The normal cellular prion protein (PrPc) is strongly expressed in bovine endocrine pancreas

Histochemistry and Cell Biology

Volumn 125, Issue 4, 2006, Pages 441-448

  Amselgruber, W M ^a   Buttner M ^b   Schlegel, T ^a   Schweiger, M ^a   Pfaff, E ^c  

^a UNIVERSITY OF HOHENHEIM   (Germany)

^b BAVARIAN HEALTH AND FOOD SAFETY AUTHORITY   (Germany)

^c FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

Bovine pancreas; Immunohistochemistry; Islets of langerhans; Prion protein; RT PCR

Indexed keywords

CHROMOGRANIN A; CHROMOGRANIN B; GLUCAGON; INSULIN; PRION PROTEIN; PROTEIN ANTIBODY; SOMATOSTATIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COW; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; NEUROECTODERM; NONHUMAN; PANCREAS ISLET CELL; PERINATAL PERIOD; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SECTION;

ANIMALS; BIOLOGICAL MARKERS; CATTLE; CHROMOGRANIN A; CHROMOGRANIN B; FETUS; ISLETS OF LANGERHANS; PRPC PROTEINS;

ANIMALIA; BOVINAE;

EID: 33644853739     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-005-0089-6     Document Type: Article

References (67)

1. Aguzzi A, Heppner FL, Heikenwalder M, Prinz M, Mertz K, Seeger H, Glatzel M (2003) Immune system and peripheral nerves in propagation of prions to CNS. Br Med Bull 66:141-156
2. Aguzzi A, Weissmann C (1997) Prion research: the next frontiers. Nature 389:795-798
3. Andreoletti O, Berthon P, Marc D, Sarradin P, Grosclaude J, van Keulen L, Schelcher F, Elsen JM, Lantier F (2000) Early accumulation of PrPSc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie. J Gen Virol 81:3115-3126
4. Atouf F, Scharfmann R, Lasmezas C, Czernichow P (1994) Tight hormonal control of PrP gene expression in endocrine pancreatic cells. Biochem Biophys Res Commun 201:1220-1226
5. Baron TGM, Madec JY, Calavas D (1999) Similar signature of the prion protein in natural sheep scrapie and bovine spongiform encephalopathy-linked diseases. J Clin Microbiol 37:3701-3704
6. Borelli MI, Villar MJ, Orezzoli A, Gagliardino JJ (1997) Presence of DOPA decarboxylase and its localisation in adult rat pancreatic islet cells. Diabetes Metabol 23:161-163
7. Bounias M, Purdey M (2002) Transmissible spongiform encephalopathies: a family of etiologically complex diseases - a review. Sci Total Environ 297:1-19
8. Brandner S, Klein MA, Frigg R, Pekarik V, Parizek P, Raeber A, Glatzel M, Schwarz P, Rulicke T, Weissmann C, Aguzzi A (2000) Neuroinvasion of prions: insights from mouse models. Exp Physiol 85:705-712
9. +) signalling in mitochondria: mechanism and role in physiology and pathology. Cell Calcium 34:399d-405
10. Brini M, Miuzzo M, Pierobon N, Negro A, Sorgato MC (2005) The prion protein and its paralogue doppel affect calcium signaling in Chinese hamster ovary (CHO) cells. Mol Biol Cell 10:2799-2808
11. Brown DR (2001) Copper and prion disease. Brain Res Bull 55:165-173
12. Brown DR, Qin KF, Herms JW, Madlung A, Manson J, Strome R, Fraser PE, Kruck T, vonBohlen A, SchulzSchaeffer W, Giese A, Westaway D, Kretzschmar H (1997) The cellular prion protein binds copper in vivo. Nature 390:684-687
13. Brown KL, Ritchie DL, Mcbride PA, Bruce ME (2000) Detection of PrP in extraneural tissues. Microsc Res Techn 50:40-45
14. Burthem J, Urban B, Pain A, Roberts DJ (2001) The normal cellular prion protein is strongly expressed by myeloid dendritic cells. Blood 98:3733-3738
15. Cetin Y, Aunis D, Bader MF, Galindo E, Jorns A, Bargsten G, Grube D (1993) Chromostatin, A Chromogranin-A-derived bioactive peptide, is present in human pancreatic insulin (beta) cells. Proc Natl Acad Sci USA 90:2360-2364
16. Choe CU, Harrison KD, Grant W, Ehrlich BE (2004) Functional coupling of chromogranin with the inositol 1,4,5-trisphosphate receptor shapes calcium signaling. J Biol Chem 279:35551-35556
17. Cirulli V, Baetens D, Rutishauser U, Halban PA, Orci L, Rouiller DG (1994) Expression of neural cell-adhesion molecule (N-Cam) in rat islets and its role in islet-cell type segregation. J Cell Sci 107:1429-1436
18. Colling SB, Khana M, Collinge J, Jefferys JGR (1997) Mossy fibre reorganization in the hippocampus of prion protein null mice. Brain Res 755:28-35
19. De Camilli P, Jahn R (1990) Pathways to regulated exocytosis in neurons. Annu Rev Physiol 52:625-645
