메뉴 건너뛰기




Volumn 211, Issue 3, 2006, Pages 198-208

Activation of ERK1/2 and p38 kinases by polycyclic aromatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis

Author keywords

Apoptosis; Cell proliferation; Mitogen activated protein kinases; p53; Polycyclic aromatic hydrocarbons

Indexed keywords

AROMATIC HYDROCARBON; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PIFITHRIN ALPHA; PROTEIN P53; SERINE; STRESS ACTIVATED PROTEIN KINASE; TUMOR SUPPRESSOR PROTEIN;

EID: 33644983705     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.06.007     Document Type: Article
Times cited : (27)

References (55)
  • 2
    • 0346362325 scopus 로고    scopus 로고
    • Characterization of the differentiation capacity of rat-derived hepatic stem cells
    • M.R. Alison Characterization of the differentiation capacity of rat-derived hepatic stem cells Semin. Liver Dis. 23 2003 325 336
    • (2003) Semin. Liver Dis. , vol.23 , pp. 325-336
    • Alison, M.R.1
  • 4
    • 0033485261 scopus 로고    scopus 로고
    • Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
    • D.V. Bulavin, S. Saito, M.C. Hollander, K. Sakaguchi, C.W. Anderson, E. Appella, and A.J. Fornace Jr. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation EMBO J. 18 1999 6845 6854
    • (1999) EMBO J. , vol.18 , pp. 6845-6854
    • Bulavin, D.V.1    Saito, S.2    Hollander, M.C.3    Sakaguchi, K.4    Anderson, C.W.5    Appella, E.6    Fornace Jr., A.J.7
  • 5
    • 0344412937 scopus 로고    scopus 로고
    • Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells
    • A.D. Burdick, J.W. Davis II, K.J. Liu, L.G. Hudson, H. Shi, M.L. Monske, and S.W. Burchiel Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells Cancer Res. 63 2003 7825 7833
    • (2003) Cancer Res. , vol.63 , pp. 7825-7833
    • Burdick, A.D.1    Davis II, J.W.2    Liu, K.J.3    Hudson, L.G.4    Shi, H.5    Monske, M.L.6    Burchiel, S.W.7
  • 6
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • L. Chang, and M. Karin Mammalian MAP kinase signalling cascades Nature 410 2001 37 40
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 7
    • 0038143266 scopus 로고    scopus 로고
    • The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis
    • S. Chen, N. Nguyen, K. Tamura, M. Karin, and R.H. Tukey The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8- dihydrodiol-9,10-epoxide-induced apoptosis J. Biol. Chem. 278 2003 19526 19533
    • (2003) J. Biol. Chem. , vol.278 , pp. 19526-19533
    • Chen, S.1    Nguyen, N.2    Tamura, K.3    Karin, M.4    Tukey, R.H.5
  • 8
    • 15744366369 scopus 로고    scopus 로고
    • ERK kinase inhibition stabilizes the aryl hydrocarbon receptor
    • S. Chen, T. Operaña, J. Bonzo, M. Nguyen, and R.H. Tukey ERK kinase inhibition stabilizes the aryl hydrocarbon receptor J. Biol. Chem. 280 2005 4350 4359
    • (2005) J. Biol. Chem. , vol.280 , pp. 4350-4359
    • Chen, S.1    Operaña, T.2    Bonzo, J.3    Nguyen, M.4    Tukey, R.H.5
  • 10
    • 0034306450 scopus 로고    scopus 로고
    • Specifity and mechanism of action of some commonly used protein kinase inhibitors
    • S.P. Davies, H. Reddy, M. Caivano, and P. Cohen Specifity and mechanism of action of some commonly used protein kinase inhibitors Biochem. J. 351 2000 95 105
    • (2000) Biochem. J. , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 11
    • 0032615587 scopus 로고    scopus 로고
    • DNA reactions, mutagenic action and stealth properties of polycyclic aromatic hydrocarbon carcinogens (review)
    • A. Dipple, Q.A. Khan, J.E. Page, I. Ponten, and J. Szeliga DNA reactions, mutagenic action and stealth properties of polycyclic aromatic hydrocarbon carcinogens (review) Int. J. Oncol. 14 1999 103 111
