Cellular expression and specific intragranular localization of chromogranin A, chromogranin B, and synaptophysin during ontogeny of pancreatic islet cells: An ultrastructural study

Pancreas

Volumn 27, Issue 1, 2003, Pages 38-46

  Lukinius, Agneta ^a,b   Stridsberg, Mats ^a   Wilander, Erik ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Chromogranin; Neuroendocrine cells; Ontogeny; Synaptophysin; Ultrastructure

Indexed keywords

CHROMOGRANIN A; CHROMOGRANIN B; INSULIN; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL GRANULE; CELL MATURATION; CELL TYPE; CELL ULTRASTRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FETUS CELL; FETUS DEVELOPMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOGOLD LABELING; IMMUNOHISTOCHEMISTRY; NEUROSECRETORY CELL; NONHUMAN; ONTOGENY; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PANCREAS ISLET DELTA CELL; PERINATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SWINE; TECHNIQUE;

ANIMALS; ANIMALS, NEWBORN; CHROMOGRANIN A; CHROMOGRANIN B; CHROMOGRANINS; CYTOPLASMIC GRANULES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; SWINE; SYNAPTOPHYSIN;

EID: 0038460805     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200307000-00006     Document Type: Article

References (42)

1. Winkler H, Apps DK, Fischer-Colbrie R. The molecular function of adrenal chromaffin granules: established facts and unresolved topics. Neuroscience 1986;18:261-290.
2. Fischer-Colbrie R, Hagn C, Schober M. Chromogranins A, B and C: widespread constituents of secretory vesicles. Ann N Y Acad Sci. 1987;493:120-134.
3. Huttner WB, Gerdes HH, Rosa P. The granin (chromogranin/secretogranin) family. Trends Biochem Sci. 1991;16:27-30.
4. Natori S, Huttner WB. Peptides derived from the granins (chromogranins/secretogranins). Biochimie. 1994;76:277-282.
5. Tatemoto K, Efendic S, Mutt V, et al. Pancreastin, a novel pancreatic peptide that inhibits insulin secretion. Nature 1986;324:476-478.
6. Natori S, Huttner WB. Chromogranin B (secretogranin I) promotes sorting to the regulated secretory pathway of processing intermediates derived from a peptide hormone precursor. Proc Natl Acad Sci USA 1996;93:4431-4436.
7. Ozawa H, Takata K. The granin family: its role in sorting and secretory granule formation. Cell Struct Funct. 1995;20:415-420.
8. Tooze SA, Chanat E, Tooze J, et al. Secretory granule formation. In: Peng Loh Y., ed. Mechanisms of Intracellular Trafficking and Processing of Proproteins, Boca Raton, FL: CRS Press; 1993;157-177.
9. Schmidt KW, Weiler R, Xu RW, et al. An immunologic study on chromogranin A and B in human endocrine and nervous tissues. Histochem J. 1989;21:365-373.
10. Lukinius A, Wilander E, Eriksson B, et al. A chromogranin peptide is co-stored with insulin in the human pancreatic islet B-cell granules. Histochem J. 1992;24:679-684.
11. Kagotani Y, Picart R, Barret A, et al. Subcellular localization of secretogranin II and synaptophysin by immuno-electron microscopy in differentiated hypothalamic neurons in culture. J Histochem Cytochem. 1991;39:1507-1518.
12. Portela-Gomes G, Stridsberg M. Selective processing of chromogranin A in the different islet cells in human pancreas. J Histochem Cytochem. 2001;49:483-490.
13. Portela-Gomes G, Stridsberg M. Region-specific antibodies to chromogranin B display various immunostaining patterns in human endocrine pancreas. J Histochem Cytochem. 2002;50:1023-1030.
14. Wiedenmann B, Franke WW. Identification and localization of synaptophysin, an integral membrane glycoprotein for Mr 38,000 characteristic of presynaptic vesicles. Cell 1985;41:1017-1028.
15. Wiedenmann B, Franke WW, Kuhn C, et al. Synaptophysin: a marker protein for neuroendocrine cells and neoplasms. Proc Natl Acad Sci USA 1986;83:3500-3504.
16. Thomas L, Hartung K, Langosch D, et al. Identification of synaptophysin as a hexameric channel protein of the synaptic vesicle membrane. Science 1988;242:1050-1053.
17. Hirano AA, Greengard P, Huganir RL. Protein tyrosine kinase activity and its endogenous substrate in rat brain: a subcellular and regional survey. J Neurochem. 1988;50:1447-1455.
18. Lukinius A, Wilander E, Westermark GT, et al. Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets. Diabetologia 1989;32:240-244.
19. Lukinius A, Ericsson JLE, Grimelius L, et al. Ultrastructural studies of the ontogeny of fetal human and porcine endocrine pancreas, with special reference to co-localization of the four major islet hormones. Dev Biol. 1992;153:376-385.
