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Volumn 11, Issue 3-4, 2006, Pages 149-159

Oncology exploration: Charting cancer medicinal chemistry space

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; ANASTROZOLE; ANTIANDROGEN; ANTIMETABOLITE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; AROMATASE INHIBITOR; BLEOMYCIN A2; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; FLUDARABINE; FLUOROURACIL; GEFITINIB; GEMCITABINE; IMATINIB; INTERCALATING AGENT; MERCAPTOPURINE; METHOTREXATE; PACLITAXEL; PHOSPHOTRANSFERASE INHIBITOR; PROTEASOME INHIBITOR; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TETRAPLATIN; TRASTUZUMAB; UNINDEXED DRUG;

EID: 33644861259     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(05)03688-3     Document Type: Review
Times cited : (44)

References (50)
  • 1
    • 4444286756 scopus 로고    scopus 로고
    • Bioinformatics and cancer target discovery
    • Desany B., Zhang Z. Bioinformatics and cancer target discovery Drug Discov. Today 9 2004 795 802
    • (2004) Drug Discov. Today , vol.9 , pp. 795-802
    • Desany, B.1    Zhang, Z.2
  • 2
    • 16844363451 scopus 로고    scopus 로고
    • Exploiting novel cell cycle targets in the development of anticancer agents
    • Wong C.F. Exploiting novel cell cycle targets in the development of anticancer agents Curr. Cancer Drug Targets 5 2005 85 102
    • (2005) Curr. Cancer Drug Targets , vol.5 , pp. 85-102
    • Wong, C.F.1
  • 4
    • 11844291970 scopus 로고    scopus 로고
    • The search of DNA-intercalators as antitumoral drugs: What it worked and what did not work
    • Martinez R., Chacon-Garcia L. The search of DNA-intercalators as antitumoral drugs: what it worked and what did not work Curr. Med. Chem. 12 2005 127 151
    • (2005) Curr. Med. Chem. , vol.12 , pp. 127-151
    • Martinez, R.1    Chacon-Garcia, L.2
  • 5
    • 2942547670 scopus 로고    scopus 로고
    • Molecular therapeutic approaches to acute myeloid leukemia: Targeting aberrant chromatin dynamics and signal transduction
    • Piazza F., Semenzato G. Molecular therapeutic approaches to acute myeloid leukemia: targeting aberrant chromatin dynamics and signal transduction Expert Rev. Anticancer Ther. 4 2004 387 400
    • (2004) Expert Rev. Anticancer Ther. , vol.4 , pp. 387-400
    • Piazza, F.1    Semenzato, G.2
  • 6
    • 14844318078 scopus 로고    scopus 로고
    • Identification of cancer genes by mutational profiling of tumor genomes
    • Benvenuti S. Identification of cancer genes by mutational profiling of tumor genomes FEBS Lett. 579 2005 1884 1890
    • (2005) FEBS Lett. , vol.579 , pp. 1884-1890
    • Benvenuti, S.1
  • 7
    • 11844251275 scopus 로고    scopus 로고
    • Development of molecular targeted anticancer agents: Successes, failures and future directions
    • Chen E.X., Siu L.L. Development of molecular targeted anticancer agents: successes, failures and future directions Curr. Pharm. Des. 11 2005 265 272
    • (2005) Curr. Pharm. Des. , vol.11 , pp. 265-272
    • Chen, E.X.1    Siu, L.L.2
  • 8
    • 0344708478 scopus 로고    scopus 로고
    • Anticancer antifolates: Current status and future directions
    • McGuire J.J. Anticancer antifolates: current status and future directions Curr. Pharm. Des. 9 2003 2593 2613
    • (2003) Curr. Pharm. Des. , vol.9 , pp. 2593-2613
    • McGuire, J.J.1
  • 9
    • 0037430585 scopus 로고    scopus 로고
    • Cytotoxic activity of 6-alkynyl- and 6-alkenylpurines
    • Brathe A. Cytotoxic activity of 6-alkynyl- and 6-alkenylpurines Bioorg. Med. Chem. Lett. 13 2003 877 880
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 877-880
    • Brathe, A.1
  • 11
    • 4043080742 scopus 로고    scopus 로고
    • Development of novel alkylating drugs as anticancer agents
    • Izbicka E., Tolcher A.W. Development of novel alkylating drugs as anticancer agents Curr. Opin. Investig. Drugs 5 2004 587 591
    • (2004) Curr. Opin. Investig. Drugs , vol.5 , pp. 587-591
    • Izbicka, E.1    Tolcher, A.W.2
  • 12
    • 0034782523 scopus 로고    scopus 로고
    • Intercalators as anticancer drugs
