-
1
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
Zimmel, P., K.M. Alberti and J. Shaw, 2001. Global and societal implications of the diabetes epidemic. Nature, 414: 782-787.
-
(2001)
Nature
, vol.414
, pp. 782-787
-
-
Zimmel, P.1
Alberti, K.M.2
Shaw, J.3
-
2
-
-
0842324779
-
Obesity wars: Molecular progress confronts an expanding epidemic
-
Flier, J.S., 2004. Obesity wars: Molecular progress confronts an expanding epidemic. Cell, 116: 337-350.
-
(2004)
Cell
, vol.116
, pp. 337-350
-
-
Flier, J.S.1
-
3
-
-
0033998334
-
The PPARs: From orphan receptors to drug discovery
-
Willson, T.M., P.J. Brown, D.D. Stembach and B.R. Henke, 2000. The PPARs: From orphan receptors to drug discovery. J. Med. Chem., 43: 527-550.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 527-550
-
-
Willson, T.M.1
Brown, P.J.2
Stembach, D.D.3
Henke, B.R.4
-
4
-
-
0035851187
-
PPAR-γ: A nuclear regulator of metabolism, differentiation and cell growth
-
Rosen, E.D. and B.M. Spiegelman, 2001. PPAR-γ: A nuclear regulator of metabolism, differentiation and cell growth. J. Biol. Chem., 276: 37731-37734.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37731-37734
-
-
Rosen, E.D.1
Spiegelman, B.M.2
-
5
-
-
0037116638
-
Oral antihyperglycemic therapy for type 2 diabetes: Scientific review
-
Inzucchi, S.E., 2002. Oral antihyperglycemic therapy for type 2 diabetes: Scientific review. JAMA., 287: 360-372.
-
(2002)
JAMA
, vol.287
, pp. 360-372
-
-
Inzucchi, S.E.1
-
6
-
-
0035124186
-
New oral therapies for type 2 diabetes mellitus: The glitazones or insulin sensitizers
-
Mudaliar, S. and R.R. Henry, 2001. New oral therapies for type 2 diabetes mellitus: The glitazones or insulin sensitizers. Ann. Rev. Med., 52: 239-259.
-
(2001)
Ann. Rev. Med.
, vol.52
, pp. 239-259
-
-
Mudaliar, S.1
Henry, R.R.2
-
7
-
-
19244365650
-
Thiazolidinediones
-
Yki-Jarvinen, H., 2004. Thiazolidinediones. N. Engl. J. Med., 351: 1106-1118.
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 1106-1118
-
-
Yki-Jarvinen, H.1
-
8
-
-
0344304678
-
Thiazolidinedione use, fluid retention and congested heart failure
-
Nesto, R.W., D. Bell, R.O. Bonow, V. Fonseca and S.M. Grundy et al., 2003. Thiazolidinedione use, fluid retention and congested heart failure. Circulation, 108: 2941-2948.
-
(2003)
Circulation
, vol.108
, pp. 2941-2948
-
-
Nesto, R.W.1
Bell, D.2
Bonow, R.O.3
Fonseca, V.4
Grundy, S.M.5
-
9
-
-
0038460622
-
Thiazolidinediones in type 2 diabetes mellitus: Current clinical evidence
-
Diamant, M. and R.J. Heine, 2003. Thiazolidinediones in type 2 diabetes mellitus: Current clinical evidence. Drugs, 63: 1373-1405.
-
(2003)
Drugs
, vol.63
, pp. 1373-1405
-
-
Diamant, M.1
Heine, R.J.2
-
10
-
-
0034614490
-
Signaling-2000 and beyond
-
Hunter, T., 2000. Signaling-2000 and beyond. Cell, 100: 113-127.
-
(2000)
Cell
, vol.100
, pp. 113-127
-
-
Hunter, T.1
-
11
-
-
0035856949
-
Insulin signaling and the regulation of glucose and lipid metabolism
-
Saltiel, A.R. and C.R. Kahn, 2001. Insulin signaling and the regulation of glucose and lipid metabolism. Nature, 414: 799-806.
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
12
-
-
0036228770
-
Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
-
Cheng, A., N. Uetani, P.D. Simoncic, V.P. Chaubey and A. Lee-Loy et al., 2002. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev. Cell, 2: 385-387.
-
(2002)
Dev. Cell
, vol.2
, pp. 385-387
-
-
Cheng, A.1
Uetani, N.2
Simoncic, P.D.3
Chaubey, V.P.4
Lee-Loy, A.5
-
13
-
-
0033525870
-
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1b gene
-
Elchebly, M., P. Payette, E. Michaliszyn, W. Cromlish and S. Collins et al., 1999. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1b gene. Science, 283: 1544-1548.
