Tyrphostin-8 enhances transferrin receptor-mediated transcytosis in Caco-2 cells and increases hypoglycemic effect of orally administered insulin-transferrin conjugate in diabetic rats

Pharmaceutical Research

Volumn 18, Issue 2, 2001, Pages 191-195

  Xia, C Q ^a   Shen, W C ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Caco 2 cells; Diabetic rats; In Tf conjugate; Oral delivery; Tyrphostin 8

Indexed keywords

BREFELDIN A; GLUCOSE; GUANOSINE TRIPHOSPHATASE; HUMAN SERUM ALBUMIN; INSULIN; STREPTOZOCIN; TRANSFERRIN RECEPTOR; TYRPHOSTIN; TYRPHOSTIN 8; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELL MEMBRANE RESISTANCE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ELECTRIC RESISTANCE; FEMALE; GASTROINTESTINAL ABSORPTION; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; TIGHT JUNCTION; TRANSCYTOSIS; TREATMENT OUTCOME;

ANIMALS; CACO-2 CELLS; CELL MOVEMENT; DIABETES MELLITUS, EXPERIMENTAL; DRUG INTERACTIONS; ENZYME INHIBITORS; FEMALE; HUMANS; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; INTESTINAL ABSORPTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFERRIN; TRANSFERRIN; TYRPHOSTINS;

EID: 0034948449     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011032502097     Document Type: Article

References (21)

1. Receptor-mediated transport of peptides and proteins across the blood-brain barrier
2. Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats
3. Brefeldin A enhances receptor-mediated transcytosis of transferrin in filter grown Madin-darby canine kidney cells
4. Transepithelial delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells
5. Epithelial polarity, villin expression and enterocytic differentiation of cultured human colon carcinoma cells: A survey of twenty cell lines
6. Brefeldin A: Insights into the control of membrane traffic and organelle structure
7. Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab 5, and Rab11
8. Sorting of membrane and fluid at the apical pole of polarized Madin-Darby canine kidney cells
9. Inhibition of GTP-utilizing enzymes by tyrphostins
10. Basolateral secretion of kappa light chain in the polarized epithelial cell line, Caco-2
11. Transferrin receptors in the human gastrointestinal tract
12. Receptor-mediated endocytosis: The intracellular journey of transferrin and its receptor
13. Oral delivery of insulin-transferrin conjugate in streptozotocin-treated CF/1 mice
14. The establishment of polarity and enhanced transcytosis of transferrin receptors in enterocyte-like Caco-2 cells
15. Enhancement of transferrin receptor-mediated transcytosis for transepithelial protein delivery
16. Receptor-mediated peptide delivery in pulmonary epithelial monolayers
17. Brefeldin A's effects on endosomes, lysosomes and TGN suggest a general mechanism for regulating organelle structure and membrane traffic
18. Brefeldin A causes a microtubule-mediated fusion of the TGN and early endosomes
19. Different effects of tyrphostin 8, a GTPase inhibitor, on transferrin receptor processing in MDCK and Caco-2 cells
20. Tyrphostin 8: A new enhancer of transferrin receptor-mediated transcytosis in Caco-2 cells
21. The influence of graded hyperglycemia with and without physiological hyperinsulinemia on forearm glucose uptake and other metabolic responses in man