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Volumn 11, Issue 2, 1997, Pages 227-235

COX-II inhibitors - A new generation of safer NSAIDs?

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 FLUOROPHENYL) 2 [(4 METHYLSULFONYL)PHENYL]CYCLOPENTENE; 4 (3,5 DI TERT BUTYL 4 HYDROXYPHENYL) 2 METHYL 1,2 OXAZIN 3 ONE; 5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; 5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; 6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; CELECOXIB; D 1367; DICLOFENAC; FLOSULIDE; IBUPROFEN; IGURATIMOD; INDOMETACIN; L 748731; L 761066; MELOXICAM; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NAPROXEN; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ICOSANOID; ISOENZYME; MEMBRANE PROTEIN; PROSTAGLANDIN SYNTHASE; PTGS2 PROTEIN, HUMAN; THIAZINE DERIVATIVE; THIAZOLE DERIVATIVE;

EID: 0031113915     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1997.154330000.x     Document Type: Review
Times cited : (138)

References (92)
  • 2
    • 50349119142 scopus 로고
    • Gastroscopic observations of the effect of aspirin and certain other substances on the stomach
    • Douthwaite A, Lintot CA. Gastroscopic observations of the effect of aspirin and certain other substances on the stomach. Lancet 1938; ii: 1222.
    • (1938) Lancet , vol.2 , pp. 1222
    • Douthwaite, A.1    Lintot, C.A.2
  • 3
    • 0020031124 scopus 로고
    • Aspirin, paracetamol, haematemesis and melaena
    • Coggon D, Langman MJS, Spiegelhalter D. Aspirin, paracetamol, haematemesis and melaena. Gut 1982; 23: 340-4.
    • (1982) Gut , vol.23 , pp. 340-344
    • Coggon, D.1    Langman, M.J.S.2    Spiegelhalter, D.3
  • 4
    • 0019497960 scopus 로고
    • 20 years of hospital admissions with peptic ulcer in the United Kingdom
    • Coggon D, Lambert P, Langman M. 20 years of hospital admissions with peptic ulcer in the United Kingdom. Lancet 1981; i: 1302-4.
    • (1981) Lancet , vol.1 , pp. 1302-1304
    • Coggon, D.1    Lambert, P.2    Langman, M.3
  • 5
    • 0022624056 scopus 로고
    • Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer
    • Somerville K, Faulkner G, Langman M. Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet 1986; i: 462-6.
    • (1986) Lancet , vol.1 , pp. 462-466
    • Somerville, K.1    Faulkner, G.2    Langman, M.3
  • 6
    • 0022639534 scopus 로고
    • Rising frequency of ulcer perforation in elderly people in the United Kingdom
    • Walt R, Katschinski B, Logan R, Ashley J, Langman M. Rising frequency of ulcer perforation in elderly people in the United Kingdom. Lancet 1986; i: 489-92.
    • (1986) Lancet , vol.1 , pp. 489-492
    • Walt, R.1    Katschinski, B.2    Logan, R.3    Ashley, J.4    Langman, M.5
  • 7
    • 0025019780 scopus 로고
    • Non-steroidal anti-inflammatory drugs and ulcers: Facts and figures multiply but do they add up?
    • Hawkey CJ. Non-steroidal anti-inflammatory drugs and ulcers: facts and figures multiply but do they add up? Br Med J 1990; 300: 278-84.
    • (1990) Br Med J , vol.300 , pp. 278-284
    • Hawkey, C.J.1
  • 8
    • 0027480994 scopus 로고
    • Nonsteroidal anti-inflammatory drugs and peptic ulcer hospitalization rates in New South Wales
    • Henry D, Robertson J. Nonsteroidal anti-inflammatory drugs and peptic ulcer hospitalization rates in New South Wales. Gastroenterology 1993; 104: 1083-91.
    • (1993) Gastroenterology , vol.104 , pp. 1083-1091
    • Henry, D.1    Robertson, J.2
  • 9
    • 0000124615 scopus 로고    scopus 로고
    • COX-2 inhibitors. Potential for reducing NSAID side-effects in treating inflammatory diseases
    • Carty TJ, Marfat A. COX-2 inhibitors. Potential for reducing NSAID side-effects in treating inflammatory diseases. Emerging Drugs 1996; 391-413.
    • (1996) Emerging Drugs , pp. 391-413
    • Carty, T.J.1    Marfat, A.2
  • 10
    • 0022367442 scopus 로고
    • Sucralfate in the relief of gastrointestinal symptoms associated with nonsteroidal anti-inflammatory drugs
    • Caldwell JR. Sucralfate in the relief of gastrointestinal symptoms associated with nonsteroidal anti-inflammatory drugs. Southern Med J 1985; 78: 938-40.
