Regulation of B cell development by variable gene complexity in mice reconstituted with human immunoglobulin yeast artificial chromosomes

Journal of Experimental Medicine

Volumn 188, Issue 3, 1998, Pages 483-495

  Green, Larry L ^a   Jakobovits, Aya ^a  

^a Abgenix Inc   (United States)

Author keywords

B cell development; Human immunoglobulin; Transgenic mice; Variable genes; Yeast artificial chromosomes

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CELL MATURATION; GENE EXPRESSION; GENE STRUCTURE; GENETIC RECOMBINATION; GENETIC VARIABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; YEAST ARTIFICIAL CHROMOSOME;

ANIMALS; B-LYMPHOCYTES; CELL DIVISION; CHROMOSOMES, ARTIFICIAL, YEAST; GENE DELETION; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, TRANSGENIC;

EID: 0032479876     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.3.483     Document Type: Article

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