Inhibitory effect of 3,4-diaryl-3-pyrrolin-2-one derivatives on cyclooxygenase 1 and 2 in murine peritoneal macrophages

Acta Pharmacologica Sinica

Volumn 23, Issue 8, 2002, Pages 762-768

  Shen, Fang ^a   Bai, Ai Ping ^a   Guo, Zong Ru ^a   Cheng, Gui Fang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cyclooxygenase 1; Cyclooxygenase 2; Indomethacin; Peritoneal macrophages; Rofecoxib

Indexed keywords

3 PYRROLIN 2 ONE DERIVATIVE; CALCIMYCIN; CARBONYL DERIVATIVE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INDOMETACIN; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; PYRROLINE DERIVATIVE; ROFECOXIB; UNCLASSIFIED DRUG; ENZYME INHIBITOR; ISOENZYME; MEMBRANE PROTEIN; PROSTAGLANDIN SYNTHASE; PTGS1 PROTEIN, MOUSE; PYRROLE DERIVATIVE;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CELL STIMULATION; DRUG DESIGN; DRUG STRUCTURE; ENZYME INHIBITION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROSTAGLANDIN SYNTHESIS; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG ANTAGONISM; MALE; METABOLISM;

ANIMAL; CELLS, CULTURED; ENZYME INHIBITORS; ISOENZYMES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE; PYRROLES; ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0036023609     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Cyclooxygenase-2: Its rich diversity of roles and possible application of its selective inhibitors
2. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
3. Expression of cyclooxygenase-1 and -2 in human colorectal cancer
4. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
5. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-y1]benze nesulfonamide (SC-58635, celecoxib)
6. Rofecoxib [Vioxx, MK-0966; 4-(4′-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: A potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles
7. Clinical experience with cyclooxygenase-2 inhibitors
8. Segregated coupling of phospholipases A2, cyclooxygenases, and terminal prostanoid synthases in different phases of prostanoid biosynthesis in rat peritoneal macrophages
9. Establishment of screening models for selective cyclooxygenase-2 inhibitors
10. A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors
11. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor
12. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
13. Effect of structural modification of enol-carboxamidetype nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity
14. Studies on the enzymatic pathways of calcium ionophore-induced phospholipid degradation and arachidonic acid mobilization in peritoneal macrophages
15. Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages