cortical bone. Calcif Tissue Int. 1981;33:567-574.
28. Cho G, Wu Y, Ackerman JL. Detection of hydroxyl ions in bone mineral by solid-state NMR spectroscopy. Science. 2003;300:1123-1127.
29. Civitelli R. In vitro and in vivo effects of ipriflavone on bone formation and bone biomechanics. Calcif Tissue Int. 1997;61:S12-S14.
30. Cohen L, Kitzes R. Infrared spectroscopy and magnesium content of bone mineral in osteoporotic women. Isr J Med Sci. 1981;17:1123-1125.
31. Conover CA, Johnstone EW, Turner RT, Evans GL, John Ballard FJ, Doran PM, Khosla S. Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis. Growth Horm IGF Res. 2002;12:178-183.
32. Coxam V. Prevention of osteopaenia by phyto-oestrogens: Animal studies. Br J Nutr. 2003;89:S75-S85.
33. Cummings SR, Eckert S, Krueger KA, Grady D, Powles TJ, Cauley JA, Norton L, Nickelsen T, Bjarnason NH, Morrow M, Lippman ME, Black D, Glusman JE, Costa A, Jordan VC. The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. JAMA. 1999;281:2189-2197.
34. Currey JD. Effects of differences in mineralization on the mechanical properties of bone. Phil Tran R Soc London. 1984;B304:509-518.
35. Currey JD. The many adaptations of bone. J Biomech. 2003;36:1487-1495.
36. Dalle Carbonare L, Giannini S. Bone microarchitecture as an important determinant of bone strength. J Endocrinol Invest. 2004;27:99-105.
37. Dawson-Hughes B, Dallal GE, Krall EA, Harris S, Sokoll LJ, Falconer G. Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Ann Intern Med. 1991;115:505-512.
38. de Mul FF, Hottenhuis MH, Bouter P, Greve J, Arends J, ten Bosch JJ. Micro-Raman line broadening in synthetic carbonated hydroxyapatite. J Dent Res. 1986;65:437-440.
39. Dresner-Pollak R, Gelb N, Rachmilewitz D, Karmeli F, Weinreb M. Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bones. Gastroenterology. 2004;127:792-801.
40. Eastell R, Blumsohn A. The value of biochemical markers of bone turnover in osteoporosis. J Rheumatol. 1997;24:1215-1217.
41. Eriksen EF, Melsen F, Sod E, Barton I, Chines A. Effects of long-term risedronate on bone quality and bone turnover in women with postmenopausal osteoporosis. Bone. 2002;31:620-625.
42. Ettinger MP. Aging bone and osteoporosis: Strategies for preventing fractures in the elderly. Arch Intern Med. 2003;163:2237-2246.
43. Ettinger B, Black DM, Mitlak BH, Knickerbocker RK, Nickelsen T, Genant HK, Christiansen C, Delmas PD, Zanchetta JR, Stakkestad J, Gluer CC, Krueger K, Cohen FJ, Eckert S, Ensrud KE, Avioli LV, Lips P, Cummings SR. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: Results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. JAMA. 1999;282:637-645.
44. Faibish D, Gomez A, Boivin G, Binderman I, Boskey A. Infrared imaging of calcified tissue in bone biopsies from adults with osteomalacia. Bone. 2005;36:6-12.
45. Fernandez D, Vega D, Goeta A. Alendronate zwitterions bind to calcium cations arranged in columns. Acta Crystallogr C. 2003;59:m543-m545.
46. Follet H, Boivin G, Rumelhart C, Meunier PJ. The degree of mineralization is a determinant of bone strength: a study on human calcanei. Bone. 2004;34:783-789.
47. Fratzl P, Roschger P, Eschberger J, Abendroth B, Klaushofer K. Abnormal bone mineralization after fluoride treatment in osteoporosis: A small-angle x-ray-scattering study. J Bone Miner Res. 1994;9:1541-1549.
48. Gadeleta SJ, Boskey AL, Paschalis E, Carlson C, Menschik F, Baldini T, Peterson M, Rimnac CM. A physical, chemical, and mechanical study of lumbar vertebrae from normal, ovariectomized, and nandrolone decanoate-treated cynomolgus monkeys (Macaca fascicularis). Bone. 2000;27:541-550.
49. Gadaleta SJ, Paschalis EP, Betts F, Mendelsohn R, Boskey AL. Fourier transform infrared spectroscopy of the solution-mediated conversion of amorphous calcium phosphate to hydroxyapatite: New correlations between X-ray diffraction and infrared data. Calcif Tissue Int. 1996;58:9-16.
