Endothelial nitric oxide synthase and endothelial dysfunction

Current Hypertension Reports

Volumn 5, Issue 6, 2003, Pages 473-480

  Huang, Paul L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FATTY ACID; HEAT SHOCK PROTEIN 90; MEMBRANE COFACTOR PROTEIN;

AGING; ATHEROSCLEROSIS; BIOAVAILABILITY; BLOOD FLOW; BLOOD VESSEL TONE; CELL INTERACTION; CELLULAR DISTRIBUTION; CLINICAL FEATURE; DIABETES MELLITUS; ENDOTHELIUM CELL; ENDOTHELIUM LESION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; FATTY ACID METABOLISM; HUMAN; HYPERTENSION; LEUKOCYTE; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION;

EID: 3142558008     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-003-0055-4     Document Type: Review

References (45)

1. Furchgott RF, Zawadzki JV: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980, 288:373-376.
2. Alderton WK, Cooper CE, Knowles RG: Nitric oxide synthases: structure, function and inhibition. Biochem J 2001, 357:593-615.
3. Brenman JE, Xia H, Chao DS, et al.: Regulation of neuronal nitric oxide synthase through alternative transcripts. Dev Neurosci 1997, 19:224-231.
4. Stamler JS: Redox signaling: nitrosylation and related target interactions of nitric oxide. Cell 1994, 78:931-936.
5. Stamler JS, Jia L, Eu JP, et al.: Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science 1997, 276:2034-2037.
6. Beckman JS, Koppenol WH: Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996, 271:C1424-C1437.
7. Mooradian DL, Hutsell TC, Keefer LK: Nitric oxide (NO) donor molecules: effect of NO release rate on vascular smooth muscle cell proliferation in vitro. J Cardiovasc Pharmacol 1995, 25:674-678.
8. Lefer AM, Ma XL: Decreased basal nitric oxide release in hypercholesterolemia increases neutrophil adherence to rabbit coronary artery endothelium. Arterioscler Thromb 1993, 13:771-776.
9. Radomski MW, Palmer RM, Moncada S: Modulation of platelet aggregation by an L-arginine-nitric oxide pathway. Trends Pharmacol Sci 1991, 12:87-88.
10. Beckman JS, Ye YZ, Anderson PC, et al.: Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biol Chem Hoppe Seyler 1994, 375:81-88.
11. Huang PL, Dawson TM, Bredt DS, et al.: Targeted disruption of the neuronal nitric oxide synthase gene. Cell 1993, 75:1273-1286.
12. Huang Z, Huang PL, Panahian N, et al.: Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 1994, 265:1883-1885.
13. Panahian N, Yoshida T, Huang PL, et al.: Attenuated hippocampal damage after global cerebral ischemia in mice mutant in neuronal nitric oxide synthase. Neuroscience 1996, 72:343-354.
14. Wei XQ, Charles IG, Smith A, et al.: Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 1995, 375:408-411.
15. MacMicking JD, Nathan C, Hom G, et al.: Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 1995, 81:641-650.
16. Laubach VE, Shesely EG, Smithies O, Sherman PA: Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccaride-induced death. Proc Natl Acad Sci U S A 1995, 92:10688-10692.
17. Kuhlencordt PJ, Chen J, Han F, et al.: Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice. Circulation 2001, 103:3099-3104.
18. Huang PL, Huang Z, Mashimo H, et al.: Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 1995, 377:239-242.
19. Gyurko R, Kuhlencordt P, Fishman MC, Huang PL: Modulation of mouse cardiac function in vivo by eNOS and ANP. Am J Physiol Heart Circ Physiol 2000, 278:H971-H981.
20. Moroi M, Zhang L, Yasuda T, et al.: Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. J Clin Invest 1998, 101:1225-1232.
21. Kuhlencordt PJ, Gyurko R, Han F, et al.: Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice. Circulation 2001, 104:448-454.
22. Chen J, Kuhlencordt PJ, Astern J, et al.: Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice. Circulation 2001, 104:2391-2394.
23. Freedman JE, Sauter R, Battinelli EM, et al.: Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. Circ Res 1999, 84:1416-1421.
24. Lefer DJ, Jones SP, Girod WG, et al.: Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice. Am J Physiol 1999, 276:H1943-H1950.
25. Janssens SP, Shimouchi A, Quertermous T, et al.: Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem 1992, 267:14519-14522.
26. Marsden PA, Schappert KT, Chen HS, et al.: Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett 1992, 307:287-293.
27. Sessa WC, Harrison JK, Barber CM, et al.: Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase. J Biol Chem 1992, 267:15274-15276.
28. Busconi L, Michel T: Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization. J Biol Chem 1993, 268:8410-8413.
29. Pollock JS, Klinghofer V, Forstermann U, Murad F: Endothelial nitric oxide synthase is myristylated. FEBS Lett 1992, 309:402-404.
30. Garcia-Cardena G, Oh P, Liu J, et al.: Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci U S A 1996, 93:6448-6453.
31. Feron O, Saldana F, Michel JB, Michel T: The endothelial nitric-oxide synthase-caveolin regulatory cycle. J Biol Chem 1998, 273:3125-3128.
32. Garcia-Cardena G, Martasek P, Masters BS, et al.: Dissecting the interaction between nitric oxide synthase (NOS) and caveolin: functional significance of the nos caveolin binding domain in vivo. J Biol Chem 1997, 272:25437-25440.
33. Dimmeler S, Fleming I, Fisslthaler B, et al.: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999, 399:601-605.
34. Fulton D, Gratton JP, McCabe TJ, et al.: Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999, 399:597-601.
35. Harris MB, Ju H, Venema VJ, et al.: Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation. J Biol Chem 2001, 276:16587-16591.
36. Michell BJ, Chen Z, Tiganis T, et al.: Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 2001, 276:17625-17628.
37. Chen ZP, Mitchelhill KI, Michell BJ, et al.: AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett 1999, 443:285-289.
38. Fulton D, Fontana J, Sowa G, et al.: Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme. J Biol Chem 2002, 277:4277-4284.
39. Montagnani M, Chen H, Barr VA, Quon MJ: Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179). J Biol Chem 2001, 276:30392-30398.
40. Hisamoto K, Ohmichi M, Kurachi H, et al.: Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem 2001, 276:3459-3467.
41. Kureishi Y, Luo Z, Shiojima I, et al.: The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 2000, 6:1004-1010.
42. Brouet A, Sonveaux P, Dessy C, et al.: Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins. Circ Res 2001, 89:866-873.
43. Du XL, Edelstein D, Dimmeler S, et al.: Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J Clin Invest 2001, 108:1341-1348.
44. Laursen JB, Somers M, Kurz S, et al.: Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 2001, 103:1282-1288.
45. d'Uscio LV, Baker TA, Mantilla CB, et al.: Mechanism of endothelial dysfunction in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2001, 21:1017-1022.