Regulation of nuclear gamma interferon gene expression by interleukin 12 (IL-12) and IL-2 represents a novel form of posttranscriptional control

Molecular and Cellular Biology

Volumn 22, Issue 6, 2002, Pages 1742-1753

  Hodge, Deborah L ^a   Martinez, Alfredo ^a   Julias, John G ^a   Taylor, Lynn S ^a   Young, Howard A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2;

ARTICLE; HUMAN; HUMAN CELL; INFLAMMATION; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

CELL LINE; CELL NUCLEUS; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-2; KILLER CELLS, NATURAL; POLYADENYLATION; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA STABILITY; RNA, MESSENGER;

EID: 0036183618     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.6.1742-1753.2002     Document Type: Article

References (61)

1. IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes
2. Poly(A), poly(A) binding protein and the regulation of mRNA stability
3. Immunomodulatory properties of interferon-gamma. An update
4. Cellular responses to interferon-gamma
5. A direct role for IFN-gamma in regulation of Th1 cell development
6. Drug and metabolite-induced perturbations in nuclear structure and function: A review
7. Over-expression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export
8. Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2
9. Induction of interferon gamma production by natural killer cell stimulatory factor: Characterization of the responder cells and synergy with other inducers
10. Negative transcriptional regulation of the interferon-gamma promoter by glucocorticoids and dominant negative mutants of c-Jun
11. Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors
12. Nuclear RNA export pathways
13. Nuclear domains involved in RNA synthesis, RNA processing, and replication
14. Estrogen regulation of peptidylglycine alpha-amidating monooxygenase messenger ribonucleic acid levels by a nuclear posttranscriptional event
15. IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells
16. Posttranscriptional regulation of human interleukin-2 gene expression at processing of precursor transcripts
17. Structure of the human immune interferon gene
18. Identification of TIAR as a protein binding to the translational regulatory AU-rich element of tumor necrosis factor alpha mRNA
19. Regulation of cellular gene expression by interferon-gamma: Involvement of multiple pathways
20. Molecular events involved in regulating human interferon-gamma gene expression during T cell activation
21. Regulation of expression of the human interferon gamma gene
22. Primary response genes induced by growth factors and tumor promoters
23. Nutritional regulation of the glucose-6-phosphate dehydrogenase gene is mediated by a nuclear posttranscriptional mechanism
24. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages
25. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
26. Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells
27. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway
28. Splicing is required for rapid and efficient mRNA export in metazoans
29. An exon that prevents transport of a mature mRNA
30. Natural killer activating receptors trigger interferon gamma secretion from T cells and natural killer cells
31. Interaction of Ly-49D+ NK cells with H-2Dd target cells leads to Dap-12 phosphorylation and IFN-gamma secretion
32. Synergistic effects of IL-7 and IL-12 on human T cell activation
33. Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine
34. Response of human intestinal lamina propria T lymphocytes to interleukin 12: Additive effects of interleukin 15 and 7
35. Selective modulation of IFN-gamma mRNA stability by IL-12/NKSF
36. The hnRNP C proteins contain a nuclear retention sequence that can override nuclear export signals
37. Transport of proteins and RNAs in and out of the nucleus
38. B cell early response gene expression coupled to B cell receptor, CD40 and interleukin-4 receptor co-stimulation: Evidence for a role of the egr-2/krox 20 transcription factor in B cell proliferation
39. Activating 1y-49 nk receptors: Central role in cytokine and chemokine production
40. mRNA stability: In trans-it
41. Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells
42. Preformed membrane-associated stores of interleukin (IL)-12 are a previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact with an intracellular parasite
43. An element of the transforming growth factor-beta 1 5′-untranslated region represses translation and specifically binds a cytosolic factor
44. The role of poly(A) in the translation and stability of mRNA
45. Messenger RNA degradation in eukaryotes
46. Modulation of perforin and granzyme messenger RNA expression in human natural killer cells
47. Interaction of NF-kappaB and NFAT with the interferon-gamma promoter
48. Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA
49. Functional hierarchy of AUUUA motifs in mediating rapid interleukin-3 mRNA decay
50. Cloning and structure of the human immune interferon-gamma chromosomal gene
51. Interferon gamma drastically modifies the regulation of interleukin 1 genes by endotoxin in U937 cells
52. Induction of tumor necrosis factor-alpha and -beta and interferon-gamma mRNA by interleukin 2 in murine lymphocytic cell lines
53. Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development
54. Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin
55. Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions
56. Cellular and molecular mechanisms of IFN-gamma production induced by IL-2 and IL-12 in a human NK cell line
57. Regulation of a cell type-specific silencer in the human interleukin-3 gene promoter by the transcription factor YY1 and an AP2 sequence-recognizing factor
58. Characterization of interleukin 2 and phorbol myristate acetate augmentation of expression of transfected human interferon-gamma genomic DNA
59. One-signal requirement for interferon-gamma production by human large granular lymphocytes
60. Reduction of hepatic insulin-like growth factor I (IGF-I) messenger ribonucleic acid (mRNA) during fasting is associated with diminished splicing of IGF-I pre-mRNA and decreased stability of cytoplasmic IGF-I mRNA