    • (1985) Southern Med J , vol.78 , pp. 938-940
    • Caldwell, J.R.1
  • 11
    • 0023634240 scopus 로고
    • Sucralfate treatment of non-steroidal anti-inflammatory drug-induced gastrointestinal symptoms and damage
    • Caldwell JR, Roth SH, Wu WC, et al. Sucralfate treatment of non-steroidal anti-inflammatory drug-induced gastrointestinal symptoms and damage. Am J Med 1987; 83: 74-82.
    • (1987) Am J Med , vol.83 , pp. 74-82
    • Caldwell, J.R.1    Roth, S.H.2    Wu, W.C.3
  • 12
    • 0022483175 scopus 로고
    • Protective effect of enprostil against aspirin induced gastroduodenal mucosal injury in man. Comparison with cimetidine and sucralfate
    • Stiel D, Ellard KT, Hills LJ, Brooks PM. Protective effect of enprostil against aspirin induced gastroduodenal mucosal injury in man. Comparison with cimetidine and sucralfate.Am J Med 1986; 81: 54-8.
    • (1986) Am J Med , vol.81 , pp. 54-58
    • Stiel, D.1    Ellard, K.T.2    Hills, L.J.3    Brooks, P.M.4
  • 13
    • 0028182869 scopus 로고
    • 2-receptor antagonists in peptic ulcer disease: Evidence for a prophylactic use
    • 2-receptor antagonists in peptic ulcer disease: evidence for a prophylactic use. Drugs 1994; 47: 862-71.
    • (1994) Drugs , vol.47 , pp. 862-871
    • Nash, J.1    Lambert, L.2    Deakin, M.3
  • 14
    • 0029162250 scopus 로고
    • Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial
    • Silverstein FE, Graham DY, Senior JR, et al. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1995; 123: 241-9.
    • (1995) Ann Intern Med , vol.123 , pp. 241-249
    • Silverstein, F.E.1    Graham, D.Y.2    Senior, J.R.3
  • 15
    • 9344236529 scopus 로고    scopus 로고
    • Famotidine for the prevention of gastric and duodenal ulcers caused by non-steroidal antiinflammatory drugs
    • Taha AS, Hudson N, Hawkey CJ, et al. Famotidine for the prevention of gastric and duodenal ulcers caused by non-steroidal antiinflammatory drugs. New Engl J Med 1996; 334: 1435-9.
    • (1996) New Engl J Med , vol.334 , pp. 1435-1439
    • Taha, A.S.1    Hudson, N.2    Hawkey, C.J.3
  • 16
    • 0001621540 scopus 로고    scopus 로고
    • Benefits of omeprazole over misoprostol in healing NSAID associated ulcers
    • Abstract
    • Hawkey CJ, Swannell AJ, Eriksson S, et al. Benefits of omeprazole over misoprostol in healing NSAID associated ulcers. Gastroenterology 1996; 110: A131 (Abstract).
    • (1996) Gastroenterology , vol.110
    • Hawkey, C.J.1    Swannell, A.J.2    Eriksson, S.3
  • 17
    • 0001621540 scopus 로고    scopus 로고
    • Lower frequency of gastroduodenal ulcers and erosions and dyspeptic symptoms in NSAID users during maintenance with omeprazole compared to ranitidine
    • Abstract
    • Hawkey CJ, Swannell AJ, Eriksson S, et al. Lower frequency of gastroduodenal ulcers and erosions and dyspeptic symptoms in NSAID users during maintenance with omeprazole compared to ranitidine. Gastroenterology 1996; 110: A131 (Abstract).
    • (1996) Gastroenterology , vol.110
    • Hawkey, C.J.1    Swannell, A.J.2    Eriksson, S.3
  • 18
    • 0028208349 scopus 로고
    • Novel oral drug formulations: Their potential in modulating adverse events
    • Florence AT, Jani PU. Novel oral drug formulations: Their potential in modulating adverse events. Drug Safety 1994; 10: 233-66.
    • (1994) Drug Safety , vol.10 , pp. 233-266
    • Florence, A.T.1    Jani, P.U.2
  • 19
    • 0029871521 scopus 로고    scopus 로고
    • Gastric mucosal injury and adaptation to oral and rectal administration of naproxen
    • Lipscomb GR, Rees WDW. Gastric mucosal injury and adaptation to oral and rectal administration of naproxen. Aliment Pharmacol Ther 1996; 10: 298-303.