    • (1999) Int. J. Oncol. , vol.14 , pp. 103-111
    • Dipple, A.1    Khan, Q.A.2    Page, J.E.3    Ponten, I.4    Szeliga, J.5
  • 12
    • 0036210375 scopus 로고    scopus 로고
    • Generation and characterization of p53 null transformed hepatic progenitor cells: Oval cells give rise to hepatocellular carcinoma
    • M.L. Dumble, E.J. Croager, G.C. Yeoh, and E.A. Quail Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma Carcinogenesis 23 2002 435 445
    • (2002) Carcinogenesis , vol.23 , pp. 435-445
    • Dumble, M.L.1    Croager, E.J.2    Yeoh, G.C.3    Quail, E.A.4
  • 13
    • 0037213389 scopus 로고    scopus 로고
    • The role of hepatocytes and oval cells in liver regeneration and repopulation
    • N. Fausto, and J.S. Campbell The role of hepatocytes and oval cells in liver regeneration and repopulation Mech. Dev. 120 2003 117 130
    • (2003) Mech. Dev. , vol.120 , pp. 117-130
    • Fausto, N.1    Campbell, J.S.2
  • 14
    • 0027159541 scopus 로고
    • Tumor-initiating activity and carcinogenicity of dibenzo[a,l]pyrene versus 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene at low doses in mouse skin
    • S. Higginbotham, N.V.S. RamaKrishna, S.L. Johansson, E.G. Rogan, and E.L. Cavalieri Tumor-initiating activity and carcinogenicity of dibenzo[a,l]pyrene versus 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene at low doses in mouse skin Carcinogenesis 14 1993 875 878
    • (1993) Carcinogenesis , vol.14 , pp. 875-878
    • Higginbotham, S.1    Ramakrishna, N.V.S.2    Johansson, S.L.3    Rogan, E.G.4    Cavalieri, E.L.5
  • 15
    • 22944470831 scopus 로고    scopus 로고
    • The p53 inhibitor pifithrin-α is a potent agonist of the aryl hydrocarbon receptor
    • 10.1124/jpet.105.084186
    • M.S. Hoagland, E.M. Hoagland, and H.I. Swanson The p53 inhibitor pifithrin-α is a potent agonist of the aryl hydrocarbon receptor J. Pharmacol. Exp. Ther. 2005 10.1124/jpet.105.084186 (Electronic publication ahead of print)
    • (2005) J. Pharmacol. Exp. Ther.
    • Hoagland, M.S.1    Hoagland, E.M.2    Swanson, H.I.3
  • 16
    • 18044387778 scopus 로고    scopus 로고
    • Evaluation of the role of c-Src and ERK in TCDD-dependent release from contact-inhibition in WB-F344 cells
    • P. Hoelper, D. Faust, F. Oesch, and C. Dietrich Evaluation of the role of c-Src and ERK in TCDD-dependent release from contact-inhibition in WB-F344 cells Arch. Toxicol. 79 2005 201 207
    • (2005) Arch. Toxicol. , vol.79 , pp. 201-207
    • Hoelper, P.1    Faust, D.2    Oesch, F.3    Dietrich, C.4
  • 17
    • 0033617288 scopus 로고    scopus 로고
    • P38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389
    • C. Huang, W.Y. Ma, A. Maxiner, Y. Sun, and Z. Dong p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389 J. Biol. Chem. 274 1999 12229 12235
    • (1999) J. Biol. Chem. , vol.274 , pp. 12229-12235
    • Huang, C.1    Ma, W.Y.2    Maxiner, A.3    Sun, Y.4    Dong, Z.5
  • 18
    • 0027751340 scopus 로고
    • Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis
    • C. Ioannides, and D.V. Parke Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis Drug Metab. Rev. 25 1993 485 501
    • (1993) Drug Metab. Rev. , vol.25 , pp. 485-501
    • Ioannides, C.1    Parke, D.V.2
  • 19
    • 0032974137 scopus 로고    scopus 로고
    • Relative potencies of PAHs and PCBs based on the response of human cells
    • J.M. Jones, and J.W. Anderson Relative potencies of PAHs and PCBs based on the response of human cells Environ. Toxicol. Pharmacol. 7 1999 19 26
    • (1999) Environ. Toxicol. Pharmacol. , vol.7 , pp. 19-26
    • Jones, J.M.1    Anderson, J.W.2
  • 20
    • 0034509118 scopus 로고    scopus 로고
