-
2
-
-
0037077208
-
Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer
-
Ayoub MA, Couturier C, Lucas-Meunier E, Angers S, Fossier P, Bouvier M, and Jockers R (2002) Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. J Biol Chem 277:21522-21528.
-
(2002)
J Biol Chem
, vol.277
, pp. 21522-21528
-
-
Ayoub, M.A.1
Couturier, C.2
Lucas-Meunier, E.3
Angers, S.4
Fossier, P.5
Bouvier, M.6
Jockers, R.7
-
3
-
-
0038392702
-
Structure-based analysis of GPCR function: Evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein
-
Baneres JL and Parello J (2003) Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein. J Mol Biol 329:815-829.
-
(2003)
J Mol Biol
, vol.329
, pp. 815-829
-
-
Baneres, J.L.1
Parello, J.2
-
4
-
-
0037862083
-
The 'magic tail' of G protein-coupled receptors: An anchorage for functional protein networks
-
Bockaert J, Marin P, Dumuis A, and Fagni L (2003) The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks. FEBS Lett 546: 65-72.
-
(2003)
FEBS Lett
, vol.546
, pp. 65-72
-
-
Bockaert, J.1
Marin, P.2
Dumuis, A.3
Fagni, L.4
-
5
-
-
0037379785
-
Delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains
-
Bourova L, Kostrnova A, Hejnova L, Moravcova Z, Moon HE, Novotny J, Milligan G, and Svoboda P (2003) delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains. J Neurochem 85:34-49.
-
(2003)
J Neurochem
, vol.85
, pp. 34-49
-
-
Bourova, L.1
Kostrnova, A.2
Hejnova, L.3
Moravcova, Z.4
Moon, H.E.5
Novotny, J.6
Milligan, G.7
Svoboda, P.8
-
6
-
-
0035318509
-
Oligomerization of G-protein-coupled transmitter receptors
-
Bouvier M (2001) Oligomerization of G-protein-coupled transmitter receptors. Nat Rev Neurosci 2:274-288.
-
(2001)
Nat Rev Neurosci
, vol.2
, pp. 274-288
-
-
Bouvier, M.1
-
7
-
-
0032562288
-
Agonist occupation of an α2A-adrenoreceptor-Gilα fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry
-
Burt AR, Sautel M, Wilson MA, Rees S, Wise A, and Milligan G (1998) Agonist occupation of an α2A-adrenoreceptor-Gilα fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry. J Biol Chem 273:10367-10375.
-
(1998)
J Biol Chem
, vol.273
, pp. 10367-10375
-
-
Burt, A.R.1
Sautel, M.2
Wilson, M.A.3
Rees, S.4
Wise, A.5
Milligan, G.6
-
8
-
-
0142149074
-
Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins
-
Carrillo JJ, Pediani J, and Milligan G (2003) Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins. J Biol Chem 278:42578-42587.
-
(2003)
J Biol Chem
, vol.278
, pp. 42578-42587
-
-
Carrillo, J.J.1
Pediani, J.2
Milligan, G.3
-
10
-
-
0033214473
-
3H]pra-zosin binding and cellular trafficking of native human alpha1A-adrenoceptors
-
3H]pra-zosin binding and cellular trafficking of native human alpha1A-adrenoceptors. Biochem J 343:231-239.
-
(1999)
Biochem J
, vol.343
, pp. 231-239
-
-
Coge, F.1
Guenin, S.P.2
Renouard-Try, A.3
Rique, H.4
Ouvry, C.5
Fabry, N.6
Beauverger, P.7
Nicolas, J.P.8
Galizzi, J.P.9
Boutin, J.A.10
-
11
-
-
0030760634
-
Dimerization of the δ opioid receptor: Implication for a role in receptor internalization
-
Cvejic S and Devi LA (1997) Dimerization of the δ opioid receptor: implication for a role in receptor internalization. J Biol Chem 273: 26959-26964.
-
(1997)
J Biol Chem
, vol.273
, pp. 26959-26964
-
-
Cvejic, S.1
Devi, L.A.2
-
12
-
-
0032442115
-
Cellular localization and pharmacological characterization of functioning alpha-1 adrenoceptors by fluorescent ligand binding and image analysis reveals identical binding properties of clustered and diffuse populations of receptors
-
Daly CJ, Milligan CM, Milligan G, Mackenzie JF, and McGrath JC (1998) Cellular localization and pharmacological characterization of functioning alpha-1 adrenoceptors by fluorescent ligand binding and image analysis reveals identical binding properties of clustered and diffuse populations of receptors J Pharmacol Exp Ther 286:984-990.
