Carboxylate bioisosteres of gabapentin

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 9, 2006, Pages 2333-2336

  Burgos Lepley, Carmen E ^a   Thompson, Lisa R ^b   Kneen, Clare O ^b   Osborne, Simon A ^b   Bryans, Justin S ^b   Capiris, Thomas ^a   Suman Chauhan, Nirmala ^b   Dooley, David J ^a   Donovan, Cindy M ^a   Field, Mark J ^b   Vartanian, Mark G ^a   Kinsora, Jack J ^a   Lotarski, Susan M ^a   El Kattan, Ayman ^a   Walters, Karen ^a   Cherukury, Madhu ^a   Taylor, Charles P ^a   Wustrow, David J ^a   Schwarz, Jacob B ^a  

^a PFIZER INC   (United States)

^b Sandwich Laboratories   (United Kingdom)

Author keywords

2 subunit; Gabapentin

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; GABAPENTIN; PREGABALIN; TETRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG INHIBITION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMA HALF LIFE; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

AMINES; ANIMALS; ANTICONVULSANTS; CARBOXYLIC ACIDS; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GAMMA-AMINOBUTYRIC ACID; MICE; MICE, INBRED DBA; MOLECULAR STRUCTURE; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

ANIMALIA;

EID: 33644967837     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.016     Document Type: Article

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