Role of the histidine residue at position 105 in the human α5 containing GABAa receptor on the affinity and efficacy of benzodiazepine site ligands

British Journal of Pharmacology

Volumn 135, Issue 1, 2002, Pages 248-256

  Kelly, M D ^b   Smith, A ^a   Banks, G ^a   Wingrove, P ^a   Whiting, P W ^a   Atack, J ^a   Seabrook, G R ^a   Maubach, K A ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b De Nova Pharmacauticals   (United Kingdom)

Author keywords

Benzodiazepine; Diazepam; Mutagenesis; subunit

Indexed keywords

2 (4 METHOXYPHENYL) 5H PYRAZOLO[4,3 C]QUINOLIN 3 ONE; 2 PHENYL 5H PYRAZOLO[4,3 C]QUINOLIN 3 ONE; 3 METHYL 6 (3 TRIFLUOROMETHYLPHENYL) 1,2,4 TRIAZOLO[4,3 B]PYRIDAZINE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 7 CHLORO 5,6 DIHYDRO 3 (5 ISOPROPYL 1,2,4 OXADIAZOL 3 YL) 5 METHYL 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPIN 6 ONE; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; ABECARNIL; ARGININE; BENZODIAZEPINE; BETA CARBOLINE 3 CARBOXYLIC ACID ETHYL ESTER; BETA CARBOLINE DERIVATIVE; BRETAZENIL; DIAZEPAM; DIMETHOXY 4 ETHYL BETA CARBOLINE 3 CARBOXYLATE; FG 8094; FLUMAZENIL; FLUNITRAZEPAM; HISTIDINE; LIGAND; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; OOCYTE; PHARMACOLOGY; PRIORITY JOURNAL; RECEPTOR AFFINITY; VOLTAGE CLAMP; XENOPUS;

ANTICONVULSANTS; ARGININE; AZIDES; BENZODIAZEPINES; BENZODIAZEPINONES; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; CELLS, CULTURED; FLUMAZENIL; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; HISTIDINE; HUMANS; LIGANDS; MUTATION; PROTEIN SUBUNITS; RECEPTORS, GABA-A;

EID: 0036155226     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704459     Document Type: Article

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