    • Brana M.F. Intercalators as anticancer drugs Curr. Pharm. Des. 7 2001 1745 1780
    • (2001) Curr. Pharm. Des. , vol.7 , pp. 1745-1780
    • Brana, M.F.1
  • 13
    • 0042346439 scopus 로고    scopus 로고
    • Catalytic topoisomerase II inhibitors in cancer therapy
    • Larsen A.K. Catalytic topoisomerase II inhibitors in cancer therapy Pharmacol. Ther. 99 2003 167 181
    • (2003) Pharmacol. Ther. , vol.99 , pp. 167-181
    • Larsen, A.K.1
  • 14
    • 14944352232 scopus 로고    scopus 로고
    • Rational approaches to the design of therapeutics targeting molecular markers: The case of chronic myelogenous leukemia
    • Saglio G. Rational approaches to the design of therapeutics targeting molecular markers: the case of chronic myelogenous leukemia Ann. N. Y. Acad. Sci. 1028 2004 423 431
    • (2004) Ann. N. Y. Acad. Sci. , vol.1028 , pp. 423-431
    • Saglio, G.1
  • 15
    • 22444444402 scopus 로고    scopus 로고
    • Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse
    • Collier L.S. Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse Nature 436 2005 272 276
    • (2005) Nature , vol.436 , pp. 272-276
    • Collier, L.S.1
  • 16
    • 20444498116 scopus 로고    scopus 로고
    • Kinomics: Characterizing the therapeutically validated kinase space
    • Vieth M. Kinomics: characterizing the therapeutically validated kinase space Drug Discov. Today 10 2005 839 846
    • (2005) Drug Discov. Today , vol.10 , pp. 839-846
    • Vieth, M.1
  • 17
    • 4344623889 scopus 로고    scopus 로고
    • Imatinib as a paradigm of targeted therapies
    • Druker B.J. Imatinib as a paradigm of targeted therapies Adv. Cancer Res. 91 2004 1 30
    • (2004) Adv. Cancer Res. , vol.91 , pp. 1-30
    • Druker, B.J.1
  • 18
    • 21344442676 scopus 로고    scopus 로고
    • Proteasome inhibition as a therapeutic strategy for hematologic malignancies
    • Mitsiades C.S. Proteasome inhibition as a therapeutic strategy for hematologic malignancies Expert Rev. Anticancer Ther. 5 2005 465 476
    • (2005) Expert Rev. Anticancer Ther. , vol.5 , pp. 465-476
    • Mitsiades, C.S.1
  • 19
    • 0036083301 scopus 로고    scopus 로고
    • Mechanism of action of antitumor drugs that interact with microtubules and tubulin
    • Jordan M.A. Mechanism of action of antitumor drugs that interact with microtubules and tubulin Curr. Med. Chem. Anti-Canc. Agents 2 2002 1 17
    • (2002) Curr. Med. Chem. Anti-Canc. Agents , vol.2 , pp. 1-17
    • Jordan, M.A.1
  • 20
    • 0037244752 scopus 로고    scopus 로고
    • Advances in the science of estrogen receptor modulation
    • Meegan M.J., Lloyd D.G. Advances in the science of estrogen receptor modulation Curr. Med. Chem. 10 2003 181 210
    • (2003) Curr. Med. Chem. , vol.10 , pp. 181-210
    • Meegan, M.J.1    Lloyd, D.G.2
  • 21
    • 7444253379 scopus 로고    scopus 로고
    • Benzoxepin-derived estrogen receptor modulators: A novel molecular scaffold for the estrogen receptor
    • Lloyd D.G. Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor J. Med. Chem. 47 2004 5612 5615
    • (2004) J. Med. Chem. , vol.47 , pp. 5612-5615
    • Lloyd, D.G.1
  • 22
    • 14844343093 scopus 로고    scopus 로고
    • A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    • Revankar C.M. A transmembrane intracellular estrogen receptor mediates rapid cell signaling Science 307 2005 1625 1630
    • (2005) Science , vol.307 , pp. 1625-1630
    • Revankar, C.M.1
  • 23
    • 0036755404 scopus 로고    scopus 로고
    • Androgen receptor as a target in androgen-independent prostate cancer
    • Balk S.P. Androgen receptor as a target in androgen-independent prostate cancer Urology 60 Suppl. 1 2002 132 138
    • (2002) Urology , vol.60 , Issue.1 SUPPL. , pp. 132-138
    • Balk, S.P.1
  • 24
    • 0026035942 scopus 로고
    • Pharmacology of antiandrogens and value of combining androgen suppression with antiandrogen therapy
    • Gaillard-Moguilewsky M. Pharmacology of antiandrogens and value of combining androgen suppression with antiandrogen therapy Urology 37 Suppl. 2 1991 5 12
    • (1991) Urology , vol.37 , Issue.2 SUPPL. , pp. 5-12
