The degree of mineralization is a determinant of bone strength: A study on human calcanei

Bone

Volumn 34, Issue 5, 2004, Pages 783-789

  Follet, H ^a   Boivin, G ^b   Rumelhart, C ^a   Meunier, P J ^b  

^a UNIVERSITÉ DE LYON   (France)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Calcaneus; Cancellous bone; Compressive test; Degree of mineralization; Quantitative microradiography

Indexed keywords

ALENDRONIC ACID;

ADULT; AGED; ARTICLE; AUTOPSY; BONE DENSITY; BONE DISEASE; BONE MATRIX; BONE MINERAL; BONE MINERALIZATION; BONE STRENGTH; BONE STRUCTURE; BONE TISSUE; CALCANEUS; CALCIFICATION; CANCELLOUS BONE; CLINICAL ARTICLE; COMPRESSION; CONTROLLED STUDY; DEATH; FEMALE; FRACTURE; HUMAN; HUMAN TISSUE; ILIAC BONE; ILIAC CREST; MACHINE; MALE; MEASUREMENT; MICRORADIOGRAPHY; MORPHOMETRICS; OSTEOPOROSIS; RISK REDUCTION; SAMPLING; TRANSDUCER; YOUNG MODULUS;

AGED; AGED, 80 AND OVER; CALCANEUS; CALCIFICATION, PHYSIOLOGIC; FEMALE; HUMANS; MALE; MIDDLE AGED;

EID: 2342655818     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2003.12.012     Document Type: Article

References (29)

1. Balena R., Toolan B.C., Shea M., Markatos A., Myers E.R., Lee S.C., et al. The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates. J. Clin. Invest. 92:1993;2577-2586
2. Boivin G., Baud C.A. Microradiographic methods for calcified tissues. Dickson G.R. Methods of calcified tissue preparation. 1984;391-411 Elsevier, Amsterdam
3. Boivin G., Lips P., Ott S.M., Harper K.D., Sarkar S., Pinette K.V., et al. Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women. J. Clin. Endocrinol. Metab. 88:2003;4199-4205
4. Boivin G., Meunier P.J. The degree of mineralization of bone tissue measured by computerized quantitative contact microradiography. Calcif. Tissue Int. 70:2002;503-511
5. Boivin G., Meunier P.J. Effects of bisphosphonates on matrix mineralization. J. Musculoskelet. Neuronal Interact. 2:2002;538-543
6. Boivin G., Meunier P.J. Histomorphometric methods applied to bone. Grupe G., Garland A.N. Histology of ancient human bone. 1993;137-156 Springer Verlag, Berlin
7. Boivin G.Y., Chavassieux P.M., Santora A.C., Yates J., Meunier P.J. Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women. Bone. 27:2000;687-694
8. Bouxsein M.L. Bone quality: where do we go from here? Osteoporos. Int. 14(Suppl. 5):2003;118-127
9. Burr D. Microdamage and bone strength. Osteoporos. Int. 14(Suppl. 5):2003;67-72
10. Cendre E., Mitton D., Roux J.P., Arlot M.E., Duboeuf F., Burt-Pichat B., et al. High-resolution computed tomography for architectural characterization of human lumbar cancellous bone: relationships with histomorphometry and biomechanics. Osteoporos. Int. 10:1999;353-360
11. Chavassieux P.M., Arlot M.E., Reda C., Wei L., Yates A.J., Meunier P.J. Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis. J. Clin. Invest. 100:1997;1475-1480
12. Ciarelli T.E., Fyhrie D.P., Parfitt A.M. Effects of vertebral bone fragility and bone formation rate on the mineralization levels of cancellous bone from White females. Bone. 32:2003;311-315
13. Currey J.D. The evolution of the mechanical properties of amniote bone. J. Biomech. 20:1987;1035-1044
14. Currey J.D., Brear K., Zioupos P. The effects of ageing and changes in mineral content in degrading the toughness of human femora. J. Biomech. 29:1996;257-260
15. Hans D., Dargent-Molina P., Schott A.M., Sebert J.L., Cormier C., Kotzki P.O., et al. Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet. 348:1996;511-514
16. Jensen N.C., Madsen L.P., Linde F. Topographical distribution of trabecular bone strength in the human os calcanei. J. Biomech. 24:1991;49-55
17. Jowsey J. The bone biopsy. 1977;Plenum, New York
18. Jowsey J., Kelly P.J., Riggs B.L., Bianco A.J., Scholz D.A., Gershon-Cohen J. Quantitative microradiographic studies of normal and osteoporotic bone. J. Bone Jt. Surg. Am. 47A:1965;785-806
19. Linde F., Hvid I., Madsen F. The effect of specimen geometry on the mechanical behaviour of trabecular bone specimens. J. Biomech. 25:1992;359-368
20. Linde F., Sorensen H.C. The effect of different storage methods on the mechanical properties of trabecular bone. J. Biomech. 26:1993;1249-1252
21. Meunier P.J., Boivin G. Bone mineral density reflects bone mass but also the degree of mineralization of bone: therapeutic implications. Bone. 21:1997;373-377
22. Mitton D., Rumelhart C., Hans D., Meunier P.J. The effects of density and test conditions on measured compression and shear strength of cancellous bone from the lumbar vertebrae of ewes. Med. Eng. Phys. 19:1997;464-474
23. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 2:1987;595-610
24. Reid S.A., Boyde A. Changes in the mineral density distribution in human bone with age: image analysis using backscattered electrons in the SEM. J. Bone Miner. Res. 2:1987;13-22
25. Roschger P., Rinnerthaler S., Yates J., Rodan G.A., Fratzl P., Klaushofer K. Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone. 29:2001;185-191
26. Turner C.H., Burr D.B. Basic biomechanical measurements of bone: a tutorial. Bone. 14:1993;595-608
27. Vogel J.M., Wasnich R.D., Ross P.D. The clinical relevance of calcaneus bone mineral measurements: a review. Bone Miner. 5:1988;35-58
28. Wasnich R.D., Ross P.D., Heilbrun L.K., Vogel J.M. Selection of the optimal skeletal site for fracture risk prediction. Clin. Ortop. 1987;262-269
29. Weaver J.K., Chalmers J. Cancellous bone: its strength and changes with aging and an evaluation of some methods for measuring its mineral content. J. Bone Jt. Surg. Am. 48:1966;289-298