Toward designing drug-like libraries: A novel computational approach for prediction of drug feasibility of compounds

Journal of Combinatorial Chemistry

Volumn 1, Issue 6, 1999, Pages 524-533

  Wang, Jing ^a   Ramnarayan, Kal ^a  

^a Structural Bioinformatics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; CONFORMATION; DRUG DESIGN; DRUG STABILITY; METHODOLOGY;

COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; DRUG STABILITY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS;

EID: 0033223647     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc990032m     Document Type: Article

References (4)

1. Fecik, R. A.; Frank, K. E.; Gentry, E. J.; Menon, S. R.; Mitscher, L. A.; Telikepalli, H. The search for orally active medications through combinatorial chemistry. Res. Rev. 1998, 18, 149-185.
2. Sadowski, J.; Kubinyi, H. A scoring scheme for discriminating between drugs and non-drugs. J. Med. Chem. 1998, 41, 3325-3329.
3. Ajay, W.; Walters, P.; Murcko, M. A. Can we learn to distinguish between "drug-like" and "non-drug-like" molecules? J. Med. Chem. 1998, 41, 3314-3324.
4. Jakoby, W. B. Enzymatic Basis of Detoxication. Volume I; Academic Press Inc.: Orlando, 1980.