Regulation of ILT3 gene expression by processing of precursor transcripts in human endothelial cells

American Journal of Transplantation

Volumn 6, Issue 1, 2006, Pages 76-82

  Kim Schulze, S ^a   Seki, T ^a   Vlad, G ^a   Scotto, L ^a   Fan, J ^a   Colombo, P C ^a   Liu, J ^a   Cortesini, R ^a   Suciu Foca, N ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Activation induced splicing; Immunoglobulin like transcript 3; Tolerogenic endothelial cells

Indexed keywords

ALPHA2A INTERFERON; IMMUNOGLOBULIN LIKE TRANSCRIPT 3; INTERLEUKIN 10; MESSENGER RNA PRECURSOR; PROTEIN; RNA; UNCLASSIFIED DRUG; CD28 ANTIGEN; CELL SURFACE RECEPTOR; LILRB4 PROTEIN, HUMAN; MESSENGER RNA; RNA PRECURSOR;

ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SUPPRESSOR CELL; WESTERN BLOTTING; CD8+ T LYMPHOCYTE; CELL NUCLEUS; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; METABOLISM; RNA PROCESSING; T LYMPHOCYTE; VASCULAR ENDOTHELIUM;

ANTIGENS, CD28; CD8-POSITIVE T-LYMPHOCYTES; CELL FRACTIONATION; CELL NUCLEUS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HUMANS; RECEPTORS, CELL SURFACE; RNA PRECURSORS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC;

EID: 33644853658     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2005.01162.x     Document Type: Article

References (37)

