Imrecoxib: A novel and selective cyclooxygenase 2 inhibitor with anti-inflammatory effect

Acta Pharmacologica Sinica

Volumn 25, Issue 7, 2004, Pages 927-931

  Chen, Xiao Hong ^a   Bai, Jin Ye ^a   Shen, Fang ^a   Bai, Ai Ping ^a   Guo, Zong Ru ^a   Cheng, Gui Fang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase inhibitors; Imrecoxib; Inflammation

Indexed keywords

ADJUVANT; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; IMRECOXIB; INDOMETACIN; MESSENGER RNA; ROFECOXIB; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CELL ASSAY; CELL STRAIN U937; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; EDEMA; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; INFLAMMATION; NONHUMAN; PERITONEUM MACROPHAGE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RODENT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; EDEMA; HUMANS; ISOENZYMES; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRROLES; RATS; RATS, WISTAR; RNA, MESSENGER; SULFIDES; U937 CELLS;

EID: 3142773384     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Marnett LJ, Rowlinson SW, Goodwin DC, Kalgutkar AS, Lanzo CA. Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition. J Biol Chem 1999; 274: 22903-6.
2. Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci USA 2002; 99: 13926-31.
3. Dinchuk JE, Liu RQ, Trzaskos JM. COX-3: in the wrong frame in mind. Immunol Lett 2003; 86: 121.
4. Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 1999; 96: 7563-8.
5. FitzGerald GA, Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med 2001; 345: 433-42.
6. Parente L, Perretti M. Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight. Biochem Pharmacol 2003; 65: 153-9.
7. Wright JM. The double-edged sword of COX-2 selective NSAIDs. CMAJ 2002; 167: 1131-7.
8. Shen F, Bai AP, Guo ZR, Cheng GF. Inhibitory effect of 3, 4-diary-3-pyrrolin-2-one derivatives on cyclooxygenase 1 and 2 in murine peritoneal macrophages. Acta Pharmacol Sin 2002; 23: 762-8.
9. Barrios-Rodiles M, Tiraloche G, Chadee K. Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1β and TNF-α. J Immunol 1999; 163: 963-9.
10. Cheng GF, Liu DP, Yang DX, He KQ, Bai JY, Zhu XY. Antiinflammatory effects of Tremulacin, a Salicin-related substance isolated from Populus Tomentosa Carr leaves. Phytomedicine 1994; 1: 209-11.
11. Dai M, Wei W, Shen YX, Zheng YQ. Glucosides of Chaenomeles specioca remit rat adjuvant arthritis by inhibiting synoviocyte activities. Acta Pharmacol Sin 2003; 24: 1161-6.
12. Barrios-Rodiles M, Keller K, Belley A, Chadee K. Nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase-2 enzyme activity but not mRNA expression in human macrophages. Biochem Biophys Res Commun 1996; 225: 896-900.