-
(1999)
Science
, vol.283
, pp. 1544-1548
-
-
Elchebly, M.1
Payette, P.2
Michaliszyn, E.3
Cromlish, W.4
Collins, S.5
-
14
-
-
0033942614
-
Increased energy expenditure, decreased adiposity and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1b-deficient mice
-
Klaman, L.D., O. Boss, O.D. Peroni, J.K. Kim and J.L. Martino et al., 2000. Increased energy expenditure, decreased adiposity and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1b-deficient mice. Mol. Cell. Biol., 20: 5479-5489.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 5479-5489
-
-
Klaman, L.D.1
Boss, O.2
Peroni, O.D.3
Kim, J.K.4
Martino, J.L.5
-
15
-
-
18344379861
-
PTP1B regulates leptin signal transduction in vivo
-
Zabolotny, J.M., K.K. Bence-Hanulec, A. Stricker-Krongrad, F. Haj and Y. Wang et al., 2002. PTP1B regulates leptin signal transduction in vivo. Dev. Cell, 2: 489-495.
-
(2002)
Dev. Cell
, vol.2
, pp. 489-495
-
-
Zabolotny, J.M.1
Bence-Hanulec, K.K.2
Stricker-Krongrad, A.3
Haj, F.4
Wang, Y.5
-
16
-
-
0038584904
-
Protein tyrosine phosphatase 1b attenuates growth hormone-mediated jak-stat signaling
-
Gu, F., N. Dube, J.W. Kim, A. Cheng, M. de Jesus Ibarra-Sanchez, M.L. Tremblay and Y.R. Boisclair, 2003. Protein tyrosine phosphatase 1b attenuates growth hormone-mediated jak-stat signaling. Mol. Cell. Biol., 23: 3753-3762.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 3753-3762
-
-
Gu, F.1
Dube, N.2
Kim, J.W.3
Cheng, A.4
de Jesus Ibarra-Sanchez, M.5
Tremblay, M.L.6
Boisclair, Y.R.7
-
17
-
-
1242296879
-
The role of protein tyrosine phosphatase 1B in Ras signaling
-
Dube, N., A. Cheng and M.L. Tremblay, 2004. The role of protein tyrosine phosphatase 1B in Ras signaling. PNAS, 101: 1834-1839.
-
(2004)
PNAS
, vol.101
, pp. 1834-1839
-
-
Dube, N.1
Cheng, A.2
Tremblay, M.L.3
-
18
-
-
0037143754
-
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose and improves insulin sensitivity in diabetic mice
-
Zinker, B.A., C.M. Rondinone, J.M. Trevillyan, R.J. Gum and J.E. Clampit et al., 2002. PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose and improves insulin sensitivity in diabetic mice. PNAS, 99: 11357-11362.
-
(2002)
PNAS
, vol.99
, pp. 11357-11362
-
-
Zinker, B.A.1
Rondinone, C.M.2
Trevillyan, J.M.3
Gum, R.J.4
Clampit, J.E.5
-
19
-
-
0037221179
-
Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice
-
Gum, R.J., L.L. Gaede, S.L. Koterski, M. Heindel and J.E. Clampit et al., 2003. Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice. Diabetes, 52: 21-28.
-
(2003)
Diabetes
, vol.52
, pp. 21-28
-
-
Gum, R.J.1
Gaede, L.L.2
Koterski, S.L.3
Heindel, M.4
Clampit, J.E.5
-
20
-
-
0037578441
-
Effects of a novel PTP1B antisense inhibitor (ISIS 113715) in cynomologous monkeys
-
Keystone, CO
-
Bhanot, S., M. Butler, S. Booten, R. Mckay, S. Murray, B.P. Monia, T.W. Beck and A.A. Levin, 2002. Effects of a novel PTP1B antisense inhibitor (ISIS 113715) in cynomologous monkeys. Diabetes Mellitus: Molecular Mechanisms, Genetics and New Therapies, Keystone, CO.
-
(2002)
Diabetes Mellitus: Molecular Mechanisms, Genetics and New Therapies
-
-
Bhanot, S.1
Butler, M.2
Booten, S.3
Mckay, R.4
Murray, S.5
Monia, B.P.6
Beck, T.W.7
Levin, A.A.8
-
21
-
-
0038199726
-
PTP1B: From the sidelines to the frontlines
-
Tonks, N.K., 2003. PTP1B: From the sidelines to the frontlines. FEBS Lett., 546: 140-148.