-
(1998)
J Pharmacol Exp Ther
, vol.286
, pp. 984-990
-
-
Daly, C.J.1
Milligan, C.M.2
Milligan, G.3
Mackenzie, J.F.4
McGrath, J.C.5
-
13
-
-
0035478438
-
Heterodimerization of G protein-coupled receptors: Pharmacology, signaling and trafficking
-
Devi LA (2001) Heterodimerization of G protein-coupled receptors: pharmacology, signaling and trafficking. Trends Pharmacol Sci 22:532-537.
-
(2001)
Trends Pharmacol Sci
, vol.22
, pp. 532-537
-
-
Devi, L.A.1
-
14
-
-
0032555657
-
Agonist-induced internalization of the G protein G11α and thyrotropin-releasing hormone receptors proceed on different time scales
-
Drmota T, Novotny J, Kim GD, Eidne KA, Milligan G, and Svoboda P (1998) Agonist-induced internalization of the G protein G11α and thyrotropin-releasing hormone receptors proceed on different time scales. J Biol Chem 273:21699-21707.
-
(1998)
J Biol Chem
, vol.273
, pp. 21699-21707
-
-
Drmota, T.1
Novotny, J.2
Kim, G.D.3
Eidne, K.A.4
Milligan, G.5
Svoboda, P.6
-
15
-
-
0038170289
-
Applications of novel resonance energy transfer techniques to study dynamic hormone receptor interactions in living cells
-
Eidne KA, Kroeger KM, and Hanyaloglu AC (2002) Applications of novel resonance energy transfer techniques to study dynamic hormone receptor interactions in living cells. Trends Endocrinol Metabol 13:415-421.
-
(2002)
Trends Endocrinol Metabol
, vol.13
, pp. 415-421
-
-
Eidne, K.A.1
Kroeger, K.M.2
Hanyaloglu, A.C.3
-
16
-
-
0030790446
-
Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: Implications for alpha1-adrenoceptor classification
-
Ford AP, Daniels DV, Chang DJ, Gever JR, Jasper JR, Lesnick JD, and Clarke DE (1997) Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications for alpha1-adrenoceptor classification. Br J Pharmacol 121:1127-1135.
-
(1997)
Br J Pharmacol
, vol.121
, pp. 1127-1135
-
-
Ford, A.P.1
Daniels, D.V.2
Chang, D.J.3
Gever, J.R.4
Jasper, J.R.5
Lesnick, J.D.6
Clarke, D.E.7
-
17
-
-
0038024615
-
The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups and fingerprints
-
Fredriksson R, Lagerstrom MC, Lundin LG, and Schioth HB (2003) The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups and fingerprints. Mol Pharmacol 63:1256-1272.
-
(2003)
Mol Pharmacol
, vol.63
, pp. 1256-1272
-
-
Fredriksson, R.1
Lagerstrom, M.C.2
Lundin, L.G.3
Schioth, H.B.4
-
18
-
-
0034714335
-
Oligomerization of μ- and δ-opioid receptors
-
George SR, Fan T, Xie Z, Tse R, Tam V, Varghese G, and O'Dowd BF (2000) Oligomerization of μ- and δ-opioid receptors. J Biol Chem 275:26128-26135.
-
(2000)
J Biol Chem
, vol.275
, pp. 26128-26135
-
-
George, S.R.1
Fan, T.2
Xie, Z.3
Tse, R.4
Tam, V.5
Varghese, G.6
O'Dowd, B.F.7
-
19
-
-
0036780743
-
G-protein-coupled receptor oligomerization and its potential for drug discovery
-
George SR, O'Dowd BF, and Lee SP (2002) G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat Rev Drug Discov 1:808-820.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 808-820
-
-
George, S.R.1
O'Dowd, B.F.2
Lee, S.P.3
-
20
-
-
0038576278
-
The fourth transmembrane segment forms the interface of the dopamine d2 receptor homodimer
-
Guo W, Shi L, and Javitch JA (2003) The fourth transmembrane segment forms the interface of the dopamine d2 receptor homodimer. J Biol Chem 278:4385-4388.
-
(2003)
J Biol Chem
, vol.278
, pp. 4385-4388
-
-
Guo, W.1
Shi, L.2
Javitch, J.A.3
-
22
-
-
0030864213
-
Subtype-specific differences in subcellular localization of α1-adrenoceptors: Chlorethylclonidine preferentially alkylates the accessible cell surface alpha1-adrenoceptors irrespective of the subtype
-
Hirasawa A, Sugawara T, Awaji T, Tsumaya K, Ito H, and Tsujimoto G (1997) Subtype-specific differences in subcellular localization of α1-adrenoceptors: chlorethylclonidine preferentially alkylates the accessible cell surface alpha1-adrenoceptors irrespective of the subtype Mol Pharmacol 52:764-770.
