4′-hydroxylation of flurbiprofen by rat liver microsomes in fasting and feeding conditions

Biological and Pharmaceutical Bulletin

Volumn 26, Issue 10, 2003, Pages 1448-1454

  Shimizu, Makiko ^a   Matsushita, Reiko ^a   Matsumoto, Yoshiaki ^a   Fukuoka, Masamichi ^a  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

4 hydroxyflurbiprofen; Cytochrome P450s (CYPs); Fasting; Flurbiprofen; Nonsteroidal anti inflammatory drug (NSAID)

Indexed keywords

AMINOPHENOL; ANILINE; CIMETIDINE; CYTOCHROME P450; CYTOCHROME P450 2C11; CYTOCHROME P450 2E1; DICLOFENAC; DISULFIRAM; FLURBIPROFEN; FURAFYLLINE; GLUCOSE 6 PHOSPHATE; KANAMYCIN; PROADIFEN; QUININE; TESTOSTERONE; TROLEANDOMYCIN; ENZYME INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DIET RESTRICTION; DRUG HYDROXYLATION; FEEDING; LIVER CELL; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; RAT; STARVATION; ANIMAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ENZYMOLOGY; FEEDING BEHAVIOR; HYDROXYLATION; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FASTING; FEEDING BEHAVIOR; FLURBIPROFEN; HYDROXYLATION; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR;

EID: 1542646170     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.26.1448     Document Type: Article

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