-
(2003)
FEBS Lett.
, vol.546
, pp. 140-148
-
-
Tonks, N.K.1
-
22
-
-
3843121119
-
Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs
-
Van Huijsduijnen, R.H., W.H.B. Sauer, A. Bombrun and D. Swinnen, 2004. Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs. J. Med. Chem., 47: 4142-4146.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 4142-4146
-
-
Van Huijsduijnen, R.H.1
Sauer, W.H.B.2
Bombrun, A.3
Swinnen, D.4
-
23
-
-
0028231388
-
Crystal structure of human protein tyrosine phosphatase 1B
-
Barford, D., A.J. Flint and N.K. Tonks, 1994. Crystal structure of human protein tyrosine phosphatase 1B. Science, 263: 1397-1404.
-
(1994)
Science
, vol.263
, pp. 1397-1404
-
-
Barford, D.1
Flint, A.J.2
Tonks, N.K.3
-
24
-
-
16644376439
-
Water-molecule network and active-site flexibility of apo protein tyrosine phosphatase 1B
-
Pedersen, A.K., G.H. Peters, K.B. Moller, L.F. Iversen and J.S. Kastrup, 2004. Water-molecule network and active-site flexibility of apo protein tyrosine phosphatase 1B. Acta Cryst., D60: 1527-1534.
-
(2004)
Acta Cryst.
, vol.D60
, pp. 1527-1534
-
-
Pedersen, A.K.1
Peters, G.H.2
Moller, K.B.3
Iversen, L.F.4
Kastrup, J.S.5
-
25
-
-
0029066496
-
Structure basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B
-
Jia, Z., D. Barford, A.J. Flint and N.K. Tonks, 1995. Structure basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. Science, 268: 1754-1758.
-
(1995)
Science
, vol.268
, pp. 1754-1758
-
-
Jia, Z.1
Barford, D.2
Flint, A.J.3
Tonks, N.K.4
-
26
-
-
0038662654
-
Crystal Structure of PTP1B complexed with a potent and selective bidentate inhibitor
-
Sun, J.P., A.A. Fedorov, S-Y. Lee, X.L. Guo, K. Shea, D.S. Lawrence, S.C. Almo and Z.Y. Zhang, 2003. Crystal Structure of PTP1B complexed with a potent and selective bidentate inhibitor. J. Biol. Chem., 278: 12406-12414.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 12406-12414
-
-
Sun, J.P.1
Fedorov, A.A.2
Lee, S.-Y.3
Guo, X.L.4
Shea, K.5
Lawrence, D.S.6
Almo, S.C.7
Zhang, Z.Y.8
-
27
-
-
0034615991
-
Structure-Based design of a low molecular weight, nonphosphorus, nonpeptide and highly selective inhibitor of protein-tyrosine phosphatase 1B
-
Iversen, L.F., H.S. Andersen, S. Branner, S.B. Mortensen, G.H. Peters and K. Norris et al., 2000. Structure-Based design of a low molecular weight, nonphosphorus, nonpeptide and highly selective inhibitor of protein-tyrosine phosphatase 1B. J. Biol. Chem., 275: 10300-10307.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 10300-10307
-
-
Iversen, L.F.1
Andersen, H.S.2
Branner, S.3
Mortensen, S.B.4
Peters, G.H.5
Norris, K.6
-
28
-
-
0032144872
-
Low-affinity binding determined by titration calorimetry using a high-affinity coupling ligand
-
Zhang, Y.L. and Z.Y. Zhang, 1998. Low-affinity binding determined by titration calorimetry using a high-affinity coupling ligand. Anal. Biochem., 261: 139-148.
-
(1998)
Anal. Biochem.
, vol.261
, pp. 139-148
-
-
Zhang, Y.L.1
Zhang, Z.Y.2
-
29
-
-
0032480809
-
Conformational and dynamic changes of yersinia protein tyrosine phosphatase induced by ligand binding and active site mutations revealed by H/D exchange and electrospray ionization fourier transform ion cyclotron reassurance mass spectrometry
-
Wang, F., W. Li, M.L. Emmelt, C.L. Hendrickson, A.G. Marchall, Y.L. Zhang, L. Wu and Z.L. Zhang, 1998. Conformational and dynamic changes of yersinia protein tyrosine phosphatase induced by ligand binding and active site mutations revealed by H/D exchange and electrospray ionization fourier transform ion cyclotron reassurance mass spectrometry. Biochemistry, 37: 15289-15299.
