Dominant expression of a 1.3 Mb human Igκ locus replacing mouse light chain production

FASEB Journal

Volumn 10, Issue 10, 1996, Pages 1227-1232

  Zou, Xiangang ^a   Xian, Jian ^a   Davies, Nicholas P ^a,b   Popov, Andrei V ^a   Brüggemann, Marianne ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

Author keywords

expression control; human antibodies; locus introduction; transgenesis

Indexed keywords

IMMUNOGLOBULIN LIGHT CHAIN;

ARTICLE; GENE LOCUS; GENE REARRANGEMENT; IMMUNOGLOBULIN PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE;

EID: 0029839956     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.10.10.8751726     Document Type: Article

References (25)

1. Zachau, H. G. (1993) The immunoglobulin K locus - or what has been learned from looking closely al one-tenth of a percent of the human genome. Gene 135, 167-173
2. Frippiat, J.-P., Williams, S. C., Tomlinson, I. M., Cook, G. P., Cherif, D., Le Paslier, D., Collins, J. E., Dunham, I., Winter, C., and Lefrane, M.-P. (1995) Organization of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2. Human Mol. Genet. 4, 983-991
3. Cook, C. P., and Tomlinson, I. M. (1995) The human immunoglobulin VH repertoire. Immunol. Today 16, 237-242
4. Betz, A. G., Milstein, C., González-Fernández, A., Pannell, R., Larson, T., and Neuberger, M. S. (1994) Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region. Cell 77, 239-248
5. Brüggemann, M., and Neuberger, M. S. (1991) Generation of antibody repertoires in transgenic mice. Methods 2, 159-165
6. Neuberger, M. S., and Milstein. C. (1995) Somatic hypermutation. Curr. Opin. Immunol. 7, 248-254
7. Brüggemann, M., Caskey, H. M., Teale, C., Waldmann, H., Williams, G. T., Surani, M. A., and Neuberger, M. S. (1989) A repertoire of monoclonal antibodies with human heavy chains from transgenic mice. Prof. Natl. Acad. Sci. USA 86, 6709-6713
8. Taylor, L. D., Carmack, C. E., Schramm, S. R., Mashayekh, R., Higgins, K. M., Kuo, C.-C., Woodhouse, C., Kay, R. M., and Lonberg, N. (1992) A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins. Nucleic Acids Res. 20, 6287-6295
9. Davies, N. P, Rosewell, I. R., Richardson, J. C., Cook, G. P., Neuberger, M. S., Brownstein, B. H., Norris, M. L., and Brüggemann, M. (1993) Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin κ locus. Bio/Technologry. 11, 911-914
10. Green, L. L., Hardy, M. C., Maynard-Curric, C. E., Tsuda, H., Louie, D. M., Mendez, M. J., Abderrahim, H., Noguchi, M., Smith, D. H., Zeug, Y., David, N. E., Sasai, H., Garza, D., Brenner, D. G., Hales, J. P., McGuinness, R. P., Capon, D. J., Klapholz, S., and Jakobovits, A. (1994) Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs. Nature Genet. 7, 13-21
11. Lamb, B. T., Sisodia, S. S., Lawler, A. M., Slunt, H. H., Kitt, C. A., Kearns, W. C., Pearson, P. L., Price, D. L., and Gearhart, J. D. (1993) Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice. Nature Genet. 5, 22-29
12. Jakobovits, A., Moore, A. L, Green, L. L., Vergara, G. J., Maynard-Currie, C. E., Austin, H. A., and Klapholz, S. (1993) Germ-line transmission and expression of a human-derived yeast artificial chromosome. Nature 362, 255-258
13. Davies, N. P., Popov, A. V., Zou, X., and Brüggemann, M. (1996) Human antibody repertoires in transgenic mice: Manipulation and transfer of YACs. In Antibody Engineering: A Practical Approach, IRL. J. McCafferty, H. R. Hoogenboom, D. J. Chiswell (editors) 59-76
14. Pech, M., Smola, H., Pohlenz. H.-D., Straubinger, B., Gerl, R., and Zachau, H. G. (1985) A large section of the gene locus encoding human immunoglobulin variable regions of the kappa type is duplicated. J. Mol. Biol. 183, 291-299
15. Davies, N. P., Rosewell, I. R., and Brüggemunn, M. (1992) Targeted alterations in yeast artificial chromosomes for inter-species gene transfer. Nucl. Acids Res. 20, 2693-2698
16. Davies, N. P., and Brüggemann, M. (1993) Extension of yeast artificial chromosomes by cosmid multimers. Nucleic Acids Res. 21, 767-768
17. Selfridge. J., Pow, A. M., McWhir, J., Magin. T. M., and Melton, D.W. (1992) Gene targeting using a mouse HPRT minigene/HPRT-deficient embryonic stem cell system: Inactivation of the mouse ERCC-1 gene. Somat. Cell Mol. Genet. 18, 325-336
18. Hogan, B., Beddington, R., Costantini, E., and Lacy E. (1994) Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
19. Guthrie, C., and Fink, G. R. (1991) Guide to Yeast Genetics and Molecular Biology, Academic Press, London
20. Zou, X., Xian, J., Popov, A. V., Rosewell, I. R, Müller, M., and Brüggemann, M. (1995) Subtle differences in antibody responses and hypermutation of λ light chains in mice with a disrupted κ constant region. Eur. J. Immunol. 25, 2154-2162
21. Klein, R., Jaenichen, R., and Zaehau, H. G. (1993) Expressed human immunoglobutin κ genes and their hypermutation. Eur. J. Immunol. 23, 3248-3271
22. Lonberg, N., Taylor, L. D., Harding, F. A., Trounstine, M., Higgins, K. M., Schramm, S. R., Kuo, C.-C., Mashayekh, R., Wymore, K., McCabe, J. G., Munoz-O'Regan, D., O'Donnell., S. L., Lapachet, E. S. G., Bengoechea, T., Fishwild, D. M., Carmack, C. E., Kay, R. M., and Huszar, D. (1994) Antigen-specific human antibodies from mice comprising four distinct genetic modifications. Nature 368, 856-859
23. Storb, U., Haasch, D., Arp, B., Sanchez, P., Cazenave, P.-A., and Miller, J. (1989) Physical linkage of mouse λ genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences. Mol. Cell. Biol. 9, 711-718
24. Hieter, P. A., Max, E. E., Seidman, J. G., Maizel J. V. J., and Leder, P. (1980) Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. Cell 22, 197-207
25. Davies, N. P. (1994) Modification, transfer and expression of yeast artificial chromosomes containing human immunoglobulin genes. Ph.D. thesis, University of Cambridge