Tandem repeat of C/EBP binding sites mediates PPARγ2 gene transcription in glucocorticoid-induced adipocyte differentiation

Journal of Cellular Biochemistry

Volumn 76, Issue 3, 2000, Pages 518-527

  Xing Ming, Shi ^a   Blair, Harry C ^a,b   Yang, Xiangli ^a   McDonald, Jay M ^a,b   Xu, Cao ^a,c  

^a University of Alabama at Birmingham   (United States)

^b BIRMINGHAM VA MEDICAL CENTER   (United States)

^c NONE   (United States)

Author keywords

Adipocyte; Bone marrow stromal cell; Glucocorticoid; Osteoblast; Osteoporosis

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

ADIPOCYTE; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; OSTEOBLAST; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; TANDEM REPEAT; TRANSACTIVATION;

ADIPOCYTES; ANIMALS; BASE SEQUENCE; BINDING SITES; BONE MARROW CELLS; CCAAT-ENHANCER-BINDING PROTEINS; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; DEXAMETHASONE; DNA; DNA PRIMERS; DNA-BINDING PROTEINS; GLUCOCORTICOIDS; HUMANS; MICE; NUCLEAR PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TANDEM REPEAT SEQUENCES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0033950211     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(20000301)76:3<518::AID-JCB18>3.0.CO;2-M     Document Type: Article

References (40)

1. Altiok S, Xu M, Spiegelman BM. 1997. PPAR induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A. Genes Dev 11:1987-1998.
2. Baxter JD, Rousseau GG. 1979. Glucocorticoid hormone action: an overview. In: Baxter JD, Rousseau GG, editors. Glucocorticoid hormone action. New York: Springer-Verlag, p 1-24.
3. Boudreau F, Blais S, Asselin C. 1996. Regulation of CCAAT/enhancer binding protein isoforms by serum and glucocorticoids in the rat intestinal epithelial crypt cell line IEC-6. Exp Cell Res 222:1-9.
4. Cao X, Ross FP, Zhang L, MacDonald PN, Chappel J, Teitelbaum SL. 1993. Cloning of the promoter for the avian integrin beta 3 subunit gene and its regulation by 1,25-dihydroxyvitamin D3. J Biol Chem 268:27371-27380.
5. Cao Z, Umek RM, McKnight SL. 1991. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev 5:1538-1552.
6. Chawla A, Schwarz EJ, Dimaculangan DD, Lazar MA. 1994. Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135:798-800.
7. Christy RJ, Kaestner KH, Geiman DE, Lane MD. 1991. CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci USA 88:2593-2597.
8. Crosson SM, Davies GF, Roesler WJ. 1997. Hepatic expression of CCAAT/enhancer binding protein alpha: hormonal and metabolic regulation in rats. Diabetologia 40:1117-1124.
9. Cui Q, Wang GJ, Balian G. 1997. Steroid-induced adipogenesis in a pluripotential cell line from bone marrow. J Bone Joint SurgAm 79:1054-1063.
10. Darlington GJ, Ross SE, MacDougald OA. 1998. The role of C/EBP genes in adipocyte differentiation. J Biol Chem 273:30057-30060.
11. Elmstedt E. 1981. Avascular bone necrosis in the renal transplant patient: a discriminant analysis of 144 cases. Clin Orthop 158:149-157.
12. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 1995. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 83:803-812.
13. Freytag SO, Paielli DL, Gilbert JD. 1994. Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev 8:1654-1663.
14. Frohnert BI, Hui TY, Bernlohr DA. 1999. Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene. J Biol Chem 274:3970-3977.
15. Gimble JM, Robinson CE, Wu X, Kelly KA, Rodriguez BR, Kliewer SA, Lehmann JM, Morris DC. 1996. Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mol Pharmacol 50:1087-1094.
16. Gregoire FM, Smas CM, Sul SH. 1998. Understanding adipocyte differentiation. Phys Rev 78:783-809.
17. Hu E, Tontonoz P, Spiegelman BM. 1995. Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha. Proc Natl Acad Sci USA 92:9856-9860.
18. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM. 1995. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83:813-819.
19. Lane MD, Lin FT, Macdougald OA, Vasseur-Cognet M. 1996. Control of adipocyte differentiation by CCAAT/enhancer binding protein alpha (C/EBP alpha). Int J Obesity Related Metab Disorders 20:Suppl: S91-S96.
20. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 270:12953-12956.
21. Lekstrom-Himes J, Xanthopoulos KG. 1998. Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J Biol Chem 273:28545-28548.
22. Lin FT, Lane MD. 1994. CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc Natl Acad Sci USA 91:8757-8761.
23. Lukert BP, Raisz LG. 1990. Glucocorticoid-induced osteoporosis: pathogenesis and management. Ann Intern Med 112:352-364.
24. Mandrup S, Lane MD. 1997. Regulating adipogenesis. J Biol Chem 272:5367-5370.
25. Meunier J, Aaron J, Edouard C, Vignon G. 1971. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop 80:147-154.
26. Miller CW, Ntambi JM. 1996. Peroxisome proliferators induce mouse liver stearoyl-CoAdesaturase 1 gene expression. Proc Natl Acad Sci USA 93:9443-9448.
27. Moitra J, Mason MM, Olive M, Krylov D, Gavrilova O, Marcus-Samuels B, Feigenbaum L, Lee E, Aoyama T, Eckhaus M, Reitman ML, Vinson C. 1998. Life without white fat: a transgenic mouse. Genes Dev 12:3168-3181.
28. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman JD, Simonetti DW, Craig S, Marshak DR. 1999. Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147.
29. Prockop DJ. 1997. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:71-74.
30. Ramos RA, Nishio Y, Maiyar AC, Simon KE, Ridder CC, Ge Y, Firestone GL. 1996. Glucocorticoid-stimulated CCAAT/enhancer-binding protein alpha expression is required for steroid-induced G1 cell cycle arrest of minimal-deviation rat hepatoma cells. Mol Cell Biol 16:5288-5301.
31. Schoonjans K, Peinado-Onsurbe J, Lefebvre AM, Heyman RA, Briggs M, Deeb S, Staels B, Auwerx J. 1996. PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J 5:5336-5348.
32. Shi XM, Yang X, Chen D, Chang Z, Cao X. 1999. Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling. J Biol Chem 274:13711-13717.
33. Tanaka T, Yoshida N, Kishimoto T, Akira S. 1997. Defective adipocyte differentiation in mice lacking the C/EBP and/or C/EBP gene. EMBOJ 16:7432-7443.
34. Tontonoz P, Hu E, Devine J, Beale EG, Spiegelman BM. 1995. PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol 15:351-357.
35. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. 1994a. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 8:1224-1234.
36. Tontonoz P, Hu E, Spiegelman BM. 1994b. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79:1147-1156.
37. Umek RM, Friedman AD, McKnight SL. 1991. CCAAT-enhancer binding protein: a component of a differentiation switch. Science 251:288-292.
38. Wu Z, Bucher NL, Farmer SR. 1996. Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids. Mol Cell Biol 16:4128-4136.
39. Wu Z, Rosen ED, Brun R, Hauser S, Adelmant G, Troy AE, McKeon C, Darlington GJ, Spiegelman BM. 1999. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell 3:151-158.
40. Yeh WC, Cao Z, Classon M, McKnight SL. 1995. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev 9:168-181.