    • Epigenetic mechanisms of chemical carcinogenesis
    • J.E. Klaunig, L.M. Kamendulis, and Y. Xu Epigenetic mechanisms of chemical carcinogenesis Hum. Exp. Toxicol. 19 2000 543 555
    • (2000) Hum. Exp. Toxicol. , vol.19 , pp. 543-555
    • Klaunig, J.E.1    Kamendulis, L.M.2    Xu, Y.3
  • 21
    • 0037127199 scopus 로고    scopus 로고
    • Mechanism of p53-dependent apoptosis induced by 3-methylcholanthrene: Involvement of p53 phosphorylation and p38 MAPK
    • Y.W. Kwon, S. Ueda, M. Ueno, J. Yodoi, and H. Masutani Mechanism of p53-dependent apoptosis induced by 3-methylcholanthrene: involvement of p53 phosphorylation and p38 MAPK J. Biol. Chem. 277 2002 1837 1844
    • (2002) J. Biol. Chem. , vol.277 , pp. 1837-1844
    • Kwon, Y.W.1    Ueda, S.2    Ueno, M.3    Yodoi, J.4    Masutani, H.5
  • 22
    • 2542610652 scopus 로고    scopus 로고
    • A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells
    • J. Li, M.S. Tang, B. Liu, X. Shi, and C. Huang A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells Oncogene 23 2004 3932 3944
    • (2004) Oncogene , vol.23 , pp. 3932-3944
    • Li, J.1    Tang, M.S.2    Liu, B.3    Shi, X.4    Huang, C.5
  • 23
    • 0035909494 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay
    • M. Machala, J. Vondráček, L. Bláha, M. Ciganek, and J. Neča Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay Mutat. Res. 497 2001 49 62
    • (2001) Mutat. Res. , vol.497 , pp. 49-62
    • MacHala, M.1    Vondráček, J.2    Bláha, L.3    Ciganek, M.4    Neča, J.5
  • 24
    • 0033955164 scopus 로고    scopus 로고
    • Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures
    • V.J. Melendez-Colon, A. Luch, A. Seidel, and W.M. Baird Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures Chem. Res. Toxicol. 13 2000 10 17
    • (2000) Chem. Res. Toxicol. , vol.13 , pp. 10-17
    • Melendez-Colon, V.J.1    Luch, A.2    Seidel, A.3    Baird, W.M.4
  • 25
    • 0141841683 scopus 로고    scopus 로고
    • Mutant p53 is constitutively phosphorylated at serine 15 in UV-induced mouse skin tumors: Involvement of ERK1/2 MAP kinase
    • V.O. Melnikova, A.B. Santamaria, S.V. Bolshakov, and H.N. Ananthaswamy Mutant p53 is constitutively phosphorylated at serine 15 in UV-induced mouse skin tumors: involvement of ERK1/2 MAP kinase Oncogene 22 2003 5958 5966
    • (2003) Oncogene , vol.22 , pp. 5958-5966
    • Melnikova, V.O.1    Santamaria, A.B.2    Bolshakov, S.V.3    Ananthaswamy, H.N.4
  • 26
    • 4344685858 scopus 로고    scopus 로고
    • Dibenzo[a,l]pyrene-induced genotoxic and carcinogenic responses are dramatically suppressed in aryl hydrocarbon receptor-deficient mice
    • Y. Nakatsuru, K. Wakabayashi, Y. Fujii-Kuriyama, T. Ishikawa, K. Kusama, and F. Ide Dibenzo[a,l]pyrene-induced genotoxic and carcinogenic responses are dramatically suppressed in aryl hydrocarbon receptor-deficient mice Int. J. Cancer 112 2004 179 183
    • (2004) Int. J. Cancer , vol.112 , pp. 179-183
    • Nakatsuru, Y.1    Wakabayashi, K.2    Fujii-Kuriyama, Y.3    Ishikawa, T.4    Kusama, K.5    Ide, F.6
  • 27
    • 2642510760 scopus 로고    scopus 로고
    • Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer
    • D.W. Nebert, T.P. Dalton, A.B. Okey, and F.J. Gonzalez Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer J. Biol. Chem. 279 2004 23847 23850
    • (2004) J. Biol. Chem. , vol.279 , pp. 23847-23850
    • Nebert, D.W.1    Dalton, T.P.2    Okey, A.B.3    Gonzalez, F.J.4
  • 28
    • 0035840335 scopus 로고    scopus 로고
    • Bcl-2 blocks cisplatin-induced apoptosis by suppression of ERK-mediated p53 accumulation in B104 cells
