Vesicular transport and apotransferrin in intestinal iron absorption, as shown in the Caco-2 cell model

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 290, Issue 2, 2006, Pages

  Moriya, Mizue ^a   Linder, Maria C ^a  

^a CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

Endocytosis; Exocytosis; Polarized Caco 2 cell monolayers

Indexed keywords

5' (4 FLUOROSULFONYLBENZOYL)ADENOSINE; APOTRANSFERRIN; BREFELDIN A; IRON; NOCODAZOLE; TYRPHOSTIN; VESICULAR TRANSPORT PROTEIN; APOPROTEIN; DIAGNOSTIC AGENT; PROTEIN SYNTHESIS INHIBITOR; TRANSFERRIN; TYRPHOSTIN A9;

ARTICLE; BASOLATERAL MEMBRANE; CELL LABELING; CELL STRAIN CACO 2; COOLING; DEPOLYMERIZATION; EXOCYTOSIS; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE CELL; IRON ABSORPTION; MICROTUBULE; MONOLAYER CULTURE; PRIORITY JOURNAL; TIGHT JUNCTION; ACTIVE TRANSPORT; ENERGY METABOLISM; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT;

APOPROTEINS; BIOLOGICAL TRANSPORT, ACTIVE; BREFELDIN A; CACO-2 CELLS; ENERGY METABOLISM; ENTEROCYTES; HUMANS; INTESTINAL ABSORPTION; IRON; IRON RADIOISOTOPES; NOCODAZOLE; PROTEIN SYNTHESIS INHIBITORS; PROTEIN TRANSPORT; TRANSFERRIN; TYRPHOSTINS;

EID: 33644869168     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00029.2005     Document Type: Article

References (50)

