Evaluation of the role of c-Src and ERK in TCDD-dependent release from contact-inhibition in WB-F344 cells

Archives of Toxicology

Volumn 79, Issue 4, 2005, Pages 201-207

  Hoelper, Peter ^a   Faust, Dagmar ^a   Oesch, Franz ^a   Dietrich, Cornelia ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

c Src; Contact inhibition; ERK; TCDD

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYCLIN A; EPIDERMAL GROWTH FACTOR RECEPTOR; GENISTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; CELL CYCLE S PHASE; CONTACT INHIBITION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; EVALUATION; GENE ACTIVATION; GENE FUNCTION; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BUTADIENES; CELL COUNT; CELL LINE; CONTACT INHIBITION; CYCLIN A; CYTOCHROME P-450 CYP1A1; DNA; ENZYME INHIBITORS; FLOW CYTOMETRY; GENES, SRC; GENISTEIN; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; RATS; RATS, INBRED F344; RECEPTOR, EPIDERMAL GROWTH FACTOR; SRC-FAMILY KINASES; TETRACHLORODIBENZODIOXIN;

RODENTIA;

EID: 18044387778     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-004-0624-6     Document Type: Article

References (38)

1. Abbott BD, Probst MR, Perdew GH, Buckalew AR (1998) AH receptor, ARNT, glucocorticoid receptor, EGF receptor, EGF, TGFα, TGFβ1, TGFβ2, and TGFβ3 expression in human embryonic palate, and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Teratology 58:30-43
2. Akiyama T, Ishida F, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, Fukami Y (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262:5592-5595
3. Bertazzi PA, Zochetti C, Guercilena S, Consonni D, Tironi A, Landi MT, Pesatori AC (1997) Dioxin exposure and cancer risk: a 15-year mortality study after the "Seveso-accident". Epidemiology 8:646-652
4. Bombick D, Matsumura F (1987) 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes elevation of the levels of the protein tyrosine kinase pp60src. J Biochem Toxicol 2:141-154
5. Choi EJ, Toscano DG, Ryan JA, Riedel N, Toscano Jr WA (1991) Dioxin induces transforming growth factor-alpha in human keratinocytes. J Biol Chem 266:9591-9597
6. Chramostova K, Vondracek J, Sindlerova L, Vojtesek B, Kozubik A, Machala M (2004) Polycyclic aromatic hydrocarbons modulate cell proliferation in rat hepatic epithelial stem-like WB-F344 cells. Toxicol Appl Pharmacol 196:136-148
7. Davis JW, Burdick AD, Lauer FT, Burchiel SW (2003) The aryl hydrocarbon receptor antagonist, 3′methoxy-4′-nitroflavone, attenuates 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent regulation of growth factor signaling and apoptosis in the MCF-10A cell line. Toxicol Appl Pharmacol 188:42-49
8. Dietrich C, Faust D, Budt S, Moskwa M, Kunz A, Bock K-W, Oesch F (2002) TCDD-dependent release from contact-inhibition in WB-F344 cells: involvement of cyclin A. Toxicol Appl Pharmacol 183:117-126
9. Dietrich C, Faust D, Moskwa M, Kunz A, Bock K-W, Oesch F (2003) TCDD-dependent downregulation of γ-catenin in rat liver epithelial cells (WB-F344). Int J Cancer 103:435-439
10. Enan E, Matsumura F (1996) Identification of c-Src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway. Biochem Pharmacol 52:1599-1612
11. Enan E, El-Sabeawy F, Scott M, Overstreet J, Lasley B (1998a) Alterations in the growth factor signal transduction pathways and modulators of the cell cycle in endocervival cells from macaques exposed to TCDD. Toxicol Appl Pharmacol 151:283-293
12. Enan E, Dunlap DY, Matsumura F (1998b) Use of c-Src and c-Fos knockout mice for the studies on the role of c-Src kinase signaling in the expression of toxicity of TCDD. J Biochem Mol Toxicol 12:263-274
13. Erpel T, Courtneidge S (1995) Src family protein tyrosine kinases and cellular signal transduction pathways. Curr Opin Cell Biol 7:176-182
14. Fernandez-Salguero P, Pineau T, Hilbert D, McPhail T, Lee S, Kimura S, Nebert D, Rudikoff S, Ward J, Gonzalez F (1995). Immune system impairment and hepatic fibrosis in mice lacking the dioxin binding Ah receptor. Science 268:722-726
