Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice

Molecular Immunology

Volumn 43, Issue 11, 2006, Pages 1827-1835

  Suárez, Eduardo ^a   Magadán, Susana ^b   Sanjuán, Irene ^c   Valladares, Mónica ^b   Molina, Ana ^b   Gambón, Francisco ^c   Díaz Espada, Fernando ^a   González Fernández, África ^b  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^b UNIVERSITY OF VIGO   (Spain)

^c HOSPITAL DO MEIXOEIRO   (Spain)

Author keywords

Human IG transgenes; Hybridomas; Immunoglobulin; Monoclonal antibodies; Somatic hypermutation

Indexed keywords

CD69 ANTIGEN; IMMUNOGLOBULIN ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN ANTIBODY REACTION; ARTICLE; CANCER CELL; COMPLEMENTARITY DETERMINING REGION; GENE MUTATION; GENETIC HETEROGENEITY; HEAVY CHAIN; IMMUNE RESPONSE; MOUSE; MYELOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALS; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; ANTIGENS; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN HEAVY CHAIN; HUMANS; HYBRIDOMAS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, TRANSGENIC; MUTATION; SEQUENCE ANALYSIS, DNA; SPLEEN; TRANSGENES;

ANIMALIA; MUS MUSCULUS;

EID: 33644964338     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2005.10.015     Document Type: Article

References (42)

