-
1
-
-
4444286756
-
Bioinformatics and cancer target discovery
-
Desany B., Zhang Z. Bioinformatics and cancer target discovery Drug Discov. Today 9 2004 795 802
-
(2004)
Drug Discov. Today
, vol.9
, pp. 795-802
-
-
Desany, B.1
Zhang, Z.2
-
2
-
-
16844363451
-
Exploiting novel cell cycle targets in the development of anticancer agents
-
Wong C.F. Exploiting novel cell cycle targets in the development of anticancer agents Curr. Cancer Drug Targets 5 2005 85 102
-
(2005)
Curr. Cancer Drug Targets
, vol.5
, pp. 85-102
-
-
Wong, C.F.1
-
4
-
-
11844291970
-
The search of DNA-intercalators as antitumoral drugs: What it worked and what did not work
-
Martinez R., Chacon-Garcia L. The search of DNA-intercalators as antitumoral drugs: what it worked and what did not work Curr. Med. Chem. 12 2005 127 151
-
(2005)
Curr. Med. Chem.
, vol.12
, pp. 127-151
-
-
Martinez, R.1
Chacon-Garcia, L.2
-
5
-
-
2942547670
-
Molecular therapeutic approaches to acute myeloid leukemia: Targeting aberrant chromatin dynamics and signal transduction
-
Piazza F., Semenzato G. Molecular therapeutic approaches to acute myeloid leukemia: targeting aberrant chromatin dynamics and signal transduction Expert Rev. Anticancer Ther. 4 2004 387 400
-
(2004)
Expert Rev. Anticancer Ther.
, vol.4
, pp. 387-400
-
-
Piazza, F.1
Semenzato, G.2
-
6
-
-
14844318078
-
Identification of cancer genes by mutational profiling of tumor genomes
-
Benvenuti S. Identification of cancer genes by mutational profiling of tumor genomes FEBS Lett. 579 2005 1884 1890
-
(2005)
FEBS Lett.
, vol.579
, pp. 1884-1890
-
-
Benvenuti, S.1
-
7
-
-
11844251275
-
Development of molecular targeted anticancer agents: Successes, failures and future directions
-
Chen E.X., Siu L.L. Development of molecular targeted anticancer agents: successes, failures and future directions Curr. Pharm. Des. 11 2005 265 272
-
(2005)
Curr. Pharm. Des.
, vol.11
, pp. 265-272
-
-
Chen, E.X.1
Siu, L.L.2
-
8
-
-
0344708478
-
Anticancer antifolates: Current status and future directions
-
McGuire J.J. Anticancer antifolates: current status and future directions Curr. Pharm. Des. 9 2003 2593 2613
-
(2003)
Curr. Pharm. Des.
, vol.9
, pp. 2593-2613
-
-
McGuire, J.J.1
-
9
-
-
0037430585
-
Cytotoxic activity of 6-alkynyl- and 6-alkenylpurines
-
Brathe A. Cytotoxic activity of 6-alkynyl- and 6-alkenylpurines Bioorg. Med. Chem. Lett. 13 2003 877 880
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 877-880
-
-
Brathe, A.1
-
11
-
-
4043080742
-
Development of novel alkylating drugs as anticancer agents
-
Izbicka E., Tolcher A.W. Development of novel alkylating drugs as anticancer agents Curr. Opin. Investig. Drugs 5 2004 587 591
-
(2004)
Curr. Opin. Investig. Drugs
, vol.5
, pp. 587-591
-
-
Izbicka, E.1
Tolcher, A.W.2
-
12
-
-
0034782523
-
Intercalators as anticancer drugs
-
Brana M.F. Intercalators as anticancer drugs Curr. Pharm. Des. 7 2001 1745 1780
-
(2001)
Curr. Pharm. Des.
, vol.7
, pp. 1745-1780
-
-
Brana, M.F.1
-
13
-
-
0042346439
-
Catalytic topoisomerase II inhibitors in cancer therapy
-
Larsen A.K. Catalytic topoisomerase II inhibitors in cancer therapy Pharmacol. Ther. 99 2003 167 181
-
(2003)
Pharmacol. Ther.
