Detection of hydroxyl ions in bone mineral by solid-state NMR spectroscopy

Science

Volumn 300, Issue 5622, 2003, Pages 1123-1127

  Cho, Gyunggoo ^a,b   Wu, Yaotang ^a,b,c   Ackerman, Jerome L ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CRYOGENICS; CRYSTAL LATTICES; HYDROXYAPATITE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STOICHIOMETRY; WATER;

HYDROXYL IONS;

IONS;

CALCIUM ION; HYDROXYAPATITE; HYDROXYL GROUP; PROTON;

BIOCHEMISTRY; BONE;

ANALYTIC METHOD; ARTICLE; BONE; BONE MATRIX; BONE METABOLISM; BONE MINERAL; CORTICAL BONE; CRYSTAL STRUCTURE; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOLID STATE; STOICHIOMETRY;

ANIMALS; BONE AND BONES; BONE DENSITY; CALCIUM PHOSPHATES; CATTLE; CRYSTALLIZATION; HUMANS; HYDROXIDES; MAGNETIC RESONANCE SPECTROSCOPY; MINERALS; RATS;

MAMMALIA;

EID: 0038287424     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1078470     Document Type: Article

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25. We thank J. P. Yesinowski, M. J. Glimcher, P. V. Hauschka, and C. E. Bronnimann for insightful discussions, and R. Millea for assistance with procurement of the human bone specimens. A. Bielecki and D. Rice obtained preliminary demonstration spectra of test specimens. Supported by NIH grants AR42258 (National Institute of Arthritis, Musculoskeletal, and Skin Disorders) and RR03264 (Division of Research Resources).