15. Gaido KW, Maness SC, Leonard LS, Greenlee WF (1992) Tetrachlorodibenzo-p- dioxin-dependent regulation of transforming growth factor-alpha and -beta 2 expression involves both transcriptional and post-transcriptional control. J Biol Chem 267:24591-24595
16. Gradin K, Whitelaw ML, Toftgard R, Poellinger L, Berghard A (1994) A tyrosine kinase-dependent pathway regulates ligand-dependent activation of the dioxin receptor in human keratinocytes. J Biol Chem 269:23800-23807
17. Hanke JH, Gardner JP, Dow RL, Changelian PS, Brisette WH, Weringer EJ, Pollok BA, Connelly PA (1996) Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. J Biol Chem 271:695-701
18. Hebert C, Cao Q-L, Birnbaum L (1990) Inhibition of high-density growth arrest in human squamous carcinoma cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Carcinogenesis 11:1335-1342
19. Hölper P, Faust D, Oesch F, Dietrich C (2004) TGF-β is not involved in TCDD-dependent release from contact-inhibition in WB-F344 cells. Arch Toxicol, in press
20. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1997). Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans. IARC Monographs on the evaluation of carcinogenic risks to humans, vol. 69, IARC Press, Lyon, France
21. Köhle C, Gschaidmeier H, Lauth D, Topell S, Zitzer H, Bock K-W (1999) TCDD-mediated membrane translocation of c-src protein kinase in liver WB-F344 cells. Arch Toxicol 73:152-158
22. Kwon MJ, Jeong KS, Choi EJ, Lee BH (2003) 2,3,7,8-Tetrachlorodibenzo-p- dioxin (TCDD)-induced activation of mitogen-activated protein kinase signaling pathway in jurkat T cells. Pharmacol Toxicol 93:186-190
23. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
24. Lemaire G, Delescluse C, Pralavorio M, Ledirac N, Lesca P, Rahmani R (2004) The role of protein tyrosine kinases in Cyp1A1 induction by omeprazole and thiabendazole in rat hepatocytes. Life Sci 74:2265-2278
25. Madhukar BV, Ebner K, Matsumura F, Bombick DW, Brewster DW, Kawamoto T (1988) 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an increase in protein kinases associated with epidermal growth factor receptor in the hepatic plasma membrane. J Biochem Toxicol 3:261-277
26. Matsumura F, Enan E, Dunlap DY, Pinkerton KE, Peake J (1997) Altered in vivo toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in c-Src deficient mice. Biochem Pharmacol 53:1397-1404
27. Münzel P, Bock-Hennig B, Schieback S, Gschaidmeier H, Beck-Gschaidmeier S, Bock K-W (1996) Growth modulation of hepatocytes and rat liver epithelial cells (WB-F344) by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Carcinogenesis 17:197-202
28. Park S, Henry E, Gasiewicz TA (2000) Regulation of DNA binding activity of the ligand-activated aryl hydrocarbon receptor by tyrosine phosphorylation. Arch Biochem Biophys 381:302-312
29. Pilot HC, Goldsworthy T, Campell HA, Poland A (1980) Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine. Cancer Res 40:3616-3620
30. Puga A, Xia Y, Elferink C (2002) Role of the aryl hydrocarbon receptor in cell cycle regulation. Chem Biol Interact 141:117-130
31. Rowlands JC, Gustafsson J-A (1997) Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol 27:109-134
32. Schwarz M, Buchmann A, Stinchcombe S, Kalkuhl A, Bock K-W (2000) Ah receptor ligands and tumor promotion: survival of neoplastic cells. Toxicol Lett 112/113:69-77
33. Smith PK, Krohn RI, Hermanson GT, Mallia A, Gartner FH, Provenzano MD, Fujimoto EK, Hoeke NM, Olson BJ, Klenk DC (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85
34. Sutter TR, Greenlee WF (1992) Classification of the Ah gene battery. Chemosphere 25:223-226
35. Tan Z, Chang X, Puga A, Xia Y (2002) Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR9 function). Biochem Pharmacol 64:771-780
36. Tolwinsky N, Shapiro P, Goueli S, Ahn N (1999) Nuclear localization of mitogen-activated protein kinase kinase 1 (MKK1) is promoted by serum stimulation and G2-M progression. J Biol Chem 274:6168-6174
37. Tsao M-S, Smith J, Nelson K, Grisham J (1984) A diploid epithelial cell line from normal adult rat liver with phenotypic properties of oval cells. Exp Cell Res 154:38-52
38. Whitlock JP (1993) Mechanistic aspects of dioxin action. Chem Res Toxicol 6:754-763