1. Abboud S and Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275: 19906-19912, 2000.
2. Alvarez-Hernandez X, Smith M, and Glass J. Regulation of iron uptake and transport by transferrin in Caco2 cells, an intestinal cell line. Biochim Biophys Acta 1192: 215-222, 1994.
3. Alvarez-Hernandez X, Smith M, and Glass J. Apo-transferrin is internalized and routed differently from Fe-transferrin by Caco-2 cells: a confocal microscopy study of vesicular transport in intestinal cells. Blood 95: 721-723, 2000.
4. Alvarez-Hernandez X, Smith M, and Glass J. The effect of apotransferrin on iron release from Caco-2 cells, an intestinal epithelial cell line. Blood 91: 3974-3979, 1998.
5. Anderson GJ, Frazer DM, McKie AT, and Vulpe CD. The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption. Blood Cells Mol Dis 29: 367-375, 2002.
6. Andrews NC. Intestinal iron absorption: current concepts circa 2000. Dig Liver Dis 32: 56-61, 2000.
7. 1+ transporter of intestinal cells. Am J Physiol Cell Physiol 284: C1525-C1530, 2003.
8. Barroso M and Sztul ES. Basolateral to apical transcytosis in polarized cells is indirect and involves BFA and trimeric G protein sensitive passage through the apical endosome. J Cell Biol 124: 83-100, 1994.
9. Chen H, Attieh ZK, Su T, Syed BA, Gao H, Alaeddine RM, Fox TC, Usta J, Naylor CE, Evans RW, McKie AT, Anderson GJ, and Vulpe CD. Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice. Blood 103: 3933-3939, 2004.
10. Chen H, Su T, Attieh ZK, Fox TC, McKie AT, and Anderson GJ, and Vulpe CD. Systemic regulation of hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency. Blood 102: 1893-1999, 2003.
11. Chung J and Wessling-Resnick M. Molecular mechanisms and regulation of iron transport. Crit Rev Clin Lab Sci 40: 151-182, 2003.
12. Conrad ME and Umbreit JN. Iron absorption and transport - an update. Am J Hematol 64: 287-298, 2000.
13. Donovan A and Andrews NC. The molecular regulation if iron metabolism. Hemat J 5: 373-380, 2004.
14. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, and Zon LI. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403: 776-781, 2000.
15. Fleming MD, Trenor CC 3rd, Su MA, Foernzler D, Beier DR, Dietrich WF, and Andrews NC. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16: 383-386, 1997.
16. Garrick MD, Dolan KG, Hornbinski C, Ghio AJ, Higgins D, Porubcin M, Moore EG, Haisworth LN, Umbreit JN, Conrad ME, Feng L, Lis A, Roth JA, Singleton S, and Garrick L. DMT1: a mammalian transporter for multiple metals. Biometals 16: 41-54, 2003.
17. Granick S. Structure and physiological function of ferritin. Physiol Rev 31: 489-511, 1951.
18. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, and Hediger MA. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388: 482-488, 1997.
19. Hughson EJ and Hopkins CR. Endocytic pathways in polarized Caco-2 cells: identification of an endosomal compartment accessible from both apical and basolateral surface. J Cell Biol 110: 337-348, 1990.
20. Hunziker W and Peters PJ. Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells. J Biol Chem 273: 15734-15741, 1998.
21. Jin M and Snider MD. Role of microtubules in transferrin receptor transport from the cell surface to endosomes and the Golgi complex. J Biol Chem 268: 18390-18397, 1993.
22. th International Conference of the International BioIron Society, Bethesda, MD, 2003.
23. Knight A, Hughson E, Hopkins CR, and Cutler DF. Membrane protein trafficking through the common apical endosome compartment of polarized Caco-2 cells. Mol Biol Cell 6: 597-610, 1995.
24. Kruszewski M. Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat Res 531: 81-92, 2003.
25. Linder MC, Dunn V, Isaacs E, Jones D, Lim S, Van Volkom M, and Munro HN. Ferritin and intestinal iron absorption: pancreatic enzymes and free iron. Am J Physiol 228: 196-204, 1975.
26. Linder MC and Munro HN. The mechanism of iron absorption and its regulation. Fed Proc 36: 2017-2023, 1977.
27. Lippincott-Schwartz J, Donaldson JG, Schweizer A, Berger EG, Hauri HP, Yuan LC, and Klausner RD. Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway. Cell 60: 821-836, 1990.
28. Lütcke A, Jansson S, Parton RG, Chavrier P, Valencia A, Huber L, Lehtonen E, and Zerial M. Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. J Cell Biol 121: 553-564, 1993.
29. Ma Y, Specian RD, Yeh KY, Yeh M, Rodriguez-Paris J, and Glass J. The transcytosis of divalent metal transporter 1 and apo-transferrin during iron uptake in intestinal epithelium. Am J Physiol Gastrointest Liver Physiol 283: G965-G974, 2002.
30. Ma Y, Yeh KY, Rodriguez-Paris J, Chen Y, Yeh M, and Glass J. The endocytic pathway of the iron transporter divalent metal transporter 1 in the intestine - evidence for interactions with cytosolic proteins. Biometals. In press.
31. McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, Hediger MA, Hentze MW, and Simpson RJ. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5: 299-309, 2000.
32. Morris Iron ER. In: Trace Elements in Human and Animal Nutrition, edited by Mertz W. San Diego, CA: Academic, 1987.
33. Nuñez MT, Nuñez-Millacura C, Beltran M, Tapia V, and Alvarez-Hernandez X. Apotransferrin and holotransferrin undergo different endocytic cycles in intestinal epithelia (Caco-2) cells. J Biol Chem 272: 19425-19428, 1997.
34. Nuñez MT and Tapia V. Transferrin stimulates iron absorption, exocytosis, and secretion in cultured intestinal cells. Am J Physiol Cell Physiol 276: C1085-C1090, 1999.
35. Okubo M, Yamada K, Hosoyamada M, Shibasaki T, and Endou H. Cadmiun transport by human Nramp2 expressed in Xenopus laevis oocytes. Toxicol Appl Pharmacol 187: 162-167, 2003.
36. Olusanya O, Andrews PD, Swedlow JR, and Smythe E. Phosphorylation of threonine 156 of the μ2 subunit of the AP2 complex is essential for endocytosis in vitro and in vivo. Curr Biol 11: 896-900, 2001.
37. Ravia JJ, Stephen RM, Ghishan FK, and Collins JF. Menkes copper ATPASE (ATP7A) is a novel metal-responsive gene in rat duodenum and immunoreactive protein is present on brush border and basolateral membrane domains. J Biol Chem, Aug 4, Epub, 2005.
38. Roth JA and Garrick MD. Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese. Biochem Pharmacol 66: 1-13, 2003.
39. Roy CN and Enns CA. Iron homeostasis: new tales from the crypt. Blood 96: 4020-4027, 2000.
40. Simovich MJ, Conrad ME, Umbreit JN, Moore EG, Hainsworth LN, and Smith HK. Cellular localization of proteins related to iron absorption and transport. Am J Hematol 69: 164-170, 2002.
41. Tallkvist J, Bowlus CL, and Lonnerdal B. DMT1 gene expression and cadmium absorption in human absorptive enterocytes. Toxicol Lett 122: 171-177, 2001.
42. Thomas C and Oates PS. Ferroportin/IREG1/MTP-1/SLC40A1 modulates the uptake of iron at the apical membrane of enterocytes. Gut 53: 44-49, 2004.
43. Thyberg J and Moskalewski S. Microtubules and the organization of the Golgi complex. Exp Cell Res 159: 1-16, 1985.
44. Turner JR and Tartakoff AM. The response of the Golgi complex to microtubule alterations: the roles of metabolic energy and membrane traffic in Golgi complex organization. J Cell Biol 109: 2081-2088, 1989.
45. Van Dam EM and Stoorvolgel W. Dynamin-dependent transferrin receptor recycling by endosome-derived clathrin-coated vesicles. Mol Biol Cell 13: 169-182, 2002.
46. Xia CQ and Shen WC. Tyrphostin-8 enhances transferrin receptor-mediated transcytosis in Caco2-cells and increases hypoglycemic effect of orally administered insulin-transferrin conjugate in diabetic rats. Pharm Res 18: 191-195, 2001.
47. Xu H, Jin J, DeFelice LJ, Andrews NC, and Clapham DE. A spontaneous recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PloS Biol 2: e50, 2004.
48. Yeh K, Yeh M, Watkins JB, Rodriguez-Paris J, and Glass J. Dietary iron induces rapid changes in rat intestinal divalent metal transporter expression. Am J Physiol Gastrointest Liver Physiol 279: G1070-G1079, 2000.
49. Zacchi P, Stenmark H, Parton RG, Orioli D, Lim F, Giner A, Mellman I, Zerial M, and Murphy C. Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells. J Cell Biol 140: 1039-1053, 1998.
50. Zerounian NR and Linder MC. Effects of copper and ceruloplasmin on iron transport in the Caco-2 cell intestinal model. J Nutr Biochem 13: 138-148, 2002.