    • (1996) Aliment Pharmacol Ther , vol.10 , pp. 298-303
    • Lipscomb, G.R.1    Rees, W.D.W.2
  • 20
    • 0028857398 scopus 로고
    • Transdermal non-steroidal anti-inflammatory agents
    • Grahame R. Transdermal non-steroidal anti-inflammatory agents. Br J Clin Prac 1995; 49: 33-5.
    • (1995) Br J Clin Prac , vol.49 , pp. 33-35
    • Grahame, R.1
  • 21
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs
    • Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs. Nature 1971; 231: 232-5.
    • (1971) Nature , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 22
    • 0026761738 scopus 로고
    • Aspirin and the potential role for prostaglandins in colon cancer
    • Marnett L. Aspirin and the potential role for prostaglandins in colon cancer. Cancer Res 1992; 52: 5575-89.
    • (1992) Cancer Res , vol.52 , pp. 5575-5589
    • Marnett, L.1
  • 23
    • 0025728865 scopus 로고
    • Prostaglandin endoperoxide synthase: Structure and catalysis
    • Smith WL, Marnett LJ. Prostaglandin endoperoxide synthase: Structure and catalysis. Biochem Biophys Acta 1991; 1083: 1-17.
    • (1991) Biochem Biophys Acta , vol.1083 , pp. 1-17
    • Smith, W.L.1    Marnett, L.J.2
  • 26
    • 0029021758 scopus 로고
    • Eicosanoids and the gastrointestinal tract
    • Eberhart CE, Du Bois RN. Eicosanoids and the gastrointestinal tract. Gastroenterology 1995; 109: 285-301.
    • (1995) Gastroenterology , vol.109 , pp. 285-301
    • Eberhart, C.E.1    Du Bois, R.N.2
  • 27
    • 0018292487 scopus 로고
    • Cytoprotection by prostaglandins
    • Robert A. Cytoprotection by prostaglandins. Gastroenterology 1969; 77: 761.
    • (1969) Gastroenterology , vol.77 , pp. 761
    • Robert, A.1
  • 28
    • 0021690166 scopus 로고
    • Effect of indomethacin on basal histamine stimulated gastric acid secretion
    • Feldman M, Colturi TJ. Effect of indomethacin on basal histamine stimulated gastric acid secretion. Gastroenterology 1984; 87: 1339-43.
    • (1984) Gastroenterology , vol.87 , pp. 1339-1343
    • Feldman, M.1    Colturi, T.J.2
  • 29
    • 0014799231 scopus 로고
    • Basal and histamine-stimulated human gastric acid secretion : Lack of effect of indomethacin in therapeutic doses
    • Winship DH, Barnhard GC. Basal and histamine-stimulated human gastric acid secretion : lack of effect of indomethacin in therapeutic doses. Gastroenterology 1970; 58: 762-6.
    • (1970) Gastroenterology , vol.58 , pp. 762-766
    • Winship, D.H.1    Barnhard, G.C.2
  • 30
    • 0023233932 scopus 로고
    • Bradykinin-stimulated eicosanoid synthesis and secretion by rabbit ileal components
    • Lawson LD, Powell DW. Bradykinin-stimulated eicosanoid synthesis and secretion by rabbit ileal components. Am J Physiol 1987; 25: G783-90.
    • (1987) Am J Physiol , vol.25
    • Lawson, L.D.1    Powell, D.W.2
  • 31
    • 0027993458 scopus 로고
    • Up-regulation of cycloxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
    • Eberhart CE, Coffey RJ, Radhika A, et al. Up-regulation of cycloxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 1994; 107: 1183-8.
    • (1994) Gastroenterology , vol.107 , pp. 1183-1188
    • Eberhart, C.E.1    Coffey, R.J.2    Radhika, A.3
  • 32
    • 0015708398 scopus 로고
    • The effects of E and A prostaglandin on gastric mucosal blood flow and acid secretion in the rat
    • Main IHM, Whitle BJR. The effects of E and A prostaglandin on gastric mucosal blood flow and acid secretion in the rat. Br J Pharmacol 1973; 49: 428.
    • (1973) Br J Pharmacol , vol.49 , pp. 428
    • Main, I.H.M.1    Whitle, B.J.R.2
  • 33
    • 0025078185 scopus 로고
    • Gastric ulceration induced by non-steroidal anti-inflammatory drugs is a neutrophil dependent process
    • Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by non-steroidal anti-inflammatory drugs is a neutrophil dependent process. Am J Physiol 1990; 259: G462.
