Targeted deletion of Kv4.2 eliminates Ito,f and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction

Circulation Research

Volumn 97, Issue 12, 2005, Pages 1342-1350

  Guo, Weinong ^a   Jung, W Edward ^b   Marionneau, Céline ^c   Aimond, Franck ^a   Xu, Haodong ^a   Yamada, Kathryn A ^a   Schwarz, Thomas L ^d   Demolombe, Sophie ^c   Nerbonne, Jeanne M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c L INSTITUT DU THORAX   (France)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Arrhythmia; Hypertrophy; Ito,s; Kv channels; Remodeling

Indexed keywords

MESSENGER RNA; PROTEIN SUBUNIT; VOLTAGE GATED POTASSIUM CHANNEL; KCNIP2 PROTEIN, MOUSE; KV CHANNEL INTERACTING PROTEIN; SHAL POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRIC ACTIVITY; GENE DELETION; GENE EXPRESSION; HEART ARRHYTHMIA; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FAMILY; TRANSGENIC MOUSE; VOLTAGE CLAMP; ANIMAL; CARDIOMEGALY; ELECTROCARDIOGRAPHY; GENETICS; HEART VENTRICLE; HEART VENTRICLE REMODELING; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CARDIOMEGALY; ELECTROCARDIOGRAPHY; HEART VENTRICLES; KV CHANNEL-INTERACTING PROTEINS; MICE; MICE, KNOCKOUT; MYOCYTES, CARDIAC; SHAL POTASSIUM CHANNELS; VENTRICULAR REMODELING;

EID: 33644670611     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000196559.63223.aa     Document Type: Article

References (32)

1. Nerbonne JM, Kass RS. Molecular physiology of cardiac repolarization. Physiol Rev. 2005;85:1205-1253.
2. + currents in adult mouse ventricular myocytes. J Gen Physiol. 1999;113:661-678.
3. + currents in adult mouse ventricles. J Physiol. 2004;559:103-120.
4. Barry DM, Xu H, Schuessler RB, Nerbonne JM. Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit. Circ Res. 1998;83:560-567.
5. + current diversity in mouse ventricular myocytes. J Physiol. 1999;521:587-599.
6. Xu H, Barry DM, Li H, Brunet S, Nerbonne JM. Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunit. Circ Res. 1999;85:623-633.
7. to,s: early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 alpha subunit. Circ Res. 2000;87:73-79, 2000.
8. K,slow and resistance to drug induced QT prolongation. Circ Res. 2001;88:940-946.
9. K,slow1, in mouse ventricular myocytes expressing a dominant negative Kv1.5 alpha subunit. Am J Physiol. 2004;286:H319-H328.
10. + currents. Circ Res. 2002;90:586-593.
11. + channel in ventricular muscle. A molecular correlate for the transient outward current Circ Res. 1996;79:659-668.
12. to: further diversity by alternative mRNA splicing. Am J Physiol 1998;275:H1963-H1970.
13. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ. Modulation of A-type potassium channels by a family of calcium sensors. Nature. 2000;403:553-556.
14. to and confers susceptibility to ventricular tachycardia. Cell. 2001;107:801-813.
15. Rosati B, Pan Z, Lypen S, Wang HS, Cohen I, Dixon JE, McKinnon D. Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol. 2001;533:119-125.
16. to? Circulation. 2002;106:423-429.
17. Rosati B, Grau F, Rodriguez S, Li H, Nerbonne JM, McKinnon D. Co-ordinate patterns of KChIP2 mRNA, protein and transient outward current expression throughout canine ventricle. J Physiol. 2003;548:815-822.
18. Dixon JE, McKinnon D. Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats. Circ Res. 1994;75:252-260.
19. + channel subunit in the mouse heart. Circ Res. 1999;85:1067-1076.
20. 2+ influx protects cardiac morphology and ventricular function in Kv4.2N transgenic mice. Circulation. 2002;105:1850-1856.
21. to causes hypertrophy in neonatal rat ventricular myocytes. Circ Res. 2002;90:578-585.
22. Zobel C, Kassiri Z, Nguyen TT, Meng Y, Backx PH. Prevention of hypertrophy by overexpression of Kv4.2 in cultured neonatal cardiomyocytes. Circulation. 2002;106:2385-2391.
23. + channels in mouse ventricular myocytes. Circ Res. 2005;96:451-458.
24. Sanguinetti MC, Johnson JH, Hammerland LG, Kelbaugh PR, Volkmann RA, Saccomano NA, Mueller AL. Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels. Mol Pharmacol. 1997;51:491-498.
25. Marionneau C, Couette B, Liu J, Li H, Mangoni ME, Nargeot J, Lei M, Escande D, Demolombe S. Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. J Physiol. 2005;562:223-234.
26. Rosati B, McKinnon D. Regulation of ion channel expression. Circ Res. 2004;94:874-883.
27. Deschenes I, Tomaselli GF. Modulation of Kv4.3 current by accessory subunits. FEBS Lett. 2002;528:183-188.
28. Wong W, Newel EW, Jugloff DG, Jones OT, Schlichter LC. Cell surface targeting and clustering interactions between heterologously expressed PSD-95 and the Shal voltage-gated potassium channel, Kv4.2. J Biol Chem. 2002;277:20423-20430.
29. Petrecca K, Miller DM, Shrier A. Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin binding protein filamin. J Neurosci. 2000;20:8736-8740.
30. Wang Z, Eldstrom JR, Jantzi J, Moore ED, Fedida D. Increased focal Kv4.2 channel expression at the plasma membrane is the result of actin depolymerization. Am J Physiol. 2004;286:H749-H759.
31. Ma D, Zerangue N, Lin YF, Collins A, Yu M, Jan YN, Jan LY. Role of ER export signals in controlling surface potassium channel numbers. Science. 2001;291:316-319.
32. Ma D, Jan LY. ER transport signals and trafficking of potassium channels and receptors. Curr Opin Neurobiol. 2002;12:287-292.