20. DeArmond SJ, Qiu Y, Sanchez H, Spilman PR, Ninchak-Casey A, Alonso D, Daggett V (1999) PrPC glycoform heterogeneity as a function of brain region: implications for selective targeting of neurons by prion strains. J Neuropathol Exp Neurol 58:1000-1009
21. Evans HE, Sack WO (1973) Prenatal development of domestic and laboratory mammals: growth curves, external features and selected references. Zentralbl Veterinarmed [C] 2:11-45
22. EMEA/ 410/01 Rev. 2 (2004) Official Journal of the European Union. C24/6
23. Farquhar CF, Dornan J, Somerville RA, Tunstall AM, Hope J (1994) Effect of sinc genotype, agent isolate and route of infection on the accumulation of protease-resistant prp in noncentral nervous-system tissues during the development of murine scrapie. J Gen Virol 75:495-504
24. Filiz S, Dalcik H, Yardimoglu M, Gonca S, Ceylan S (2002) Localization of neural cell adhesion molecule (N-CAM) immunoreactivity in adult rat tissues. Biotechn Histochem 77:127-135
25. Ford M, Li H, Burton L, Jen A, Morris R, Hall S (2000) Cellular prion protein expression in the mouse. Eur J Neurosci 12:116
26. Fournier JG, Escaig-Haye F, de Villemeur TB, Robain O, Lasmezas CI, Deslys JP, Dormont D, Brown P (1998) Distribution and submicroscopic immunogold localization of cellular prion protein (PrPc) in extracerebral tissues. Cell Tissue Res 292:77-84
27. Gauczynski S, Peyrin JM, Haik S, Leucht C, Hundt C, Rieger R, Krasemann S, Deslys JP, Dormont D, Lasmezas CI, Weiss S (2001) The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein. EMBO J 20:5863-5875
28. Harmeyer S, Pfaff E, Groschup MH (1998) Synthetic peptide vaccines yield monoclonal antibodies to cellular and pathological prion proteins of ruminants. J Gen Virol 79:937-945
29. Herms JW, Korte S, Gall S, Schneider I, Dunker S, Kretzschmar HA (2000) Altered intracellular calcium homeostasis in cerebellar granule cells of prion protein-deficient mice. J Neurochem 75:1487-1492
30. 2+-activated K+ currents in cerebellar purkinje cells. Neurobiol Dis 8:324-330
31. Hetz C, Maundrell K, Soto C (2003a) Is loss of function of the prion protein the cause of prion disorders? Trends Mol Med 9:237-243
32. Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C (2003b) Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. Embo J 22:5435-5445
33. c) exists in many nonneuronal tissues of sheep. J Gen Virol 76:2583-2587
34. Huang FP, Farquhar CF, Mabbott NA, Bruce ME, MacPherson GG (2002) Migrating intestinal dendritic cells transport PrPsc from the gut. J Gen Virol 83:267-271
35. Jackson GS, Clarke AR (2000) Mammalian prion proteins. Curr Opin Struct Biol 10:69-74
36. Kawahara M, Kuroda Y, Arispe N, Rojas E (2000) Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line. J Biol Chem 275:14077-14083
37. Lezmi S, Bencsik A, Monks E, Petit T, Baron T (2003) First case of feline spongiform encephalopathy in a captive cheetah born in France: PrPsc analysis in various tissues revealed unexpected targeting of kidney and adrenal gland. Histochem Cell Biol 119:415-422
38. Lucini C, Costagliola C, Borzacchiello G, Castaldo L (2003) Neurotrophin 3 and its receptor TrkC immunoreactivity in glucagon cells of buffalo pancreas. Anat Histol Embryol J Vet Med Ser C 32:253-256
39. Lukinius A, Stridsberg M, Wilander E (2003) Cellular expression and specific intragranular localization of chromogranin A, chromogranin B, and synaptophysin during ontogeny of pancreatic islet cells: an ultrastructural study. Pancreas 27:38-46
40. Mabbott NA, Brown KL, Manson J, Bruce ME (1997) T-lymphocyte activation and the cellular form of the prion protein. Immunology 92:161-165
41. Mabbott NA, Farquhar CF, Brown KL, Bruce ME (1998) Involvement of the immune system in TSE pathogenesis. Immunol Today 19:201-203
42. Madec JY, Groschup MH, Calavas D, Junghans F, Baron T (2000) Protease-resistant prion protein in brain and lymphoid organs of sheep within a naturally scrapie-infected flock. Microbial Pathogen 28:353-362
43. Martins VR, Graner E, Garcia-Abreu J, de Souza SJ, Mercadante AF, Veiga SS, Zanata SM, Neto VM, Brentani RR (1997) Complementary hydropathy identifies a cellular prion protein receptor. Nat Med 3:1376-1382