    • (1990) Am J Physiol , vol.259
    • Wallace, J.L.1    Keenan, C.M.2    Granger, D.N.3
  • 35
    • 8244230906 scopus 로고
    • Basic fibroblast growth factor and transforming growth factor alpha and gastric ulceration
    • Abstract
    • Hull MA, Cullen DJE, Atherton JC, Hawkey CJ. Basic fibroblast growth factor and transforming growth factor alpha and gastric ulceration. Gut 1993; 34: S51 (Abstract).
    • (1993) Gut , vol.34
    • Hull, M.A.1    Cullen, D.J.E.2    Atherton, J.C.3    Hawkey, C.J.4
  • 36
    • 0025033747 scopus 로고
    • Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing
    • Levi S, Goodlad RA, Lee CY, et al. Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing. Lancet 1990; 336: 840-3.
    • (1990) Lancet , vol.336 , pp. 840-843
    • Levi, S.1    Goodlad, R.A.2    Lee, C.Y.3
  • 37
    • 0017094798 scopus 로고
    • An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
    • Moncada, S, Grygewlski R, Bunting S, Vane JR. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 1976; 263: 663-5.
    • (1976) Nature , vol.263 , pp. 663-665
    • Moncada, S.1    Grygewlski, R.2    Bunting, S.3    Vane, J.R.4
  • 39
    • 0026788165 scopus 로고
    • Gastrointestinal damage associated with the use of non-steroidal anti-inflammatory drugs
    • Allison MC, Howat AG, Torrance CJ, Lee FD, Russell RI. Gastrointestinal damage associated with the use of non-steroidal anti-inflammatory drugs. New Engl J Med 1992; 327: 749-54.
    • (1992) New Engl J Med , vol.327 , pp. 749-754
    • Allison, M.C.1    Howat, A.G.2    Torrance, C.J.3    Lee, F.D.4    Russell, R.I.5
  • 41
    • 0025187588 scopus 로고
    • Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice
    • Masferrer JL, Zweifel BS, Seibert K, Needleman P. Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice. J Clin Invest 1990; 86: 1375-9.
    • (1990) J Clin Invest , vol.86 , pp. 1375-1379
    • Masferrer, J.L.1    Zweifel, B.S.2    Seibert, K.3    Needleman, P.4
  • 42
    • 0026588961 scopus 로고
    • Mitogen-inducible prostaglandin G/H synthase: A new target for nonsteroidal anti-inflammatory drugs
    • Xie W, Robertson DL, Simmons DL. Mitogen-inducible prostaglandin G/H synthase: a new target for nonsteroidal anti-inflammatory drugs. Drug Dev Res 1992; 25: 249-65.
    • (1992) Drug Dev Res , vol.25 , pp. 249-265
    • Xie, W.1    Robertson, D.L.2    Simmons, D.L.3
  • 43
    • 0025754779 scopus 로고
    • Expression of mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing
    • Xie W, Chipman JG, Robertson DL, Erikson RL, Simmons DL. Expression of mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 1991; 88: 2692-5.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2692-2695
    • Xie, W.1    Chipman, J.G.2    Robertson, D.L.3    Erikson, R.L.4    Simmons, D.L.5
  • 44
    • 0025871150 scopus 로고
    • TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/ cyclooxygenase homologue
    • Kujubu DA, Fletcher BS, Varnum BC, Lim RW, Herschman HR. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/ cyclooxygenase homologue. J Biol Chem 1991; 266: 12866-72.
    • (1991) J Biol Chem , vol.266 , pp. 12866-12872
    • Kujubu, D.A.1    Fletcher, B.S.2    Varnum, B.C.3    Lim, R.W.4    Herschman, H.R.5
  • 45
    • 0027076645 scopus 로고
    • Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide
    • Lee SH, Soyoola E, Chanmugam P, et al. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 1992; 267(36): 25934-8.
    • (1992) J Biol Chem , vol.267 , Issue.36 , pp. 25934-25938
    • Lee, S.H.1    Soyoola, E.2    Chanmugam, P.3
  • 46
    • 0028344102 scopus 로고
    • Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-α and phorbol ester
    • Du Bois RN, Awad J, Morrow J, et al. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-α and phorbol ester. J Clin Invest 1994; 93: 493-8.
    • (1994) J Clin Invest , vol.93 , pp. 493-498
    • Du Bois, R.N.1    Awad, J.2    Morrow, J.3
  • 47
    • 0026716651 scopus 로고
    • Regulation of mesangial cell cyclooxygenase synthesis by cytokines and glucocorticoids
    • Coyne DW, Nickols M, Bertrand W, et al. Regulation of mesangial cell cyclooxygenase synthesis by cytokines and glucocorticoids. Am J Physiol 1992; 263: F97-102.
