Effects of Triiodothyronine and Estrogen Administration on Bone Mass, Mineral Content and Bone Strength in Male Rats

Hormone and Metabolic Research

Volumn 35, Issue 9, 2003, Pages 527-531

  Broulik, P D ^a   Rosenkrancova J ^b   Ruzicka P ^b   Sedlacek R ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b CZECH TECHNICAL UNIVERSITY IN PRAGUE   (Czech Republic)

Author keywords

Bone Mineral Density; Estradiol; Hyperthyroidism; Male Rats; Mechanical Strength

Indexed keywords

ESTRADIOL BENZOATE; LIOTHYRONINE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MASS; BONE MINERAL; BONE STRENGTH; CONTROLLED STUDY; CORTICAL BONE; DRUG EFFECT; ESTROGEN ACTIVITY; FEMUR; HORMONAL REGULATION; HYPERTHYROIDISM; MALE; NONHUMAN; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; RAT; SEMINAL VESICLE; SKELETON; TESTOSTERONE BLOOD LEVEL; THICKNESS;

ANIMALS; BONE DENSITY; BONE DISEASES, METABOLIC; BONE RESORPTION; ESTRADIOL; HYPERTHYROIDISM; MALE; MATCHED-PAIR ANALYSIS; ORGAN SIZE; RATS; RATS, WISTAR; SEMINAL VESICLES; TESTOSTERONE; TRIIODOTHYRONINE;

ANIMALIA;

EID: 0141921966     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-42653     Document Type: Article

References (26)

1. Mosekilde L, Eriksen EF, Charles P. Effects of thyroid hormones on bone and mineral metabolism. Endocrinol Metab Clin North Am 1990; 19: 35-63
2. Broulik PD, Stěpán J. Bone isoenzyme of serum alkaline phosphatase and urinary hydroxyproline, excretion in thyrotoxicosis. Endocrinologia Exp 1985; 19: 165-169
3. Pantazi H, Papapetrou PD. Changes in parameters of bone and mineral metabolism during therapy for hyperthyroidism. J Clin Endocrinol Metab 2000; 85: 1099-1106
4. di Pippo VA. Lindsay R, Powers CA. Estradiol and tamoxifen interactions with thyroid hormone in the ovariectomized, thyroidectomized rat. Endocrinology 1995; 136: 1020-1033
5. Orwell ES, Nelson HD. Does estrogen adequately protect postmenopausal women against osteoporosis: An iconoclastic perspective. J Clin Endocrinol Metab 1999; 84: 1872-1874
6. Gomez JM, Gomez N, Fiter J, Soler J. Effects of long term treatment with GH in the bone mineral density of adults with hypopituitarism and GH deficiency and after discontinuation of GH replacement. Horm Metab Res 2000; 32: 66-70
7. Seeman E. Pathogenesis of bone fragility in women and men. Lancet 2002; 359: 1841-1850
8. 3 in male rats: pharmacologically distinct classes of estrogen responses affecting growth, bone, and lipid metabolism and their relation to serum GH and IGF 1. Endocrinology 2001; 142: 4223-4235
9. Kalu DN, Hardin RR, Cockerham R. Evaluation of the pathogenesis of skeletal changes in ovariectomized rats. Endocrinology 1994; 115: 507-511
10. Gitelman HJ. An improved automated procedure for the determination of calcium in biological specimens. Anal Biochem 1967; 18: 521-531
11. Kraml J. A semiautomated determination of phospholipids. Clin Chim Acta 1966; 13: 442-448
12. Beall PT, Misra LK, Young RL, Spjut HJ, Evans HJ, Le Blame A. Clomiphene protects against osteoporosis in the mature ovariectomized rat. Calcif Tissue Int 1984; 36: 123-125
13. Vanderschueren DE, Vautterck AMH, Suiker WJ, Wisser LPC, Schot R, Bouillon R. Bone and mineral metabolism in aged male rats. Short and long term effects of androgen deficiency. Endocrinology 1992; 130: 2906-2916
14. Turner CH, Burr DB. Basic Biomechanical measurements of bone: A tutorial. Bone 1993; 14: 595-608
15. Růžička R, Michálek J, Rosenkrancová J, Sedláček R. Cross section parameters acquisition from digital images. Prague: Proc. of workshop 2002, Prague CTU, 2002; B: 910-911
16. Duncan D. Multiple range and multiple F test. Biometrics 1955; 11: 1-4
17. Compston JE. Sex steroids and bone. Physiol Rev 2001; 81: 419-447
18. Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Spelsperg TC, Riggs BL. Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells. Endocrinology 1999; 140: 4367-4370
19. Khosla S, Melton LJ, Atkinson EJ, O'Fallon WA, Klee GG, Riggs BL. Relationship of serum sex steroid levels and bone turnover markers with bone density in men and women a key role for bioavailable estrogen. J Clin Endocrin Metab 1998; 83: 2266-2274
20. Szulc P, Munoz F, Claustrat B, Garnero P, Marchand F, Duboeuf F, Delmas PD. Bioavailable estradiol may be an important determinant of osteoporosis in men: The MINOS study. J Clin Endocrinol Metab 2001; 86: 192-199
21. Colvard DS, Eriksen EP, Keeting PE, Wilson EM, Lubahn DB, French FS, Riggs BL, Spelberg TC. Identification of androgen receptors in normal human osteoblast-line cells. Proc Natl Acad Sci USA 1989; 86: 854-857
22. Bruch HB, Wolf L, Budde R, Romato G, Schweikert HU. Androstenedione metabolism in cultured human osteoblast-like cells. J Clin Endocrinol Metab 1992; 75: 101-105
23. Morishima A, Grumbach MM, Simpson ER, Fischer C, Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 1995; 80: 3689-3698
24. Lubahn DB, Mayer JS, Golding TS, Couse JF, Korach KS, Smithies O. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc natl Acad Sci USA 1993; 90: 11162-11166
25. Smith E, Boyd J, Frank GR, Takahashi H, Cohem RM, Specker B, Williams TC, Lubahn DB, Korach KS. Estrogen resistance caused by a mutation in the estrogen-receptor gene in man. N Engl J med 1994; 331: 1056-1061
26. Vanderschueren DE, van Herck E, Nijs J, Ederveen AGH, de Coster R, Bouillon R. Aromatase inhibition impairs skeletal modeling and decreases bone mineral density In growing male rats. Endocrinology 1997; 138: 2301-2307