-
(1998)
Biochemistry
, vol.37
, pp. 15289-15299
-
-
Wang, F.1
Li, W.2
Emmelt, M.L.3
Hendrickson, C.L.4
Marchall, A.G.5
Zhang, Y.L.6
Wu, L.7
Zhang, Z.L.8
-
30
-
-
0034602144
-
Thermodynamic study of ligand binding to protein-tyrosine phosphatase 1B and its substrate-trapping mutants
-
Zhang, Y.L., Z.J. Yao, M. Sarmiento, L. Wu, T.R. Burke and Z.Y. Zhang, 2000. Thermodynamic study of ligand binding to protein-tyrosine phosphatase 1B and its substrate-trapping mutants. J. Biol. Chem., 275: 34205-12.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34205-34212
-
-
Zhang, Y.L.1
Yao, Z.J.2
Sarmiento, M.3
Wu, L.4
Burke, T.R.5
Zhang, Z.Y.6
-
31
-
-
0031457541
-
Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design
-
Puius, Y.A., Y. Zhao, M. Sullivan, D.S. Lawrence, S.C. Almo and Z.Y. Zhang, 1997. Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design. Prococeeding of National Academy of Science, 94: 13420-13425.
-
(1997)
Prococeeding of National Academy of Science
, vol.94
, pp. 13420-13425
-
-
Puius, Y.A.1
Zhao, Y.2
Sullivan, M.3
Lawrence, D.S.4
Almo, S.C.5
Zhang, Z.Y.6
-
32
-
-
0036654436
-
Recent advances in the development of small molecule inhibitors of PTP1b for the treatment of insulin resistance and type 2 diabetes
-
Tobin, J.F. and S. Tam, 2002. Recent advances in the development of small molecule inhibitors of PTP1b for the treatment of insulin resistance and type 2 diabetes. Curr. Opin. Drug Dicov. Dev., 5: 500-512.
-
(2002)
Curr. Opin. Drug Dicov. Dev.
, vol.5
, pp. 500-512
-
-
Tobin, J.F.1
Tam, S.2
-
34
-
-
0033778926
-
Protein tyrosine phosphatases (PTPs) as drug targets: Inhibitors of PTP-1b for the treatment of diabetes
-
Moller, N.P.H., L.F. Iversen, H.S. Andersen and J.G. McCormack, 2000. Protein tyrosine phosphatases (PTPs) as drug targets: Inhibitors of PTP-1b for the treatment of diabetes. Curr. Opin. Drug Discov. Dev., 3: 527-540.
-
(2000)
Curr. Opin. Drug Discov. Dev.
, vol.3
, pp. 527-540
-
-
Moller, N.P.H.1
Iversen, L.F.2
Andersen, H.S.3
McCormack, J.G.4
-
35
-
-
0037161605
-
Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B
-
Doman, T.N., S.L. McGovern, B.J. Witherbee, T.P. Kasten, R. Kurumbail, W.C. Stallings, D.T. Connolly and B.K. Shoichet, 2002. Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B. J. Med. Chem., 45: 2213-2221.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 2213-2221
-
-
Doman, T.N.1
McGovern, S.L.2
Witherbee, B.J.3
Kasten, T.P.4
Kurumbail, R.5
Stallings, W.C.6
Connolly, D.T.7
Shoichet, B.K.8
-
36
-
-
0037061628
-
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening
-
McGovern, S.L., E. Caselli, N. Grigorieff and B.K. Shoichet, 2002. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J. Med. Chem., 45: 1712-1722.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1712-1722
-
-
McGovern, S.L.1
Caselli, E.2
Grigorieff, N.3
Shoichet, B.K.4
-
37
-
-
19944427190
-
Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms
-
Erbe, D.V., S. Wang, Y.L. Zhang, K. Harding and L. Kung et al., 2005. Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms. Mol. Pharm., 67: 69-77.
-
(2005)
Mol. Pharm.
, vol.67
, pp. 69-77
-
-
Erbe, D.V.1
Wang, S.2
Zhang, Y.L.3
Harding, K.4
Kung, L.5
-
38
-
-
3543017313
-
Allosteric inhibition of protein tyrosine phosphatase 1B
-
Weismann, C., K.J. Barr, J. Kung, J. Zhu and D.A. Erlanson et al., 2004. Allosteric inhibition of protein tyrosine phosphatase 1B. Natl. Struct. Mol. Biol., 11: 730-737.
-
(2004)
Natl. Struct. Mol. Biol.
, vol.11
, pp. 730-737
-
-
Weismann, C.1
Barr, K.J.2
Kung, J.3
Zhu, J.4
Erlanson, D.A.5
|