    • (1992) Am J Physiol , vol.263
    • Coyne, D.W.1    Nickols, M.2    Bertrand, W.3
  • 48
    • 0013181383 scopus 로고
    • Identification of a phorbol ester-repressible v-src-inducible gene
    • Simmons DL, Levy DB, Yannoni Y, et al. Identification of a phorbol ester-repressible v-src-inducible gene. Proc Natl Acad Sci USA 1989; 86: 1178-82.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 1178-1182
    • Simmons, D.L.1    Levy, D.B.2    Yannoni, Y.3
  • 49
    • 0028926813 scopus 로고
    • New insights into the mode of action of anti-inflammatory drugs
    • Vane JR, Botting RM. New insights into the mode of action of anti-inflammatory drugs. Inflamm Res 1995; 44: 1-10.
    • (1995) Inflamm Res , vol.44 , pp. 1-10
    • Vane, J.R.1    Botting, R.M.2
  • 50
    • 0028961611 scopus 로고
    • Prostaglandin H synthase-1 : Evaluation of C-terminus function
    • Ren Y, Loose Mitchell DS, Kulmacz RJ, Prostaglandin H synthase-1 : Evaluation of C-terminus function. Arch Biochem Biophys 1995; 316: 751-7.
    • (1995) Arch Biochem Biophys , vol.316 , pp. 751-757
    • Ren, Y.1    Loose Mitchell, D.S.2    Kulmacz, R.J.3
  • 51
    • 0029979358 scopus 로고    scopus 로고
    • Safety of meloxicam: A global analysis of clinical trials
    • Distel M, Mueller C, Blumkhi E, Fries J. Safety of meloxicam: A global analysis of clinical trials. Br J Rheum 1996; 35: S168-77.
    • (1996) Br J Rheum , vol.35
    • Distel, M.1    Mueller, C.2    Blumkhi, E.3    Fries, J.4
  • 52
    • 0028353941 scopus 로고
    • Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs
    • Langman MJS, Weil J, Wainwright P, et al. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet 1994; 343: 1075-8.
    • (1994) Lancet , vol.343 , pp. 1075-1078
    • Langman, M.J.S.1    Weil, J.2    Wainwright, P.3
  • 53
    • 0028327671 scopus 로고
    • Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs
    • Garcia-Rodriguez LA, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs. Lancet 1994; 343: 769-72.
    • (1994) Lancet , vol.343 , pp. 769-772
    • Garcia-Rodriguez, L.A.1    Jick, H.2
  • 54
    • 0029589858 scopus 로고
    • Clinical update of the relative safety of nabumetone in long-term clinical trials
    • Lipani JA, Poland M. Clinical update of the relative safety of nabumetone in long-term clinical trials. Inflammopharmacology 1995; 3: 351-61.
    • (1995) Inflammopharmacology , vol.3 , pp. 351-361
    • Lipani, J.A.1    Poland, M.2
  • 56
    • 0000000869 scopus 로고
    • The preferential inhibition of COX-2 by meloxicam is highly dependent on the structure of the drug
    • Pairet M, Engelhardt G. The preferential inhibition of COX-2 by meloxicam is highly dependent on the structure of the drug. Rheumatol Eur 1995; 24(Suppl. 3): 272.
    • (1995) Rheumatol Eur , vol.24 , Issue.3 SUPPL. , pp. 272
    • Pairet, M.1    Engelhardt, G.2
  • 57
    • 0029619752 scopus 로고
    • Meloxicam: A potent inhibitor of adjuvant arthritis in the Lewis rat
    • Engelhardt G, Homma D, Schnitzler C. Meloxicam: A potent inhibitor of adjuvant arthritis in the Lewis rat. Inflamm Res 1995; 44: 548-55.
    • (1995) Inflamm Res , vol.44 , pp. 548-555
    • Engelhardt, G.1    Homma, D.2    Schnitzler, C.3
  • 58
    • 0029866403 scopus 로고    scopus 로고
    • A 4-week, double-blind, parallel-group study to compare the gastrointestinal effects of meloxicam 7.5 mg, meloxicam 15 mg, piroxicam 20 mg and placebo by means of faecal blood loss, endoscopy and symptom evaluation in healthy volunteers
    • Patoia L, Santucci L, Furno P, et al. A 4-week, double-blind, parallel-group study to compare the gastrointestinal effects of meloxicam 7.5 mg, meloxicam 15 mg, piroxicam 20 mg and placebo by means of faecal blood loss, endoscopy and symptom evaluation in healthy volunteers. Br J Rheum 1996; 35: S161-7.