1. Torkar M Norgate Z Colonna M Trowsdale J Wilson MJ Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex Eur J Immunol 1998 28 3959 3967
2. Wilson MJ Torkar M Haude A et al Plasticity in the organization and sequences of human KIR/ILT gene families Proc Natl Acad Sci U S A 2000 97 4778 4783
3. Colonna M Nakajima H Navarro F Lopez-Botet M A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells J Leukoc Biol 1999 66 375 381
4. Cella M Dohring C Samaridis J et al A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing J Exp Med 1997 185 1743 1751
5. Colonna M Nakajima H Cella M A family of inhibitory and activating Ig-like receptors that modulate function of lymphoid and myeloid cells Semin Immunol 2000 12 121 127
6. Colonna M Samaridis J Cella M et al Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules J Immunol 1998 160 3096 3100
7. Chang CC Ciubotariu R Manavalan JS et al Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4 Nat Immunol 2002 3 237 243
8. Manavalan JS Kim-Schulze S Scotto L et al Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity Int Immunol 2004 16 1055 1068
9. Pober JS Orosz CG Rose ML Savage CO Can graft endothelial cells initiate a host anti-graft immune response¿ Transplantation 1996 61 343 349
10. Kreisel D Krupnick AS Gelman AE et al Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition Nat Med 2002 8 233 239
11. Bian H Harris PE Mulder A Reed EF Anti-HLA antibody ligation to HLA class I molecules expressed by endothelial cells stimulates tyrosine phosphorylation, inositol phosphate generation, and proliferation Hum Immunol 1997 53 90 97
12. Liu Z Tugulea S Cortesini R Suciu-Foca N Specific suppression of T helper alloreactivity by allo-MHC class I-restricted CD8+CD28- T cells Int Immunol 1998 10 775 783
13. Rissoan MC Soumelis V Kadowaki N et al Reciprocal control of T helper cell and dendritic cell differentiation Science 1999 283 1183 1186
14. Sallusto F Lanzavecchia A Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha J Exp Med 1994 179 1109 1118
15. Liu J Liu Z Witkowski P et al Rat CD8+ FOXP3+ T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection Transpl Immunol 2004 13 239 247
16. Colovai AI Mirza M Vlad G et al Regulatory CD8+CD28- T cells in heart transplant recipients Hum Immunol 2003 64 31 37
17. Scotto L Naiyer AJ Galluzzo S et al Overlap between molecular markers expressed by naturally occurring CD4+CD25+ regulatory T cells and antigen specific CD4+CD25+ and CD8+CD28- T suppressor cells Hum Immunol 2004 65 1297 1306
18. Nakamura A Kobayashi E Takai T Exacerbated graft-versus-host disease in Pirb-/- mice Nat Immunol. 2004 5 623 629
19. Jarrous N Osman F Kaempfer R 2-Aminopurine selectively inhibits splicing of tumor necrosis factor alpha mRNA Mol Cell Biol 1996 16 2814 2822
20. Alberti L Bachelot T Duc A Biota C Blay JY A spliced isoform of interleukin 6 mRNA produced by renal cell carcinoma encodes for an interleukin 6 inhibitor Cancer Res 2005 65 2 5
21. O'Connor V Genin A Davis S et al Differential amplification of intron-containing transcripts reveals long term potentiation-associated up-regulation of specific Pde10A phosphodiesterase splice variants J Biol Chem 2004 279 15841 15849
22. Kotera J Sasaki T Kobayashi T Fujishige K Yamashita Y Omori K Subcellular localization of cyclic nucleotide phosphodiesterase type 10A variants, and alteration of the localization by cAMP-dependent protein kinase-dependent phosphorylation J Biol Chem 2004 279 4366 4375
23. Holmberg J Clarke DL Frisen J Regulation of repulsion versus adhesion by different splice forms of an Eph receptor Nature 2000 408 203 206
24. Black DL Mechanisms of alternative pre-messenger RNA splicing Annu Rev Biochem 2003 72 291 336
25. Modrek B Lee CJ Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss Nat Genet 2003 34 177 180
26. Mikolajczak SA Ma BY Yoshida T Yoshida R Kelvin DJ Ochi A The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells J Exp Med 2004 199 1025 1031
27. Jarrous N Kaempfer R Induction of human interleukin-1 gene expression by retinoic acid and its regulation at processing of precursor transcripts J Biol Chem 1994 269 23141 23149
28. Yang Y Chang JF Parnes JR Fathman CG T cell receptor (TCR) engagement leads to activation-induced splicing of tumor necrosis factor (TNF) nuclear pre-mRNA J Exp Med 1998 188 247 254
29. Li CY Chu JY Yu JK et al Regulation of alternative splicing of Bcl-x by IL-6, GM-CSF and TPA Cell Res 2004 14 473 479
30. Gerez L Arad G Efrat S Ketzinel M Kaempfer R Post-transcriptional regulation of human interleukin-2 gene expression at processing of precursor transcripts J Biol Chem 1995 270 19569 19575
31. Gudas JM Knight GB Pardee AB Nuclear posttranscriptional processing of thymidine kinase mRNA at the onset of DNA synthesis Proc Natl Acad Sci U S A 1988 85 4705 4709
32. Zhang F Cole CN Identification of a complex associated with processing and polyadenylation in vitro of herpes simplex virus type 1 thymidine kinase precursor RNA Mol Cell Biol 1987 7 3277 3286
33. Tao H Szeszel-Fedorowicz W Amir-Ahmady B Gibson MA Stabile LP Salati LM Inhibition of the splicing of glucose-6-phosphate dehydrogenase precursor mRNA by polyunsaturated fatty acids J Biol Chem 2002 277 31270 31278
34. Konig G Monning U Czech C et al Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells J Biol Chem 1992 267 10804 10809
35. Hodge DL Martinez A Julias JG Taylor LS Young HA Regulation of nuclear gamma interferon gene expression by interleukin 12 (IL-12) and IL-2 represents a novel form of posttranscriptional control Mol Cell Biol 2002 22 1742 1753
36. Tao H Szeszel-Fedorowicz W Amir-Ahmady B Gibson MA Stabile LP Salati LM Inhibition of the splicing of glucose-6-phosphate dehydrogenase precursor mRNA by polyunsaturated fatty acids J Biol Chem 2002 277 31270 31278
37. Vlad G Cortesini R Suciu-Foca N License to heal: bidirectional interaction of antigen-specific regulatory T cells and tolerogenic APC J Immunol 2005 174 5907 5914