44. Mattson MP, Goodman Y (1995) Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium. Brain Res 676:219-224
45. McBride PA, Eikelenboom P, Kraal G, Fraser H, Bruce ME (1992) PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice. J Pathol 168:413-418
46. Miknyoczki SJ, Lang D, Huang LY, Klein-Szanto AJP, Dionne CA, Ruggeri BA (1999) Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: Expression patterns and effects on in vitro invasive behavior. Int J Cancer 81:417-427
47. Mulder H, Myrsen-Axcrona U, Gebre-Medhin S, Ekblad E, Sundler F (1998) Expression of non-classical islet hormone-like peptides during the embryonic development of the pancreas. Microsc Res Techn 43:313-321
48. Ohta T, Numata M, Tsukioka Y, Futagami F, Kayahara M, Kitagawa H, Nagakawa T, Yamamoto M, Wakayama T, Kitamura Y, Nakanuma Y (1997) Neurotrophin-3 expression in human pancreatic cancers. J Pathol 181:405-412
49. Pammer J, Cross HS, Frobert Y, Tschachler E, Oberhuber G (2000) The pattern of prion-related protein expression in the gastrointestinal tract. Virchows Archiv Int J Pathol 436:466-472
50. Pammer J, Weninger W, Tschachler E (1999) Expression of cellular prion-related-protein by human and bovine keratinocytes in situ and in vitro. J Investig Dermatol 112:651
51. Persson-Sjogren S, Forsgren S, Taljedal IB (2002) Tyrosine hydroxylase in mouse pancreatic islet cells, in situ and after syngeneic transplantation to kidney. Histol Histopathol 17:113-121
52. Peters J, Miller JM, Jenny AL, Peterson TL, Carmichael KP (2000) Immunohistochemical diagnosis of chronic wasting disease in preclinically affected elk from a captive herd. J Vet Diagn Investig 12:579-582
53. Prinz M, Montrasio F, Klein MA, Schwarz P, Priller J, Odermatt B, Pfeffer K, Aguzzi A (2002) Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells. PNAS 99: 919-924
54. Prusiner SB (1998) The prion diseases. Brain Pathol 8:499-513
55. Rangon CM, Haik S, Faucheux BA, Metz-Boutigue MH, Fierville F, Fuchs JP, Hauw JJ, Aunis D (2003) Different chromogranin immunoreactivity between prion and a-beta amyloid plaque. Neuroreport 14:755-758
56. Rieger R, Edenhofer F, Lasmezas CI, Weiss S (1997) The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells. Nat Med 3:1383-1388
57. Saito M, Sugiyama K (2000) A distinct ganglioside composition of rat pancreatic islets. Arch Biochem Biophys 376:371-376
58. Sakaguchi S, Katamine S, Nishida N, Moriuchi R, Shigematsu K, Sugimoto T, Nakatani A, Kataoka Y, Houtani T, Shirabe S, Okada H, Hasegawa S, Miyamoto T, Noda T (1996) Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene. Nature 380:528-531
59. Sigurdson CJ, Spraker TR, Miller MW, Oesch B, Hoover EA (2001) PrP (CWD) in the myenteric plexus, vagosympathetic trunk and endocrine glands of deer with chronic wasting disease. J Gen Virol 82:2327-2334
60. Singh N, Zanusso G, Chen SG, Fujioka H, Richardson S, Gambetti P, Petersen RB (1997) Prion protein aggregation reverted by low temperature in transfected cells carrying a prion protein gene mutation. J Biol Chem 272:28461-28470
61. Takayanagi M, Watanabe T (1996) Immunocytochemical colocalizations of insulin, aromatic L-amino acid decarboxylase, dopamine beta-hydroxylase, S-100 protein and chromogranin A in B-cells of the chicken endocrine pancreas. Tissue Cell 28:17-24
62. + channel. J Biol Chem 278:49699-49706
63. Thrower EC, Park HY, So SH, Yoo SH, Ehrlich BE (2002) Activation of the inositol 1,4,5-trisphosphate receptor by the calcium storage protein chromogranin A. J Biol Chem 277:15801-15806
64. Tobler I, Deboer T, Fischer M (1997) Sleep and sleep regulation in normal and prion protein-deficient mice. J Neurosci 17:1869-1879
65. Ye X, Carp RI, Kascsak RJ (1994) Histopathological changes in the islets of Langerhans in scrapie 139H-affected hamsters. J Comp Pathol 110:153-167
66. Ye X, Scallet AC, Carp RI (1997) The 139H scrapie agent produces hypothalamic neurotoxicity and pancreatic islet histopathology: electron microscopic studies. Neurotoxicology 18:533-545
67. Zanusso G, Petersen RB, Jin TC, Jing Y, Kanoush R, Ferrari S, Gambetti P, Singh N (1999) Proteasomal degradation and N-terminal protease resistance of the codon 145 mutant prion protein. J Biol Chem 274:23396-23404