    • Gaillard-Moguilewsky, M.1
  • 25
    • 6444233171 scopus 로고    scopus 로고
    • Aromatase inhibitors: A new paradigm in breast cancer treatment
    • Narashimamurthy J. Aromatase inhibitors: a new paradigm in breast cancer treatment Curr. Med. Chem. Anti-Canc. Agents 4 2004 523 534
    • (2004) Curr. Med. Chem. Anti-Canc. Agents , vol.4 , pp. 523-534
    • Narashimamurthy, J.1
  • 26
    • 23744497928 scopus 로고    scopus 로고
    • Aromatase inhibitors for therapy of advanced breast cancer
    • Ingle J.N., Suman V.J. Aromatase inhibitors for therapy of advanced breast cancer J. Steroid Biochem. Mol. Biol. 95 2005 113 119
    • (2005) J. Steroid Biochem. Mol. Biol. , vol.95 , pp. 113-119
    • Ingle, J.N.1    Suman, V.J.2
  • 27
    • 0033223647 scopus 로고    scopus 로고
    • Toward designing drug-like libraries: A novel computational approach for prediction of drug feasibility of compounds
    • Wang J., Ramnarayan K. Toward designing drug-like libraries: a novel computational approach for prediction of drug feasibility of compounds J. Comb. Chem. 1 1999 524 533
    • (1999) J. Comb. Chem. , vol.1 , pp. 524-533
    • Wang, J.1    Ramnarayan, K.2
  • 29
    • 0036670797 scopus 로고    scopus 로고
    • Virtual screening: A real screening complement to high-throughput screening
    • Mestres J. Virtual screening: a real screening complement to high-throughput screening Biochem. Soc. Trans. 30 2002 797 799
    • (2002) Biochem. Soc. Trans. , vol.30 , pp. 797-799
    • Mestres, J.1
  • 30
    • 1642350394 scopus 로고    scopus 로고
    • Recent development and application of virtual screening in drug discovery: An overview
    • Hou T., Xu X. Recent development and application of virtual screening in drug discovery: an overview Curr. Pharm. Des. 10 2004 1011 1033
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 1011-1033
    • Hou, T.1    Xu, X.2
  • 31
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski C.A. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Deliv. Rev. 23 1997 3 25
    • (1997) Adv. Drug Deliv. Rev. , vol.23 , pp. 3-25
    • Lipinski, C.A.1
  • 32
    • 0141726877 scopus 로고    scopus 로고
    • A 'Rule of Three' for fragment-based lead discovery?
    • Congreve M. A 'Rule of Three' for fragment-based lead discovery? Drug Discov. Today 8 2003 876 877
    • (2003) Drug Discov. Today , vol.8 , pp. 876-877
    • Congreve, M.1
  • 33
    • 1242271305 scopus 로고    scopus 로고
    • Molecular recognition: The fragment approach in lead generation
    • Fattori D. Molecular recognition: The fragment approach in lead generation Drug Discov. Today 9 2004 229 238
    • (2004) Drug Discov. Today , vol.9 , pp. 229-238
    • Fattori, D.1
  • 34
    • 0034256065 scopus 로고    scopus 로고
    • The in silico world of virtual libraries
    • Leach A.R., Hann M.M. The in silico world of virtual libraries Drug Discov. Today 5 2000 326 336
    • (2000) Drug Discov. Today , vol.5 , pp. 326-336
    • Leach, A.R.1    Hann, M.M.2
  • 35
    • 19044394524 scopus 로고    scopus 로고
    • Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization
    • Shuttleworth S.J. Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization Curr. Med. Chem. 12 2005 1239 1281
    • (2005) Curr. Med. Chem. , vol.12 , pp. 1239-1281
    • Shuttleworth, S.J.1
  • 36
    • 21444448621 scopus 로고    scopus 로고
    • Strategies for compound selection
    • Olah M.M. Strategies for compound selection Curr. Drug Disc. Tech. 1 2004 211 220
    • (2004) Curr. Drug Disc. Tech. , vol.1 , pp. 211-220
    • Olah, M.M.1
  • 37
    • 20144366000 scopus 로고    scopus 로고
    • Focused combinatorial library design based on structural diversity, druglikeness and binding affinity score
    • Chen G. Focused combinatorial library design based on structural diversity, druglikeness and binding affinity score J. Comb. Chem. 7 2005 398 406
    • (2005) J. Comb. Chem. , vol.7 , pp. 398-406
    • Chen, G.1
  • 38
    • 0036589285 scopus 로고    scopus 로고
    • Lead structure searching: Are we looking at the appropriate property?