    • S.A. Park, H.J. Park, B.I. Lee, Y.H. Ahn, S.U. Kim, and K.S. Choi Bcl-2 blocks cisplatin-induced apoptosis by suppression of ERK-mediated p53 accumulation in B104 cells Brain Res. Mol. Brain Res. 93 2001 18 26
    • (2001) Brain Res. Mol. Brain Res. , vol.93 , pp. 18-26
    • Park, S.A.1    Park, H.J.2    Lee, B.I.3    Ahn, Y.H.4    Kim, S.U.5    Choi, K.S.6
  • 29
    • 0036395092 scopus 로고    scopus 로고
    • Benzo(a)pyrene activates extracellular signal-related and p38 mitogen-activated protein kinases in HT29 colon adenocarcinoma cells: Involvement in NAD(P)H:quinone reductase activity and cell proliferation
    • E. Patten Hitt, M.J. DeLong, and A.H. Merrill Jr. Benzo(a)pyrene activates extracellular signal-related and p38 mitogen-activated protein kinases in HT29 colon adenocarcinoma cells: involvement in NAD(P)H:quinone reductase activity and cell proliferation Toxicol. Appl. Pharmacol. 183 2002 160 167
    • (2002) Toxicol. Appl. Pharmacol. , vol.183 , pp. 160-167
    • Patten Hitt, E.1    Delong, M.J.2    Merrill Jr., A.H.3
  • 30
    • 0022969614 scopus 로고
    • The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons
    • J. Piskorska-Pliszczynska, B. Keys, S. Safe, and M.S. Newman The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons Toxicol. Lett. 34 1986 67 74
    • (1986) Toxicol. Lett. , vol.34 , pp. 67-74
    • Piskorska-Pliszczynska, J.1    Keys, B.2    Safe, S.3    Newman, M.S.4
  • 32
    • 0033001404 scopus 로고    scopus 로고
    • Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity
    • A.M. Rummel, J.E. Trosko, M.R. Wilson, and B.L. Upham Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity Toxicol. Sci. 49 1999 232 240
    • (1999) Toxicol. Sci. , vol.49 , pp. 232-240
    • Rummel, A.M.1    Trosko, J.E.2    Wilson, M.R.3    Upham, B.L.4
  • 33
    • 0034193343 scopus 로고    scopus 로고
    • A role for the p38 mitogen-activated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents
    • R. Sanchez-Prieto, J.M. Rojas, Y. Taya, and J.S. Gutkind A role for the p38 mitogen-activated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents Cancer Res. 60 2000 2464 2472
    • (2000) Cancer Res. , vol.60 , pp. 2464-2472
    • Sanchez-Prieto, R.1    Rojas, J.M.2    Taya, Y.3    Gutkind, J.S.4
  • 34
    • 5644298876 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase mediate macrophage proliferation induced by oxidized low-density lipoprotein
    • T. Senokuchi, T. Matsumura, M. Sakai, T. Matsuo, M. Yano, S. Kiritoshi, K. Sonoda, D. Kukidome, T. Nishikawa, and E. Araki Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase mediate macrophage proliferation induced by oxidized low-density lipoprotein Atherosclerosis 176 2004 233 245
    • (2004) Atherosclerosis , vol.176 , pp. 233-245
    • Senokuchi, T.1    Matsumura, T.2    Sakai, M.3    Matsuo, T.4    Yano, M.5    Kiritoshi, S.6    Sonoda, K.7    Kukidome, D.8    Nishikawa, T.9    Araki, E.10
  • 35
    • 0034617077 scopus 로고    scopus 로고
    • ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation
    • Q.B. She, N. Chen, and Z. Dong ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation J. Biol. Chem. 275 2000 20444 20449
    • (2000) J. Biol. Chem. , vol.275 , pp. 20444-20449
    • She, Q.B.1    Chen, N.2    Dong, Z.3
  • 36
    • 0035866404 scopus 로고    scopus 로고
    • Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase
    • Q.B. She, A.M. Bode, W.Y. Ma, N.Y. Chen, and Z. Dong Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase Cancer Res. 61 2001 1604 1610
    • (2001) Cancer Res. , vol.61 , pp. 1604-1610
    • She, Q.B.1    Bode, A.M.2    Ma, W.Y.3    Chen, N.Y.4    Dong, Z.5
  • 37
    • 1142275258 scopus 로고    scopus 로고
    • Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1
    • T. Shimada, and Y. Fujii-Kuriyama Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1 Cancer Sci. 95 2004 1 6
    • (2004) Cancer Sci. , vol.95 , pp. 1-6
    • Shimada, T.1    Fujii-Kuriyama, Y.2
  • 38
    • 13444287101 scopus 로고    scopus 로고
    • Role of cell signalling involved in induction of apoptosis by benzo[a]pyrene and cyclopenta[c,d]pyrene in Hepa1c1c7 cells
    • A. Solhaug, M. Refsnes, and J.A. Holme Role of cell signalling involved in induction of apoptosis by benzo[a]pyrene and cyclopenta[c,d]pyrene in Hepa1c1c7 cells J. Cell. Biochem. 93 2004 1143 1154
    • (2004) J. Cell. Biochem. , vol.93 , pp. 1143-1154
    • Solhaug, A.1    Refsnes, M.2    Holme, J.A.3
  • 39
    • 0036711207 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: Role in the regulation of aryl hydrocarbon receptor (AHR) function
    • Z. Tan, X. Chang, A. Puga, and Y. Xia Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function Biochem. Pharmacol. 64 2002 771 780
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 771-780
    • Tan, Z.1    Chang, X.2    Puga, A.3    Xia, Y.4
  • 40
    • 8444245911 scopus 로고    scopus 로고
    • A critical role for MAP kinases in the control of Ah receptor complex activity
    • Z. Tan, M. Huang, A. Puga, and Y. Xia A critical role for MAP kinases in the control of Ah receptor complex activity Toxicol. Sci. 82 2004 80 87
    • (2004) Toxicol. Sci. , vol.82 , pp. 80-87
    • Tan, Z.1    Huang, M.2    Puga, A.3    Xia, Y.4
  • 42
    • 0031595405 scopus 로고    scopus 로고
    • Benzo[a]pyrene- and TCDD-induced alterations in tyrosine phosphorylation and insulin-like growth factor signaling pathways in the MCF-10A human mammary epithelial cell line
    • S.L. Tannheimer, S.P. Ethier, K.K. Caldwell, and S.W. Burchiel Benzo[a]pyrene- and TCDD-induced alterations in tyrosine phosphorylation and insulin-like growth factor signaling pathways in the MCF-10A human mammary epithelial cell line Carcinogenesis 19 1998 1291 1297
    • (1998) Carcinogenesis , vol.19 , pp. 1291-1297
    • Tannheimer, S.L.1    Ethier, S.P.2    Caldwell, K.K.3    Burchiel, S.W.4
  • 43
    • 0021149409 scopus 로고
    • A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells
    • M.S. Tsao, J.D. Smith, K.G. Nelson, and J.W. Grisham A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells Exp. Cell Res. 154 1984 38 52
    • (1984) Exp. Cell Res. , vol.154 , pp. 38-52
    • Tsao, M.S.1    Smith, J.D.2    Nelson, K.G.3    Grisham, J.W.4
  • 45
    • 0017714532 scopus 로고
    • Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. a new method for rapid isolation and staining of nuclei
    • L.L. Vindelov Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. A new method for rapid isolation and staining of nuclei Virchows Arch. B Cell. Pathol. 24 1977 227 242
    • (1977) Virchows Arch. B Cell. Pathol. , vol.24 , pp. 227-242
    • Vindelov, L.L.1
  • 46
    • 0034703742 scopus 로고    scopus 로고
    • P53: Death star
    • K.H. Vousden p53: death star Cell 103 2000 691 694
    • (2000) Cell , vol.103 , pp. 691-694
    • Vousden, K.H.1
  • 47
    • 12344289296 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-activating polychlorinated biphenyls and their hydroxylated metabolites induce cell proliferation in contact-inhibited rat liver epithelial cells
    • J. Vondráček, M. Machala, V. Bryja, K. Chramostová, P. Krčmář, C. Dietrich, A. Hampl, and A. Kozubík Aryl hydrocarbon receptor-activating polychlorinated biphenyls and their hydroxylated metabolites induce cell proliferation in contact-inhibited rat liver epithelial cells Toxicol. Sci. 83 2005 53 63