, vol.99
, pp. 167-181
-
-
Larsen, A.K.1
-
14
-
-
14944352232
-
Rational approaches to the design of therapeutics targeting molecular markers: The case of chronic myelogenous leukemia
-
Saglio G. Rational approaches to the design of therapeutics targeting molecular markers: the case of chronic myelogenous leukemia Ann. N. Y. Acad. Sci. 1028 2004 423 431
-
(2004)
Ann. N. Y. Acad. Sci.
, vol.1028
, pp. 423-431
-
-
Saglio, G.1
-
15
-
-
22444444402
-
Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse
-
Collier L.S. Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse Nature 436 2005 272 276
-
(2005)
Nature
, vol.436
, pp. 272-276
-
-
Collier, L.S.1
-
16
-
-
20444498116
-
Kinomics: Characterizing the therapeutically validated kinase space
-
Vieth M. Kinomics: characterizing the therapeutically validated kinase space Drug Discov. Today 10 2005 839 846
-
(2005)
Drug Discov. Today
, vol.10
, pp. 839-846
-
-
Vieth, M.1
-
17
-
-
4344623889
-
Imatinib as a paradigm of targeted therapies
-
Druker B.J. Imatinib as a paradigm of targeted therapies Adv. Cancer Res. 91 2004 1 30
-
(2004)
Adv. Cancer Res.
, vol.91
, pp. 1-30
-
-
Druker, B.J.1
-
18
-
-
21344442676
-
Proteasome inhibition as a therapeutic strategy for hematologic malignancies
-
Mitsiades C.S. Proteasome inhibition as a therapeutic strategy for hematologic malignancies Expert Rev. Anticancer Ther. 5 2005 465 476
-
(2005)
Expert Rev. Anticancer Ther.
, vol.5
, pp. 465-476
-
-
Mitsiades, C.S.1
-
19
-
-
0036083301
-
Mechanism of action of antitumor drugs that interact with microtubules and tubulin
-
Jordan M.A. Mechanism of action of antitumor drugs that interact with microtubules and tubulin Curr. Med. Chem. Anti-Canc. Agents 2 2002 1 17
-
(2002)
Curr. Med. Chem. Anti-Canc. Agents
, vol.2
, pp. 1-17
-
-
Jordan, M.A.1
-
20
-
-
0037244752
-
Advances in the science of estrogen receptor modulation
-
Meegan M.J., Lloyd D.G. Advances in the science of estrogen receptor modulation Curr. Med. Chem. 10 2003 181 210
-
(2003)
Curr. Med. Chem.
, vol.10
, pp. 181-210
-
-
Meegan, M.J.1
Lloyd, D.G.2
-
21
-
-
7444253379
-
Benzoxepin-derived estrogen receptor modulators: A novel molecular scaffold for the estrogen receptor
-
Lloyd D.G. Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor J. Med. Chem. 47 2004 5612 5615
-
(2004)
J. Med. Chem.
, vol.47
, pp. 5612-5615
-
-
Lloyd, D.G.1
-
22
-
-
14844343093
-
A transmembrane intracellular estrogen receptor mediates rapid cell signaling
-
Revankar C.M. A transmembrane intracellular estrogen receptor mediates rapid cell signaling Science 307 2005 1625 1630
-
(2005)
Science
, vol.307
, pp. 1625-1630
-
-
Revankar, C.M.1
-
23
-
-
0036755404
-
Androgen receptor as a target in androgen-independent prostate cancer
-
Balk S.P. Androgen receptor as a target in androgen-independent prostate cancer Urology 60 Suppl. 1 2002 132 138
-
(2002)
Urology
, vol.60
, Issue.1 SUPPL.
, pp. 132-138
-
-
Balk, S.P.1
-
24
-
-
0026035942
-
Pharmacology of antiandrogens and value of combining androgen suppression with antiandrogen therapy
-
Gaillard-Moguilewsky M. Pharmacology of antiandrogens and value of combining androgen suppression with antiandrogen therapy Urology 37 Suppl. 2 1991 5 12
-
(1991)
Urology
, vol.37
, Issue.2 SUPPL.