50. Gao H, Ji B, Jager IL, Arzt E, Fratzl P. Materials become insensitive to flaws at nanoscale: Lessons from nature. Proc Natl Acad Sci U S A. 2003;100:5597-5600.
51. Giardino R, Fini M, Nicoli Aldini N, Gnudi S, Biagini G, Gandolfi MG, Mongiorgi R. Effects of synthetic salmon calcitonin and alendronate on bone quality in ovariectomized rats. Minerva Med. 1997;88:469-477.
52. Glatt M, Pataki A, Evans GP, Hornby SB, Green JR. Loss of vertebral bone and mechanical strength in estrogen-deficient rats is prevented by long-term administration of zoledronic acid. Osteoporos Int. 2004;15:707-715.
53. Grynpas MD, Acito A, Dimitriu M, Mertz BP, Very JM. Changes in bone mineralization, architecture and mechanical properties due to long-term (1 year) administration of pamidronate (APD) to adult dogs. Osteoporos Int. 1992;2:74-81.
54. Grynpas MD, Holmyard D. Changes in quality of bone mineral on aging and in disease. Scanning Microsc. 1988;2:1045-1054.
55. Grynpas MD, Huckell B, Pritzker KP, Hancock RG, Kessler MJ. Bone mineral and osteoporosis in aging rhesus monkeys. P R Health Sci J. 1989;8:197-204.
56. Grynpas MD, Marie PJ. Effects of low doses of strontium on bone quality and quantity in rats. Bone. 1990;11:313-319.
57. Grynpas MD, Rey C. The effect of fluoride treatment on bone mineral crystals in the rat. Bone. 1992;13:423-429.
58. Hassenkam T, Fantner GE, Cutroni JA, Weaver JC, Morse DE, Hansma PK. High-resolution AFM imaging of intact and fractured trabecular bone. Bone. 2004;35:4-10.
59. Hirabayashi H, Fujisaki J. Bone-specific drug delivery systems: Approaches via chemical modification of bone-seeking agents. Clin Pharmacokinet. 2003;42:1319-1330.
60. Hornby SB, Evans GP, Hornby SL, Pataki A, Glatt M, Green JR. Long-term zoledronic acid treatment increases bone structure and mechanical strength of long bones of ovariectomized adult rats. Calcif Tissue Int. 2003;72:519-527.
61. Huang RY, Miller LM, Carlson CS, Chance MR. Characterization of bone mineral composition in the proximal tibia of cynomolgus monkeys: Effect of ovariectomy and nandrolone decanoate treatment. Bone. 2002;30:492-497.
62. Huang RY, Miller LM, Carlson CS, Chance MR. In situ chemistry of osteoporosis revealed by synchrotron infrared microspectroscopy. Bone. 2003;33:514-521.
63. Hudelmaier M, Kuhn V, Lochmuller EM, Well H, Priemel M, Link TM, Eckstein F. Can geometry-based parameters from pQCT and material parameters from quantitative ultrasound (QUS) improve the prediction of radial bone strength over that by bone mass (DXA)? Osteoporos Int. 2004;15:375-381.
64. Jarvis MF, Burns CJ, Pauls HW, Assal A, Kim JS, Cheney DL, Youssefyeh RD. Characterization of the bisphosphonate recognition site on hydroxyapatite using radioligand binding techniques with [14C] citric acid. Calcif Tissue Int. 1993;52:372-377.
65. Jerome CP. Hormonal therapies and osteoporosis. ILAR J. 2004;45:170-178.
66. Jerome CP, Carlson CS, Jayo MJ, Register TC, Weaver DS, Lees CJ, Adams MR. Histomorphometric and mineral density fractionation studies of lumbar vertebrae of intact and ovariectomized (OVX) monkeys. Bone Miner. 1994;26:275-278.
67. Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002;359:1929-1936.
68. Kim HJ, Bae YC, Park RW, Choi SW, Cho SH, Choi YS, Lee WJ. Bone-protecting effect of safflower seeds in ovariectomized rats. Calcif Tissue Int. 2002;71:88-94.
69. Koh LK, Ng DC. Osteoporosis risk factor assessment and bone densitometry: Current status and future trends. Ann Acad Med Singapore. 2002;31:37-42.
70. Koivukangas A, Tuukkanen J, Hannuniemi R, Jamsa T, Kippo K, Jalovaara P. Effects of long-term administration of clodronate on growing rat bone. Calcif Tissue Int. 2001;69:350-355.
71. Kolosova NG, Kutorgin GD, Safina AF. Bone mineralization in senescence-accelerated OXYS rats. Bull Exp Biol Med. 2002;133:171-174.