    • (2005) Toxicol. Sci. , vol.83 , pp. 53-63
    • Vondráček, J.1    MacHala, M.2    Bryja, V.3    Chramostová, K.4    Krčmář, P.5    Dietrich, C.6    Hampl, A.7    Kozubík, A.8
  • 48
    • 0032585649 scopus 로고    scopus 로고
    • Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation
    • R.G. Watts, C. Huang, M.R. Young, J.J. Li, Z. Dong, W.D. Pennie, and N.H. Colburn Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation Oncogene 17 1998 3493 3498
    • (1998) Oncogene , vol.17 , pp. 3493-3498
    • Watts, R.G.1    Huang, C.2    Young, M.R.3    Li, J.J.4    Dong, Z.5    Pennie, W.D.6    Colburn, N.H.7
  • 50
    • 0030795369 scopus 로고    scopus 로고
    • Characterization of the H4IIE rat hepatoma cell bioassay for evaluation of environmental samples containing polynuclear aromatic hydrocarbons (PAHs)
    • K.L. Willett, P.R. Gardinali, J.L. Sericano, T.L. Wade, and S.H. Safe Characterization of the H4IIE rat hepatoma cell bioassay for evaluation of environmental samples containing polynuclear aromatic hydrocarbons (PAHs) Arch. Environ. Contam. Toxicol. 32 1997 442 448
    • (1997) Arch. Environ. Contam. Toxicol. , vol.32 , pp. 442-448
    • Willett, K.L.1    Gardinali, P.R.2    Sericano, J.L.3    Wade, T.L.4    Safe, S.H.5
  • 51
    • 0036452342 scopus 로고    scopus 로고
    • Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines
    • W. Woessmann, X. Chen, and A. Borkhardt Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines Cancer Chemother. Pharmacol. 50 2002 397 404
    • (2002) Cancer Chemother. Pharmacol. , vol.50 , pp. 397-404
    • Woessmann, W.1    Chen, X.2    Borkhardt, A.3
  • 52
    • 0034681399 scopus 로고    scopus 로고
    • Benzo[a]pyrene induces the transcription of cyclooxygenase-2 in vascular smooth muscle cells. Evidence for the involvement of extracellular signal-regulated kinase and NF-kappaB
    • Z. Yan, K. Subbaramaiah, T. Camilli, F. Zhang, T. Tanabe, T.A. McCaffrey, A.J. Dannenberg, and B.B. Weksler Benzo[a]pyrene induces the transcription of cyclooxygenase-2 in vascular smooth muscle cells. Evidence for the involvement of extracellular signal-regulated kinase and NF-kappaB J. Biol. Chem. 275 2000 4949 4955
    • (2000) J. Biol. Chem. , vol.275 , pp. 4949-4955
    • Yan, Z.1    Subbaramaiah, K.2    Camilli, T.3    Zhang, F.4    Tanabe, T.5    McCaffrey, T.A.6    Dannenberg, A.J.7    Weksler, B.B.8
  • 53
    • 0037223730 scopus 로고    scopus 로고
    • Protein kinases and their involvement in the cellular responses to genotoxic stress
    • J. Yang, Y. Yu, and P.J. Duerksen-Hughes Protein kinases and their involvement in the cellular responses to genotoxic stress Mutat. Res. 543 2003 31 58
    • (2003) Mutat. Res. , vol.543 , pp. 31-58
    • Yang, J.1    Yu, Y.2    Duerksen-Hughes, P.J.3
  • 54
    • 2442639165 scopus 로고    scopus 로고
    • Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death
    • P.Y. Yeh, S.E. Chuang, K.H. Yeh, Y.C. Song, L.L. Chang, and A.L. Cheng Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death Oncogene 23 2004 3580 3588
    • (2004) Oncogene , vol.23 , pp. 3580-3588
    • Yeh, P.Y.1    Chuang, S.E.2    Yeh, K.H.3    Song, Y.C.4    Chang, L.L.5    Cheng, A.L.6
  • 55
    • 4143054680 scopus 로고    scopus 로고
    • Inhibition of the MEK-1/p42 MAP kinase reduces aryl hydrocarbon receptor-DNA interactions
    • S. Yim, M. Oh, S.M. Choi, and H. Park Inhibition of the MEK-1/p42 MAP kinase reduces aryl hydrocarbon receptor-DNA interactions Biochem. Biophys. Res. Commun. 322 2004 9 16
    • (2004) Biochem. Biophys. Res. Commun. , vol.322 , pp. 9-16
    • Yim, S.1    Oh, M.2    Choi, S.M.3    Park, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.