Actin cytoskeleton organization and posttranscriptional regulation of endothelial nitric oxide synthase during cell growth

Circulation Research

Volumn 95, Issue 5, 2004, Pages 488-495

  Searles, Charles D ^a   Ide, Lucienne ^a   Davis, Michael E ^a   Cai, Hua ^a   Weber, Martina ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

3 untranslated region; Cytoskeletal dynamics; Endothelial nitric oxide synthase; mRNA binding protein; mRNA stability

Indexed keywords

ACTIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; F ACTIN; G ACTIN; MESSENGER RNA; MONOMER; RIBONUCLEOPROTEIN;

3' UNTRANSLATED REGION; ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CATTLE; CELL FRACTIONATION; CELL GROWTH; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; CROSS LINKING; CYTOPLASM; CYTOSKELETON; ENDOTHELIUM CELL; ENZYME LOCALIZATION; EXTRACELLULAR MATRIX; FLUORESCENCE IN SITU HYBRIDIZATION; HOMEOSTASIS; NONHUMAN; PATHOPHYSIOLOGY; POLYSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN RNA BINDING; REGULATORY MECHANISM; RNA STABILITY; STIMULUS;

3' UNTRANSLATED REGIONS; ACTINS; ANIMALS; BINDING SITES; CATTLE; CELL PROLIFERATION; CELLS, CULTURED; DEPSIPEPTIDES; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MARINE TOXINS; MICROFILAMENT PROTEINS; MICROFILAMENTS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; RIBONUCLEOPROTEINS; RNA STABILITY; RNA, MESSENGER;

EID: 4444250473     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000138953.21377.80     Document Type: Article

References (41)

1. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987;327:524-526.
2. Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromocyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 1989;83:1774-1777.
3. Alheid U, Frolich JC, Forstermann U. Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. Thromb Res. 1987;47:561-571.
4. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A. 1991;88:4651-4655.
5. Nishida K, Harrison DG, Navas JP, Fisher AA, Dockery SP, Uematsu M, Nerem RM, Alexander RW, Murphy TJ. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest. 1992;90:2092-2096.
6. Zembowicz A, Tang JL, Wu KK. Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine. J Biol Chem. 1995;270:17006-17010.
7. Hirata K, Miki N, Kuroda Y, Sakoda T, Kawashima S, Yokoyama M. Low concentration of oxidized low-density lipoprotein and lysophosphatidylcholine upregulate constitutive nitric oxide synthase mRNA expression in bovine aortic endothelial cells. Circ Res. 1995;76:958-962.
8. Ramasamy S, Parthasarathy S, Harrison DG. Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid. J Lipid Res. 1998;39:268-276.
9. Laufs U, La Fata V, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation. 1998;97:1129-1135.
10. Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circ Res. 2000;86:347-354.
11. Yoshizumi M, Perrella MA, Burnett JC, Jr., Lee ME. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res. 1993;73:205-209.
12. McQuillan LP, Leung GK, Marsden PA, Kostyk SK, Kourembanas S. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. Am J Physiol. 1994;267:H1921-H1927.
13. Lu JL, Schmiege LM, 3rd, Kuo L, Liao JC. Downregulation of endothelial constitutive nitric oxide synthase expression by lipopolysaccharide. Biochem Biophys Res Commun. 1996;225:1-5.
14. Eto M, Barandier C, Rathgeb L, Kozai T, Joch H, Yang Z, Luscher TF. Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: role of Rho/ROCK and mitogen-activated protein kinase. Circ Res. 2001;89:583-590.
15. Liao JK, Shin WS, Lee WY, Clark SL. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem. 1995;270:319-324.
16. Arnal JF, Yamin J, Dockery S, Harrison DG. Regulation of endothelial nitric oxide synthase mRNA, protein, and activity during cell growth. Am J Physiol. 1994;267:C1381-C1388.
17. Searles CD, Miwa Y, Harrison DG, Ramasamy S. Posttranscriptional regulation of endothelial nitric oxide synthase during cell growth. Circ Res. 1999;85:588-595.
18. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 1983;11:1475-1499.
19. Campbell GP, Hesketh JE. Distribution of glutathione peroxidase mRNAs between free and cytoskeletal-bound polysomes in H4 hepatoma cells. Biochem Soc Trans. 1996;24:189S.
20. Hesketh JE, Campbell GP, Whitelaw PF. c-myc mRNA in cytoskeletal-bound polysomes in fibroblasts. Biochem J. 1991;274:607-609.
21. Hovland R, Campbell G, Pryme I, Hesketh J. The mRNAs for cyclin A, c-myc and ribosomal proteins L4 and S6 are associated with cytoskeletal-bound polysomes in HepG2 cells. Biochem J. 1995;310:193-196.
22. Szocs K, Lassegue B, Sorescu D, Hilenski LL, Valppu L, Couse TL, Wilcox JN, Quinn MT, Lambeth JD, Griendling KK. Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury. Arterioscler Thromb Vasc Biol. 2002;22:21-27.
23. dos Remedios CG, Chhabra D, Kekic M, Dedova IV, Tsubakihara M, Berry DA, Nosworthy NJ. Actin binding proteins: regulation of cytoskeletal microfilaments. Physiol Rev. 2003;83:433-473.
24. Huff T, Muller CS, Otto AM, Netzker R, Hannappel E. beta-Thymosins, small acidic peptides with multiple functions. Int J Biochem Cell Biol. 2001;33:205-220.
25. Ballweber E, Hannappel E, Huff T, Mannherz HG. Mapping the binding site of thymosin beta4 on actin by competition with G-actin binding proteins indicates negative cooperativity between binding sites located on opposite subdomains of actin. Biochem J. 1997;327:787-793.
26. Carlier MF, Valentin-Ranc C, Combeau C, Fievez S, Pantoloni D. Actin polymerization: regulation by divalent metal ion and nucleotide binding, ATP hydrolysis and binding of myosin. Adv Exp Med Biol. 1994;358:71-81.
27. Spector I, Braet F, Shochet NR, Bubb MR. New anti-actin drugs in the study of the organization and function of the actin cytoskeleton. Microsc Res Tech. 1999;47:18-37.
28. Bubb MR, Spector I, Bershadsky AD, Korn ED. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. J Biol Chem. 1995;270:3463-3466.
29. Gotlieb AI, Lee TY. Endothelial repair in atherogenesis. Curr Top Pathol. 1999;93:157-166.
30. Lee TY, Rosenthal A, Gotlieb AI. Transition of aortic endothelial cells from resting to migrating cells is associated with three sequential patterns of microfilament organization. J Vasc Res. 1996;33:13-24.
31. Kim DW, Langille BL, Wong MK, Gotlieb AI. Patterns of endothelial microfilament distribution in the rabbit aorta in situ. Circ Res. 1989;64:21-31.
32. Langille BL, Graham JJ, Kim D, Gotlieb AI. Dynamics of shear-induced redistribution of F-actin in endothelial cells in vivo. Arterioscler Thromb. 1991;11:1814-1820.
33. Hesketh JE. Sorting of messenger RNAs in the cytoplasm: mRNA localization and the cytoskeleton. Exp Cell Res. 1996;225:219-236.
34. Henics T, Nagy E, Szekeres-Bartho J. Interaction of AU-rich sequence binding proteins with actin: possible involvement of the actin cytoskeleton in lymphokine mRNA turnover. J Cell Physiol. 1997;173:19-27.
35. Henics T. Microfilament-dependent modulation of cytoplasmic protein binding to TNFalpha mRNA AU-rich instability element in human lymphoid cells. Cell Biol Int. 1999;23:561-570.
36. Lyubimova A, Bershadsky AD, Ben-Ze'ev A. Autoregulation of actin synthesis responds to monomeric actin levels. J Cell Biochem. 1997;65:469-478.
37. Laufs U, Endres M, Stagliano N, Amin-Hanjani S, Chui DS, Yang SX, Simoncini T, Yamada M, Rabkin E, Allen PG, Huang PL, Bohm M, Schoen FJ, Moskowitz MA, Liao JK. Neuroprotection mediated by changes in the endothelial actin cytoskeleton. J Clin Invest. 2000;106:15-24.
38. Zhao Y, Davis HW. Hydrogen peroxide-induced cytoskeletal rearrangement in cultured pulmonary endothelial cells. J Cell Physiol. 1998;174:370-379.
39. Laufs U, Liao JK. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem. 1998;273:24266-24271.
40. Su Y, Edwards-Bennett S, Bubb MR, Block ER. Regulation of endothelial nitric oxide synthase by the actin cytoskeleton. Am J Physiol Cell Physiol. 2003;284:C1542-C1549.
41. Lai PF, Mohamed F, Monge JC, Stewart DJ. Downregulation of eNOS mRNA expression by TNFalpha: identification and functional characterization of RNA-protein interactions in the 3′UTR. Cardiovasc Res. 2003; 59:160-168.