20. Ehrhart M, Grube D, Barder M-F, et al. Chromogranin A in the pancreatic islet: cellular and subcellular distribution. J Histochem Cytochem. 1986;34:1673-1682.
21. Tougard C, Nasciutti LE, Picart R, et al. Subcellular distribution of secretogranins I and II in GH3 rat tumoral prolactin (PRL) cells as revealed by electron microscopic immunocytochemistry. J Histochem Cytochem. 1989;37:1329-1336.
22. Steiner HJ, Schmid KW, Fischer-Colbrie R, et al. Co-localization of chromogranin A and B, secretogranin II and neuropeptide Y in chromaffin granules of rat adrenal medulla studied by electron microscopic immunocytochemistry. Histochemistry 1989;91:473-477.
23. Bassetti M, Huttner WB, Zanini A, et al. Co-localization of secretogranins/chromogranins with thyrotropin and luteinizing hormone in secretory granules of cow anterior pituitary. J Histochem Cytochem. 1990;38:1353-1363.
24. Lukinius A, Korsgren O, Grimelius L, et al. Expression of islet amyloid polypeptide in fetal and adult porcine and human pancreatic islet cells. Endocrinology 1996;137:5319-5325.
25. + on heterodimer and heterotetramer formation by chromogranin A and chromogranin B. J Biol Chem. 1996;271:17041-17046.
26. Yoo SH. pH and Ca2+-dependent aggregation property of secretory vesicle matrix proteins and the potential role of chromogranins A and B in secretory vesicle biogenesis. J Biol Chem. 1996;271:1558-1565.
27. Hagn C, Schmid KW, Fischer Colbrie R, et al. Chromogranin A, B, and C in human adrenal medulla and endocrine tissues. Lab Invest. 1986;55:405-411.
28. Eiden LE. Is chromogranin a prohormone? Nature 1987;325:301-301.
29. Helle KB, Angeletti RH. Chromogranin A: a multipurpose prohormone. Acta Physiol Scand. 1994;152:1-10.
30. Aardal S, Helle KB. The vasoinhibitory activity of bovine chromogranin A fragment (vasostatin) and its independence of extracellular calcium in isolated segments of human blood vessels. Regul Pept. 1992;41:9-18.
31. Angeletti RH, Aardal S, Serck-Hanssen G, et al. Vasoinhibitory activity of synthetic peptides from the amino terminus of chromogranin A. Acta Physiol Scand. 1994;152:11-19.
32. Fasciotto BH, Gorr SU, Bourdeau AM, et al. Autocrine regulation of parathyroid secretion: inhibition of secretion by chromogranin-A (secretory protein-I) and potentiation of secretion by chromogranin-A and pancreastatin antibodies. Endocrinology 1990;127:1329-1335.
33. Drees BM, Rouse J, Johnson J, et al. Bovine parathyroid glands secrete a 26-kDa N-terminal fragment of chromogranin-A which inhibits parathyroid cell secretion. Endocrinology 1991;129:3381-3387.
34. Angeletti RH, Mints L, Aber C, et al. Determination of residues in chromogranin A-(16-40) required for inhibition of parathyroid hormone secretion. Endocrinology 1996;137:2918-2922.
35. Mahata S, O'Connor DT, Mahata M, et al. Novel autocrine feedback control of catecholamine release: a discrete chromogranin A fragment is a noncompetitive nicotinic cholinergic antagonist. J Clin Invest. 1997;100:1623-1633.
36. Strub J-M, Garcia-Sablone P, Lonning K, et al. Processing of chromogranin B in bovine adrenal medulla: identification of secretolytin, the endogenous C-terminal fragment of residues 614-626 with antibacterial activity. Euro J Biochem. 1995;229:356-368.
37. Metz-Boutigue MH, Goumon Y, Lugardon K, et al. Antibacterial peptides are present in chromaffin cell secretory granules. Cell Mol Neurobiol. 1998;18:249-266.
38. Sanchez Margalet V, Goberna R. Pancreastatin inhibits insulin-stimulated glycogen synthesis but not glycolysis in rat hepatocytes. Regul Pept. 1994;51:215-220.
39. Syversen U, Opsjon SL, Stridsberg M, et al. Chromogranin A and pancreastatin-like immunoreactivity in normal pregnancies. J Clin Endocrinol Metabol. 1996;81:4470-4475.
40. Lukinius A, Korsgren O. The transplanted fetal endocrine pancreas undergoes an inherent sequential differentiation similar to that in the native pancreas: an ultrastructural study in the pig-to-mouse model. Diabetes 2001;50:962-971.
41. Stridsberg M, Öberg K, Li Q, Engström U, et al. Measurements of chromogranin A, chromogranin B (secretogranin D, chromogranin C (secretogranin II) and pancreastatin in plasma and urine from patients with carcinoid tumors and endocrine pancreatic tumors. J Endocrinol. 1995;144:49-59.
42. Stridsberg M, Lundqvist G, Engström U, et al. Development of polyclonal antibodies and evaluation of a sensitive radioimmunoassay for detection and measurement of synaptophysin. Acta Neuropathologica 1994;87:635-641.