Effect of phenobarbital and spironolactone treatment on the oxidative metabolism of antipyrine by rat liver microsomes

Polish Journal of Pharmacology

Volumn 53, Issue 1, 2001, Pages 11-19

  Szakacs T ^a   Veres, Z ^a   Vereczkey, L ^a  

^a CHEMICAL RESEARCH CENTER   (Hungary)

Author keywords

Methyldopa; Antipyrine; Cytochrome P 450; Liver microsomes; Phenobarbital; Rat; Spironolactone

Indexed keywords

4 HYDROXYPHENAZONE; CHLORAMPHENICOL; CIMETIDINE; CYTOCHROME P450; CYTOCHROME P450 2C11; CYTOCHROME P450 3A; ENZYME INHIBITOR; METHYLDOPA; N DEMETHYLASE; PHENAZONE; PHENOBARBITAL; SPIRONOLACTONE; TROLEANDOMYCIN;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DRUG EFFECT; HYDROXYLATION; IN VITRO STUDY; LIVER MICROSOME; NONHUMAN; OXIDATION; RAT; SYNTHESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICONVULSANTS; ANTIPYRINE; CHLORAMPHENICOL; CIMETIDINE; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ENZYME INDUCTION; ENZYME INHIBITORS; MALE; METHYLDOPA; MICROSOMES, LIVER; NADP; OXIDATION-REDUCTION; PHENOBARBITAL; RATS; RATS, WISTAR; SPIRONOLACTONE; SYMPATHOLYTICS;

EID: 0035071168     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

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