Role of rat liver cytochrome P450 3A and 2D in metabolism of imrecoxib

Acta Pharmacologica Sinica

Volumn 27, Issue 3, 2006, Pages 372-380

  Xu, Hai Yan ^a   Xie, Zhi Yong ^a   Zhang, Peng ^a   Sun, Jin ^a   Chu, Feng Ming ^b   Guo, Zong Ru ^b   Zhong, Da Fang ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cytochrome P450; Imrecoxib; Liver microsomes; Metabolism

Indexed keywords

4' HYDROXYMETHYL 5 CARBONYL IMRECOXIB; 4' HYDROXYMETHYL 5 HYDROXYLIMRECOXIB; 4' HYDROXYMETHYLIMRECOXIB; ALPHA NAPHTHOFLAVONE; BETA NAPHTHOFLAVONE; CIMETIDINE; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME P450 2D; CYTOCHROME P450 3A; CYTOCHROME P450 INHIBITOR; DEXAMETHASONE; DRUG METABOLITE; IMRECOXIB; ISONIAZID; KETOCONAZOLE; METHYLPYRAZOLE; QUININE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; IN VITRO STUDY; LIVER; LIVER MICROSOME; MALE; METABOLIC RATE; MICHAELIS MENTEN KINETICS; NONHUMAN; PROTEIN FUNCTION; RAT; ULTRACENTRIFUGE;

ANIMALS; BIOTRANSFORMATION; CYCLOOXYGENASE 2 INHIBITORS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; MALE; MICROSOMES, LIVER; PYRROLES; QUININE; RATS; RATS, WISTAR; SULFIDES;

EID: 33644820289     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00265.x     Document Type: Article

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