-
(1997)
Mol Pharmacol
, vol.52
, pp. 764-770
-
-
Hirasawa, A.1
Sugawara, T.2
Awaji, T.3
Tsumaya, K.4
Ito, H.5
Tsujimoto, G.6
-
23
-
-
0033578005
-
G-protein-coupled receptor heterodimerization modulates receptor function
-
Jordan BA and Devi LA (1999) G-protein-coupled receptor heterodimerization modulates receptor function. Nature (Lond) 399:697-700.
-
(1999)
Nature (Lond)
, vol.399
, pp. 697-700
-
-
Jordan, B.A.1
Devi, L.A.2
-
24
-
-
0346996861
-
Functional interactions between μ opioid and α2A-adrenergic receptors
-
Jordan BA, Gomes I, Rios C, Filipovska J, and Devi LA (2003) Functional interactions between μ opioid and α2A-adrenergic receptors. Mol Pharmacol 64:1317-1324.
-
(2003)
Mol Pharmacol
, vol.64
, pp. 1317-1324
-
-
Jordan, B.A.1
Gomes, I.2
Rios, C.3
Filipovska, J.4
Devi, L.A.5
-
25
-
-
0035793079
-
Oligomerization of opioid receptors with β2-adrenergic receptors: A role in trafficking and mitogen-activated protein kinase activation
-
Jordan BA, Trapaidze N, Gomes I, Nivarthi R, and Devi LA (2001) Oligomerization of opioid receptors with β2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc Natl Acad Sci USA 98:343-348.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 343-348
-
-
Jordan, B.A.1
Trapaidze, N.2
Gomes, I.3
Nivarthi, R.4
Devi, L.A.5
-
26
-
-
0038159530
-
Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes
-
Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, and Engel A (2003) Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J Biol Chem 278: 21655-21662.
-
(2003)
J Biol Chem
, vol.278
, pp. 21655-21662
-
-
Liang, Y.1
Fotiadis, D.2
Filipek, S.3
Saperstein, D.A.4
Palczewski, K.5
Engel, A.6
-
27
-
-
0037067773
-
Effective information transfer from the α1b-adrenoceptor to Gα 11 requires both β/γ interactions and an aromatic group four amino acids from the C terminus of the G protein
-
Liu S, Carrillo JJ, Pediani J, and Milligan G (2002) Effective information transfer from the α1b-adrenoceptor to Gα 11 requires both β/γ interactions and an aromatic group four amino acids from the C terminus of the G protein J Biol Chem 277:25707-25714.
-
(2002)
J Biol Chem
, vol.277
, pp. 25707-25714
-
-
Liu, S.1
Carrillo, J.J.2
Pediani, J.3
Milligan, G.4
-
28
-
-
0035958023
-
Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer: The human δ opioid receptor displays constitutive oligomerization at the cell surface which is not regulated by receptor occupancy
-
McVey M, Ramsay D, Kellett E, Rees S, Wilson S, Pope AJ, and Milligan G (2001) Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer: the human δ opioid receptor displays constitutive oligomerization at the cell surface which is not regulated by receptor occupancy. J Biol Chem 276:14092-14099.
-
(2001)
J Biol Chem
, vol.276
, pp. 14092-14099
-
-
McVey, M.1
Ramsay, D.2
Kellett, E.3
Rees, S.4
Wilson, S.5
Pope, A.J.6
Milligan, G.7
-
30
-
-
0037160105
-
Quantitative assessment of β1- and β2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer
-
Mercier JF, Salahpour A, Angers S, Breit A, and Bouvier M (2002) Quantitative assessment of β1- and β2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer. J Biol Chem 277:44925-44931.
-
(2002)
J Biol Chem
, vol.277
, pp. 44925-44931
-
-
Mercier, J.F.1
Salahpour, A.2
Angers, S.3
Breit, A.4
Bouvier, M.5
-
31
-
-
0035032316
-
Oligomerisation of G-protein-coupled receptors
-
Milligan G (2001) Oligomerisation of G-protein-coupled receptors. J Cell Sci 114: 1265-1271.
-
(2001)
J Cell Sci
, vol.114
, pp. 1265-1271
-
-
Milligan, G.1
-
32
-
-
0037305047
-
35S]GTP gamma S binding assays
-
35S]GTP gamma S binding assays. Trends Pharmacol Sci 24:87-90.
-
(2003)
Trends Pharmacol Sci
, vol.24
, pp. 87-90
-
-
Milligan, G.1
-
33
-
-
0035478746
-
Protein-protein interactions at G-protein-coupled receptors
-
Milligan G and White JH (2001) Protein-protein interactions at G-protein-coupled receptors. Trends Pharmacol Sci 22:513-518.