72. Komatsubara S, Mori S, Mashiba T, Li J, Nonaka K, Kaji Y, Akiyama T, Miyamoto K, Cao Y, Kawanishi J, Norimatsu H. Suppressed bone turnover by long-term bisphosphonate treatment accumulates microdamage but maintains intrinsic material properties in cortical bone of dog rib. J Bone Miner Res. 2004;19:999-1005.
73. Lanyon L, Armstrong V, Ong D, Zaman G, Price J. Is estrogen receptor alpha key to controlling bones' resistance to fracture? J Endocrinol. 2004;182:183-191.
74. Lewis EN, Kidder LH, Levin IW, Kalasinsky VF, Hanig JP, Lester DS. Applications of Fourier transform infrared imaging microscopy in neurotoxicity. Ann N Y Acad Sci. 1997;820:234-246.
75. Marcott C, Reeder RC, Paschalis EP, Tatakis DN, Boskey AL, Mendelsohn R. Infrared microspectroscopic imaging of biomineralized tissues using a mercury-cadmium-telluride focal-plane array detector. Cell Mol Biol. 1998;44:109-115.
76. McCalden RW, McGeough JA, Court-Brown CM. Age-related changes in the compressive strength of cancellous bone. The relative importance of changes in density and trabecular architecture. J Bone Joint Surg. 1997;79A:421-427.
77. Mendelsohn R, Paschalis EP, Boskey AL. Infrared spectroscopy, microscopy, and microscopic imaging of mineralizing tissues: Spectra-structure correlations from human iliac crest biopsies. J Biomed Opt. 1999;4:14-21.
78. Meunier PJ, Boivin G. Bone mineral density reflects bone mass but also the degree of mineralization of bone: Therapeutic implications. Bone. 1997;21:373-377.
79. Miller LM, Novatt JT, Hamerman D, Carlson CS. Alterations in mineral composition observed in osteoarthritic joints of cynomolgus monkeys. Bone. 2004;35:498-506.
80. Mongiorgi R, Maggi G, Bertocchi G, Moroni A, Rollo G, Gnudi S, Ponziani L, Coppola G. Influence of calcitonin treatment on the bone structure and mineral content in osteoarthritis. Boll Soc Ital Biol Sper. 1992;68:85-89.
81. Monier-Faugere MC, Geng Z, Paschalis EP, Qi Q, Arnala I, Bauss F, Boskey AL, Malluche HH. Intermittent and continuous administration of the bisphosphonate ibandronate in ovariohysterectomized beagle dogs: Effects on bone morphometry and mineral properties. J Bone Miner Res. 1999;14:1768-1778.
82. Myers ER, Sebeny EA, Hecker AT, Corcoran TA, Hipp JA, Greenspan SL, Hayes WC. Correlations between photon absorption properties and failure load of the distal radius in vitro. Calcif Tissue Int. 1991;49:292-297.
83. Nagant de Deuxchaisnes C, Devogelaer JP, Depresseux G, Malghem J, Maldague B. Treatment of the vertebral crush fracture syndrome with enteric-coated sodium fluoride tablets and calcium supplements. J Bone Miner Res. 1990;51:S5-S26.
84. Nisslein T, Freudenstein J. Effects of an isopropanolic extract of Cimicifuga racemosa on urinary crosslinks and other parameters of bone quality in an ovariectomized rat model of osteoporosis. J Bone Miner Metab. 2003;21:370-376.
85. Nguyen TV. Center JR, Pocock NA, Eisman JA. Limited utility of clinical indices for the prediction of symptomatic fracture risk in postmenopausal women. Osteoporos Int. 2004;15:49-55.
86. O'Brien KO. Combined calcium and vitamin D supplementation reduces bone loss and fracture incidence in older men and women. Nutr Rev. 1998;56:148-150.
87. Okamoto Y, Hidaka S, Yamada Y, Ouchi K, Miyazaki K, Liu SY. Thermal analysis of bones from ovariectomized rats. J Biomed Mater Res. 1998;41:221-226.
88. Ortoft G, Oxlund H. Qualitative alterations of cortical bone in female rats after long-term administration of growth hormone and glucocorticoid. Bone. 1996;18:581-590.
89. Ou-Yang H, Paschalis EP, Boskey AL, Mendelsohn R. Chemical structure-based 3D reconstruction of human cortical bone from 2D-IR Images. Appl Spectrosc. 2002;56:419-422.
90. Ou-Yang H, Sherman PJ, Paschalis EP, Boskey AL, Mendelsohn R. Fourier transform infrared microscopic imaging: effects of estrogen and estrogen deficiency on fracture healing in rat femurs. Appl Spectrosc. 2004;58:1-9.