    • (1996) Br J Rheum , vol.35
    • Patoia, L.1    Santucci, L.2    Furno, P.3
  • 59
    • 0029865433 scopus 로고    scopus 로고
    • A six-month double-blind trial to compare the efficacy and safety of meloxicam 7.5mg daily and naproxen 750mg daily in patients with rheumatoid arthritis
    • Wotjulewski JA, Schattenkirchner M, Barcelo P, et al. A six-month double-blind trial to compare the efficacy and safety of meloxicam 7.5mg daily and naproxen 750mg daily in patients with rheumatoid arthritis. Br J Rheum 1996; 35: S122-8.
    • (1996) Br J Rheum , vol.35
    • Wotjulewski, J.A.1    Schattenkirchner, M.2    Barcelo, P.3
  • 61
  • 62
    • 0025160887 scopus 로고
    • Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor
    • Gans KR, Galbraith W, Roman RJ, et al. Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor. J Pharmacol Exp Ther 1990; 254: 180-7.
    • (1990) J Pharmacol Exp Ther , vol.254 , pp. 180-187
    • Gans, K.R.1    Galbraith, W.2    Roman, R.J.3
  • 63
    • 0026601905 scopus 로고
    • Anti-inflammatory activity of BF389, a di-T-butylphenol, in animal models of arthritis
    • Bendele AM, Benslay DN, Hom JT, et al. Anti-inflammatory activity of BF389, a di-T-butylphenol, in animal models of arthritis. J Pharm Exp Ther 1992; 260: 300-5.
    • (1992) J Pharm Exp Ther , vol.260 , pp. 300-305
    • Bendele, A.M.1    Benslay, D.N.2    Hom, J.T.3
  • 65
    • 0028122558 scopus 로고
    • Nimesulide: An update on its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy
    • Davis R, Brogden RN. Nimesulide: an update on its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs, 1994; 48: 431-54.
    • (1994) Drugs , vol.48 , pp. 431-454
    • Davis, R.1    Brogden, R.N.2
  • 66
    • 85080853195 scopus 로고
    • From indomethacin to a selective COX-2 inhibitor: Development of indolalkalonic acids as potent and selective cyclooxygenase-2 inhibitors
    • Black WC, Belley M, Chan C, et al. From indomethacin to a selective COX-2 inhibitor: development of indolalkalonic acids as potent and selective cyclooxygenase-2 inhibitors. Inflamm Res 1995; 44(Suppl. 3): S270.
    • (1995) Inflamm Res , vol.44 , Issue.3 SUPPL.
    • Black, W.C.1    Belley, M.2    Chan, C.3
  • 67
    • 0029033219 scopus 로고
    • Pharmacology of a selective cyclooxygenase inhibitor, L-745.337: A novel non-steroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach
    • Chan CC, Boyce S, Brideau C, et al. Pharmacology of a selective cyclooxygenase inhibitor, L-745.337: A novel non-steroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. J Pharm Exp Ther 1995; 274: 1531-7.
    • (1995) J Pharm Exp Ther , vol.274 , pp. 1531-1537
    • Chan, C.C.1    Boyce, S.2    Brideau, C.3
  • 68
    • 0029980668 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of both enantiomers of L-761,000 as inhibitors of cyclooxygenase 1 and 2
    • Leblanc Y, Black WC, Chan CC, et al. Synthesis and biological evaluation of both enantiomers of L-761,000 as inhibitors of cyclooxygenase 1 and 2. Bioorg Med Chem Lett 1996; 6: 731-6.
    • (1996) Bioorg Med Chem Lett , vol.6 , pp. 731-736
    • Leblanc, Y.1    Black, W.C.2    Chan, C.C.3
  • 69
    • 0029016804 scopus 로고
    • T-614, a novel antirheumatic drug, inhibits both the activity and induction of cyclooxygenase 2 (COX-2) in cultured fibroblasts
    • Tanaka K, Kawasaki H, Kurata K, Aikawa Y, Tsukamoto Y, Inaba T. T-614, a novel antirheumatic drug, inhibits both the activity and induction of cyclooxygenase 2 (COX-2) in cultured fibroblasts. Jpn J Pharmacol 1995; 67: 305-14.
    • (1995) Jpn J Pharmacol , vol.67 , pp. 305-314
    • Tanaka, K.1    Kawasaki, H.2    Kurata, K.3    Aikawa, Y.4    Tsukamoto, Y.5    Inaba, T.6
  • 70
    • 0024460216 scopus 로고
    • Effect of nimesulide on cyclooxygenase activity in rat gastric mucosa and inflammatory exudate
    • Tofanetti O, Casciarri I, Cipolla PV, Cazzulani P, Omini C. Effect of nimesulide on cyclooxygenase activity in rat gastric mucosa and inflammatory exudate. Med Sci Res 1989; 17: 745-6.
