Targeted replacement of Kv1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of IK,slow and resistance to drug-induced QT prolongation

Circulation Research

Volumn 88, Issue 9, 2001, Pages 940-946

  London, Barry ^a   Guo, Weinong ^b   Pan, Xiang Hua ^a   Lee, Joon S ^a   Shusterman, Vladimir ^a   Rocco, Christopher J ^a   Logothetis, Diomedes A ^c   Nerbonne, Jeanne M ^b   Hill, Joseph A ^d  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

Arrhythmias; Drug induced long QT syndrome; Genetically engineered mice; Heart; Potassium channels

Indexed keywords

4 AMINOPYRIDINE; POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTRIC POTENTIAL; GENE TARGETING; GENETIC ENGINEERING; HEART ARRHYTHMIA; HEART REPOLARIZATION; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QT INTERVAL; TELEMETRY; TRANSGENIC MOUSE;

EID: 0035843896     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh0901.090929     Document Type: Article

References (32)

1. + channel function in the cardiovascular system. In: Archer SA, Rusch NJ, ed. Potassium Channels in Cardiovascular Biology. New York, NY: Plenum Publishing. In press.
2. + channel diversity in mammalian myocardium. J Physiol (Lond). 2000;525: 285-298.
3. London B, Jeron A. Zhou J, Buckett P, Han X, Mitchell GF, Koren G. Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel. Proc Natl Acad Sci U S A. 1998;95:2926-2931.
4. Xu H, Barry DM, Li H, Brunet S, Guo W, Nerbonne JM. Attenuation of the slow component of the delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 α subunit. Circ Res, 1999;85:623-633.
5. Barry DM, Xu H, Schussler RB, Nerbonne JM. Functional knockout of the transient outward current, long QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 α subunit, Circ Res. 1998;83:560-567.
6. + channel subunit in the mouse heart. Circ Res. 1999;85:1067-1076.
7. + current by overexpression of the long-QT syndrome HER G628S mutation in transgenic mice. Circ Res. 1998;83:668-678.
8. London B, Wang DW, Hill JA, Bennett PB. The transient outward current in mice lacking the potassium channel gene Kv1.4. J Physoil (Lond). 1998;509:171-182.
9. Guo W, Xu H, London B, Nerbonne JM. Molecular basis of transient outward current diversity in mouse ventricular myocytes. J Physiol (Lond). 1999;521:587-599.
10. Wickman K, Nemec J, Gendler SJ, Clapham DE. Abnormal heart rate regulation in GIRK4 knockout mice. Neuron. 1998;20:103-114.
11. + channel in heart rate control of repolarization in a murine engineered model of Jervell and Lange-Nielsen syndrome. Circ Res. 1998;83:95-102.
12. Kupershnitdt S, Yang T, Anderson ME, Wessels A, Niswender KD, Magnuson MA, Roden DM. Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circ Res. 1999;84:146-152.
13. Zaritsky JI, Schwarz TL. Targeted disruption of the Kir2.1 and Kir2.2 genes in mice and the physiological consequences in the heart. Circulation. 1999;100(suppl I):1-351. Abstract.
14. to, s: early afterdepolarizations, atrioventricular block and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 α subunit. Circ Res. 2000;87:73-79.
15. Zhou J, Jeron A, London B, Han X, Koren G. Characterization of a slowly inactivating outward current in adult mouse ventricular myocytes. Circ Res. 1998;83:806-814.
16. Jeron A, Mitchell GF, Zhou J, Murata M, London B, Buckett P, Wiviott SD, Koren G. Inducible polymorphic ventricular tachycardia in a transgenic mouse model with a long Q-T phenotype. Am J Physiol. 2000;278:H1891-H1898.
17. Baker LC, London B, Choi B-R, Koren G, Salama G. Enhanced dispersion of repolarization and refractoriness in transgenic mouse hearts promotes reentrant ventricular tachycardia. Circ Res. 2000;86:396-407.
18. + current. Circ Res. 1998;81:870-878.
19. + channels are due to the specific charge content of their respective S4 regions. Neuron. 1993;10:1121-1129.
20. + currents in adult mouse ventricular myocytes. J Gen Physiol. 1999;113:661-678.
21. Mitchell GF, Jeron A, Koren G. Measurement of heart rate and Q-T interval in the conscious mouse. Am J Physiol. 1998;274:H747-H751.
22. + channels in terminal and juxtranodal regions of neurons. Nature. 1993;365:75-79.
23. + channel current. Circ Res. 1993;73:210-216.
24. Snyders DJ, Tamkun MM, Bennett PB. A rapidly activating and slowly inactivating potassium channel cloned from human heart: functional analysis after stable mammalian cell culture expression. J Gen Physiol. 1993;101:513-543.
25. Matsubara H, Liman ER, Hess P, Koren G. Pretranslational mechanisms determine the type of potassium channels expressed in the rat skeletal and cardiac muscles. J Biol Chem. 1991;266:13324-13328.
26. + current similar to Kv1.5 cloned channel currents, Circ Res. 1993;73: 1061-1076.
27. + current modulates repolarization and excitation-contraction coupling in adult mouse ventricle. J Physiol (Lond). 1997;50:557-563.
28. + current in cultured human atrial myocytes. Circ Res. 1997;80:572-579.
29. + currents in rat atrial myocytes. J Physiol (Lond). 1999;517:407-420.
30. + channel regulatory protein, KChAP. J Biol Chem. 1998;273:11745-11751.
31. Li D, Takimoto K, Levitan ES. Surface expression of Kv1 channels is governed by a C-terminal motif. J Biol Chem. 2000;275:11597-11602.
32. + current in rat hippocampal neurons. J Neurosci. 2000;19:1728-1735.