91. Paschalis EP, Betts F, DiCarlo E, Mendelsohn R, Boskey AL. FTIR microspectroscopic analysis of human iliac crest biopsies from untreated osteoporotic bone. Calcif Tissues Int. 1997;61:487-492.
92. Paschalis EP, Boskey AL, Kassem M, Eriksen EF. Effect of hormone replacement therapy on bone quality in early postmenopausal women. J Bone Miner Res. 2003;18:955-959.
93. Paschalis EP, Burr DB, Mendelsohn R, Hock JM, Boskey AL. Bone mineral and collagen quality in humeri of ovariectomized cynomolgus monkeys given rhPTH(1-34) for 18 months. J Bone Miner Res. 2003;18:769-775.
94. Paschalis EP, Recker R, DiCarlo E, Doty SB, Atti E, Boskey AL. Distribution of collagen cross-links in normal human trabecular bone. J Bone Miner Res. 2003;18:1942-1946.
95. Paschalis EP, Shane E, Lyritis G, Skarantavos G, Mendelsohn R, Boskey AL. Bone Fragility and collagen cross-links. J Bone Miner Res. 2004;19:2000-2004.
96. Paschalis EP, Verdelis K, Doty SB, Boskey AL, Mendelsohn R, Yamauchi M. Spectroscopic characterization of collagen crosslinks in bone. J Bone Miner Res. 2001;16:1821-1828.
97. Patlas N, Zadik Y, Yaffe P, Schwartz Z, Ornoy A. Oophorectomy-induced osteopenia in rats in relation to age and time postoophorectomy. Cells Tissues Organs. 2000;166:267-274.
98. Penel G, Leroy G, Rey C, Bres E. MicroRaman spectral study of the PO4 and CO3 vibrational modes in synthetic and biological apatites. Calcif Tissue Int. 1998;63:475-481.
99. Peng Z, Tuukkanen J, Zhang H, Jamsa T, Vaananeo HK. The mechanical strength of bone in different rat models of experimental osteoporosis. Bone. 1994;15:523-532.
100. Picherit C, Coxam V, Bennetau-Pelissero C, Kati-Coulibaly S, Davicco MJ, Lebecque P, Barlet JP. Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats. J Nutr. 2000;130:1675-1681.
101. Pienkowski D, Doers TM, Monier-Faugere MC, Geng Z, Camacho NP, Boskey AL, Malluche HH. Calcitonin alters bone quality in beagle dogs. J Bone Miner Res. 1997;12:1936-1943.
102. Pitkin J, Rees MC, Gray S, Lumsden MA, Stevenson J, Williamson J; Writing Group for the British Menopause Society Council. Managing the menopause - British Menopause Society Council consensus statement on hormone replacement therapy. J Br Menopause Soc. 2003;9:129-131.
103. Register TC. Jayo MJ, Anthony MS: Soy phytoestrogens do not prevent bone loss in postmenopausal monkeys. J Clin Endocrinol Metab. 2003;88:4362-4370.
104. Rey C, Collins B, Goehl T, Dickson IR, Glimeher MJ: The carbonate environment in bone mineral: a resolution-enhanced Fourier transform infrared spectroscopy study. Calcif Tissue Int. 1989;45:157-164.
105. Rey C, Shimizu M, Collins B, Glimcher MJ. Resolution-enhanced Fourier transform infrared spectroscopy study of the environment of phosphate ion in the early deposits of a solid phase of calcium phosphate in bone and enamel and their evolution with age: 2. Investigations in the nu3PO4 domain. Calcif Tissue Int. 1991;49:383-388.
106. Riggs BL, Baylink DJ, Kleerekoper M, Lane JM, Melton LJ 3rd, Meunier PJ. Incidence of hip fractures in osteoporotic women treated with sodium fluoride. J Bone Miner Res. 1987;2:123-126.
107. Rohanizadeh R, LeGeros RZ, Bohic S, Pilet P, Barbier A, Daculsi G. Ultrastructural properties of bone mineral of control and tiludronate-treated osteoporotic rat. Calcif Tissue Int. 2000;67:330-336.
108. Roschger P, Fratzl P, Klaushofer K, Rodan G. Mineralization of cancellous bone after alendronate and sodium fluoride treatment: A quantitative backscattered electron imaging study on minipig ribs. Bone. 1997;20:393-397.
109. Roschger P, Matsuo K, Misof BM, Tesch W, Jochum W, Wagner EF, Fratzl P, Klaushofer K. Normal mineralization and nanostructure of sclerotic bone in mice overexpressing Fra-1. Bone. 1997;34:776-782.