, pp. 5-12
-
-
Gaillard-Moguilewsky, M.1
-
25
-
-
6444233171
-
Aromatase inhibitors: A new paradigm in breast cancer treatment
-
Narashimamurthy J. Aromatase inhibitors: a new paradigm in breast cancer treatment Curr. Med. Chem. Anti-Canc. Agents 4 2004 523 534
-
(2004)
Curr. Med. Chem. Anti-Canc. Agents
, vol.4
, pp. 523-534
-
-
Narashimamurthy, J.1
-
26
-
-
23744497928
-
Aromatase inhibitors for therapy of advanced breast cancer
-
Ingle J.N., Suman V.J. Aromatase inhibitors for therapy of advanced breast cancer J. Steroid Biochem. Mol. Biol. 95 2005 113 119
-
(2005)
J. Steroid Biochem. Mol. Biol.
, vol.95
, pp. 113-119
-
-
Ingle, J.N.1
Suman, V.J.2
-
27
-
-
0033223647
-
Toward designing drug-like libraries: A novel computational approach for prediction of drug feasibility of compounds
-
Wang J., Ramnarayan K. Toward designing drug-like libraries: a novel computational approach for prediction of drug feasibility of compounds J. Comb. Chem. 1 1999 524 533
-
(1999)
J. Comb. Chem.
, vol.1
, pp. 524-533
-
-
Wang, J.1
Ramnarayan, K.2
-
29
-
-
0036670797
-
Virtual screening: A real screening complement to high-throughput screening
-
Mestres J. Virtual screening: a real screening complement to high-throughput screening Biochem. Soc. Trans. 30 2002 797 799
-
(2002)
Biochem. Soc. Trans.
, vol.30
, pp. 797-799
-
-
Mestres, J.1
-
30
-
-
1642350394
-
Recent development and application of virtual screening in drug discovery: An overview
-
Hou T., Xu X. Recent development and application of virtual screening in drug discovery: an overview Curr. Pharm. Des. 10 2004 1011 1033
-
(2004)
Curr. Pharm. Des.
, vol.10
, pp. 1011-1033
-
-
Hou, T.1
Xu, X.2
-
31
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski C.A. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Deliv. Rev. 23 1997 3 25
-
(1997)
Adv. Drug Deliv. Rev.
, vol.23
, pp. 3-25
-
-
Lipinski, C.A.1
-
32
-
-
0141726877
-
A 'Rule of Three' for fragment-based lead discovery?
-
Congreve M. A 'Rule of Three' for fragment-based lead discovery? Drug Discov. Today 8 2003 876 877
-
(2003)
Drug Discov. Today
, vol.8
, pp. 876-877
-
-
Congreve, M.1
-
33
-
-
1242271305
-
Molecular recognition: The fragment approach in lead generation
-
Fattori D. Molecular recognition: The fragment approach in lead generation Drug Discov. Today 9 2004 229 238
-
(2004)
Drug Discov. Today
, vol.9
, pp. 229-238
-
-
Fattori, D.1
-
34
-
-
0034256065
-
The in silico world of virtual libraries
-
Leach A.R., Hann M.M. The in silico world of virtual libraries Drug Discov. Today 5 2000 326 336
-
(2000)
Drug Discov. Today
, vol.5
, pp. 326-336
-
-
Leach, A.R.1
Hann, M.M.2
-
35
-
-
19044394524
-
Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization
-
Shuttleworth S.J. Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization Curr. Med. Chem. 12 2005 1239 1281
-
(2005)
Curr. Med. Chem.
, vol.12
, pp. 1239-1281
-
-
Shuttleworth, S.J.1
-
36
-
-
21444448621
-
Strategies for compound selection
-
Olah M.M. Strategies for compound selection Curr. Drug Disc. Tech. 1 2004 211 220
-
(2004)
Curr. Drug Disc. Tech.
, vol.1
, pp. 211-220
-
-
Olah, M.M.1
-
37
-
-
20144366000
-
Focused combinatorial library design based on structural diversity, druglikeness and binding affinity score
-
Chen G. Focused combinatorial library design based on structural diversity, druglikeness and binding affinity score J. Comb. Chem. 7 2005 398 406
-
(2005)
J. Comb. Chem.
, vol.7
, pp. 398-406
-
-
Chen, G.1
-
38
-
-
0036589285
-
Lead structure searching: Are we looking at the appropriate property?