    • (1989) Med Sci Res , vol.17 , pp. 745-746
    • Tofanetti, O.1    Casciarri, I.2    Cipolla, P.V.3    Cazzulani, P.4    Omini, C.5
  • 71
    • 0028122558 scopus 로고
    • Nimesulide. An update on its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy
    • Davis R, Brogden RN. Nimesulide. An update on its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 1994; 48: 431-54.
    • (1994) Drugs , vol.48 , pp. 431-454
    • Davis, R.1    Brogden, R.N.2
  • 73
    • 0027973091 scopus 로고
    • Effects of some naturally occurring prostanoids and some cyclooxygenase inhibitors on the contraction of the human uterine segment in vivo
    • Crankshaw DJ, Dyal R. Effects of some naturally occurring prostanoids and some cyclooxygenase inhibitors on the contraction of the human uterine segment in vivo. Can J Phys Pharm 1994; 870-4.
    • (1994) Can J Phys Pharm , pp. 870-874
    • Crankshaw, D.J.1    Dyal, R.2
  • 74
    • 0028034970 scopus 로고
    • Cyclooxygenase-2 is associated with the macula densa of the kidney and increases with salt restriction
    • Harris RC, McKanna JA, Akai Y, Jacobson HR, Du Bois RN, Breyer MD. Cyclooxygenase-2 is associated with the macula densa of the kidney and increases with salt restriction. J Clin Inv 1994; 94: 2504-10.
    • (1994) J Clin Inv , vol.94 , pp. 2504-2510
    • Harris, R.C.1    McKanna, J.A.2    Akai, Y.3    Jacobson, H.R.4    Du Bois, R.N.5    Breyer, M.D.6
  • 75
    • 0013363709 scopus 로고    scopus 로고
    • Elevated inducible cyclooxygenase in H. pylori infected gastric mucosa and gastric cancer
    • Abstract
    • Donnelly MT, Bishop AE, Polak J, Hawkey CJ. Elevated inducible cyclooxygenase in H. pylori infected gastric mucosa and gastric cancer. Gastroenterology 1996; 110: A897 (Abstract).
    • (1996) Gastroenterology , vol.110
    • Donnelly, M.T.1    Bishop, A.E.2    Polak, J.3    Hawkey, C.J.4
  • 76
    • 0006133860 scopus 로고    scopus 로고
    • L-745, 337, a selective inhibitor of COX-2, delays healing of experimental gastric ulcers comparable to traditional NSAIDs
    • Abstract
    • Schmassmann A, Settler C, Netzer P, Flogerzi B, Peskar B, Halter F. L-745, 337, a selective inhibitor of COX-2, delays healing of experimental gastric ulcers comparable to traditional NSAIDs. Gastroenterology 1996; 110: A252 (Abstract).
    • (1996) Gastroenterology , vol.110
    • Schmassmann, A.1    Settler, C.2    Netzer, P.3    Flogerzi, B.4    Peskar, B.5    Halter, F.6
  • 77
    • 0027244454 scopus 로고
    • Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans
    • Bjarnason I, Hayllar J, MacPherson, Russell AS. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 1993; 104: 1832-47.
    • (1993) Gastroenterology , vol.104 , pp. 1832-1847
    • Bjarnason, I.1    Hayllar, J.2    MacPherson3    Russell, A.S.4
  • 78
    • 0027373015 scopus 로고
    • Cellular immune mechanisms in rheumatoid arthritis and other inflammatory arthritides
    • Lanchbury JS, Pitzalis C. Cellular immune mechanisms in rheumatoid arthritis and other inflammatory arthritides. Curr Op Immun 1993; 5: 918-24.
    • (1993) Curr Op Immun , vol.5 , pp. 918-924
    • Lanchbury, J.S.1    Pitzalis, C.2
  • 79
    • 0028807498 scopus 로고
    • Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
    • Morham SG, Langerbach R, Loftin CD, et al. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 1995; 83: 473-82.
    • (1995) Cell , vol.83 , pp. 473-482
    • Morham, S.G.1    Langerbach, R.2    Loftin, C.D.3
  • 80
    • 0020565187 scopus 로고
    • Sulindac for polyposis of the colon
    • Waddell WR, Loughry RW. Sulindac for polyposis of the colon. J Surg Onc 1983; 24: 83-7.