-
(2001)
Trends Pharmacol Sci
, vol.22
, pp. 513-518
-
-
Milligan, G.1
White, J.H.2
-
34
-
-
0027244086
-
Enhanced degradation of the phosphoinositidase C-linked guanine-nucleotide-binding protein Gq alpha/G11 alpha following activation of the human M1 muscarinic acetylcholine receptor expressed in CHO cells
-
Mitchell FM, Buckley NJ, and Milligan G (1993) Enhanced degradation of the phosphoinositidase C-linked guanine-nucleotide-binding protein Gq alpha/G11 alpha following activation of the human M1 muscarinic acetylcholine receptor expressed in CHO cells. Biochem J 293:495-499.
-
(1993)
Biochem J
, vol.293
, pp. 495-499
-
-
Mitchell, F.M.1
Buckley, N.J.2
Milligan, G.3
-
35
-
-
0038521270
-
Promiscuous coupling at receptor-Gα fusion proteins. The receptor of one covalent complex interacts with the α-subunit of another
-
Molinari P, Ambrosio C, Riitano D, Sbraccia M, Gro C, and Costa T (2003) Promiscuous coupling at receptor-Gα fusion proteins. The receptor of one covalent complex interacts with the α-subunit of another. J Biol Chem 278:15778-15788.
-
(2003)
J Biol Chem
, vol.278
, pp. 15778-15788
-
-
Molinari, P.1
Ambrosio, C.2
Riitano, D.3
Sbraccia, M.4
Gro, C.5
Costa, T.6
-
36
-
-
0036829815
-
The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor
-
Overton MC and Blumer KJ (2002) The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor. J Biol Chem 277:41463-41472.
-
(2002)
J Biol Chem
, vol.277
, pp. 41463-41472
-
-
Overton, M.C.1
Blumer, K.J.2
-
37
-
-
0034742707
-
αl-Adrenergic receptors: New insights and directions
-
Piascik MT and Perez DM (2001) αl-Adrenergic receptors: new insights and directions. J Pharmacol Exp Ther 298:403-410.
-
(2001)
J Pharmacol Exp Ther
, vol.298
, pp. 403-410
-
-
Piascik, M.T.1
Perez, D.M.2
-
38
-
-
0035545309
-
Clinical significance of alpha1-adrenoceptor selectivity in the management of benign prostatic hyperplasia
-
Pool JL and Kirby RS (2001) Clinical significance of alpha1-adrenoceptor selectivity in the management of benign prostatic hyperplasia. Int Urol Nephrol 33:407-412.
-
(2001)
Int Urol Nephrol
, vol.33
, pp. 407-412
-
-
Pool, J.L.1
Kirby, R.S.2
-
39
-
-
0037101774
-
Homo- and heterooligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): Hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences
-
Ramsay D, Kellett E, McVey M, Rees S, and Milligan G (2002) Homo- and heterooligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences. Biochem J 365:429-440.
-
(2002)
Biochem J
, vol.365
, pp. 429-440
-
-
Ramsay, D.1
Kellett, E.2
McVey, M.3
Rees, S.4
Milligan, G.5
-
40
-
-
0034616021
-
Receptors for dopamine and somatostatin: Formation of hetero-oligomers with enhanced functional activity
-
Rocheville M, Lange DC, Kumar U, Patel SC, Patel RC, and Patel YC (2000) Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science (Wash DC) 288:154-157.
-
(2000)
Science (Wash DC)
, vol.288
, pp. 154-157
-
-
Rocheville, M.1
Lange, D.C.2
Kumar, U.3
Patel, S.C.4
Patel, R.C.5
Patel, Y.C.6
-
41
-
-
0037013265
-
Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation
-
Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, et al. (2002) Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation. J Biol Chem 277:15482-15485.
-
(2002)
J Biol Chem
, vol.277
, pp. 15482-15485
-
-
Salim, K.1
Fenton, T.2
Bacha, J.3
Urien-Rodriguez, H.4
Bonnert, T.5
Skynner, H.A.6
Watts, E.7
Kerby, J.8
Heald, A.9
Beer, M.10
-
43
-
-
0346366929
-
Subtype-specific dimerization of α1-adrenoceptors: Effects on receptor expression and pharmacological properties
-
Uberti MA, Hall RA, and Minneman KP (2003) Subtype-specific dimerization of α1-adrenoceptors: effects on receptor expression and pharmacological properties. Mol Pharmacol 64:1379-1390.
-
(2003)
Mol Pharmacol
, vol.64
, pp. 1379-1390
-
-
Uberti, M.A.1
Hall, R.A.2
Minneman, K.P.3
|