    • Oprea T.I. Lead structure searching: are we looking at the appropriate property? J. Comput. Aided Mol. Des. 16 2002 325 334
    • (2002) J. Comput. Aided Mol. Des. , vol.16 , pp. 325-334
    • Oprea, T.I.1
  • 39
    • 0037107887 scopus 로고    scopus 로고
    • Structure-based virtual screening: An overview
    • Lyne P.D. Structure-based virtual screening: an overview Drug Discov. Today 7 2002 1047 1055
    • (2002) Drug Discov. Today , vol.7 , pp. 1047-1055
    • Lyne, P.D.1
  • 40
    • 0034073605 scopus 로고    scopus 로고
    • Property distribution of drug-related chemical databases
    • Oprea T.I. Property distribution of drug-related chemical databases J. Comput. Aided Mol. Des. 14 2000 251 264
    • (2000) J. Comput. Aided Mol. Des. , vol.14 , pp. 251-264
    • Oprea, T.I.1
  • 41
    • 1542724421 scopus 로고    scopus 로고
    • Design of a compound screening collection for use in high-throughput screening
    • Harper G. Design of a compound screening collection for use in high-throughput screening Comb. Chem. High Throughput Screen 7 2004 63 70
    • (2004) Comb. Chem. High Throughput Screen , vol.7 , pp. 63-70
    • Harper, G.1
  • 42
    • 2942564021 scopus 로고    scopus 로고
    • Pursuing the leadlikeness concept in pharmaceutical research
    • Hann M.M., Oprea T.I. Pursuing the leadlikeness concept in pharmaceutical research Curr. Opin. Chem. Biol. 8 2004 255 263
    • (2004) Curr. Opin. Chem. Biol. , vol.8 , pp. 255-263
    • Hann, M.M.1    Oprea, T.I.2
  • 44
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the cause of poor solubility and poor permeability
    • Lipinski C.A. Drug-like properties and the cause of poor solubility and poor permeability J. Pharmacol. Toxicol. Methods 44 2000 235 249
    • (2000) J. Pharmacol. Toxicol. Methods , vol.44 , pp. 235-249
    • Lipinski, C.A.1
  • 45
    • 0000262640 scopus 로고    scopus 로고
    • A new atom-additive method for calculating partition coefficients
    • Wang R. A new atom-additive method for calculating partition coefficients J. Chem. Inf. Comput. Sci. 37 1997 615 621
    • (1997) J. Chem. Inf. Comput. Sci. , vol.37 , pp. 615-621
    • Wang, R.1
  • 47
    • 0042202919 scopus 로고    scopus 로고
    • Chemography: The art of navigating in chemical space
    • Oprea T.I., Gottfries J. Chemography: the art of navigating in chemical space J. Comb. Chem. 3 2001 157 166
    • (2001) J. Comb. Chem. , vol.3 , pp. 157-166
    • Oprea, T.I.1    Gottfries, J.2
  • 48
    • 84968923096 scopus 로고    scopus 로고
    • WOMBAT: World of molecular bioactivity
    • Oprea T.I. Wiley-VCH
    • Olah M. WOMBAT: world of molecular bioactivity Oprea T.I. Chemoinformatics in drug discovery 2004 Wiley-VCH 223 239
    • (2004) Chemoinformatics in Drug Discovery , pp. 223-239
    • Olah, M.1
  • 49
    • 13844312649 scopus 로고    scopus 로고
    • ZINC - A free database of commercially available compounds for virtual screening
    • Irwin J.J., Shoichet B.K. ZINC - a free database of commercially available compounds for virtual screening J. Chem. Inf. Model. 45 2005 177 182
    • (2005) J. Chem. Inf. Model. , vol.45 , pp. 177-182
    • Irwin, J.J.1    Shoichet, B.K.2
  • 50
    • 5644251993 scopus 로고    scopus 로고
    • Mapping chemical space using molecular descriptors and chemical genetics: Deacetylase inhibitors
    • Haggarty S.J. Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors Comb. Chem. High Throughput Screen 7 2004 669 676
    • (2004) Comb. Chem. High Throughput Screen , vol.7 , pp. 669-676
    • Haggarty, S.J.1


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