    • (1983) J Surg Onc , vol.24 , pp. 83-87
    • Waddell, W.R.1    Loughry, R.W.2
  • 81
    • 0028344925 scopus 로고
    • Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer
    • Peleg I, Maibach HT, Brown SH, Wilcox CM. Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer. Arch Int Med 1994; 154: 394-9.
    • (1994) Arch Int Med , vol.154 , pp. 394-399
    • Peleg, I.1    Maibach, H.T.2    Brown, S.H.3    Wilcox, C.M.4
  • 82
    • 0029021758 scopus 로고
    • Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
    • Eberhart CE, Coffey RJ, Radhika A, et al. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 1995; 109: 285-301.
    • (1995) Gastroenterology , vol.109 , pp. 285-301
    • Eberhart, C.E.1    Coffey, R.J.2    Radhika, A.3
  • 83
    • 0029115954 scopus 로고
    • Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells
    • Shiff SJ, Qiao L, Tsai LL, Rigas B. Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells. J Clin Inv 1995; 96: 491-503.
    • (1995) J Clin Inv , vol.96 , pp. 491-503
    • Shiff, S.J.1    Qiao, L.2    Tsai, L.L.3    Rigas, B.4
  • 84
    • 0028803728 scopus 로고
    • Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
    • Tsujii M, Du Bois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 1995; 83: 493-501.
    • (1995) Cell , vol.83 , pp. 493-501
    • Tsujii, M.1    Du Bois, R.N.2
  • 85
    • 0029100370 scopus 로고
    • A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats
    • Elliott SN, McKnight W, Cirino G, Wallace JL. A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology 1995; 109: 524-30.
    • (1995) Gastroenterology , vol.109 , pp. 524-530
    • Elliott, S.N.1    McKnight, W.2    Cirino, G.3    Wallace, J.L.4
  • 86
    • 0028939954 scopus 로고
    • Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids : Insight into the mechanism and reversal of NSAID-induced gastrointestinal injury
    • Lichtenberger LM, Wang ZM, Romero JJ, et al. Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids : Insight into the mechanism and reversal of NSAID-induced gastrointestinal injury. Nat Med 1995; 1: 154-8.
    • (1995) Nat Med , vol.1 , pp. 154-158
    • Lichtenberger, L.M.1    Wang, Z.M.2    Romero, J.J.3
  • 87
    • 0002827472 scopus 로고    scopus 로고
    • Differential inhibition of COX-1 and COX-2 in vitro and pharmacological profile in vivo of NSAIDs
    • Vane J, Botting J, Botting R, eds. Dordrecht/Boston/London: Kluwer Academic
    • Pairet M, Engelhardt G. Differential inhibition of COX-1 and COX-2 in vitro and pharmacological profile in vivo of NSAIDs. In: Vane J, Botting J, Botting R, eds. Improved Non-steroidal Anti-inflammatory Drugs. Dordrecht/Boston/London: Kluwer Academic, 1996: 103-19.
    • (1996) Improved Non-steroidal Anti-inflammatory Drugs , pp. 103-119
    • Pairet, M.1    Engelhardt, G.2
  • 88
    • 0027146692 scopus 로고
    • Selectivity of non-steroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase
    • Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of non-steroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci 1994; 90: 11693-7.
    • (1994) Proc Natl Acad Sci , vol.90 , pp. 11693-11697
    • Mitchell, J.A.1    Akarasereenont, P.2    Thiemermann, C.3    Flower, R.J.4    Vane, J.R.5
  • 89
    • 0027293391 scopus 로고
    • Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues
    • O'Neill GP, Ford-Hutchinson AW. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett 1993; 330: 156-60.
    • (1993) FEBS Lett , vol.330 , pp. 156-160
    • O'Neill, G.P.1    Ford-Hutchinson, A.W.2
  • 91
    • 0027748232 scopus 로고
    • Acemetacin and indomethacin: Differential inhibition of constitutive and inducible cyclooxygenases in human gastric mucosa and leucocytes
    • Tavares IA, Bennett A. Acemetacin and indomethacin: Differential inhibition of constitutive and inducible cyclooxygenases in human gastric mucosa and leucocytes. Int J Tissue React 1993; 15: 49-53
    • (1993) Int J Tissue React , vol.15 , pp. 49-53
    • Tavares, I.A.1    Bennett, A.2
  • 92
    • 0027940487 scopus 로고
    • Biochemical and pharmacological characterisation of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases
    • Patrignani P, Panara MR, Greco A, et al. Biochemical and pharmacological characterisation of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. J Pharm Exp Ther 1994; 271: 1705-12.
    • (1994) J Pharm Exp Ther , vol.271 , pp. 1705-1712
    • Patrignani, P.1    Panara, M.R.2    Greco, A.3


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