110. Roschger P, Rinnerthaler S, Yates J, Rodan GA, Fratzl P, Klaushofer K. Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone. 2001;29:185-191.
111. Rosen HN, Chen V, Cittadini A, Greenspan SL, Douglas PS, Moses AC, Beamer WG. Treatment with growth hormone and IGF-I in growing rats increases bone mineral content but not bone mineral density. J Bone Miner Res. 1995;10:1352-1358.
112. Russell RG, Rogers MJ. Bisphosphonates: from the laboratory to the clinic and back again. Bone. 1999;25:97-106.
113. Sato M, Westmore M, Clendenon J, Smith S, Hannum B, Zeng GQ, Brommage R, Turner CH. Three-dimensional modeling of the effects of parathyroid hormone on bone distribution in lumbar vertebrae of ovariectomized cynomolgus macaques. Osteoporos Int. 2000;11:871-880.
114. Shapiro R, Heaney RP. Co-dependence of calcium and phosphorus for growth and bone development under conditions of varying deficiency. Bone. 2003;32:532-540.
115. Staren ED, Omer S. Hormone replacement therapy in postmenopausal women. Am J Surg. 2004;188:136-149.
116. Tannenbaum PJ, Schraer H, Posner AS. Crystalline changes in avian bone related to the reproductive cycle. II. Percent crystallinity changes. Calcif Tissue Res. 1974;14:83-86.
117. Tarnowski CP, Ignelzi MA Jr, Morris MD. Mineralization of developing mouse calvaria as revealed by Raman microspectroscopy. J Bone Miner Res. 2002;17:1118-1126.
118. Thompson DD, Posner AS, Laughlin WS, Blumenthal NC. Comparison of bone apatite in osteoporotic and normal Eskimos. Calcif Tissue Int. 1983;35:392-393.
119. Tong W, Glimcher MJ, Katz JL, Kuhn L, Eppell SJ. Size and shape of mineralites in young bovine bone measured by atomic force microscopy. Calcif Tissue Int. 2003;72:592-598.
120. Tsaih SW, Korrick S, Schwartz J, Lee ML, Amarasiriwardena C, Aro A, Sparrow D, Hu H. Influence of bone resorption on the mobilization of lead from bone among middle-aged and elderly men: The Normative Aging Study. Environ Health Perspect. 2001;109:995-999.
121. Turner CH, Garetto LP, Dunipace AJ, Zhang W, Wilson ME, Grynpas MD, Chachra D, McClintock R, Peacock M, Stookey GK. Fluoride treatment increased serum IGF-1, bone turnover, and bone mass, but not bone strength, in rabbits. Calcif Tissue Int. 1997;61:77-83.
122. Turner IG, Jenkins GM. The spatial arrangement of bone mineral as revealed by ion bombardment. Biomaterials. 1981;2:234-238.
123. U.S. Department of Health and Human Services. Bone Health and Osteoporosis. A report of the US Surgeon General, Rockville MD, 2004.
124. van der Linden JC, Day JS, Verhaar JA, Weinans H. Altered tissue properties induce changes in cancellous bone architecture in aging and diseases. J Biomech. 2004;37:367-374.
125. Vanderschueren D, Van Herck E, Schot P, Rush E, Einhorn T, Geusens P, Bouillon R. The aged male rat as a model for human osteoporosis: Evaluation by nondestructive measurements and biomechanical testing. Calcif Tissue Int. 1993;53:342-347.
126. Wachter NJ, Augat P, Krischak GD, Mentzel M, Kinzl L, Claes L. Prediction of cortical bone porosity in vitro by microcomputed tomography. Calcif Tissue Int. 2001;68:38-42.
127. Wallach S, Rousseau G, Martin L, Azria M. Effects of calcitonin on animal and in vitro models of skeletal metabolism. Bone. 1999;25:509-516.
128. Wu Y, Ackerman JL, Strawich ES, Rey C, Kim HM, Glimcher MJ. Phosphate ions in bone: Identification of a calcium-organic phosphate complex by 31P solid-state NMR spectroscopy at early stages of mineralization. Calcif Tissue Int. 2003;72:610-626.
129. Yudoh K, Nishioka K. Telomerized presenescent osteoblasts prevent bone mass loss in vivo. Gene Ther. 2004;11:909-915.
130. Xu T, Bianco P, Fisher LW, Longenecker G, Smith E, Goldstein S, Bonadio J, Boskey A, Heegaard AM, Sommer B, Satomura K, Dominguez P, Zhao C, Kulkarni AB, Robey PG, Young MF. Targeted disruption of the biglycan gene leads to osteoporosis in mice. Nat Genet. 1998;20:78-86.