1. Y. Barrios, R. Cabrera, R. Yañez, M. Briz, A. Plaza, R. Fores, M.N. Fernández, and F. Díaz-Espada Anti-idiotypic vaccination in the treatment of low-grade B-cell lymphoma Haematologica 87 2002 400 407
2. H.P. Brezinschek, R.I. Brezinschek, and P.E. Lipsky Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction J. Immunol. 155 1995 190 202
3. M. Brüggemann, and M.S. Neuberger Strategies for expressing human antibody repertoires in transgenic mice Immunol. Today 17 1996 391 397
4. M. Brüggemann, and M.J. Taussig Production of human antibody repertoires in transgenic mice Curr. Opin. Biotechnol. 8 1997 455 458
5. J.E. Butler Immunoglobulin diversity, B-cell and antibody repertoire development in large farm animals Rev. Sci. Tech. 17 1998 43 70
6. N.P. Davies, I.R. Rosewell, J.C. Richardson, G.P. Cook, M.S. Neuberger, B.H. Brownstein, M.L. Norris, and M. Brüggemann Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin kappa locus Biotechnology (NY) 11 1993 911 914
7. P.A. Edwards, C.M. Smith, A.M. Neville, and M.J. O'Hare A human-hybridoma system based on a fast-growing mutant of the ARH-77 plasma cell leukemia-derived line Eur. J. Immunol. 12 1982 641 648
8. O. Elemento, and M.P. Lefranc IMGT/PhyloGene: an on-line tool for comparative analysis of immunoglobulin and T cell receptor genes Dev. Comp. Immunol. 27 2003 55 77
9. G. Galfre, and C. Milstein Preparation of monoclonal antibodies: strategies and procedures Methods Enzymol. 73 1981 3 46
10. V. Giudicelli, D. Chaume, and M.P. Lefranc IMGT/V QUEST, an integrated software for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis Nucleic Acids Res. 32 2004 W435 W440
11. V. Giudicelli, D. Chaume, and M.P. Lefranc IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes Nucleic Acids Res. 33 2005 D593 D597
12. L.L. Green Antibody engineering via genetic engineering of the mouse: XenoMouse strains are a vehicle for the facile generation of therapeutic human monoclonal antibodies J. Immunol. Methods 231 1999 11 23
13. L.L. Green, and A. Jakobovits Regulation of B cell development by variable gene complexity in mice reconstituted with human immunoglobulin yeast artificial chromosomes J. Exp. Med. 188 1998 483 495
14. L.L. Green, M.C. Hardy, C.E. Maynard-Currie, H. Tsuda, D.M. Louie, M.J. Mendez, H. Abderrahim, M. Noguchi, D.H. Smith, and Y. Zeng Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs Nat. Genet. 7 1994 13 21
15. A. Jakobovits Production of fully human antibodies by transgenic mice Curr. Opin. Biotechnol. 6 1995 561 566
16. D. Kitamura, J. Roes, R. Kuhn, and K. Rajewsky A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene Nature 350 1991 423 426
17. M.P. Lefranc Nomenclature of the human immunoglobulin heavy (IHG) genes Exp. Clin. Immunogenet. 18 2001 100 116
18. M.P. Lefranc Nomenclature of the human immunoglobulin kappa (IGK) genes Exp. Clin. Immunogenet. 18 2001 161 174
19. M.P. Lefranc Nomenclature of the human immunoglobulin lambda (IGL) genes Exp. Clin. Immunogenet. 18 2001 242 254
20. M.P. Lefranc IMGT, the international imMunoGeneTics information system Methods Mol. Biol. 248 2004 27 49 http://imgt.cines.fr
21. M.P. Lefranc, and G. Lefranc The Immunoglobulin FactsBook 2001 Academic Press
22. M.P. Lefranc, C. Pommie, M. Ruiz, V. Giudicelli, E. Foulquier, L. Truong, V. Thouvenin-Contet, and G. Lefranc IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains Dev. Comp. Immunol. 27 2003 55 77
23. M.P. Lefranc, V. Giudicelli, Q. Kaas, E. Duprat, J. Jabado-Michaloud, D. Scaviner, C. Ginestoux, O. Clement, D. Chaume, and G. Lefranc IMGT, the international ImmMunoGeneTics information system Nucleic Acids Res. 33 2005 D593 D597
24. M.P. Lefranc, O. Clément, Q. Kaas, E. Duprat, P. Chastellan, I. Coelho, K. Combres, C. Ginestoux, V. Giudicelli, D. Chaume, and G. Lefranc IMGT - choreography for immunogenetics and immunoinformatics In Silico Biol. 5 2005 45 60
25. M. Llorente, S. Sánchez-Palomino, S. Manes, P. Lucas, L. Kremer, I.M. De Alboran, J.L. Toran, J. Alcami, G. Del Real, and C. Martínez-A Natural human antibodies retrieved by phage display libraries from healthy donors: polyreactivity and recognition of human immunodeficiency virus type 1gp120 epitopes Scand. J. Immunol. 50 1999 270 279
26. N. Lonberg, L.D. Taylor, F.A. Harding, M. Trounstine, K.M. Higgins, S.R. Schramm, C.C. Kuo, R. Mashayekh, K. Wymore, and J.G. McCabe Antigen-specific human antibodies from mice comprising four distinct genetic modifications Nature 368 1994 856 859
27. I.S. Lossos, R. Tibshirani, B. Narasimhan, and R. Levy The inference of antigen selection on Ig genes J. Immunol. 165 2000 5122 5126
28. S. Magadán, M. Valladares, E. Suárez, I. Sanjuan, A. Molina, C. Ayling, S.L. Davies, X. Zou, G.T. Williams, M.S. Neuberger, M. Brüggemann, F. Gambón, F. Díaz-Espada, and A. González-Fernández Production of antigen-specific human monoclonal antibodies: comparison of mice carrying IgH/kappa or IgH/kappa/lambda transloci Biotechniques 33 2002 680 690
29. J.D. Mark, H.R. Hoogenboom, T.P. Bonnert, J. McCafferty, A.D. Griffiths, and G. Winter By passing immunization. Human antibodies from V-gene libraries displayed on phage J. Mol. Biol. 222 1991 581 597
30. M.J. Mendez, L.L. Green, J.R. Corvalan, X.C. Jia, C.E. Maynard-Currie, X.D. Yang, M.L. Gallo, D.M. Louie, D.V. Lee, K.L. Erickson, J. Luna, C.M. Roy, H. Abderrahim, F. Kirschenbaum, M. Noguchi, D.H. Smith, A. Fukushima, J.F. Hales, S. Klapholz, M.H. Finer, C.G. Davis, K.M. Zsebo, and A. Jakobovits Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice Nat. Genet. 15 1997 146 156
31. A. Molina, M. Valladares, S. Magadán, D. Sancho, F. Viedma, I. Sanjuan, F. Gambón, F. Sánchez-Madrid, and A. González- Fernández The use of transgenic mice for the production of a human monoclonal antibody specific for human CD69 antigen J. Immunol. Methods 282 2003 147 158
32. I.C. Nicholson, X. Zou, A.V. Popov, G.P. Cook, E.M. Corps, S. Humphries, C. Ayling, B. Goyenechea, J. Xian, M.J. Taussig, M.S. Neuberger, and M. Brüggemann Antibody repertoires of four- and five-feature translocus mice carrying human immunoglobulin heavy chain and kappa and lambda light chain yeast artificial chromosomes J. Immunol. 163 1999 6898 6906
33. M. Pech, H. Smola, H.D. Pohlenz, B. Straubinger, R. Gerl, and H.G. Zachau A large section of the gene locus encoding human immunoglobulin variable regions of the kappa type is duplicated J. Mol. Biol. 183 1985 291 299
34. A.V. Popov, C. Butzler, J.P. Frippiat, M.P. Lefranc, and M. Brüggemann Assembly and extension of yeast artificial chromosomes to build up a large locus Gene 177 1996 195 201
35. D. Sancho, A.G. Santis, J.L. Alonso-Lebrero, F. Viedma, R. Tejedor, and F. Sánchez-Madrid Functional analysis of ligand-binding and signal transduction domains of CD69 and CD23 C-type lectin leukocyte receptors J. Immunol. 165 2000 3868 3875
36. M.C. Sinclair, J. Gilchrist, and R. Aitken Bovine IgG repertoire is dominated by a single diversified VH gene family J. Immunol. 159 1997 3883 3889
37. E. Suárez, R. Yañez, Y. Barrios, and F. Díaz-Espada Human monoclonal antibodies produced in transgenic BABκ,λ mice recognising idiotypic immunoglobulins of human lymphoma cells Mol. Immunol. 41 2004 519 526
38. K.D. Victor, K. Vu, and A.J. Feeney Limited junctional diversity in kappa light chains. Junctional sequences from CD43 + B220 + early B cell progenitors resemble those from peripheral B cells J. Immunol. 152 1994 3467 3475
39. S.D. Wagner, G. Gross, G.P. Cook, S.L. Davies, and M.S. Neuberger Antibody expression from the core region of the human IgH locus reconstructed in transgenic mice using bacteriophage P1 clones Genomics 35 1996 405 414
40. M. Yamada, R. Wasserman, B.A. Reichard, S. Shane, A.J. Caton, and G. Rovera Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes J. Exp. Med. 173 1991 395 407
41. X. Zou, J. Xian, A.V. Popov, I.R. Rosewell, M. Muller, and M. Brüggemann Subtle differences in antibody responses and hypermutation of lambda light chains in mice with a disrupted chi constant region Eur. J. Immunol. 25 1995 2154 2162
42. X. Zou, J. Xian, N.P. Davies, A.V. Popov, and M. Brüggemann Dominant expression of a 1.3 Mb human Ig kappa locus replacing mouse light chain production FASEB J. 10 1996 1227 1232