-
Oprea T.I. Lead structure searching: are we looking at the appropriate property? J. Comput. Aided Mol. Des. 16 2002 325 334
-
(2002)
J. Comput. Aided Mol. Des.
, vol.16
, pp. 325-334
-
-
Oprea, T.I.1
-
39
-
-
0037107887
-
Structure-based virtual screening: An overview
-
Lyne P.D. Structure-based virtual screening: an overview Drug Discov. Today 7 2002 1047 1055
-
(2002)
Drug Discov. Today
, vol.7
, pp. 1047-1055
-
-
Lyne, P.D.1
-
40
-
-
0034073605
-
Property distribution of drug-related chemical databases
-
Oprea T.I. Property distribution of drug-related chemical databases J. Comput. Aided Mol. Des. 14 2000 251 264
-
(2000)
J. Comput. Aided Mol. Des.
, vol.14
, pp. 251-264
-
-
Oprea, T.I.1
-
41
-
-
1542724421
-
Design of a compound screening collection for use in high-throughput screening
-
Harper G. Design of a compound screening collection for use in high-throughput screening Comb. Chem. High Throughput Screen 7 2004 63 70
-
(2004)
Comb. Chem. High Throughput Screen
, vol.7
, pp. 63-70
-
-
Harper, G.1
-
42
-
-
2942564021
-
Pursuing the leadlikeness concept in pharmaceutical research
-
Hann M.M., Oprea T.I. Pursuing the leadlikeness concept in pharmaceutical research Curr. Opin. Chem. Biol. 8 2004 255 263
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 255-263
-
-
Hann, M.M.1
Oprea, T.I.2
-
44
-
-
0034461768
-
Drug-like properties and the cause of poor solubility and poor permeability
-
Lipinski C.A. Drug-like properties and the cause of poor solubility and poor permeability J. Pharmacol. Toxicol. Methods 44 2000 235 249
-
(2000)
J. Pharmacol. Toxicol. Methods
, vol.44
, pp. 235-249
-
-
Lipinski, C.A.1
-
45
-
-
0000262640
-
A new atom-additive method for calculating partition coefficients
-
Wang R. A new atom-additive method for calculating partition coefficients J. Chem. Inf. Comput. Sci. 37 1997 615 621
-
(1997)
J. Chem. Inf. Comput. Sci.
, vol.37
, pp. 615-621
-
-
Wang, R.1
-
47
-
-
0042202919
-
Chemography: The art of navigating in chemical space
-
Oprea T.I., Gottfries J. Chemography: the art of navigating in chemical space J. Comb. Chem. 3 2001 157 166
-
(2001)
J. Comb. Chem.
, vol.3
, pp. 157-166
-
-
Oprea, T.I.1
Gottfries, J.2
-
48
-
-
84968923096
-
WOMBAT: World of molecular bioactivity
-
Oprea T.I. Wiley-VCH
-
Olah M. WOMBAT: world of molecular bioactivity Oprea T.I. Chemoinformatics in drug discovery 2004 Wiley-VCH 223 239
-
(2004)
Chemoinformatics in Drug Discovery
, pp. 223-239
-
-
Olah, M.1
-
49
-
-
13844312649
-
ZINC - A free database of commercially available compounds for virtual screening
-
Irwin J.J., Shoichet B.K. ZINC - a free database of commercially available compounds for virtual screening J. Chem. Inf. Model. 45 2005 177 182
-
(2005)
J. Chem. Inf. Model.
, vol.45
, pp. 177-182
-
-
Irwin, J.J.1
Shoichet, B.K.2
-
50
-
-
5644251993
-
Mapping chemical space using molecular descriptors and chemical genetics: Deacetylase inhibitors
-
Haggarty S.J. Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors Comb. Chem. High Throughput Screen 7 2004 669 676
-
(2004)
Comb. Chem. High Throughput Screen
, vol.7
, pp. 669-676
-
-
Haggarty, S.J.1
|