The conundrum of CD40 function: Host protection or disease promotion?

Trends in Parasitology

Volumn 22, Issue 3, 2006, Pages 117-122

  Mathur, Ram K ^a   Awasthi, Amit ^a   Saha, Bhaskar ^a  

^a NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; BACTERIAL ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; INTERLEUKIN 4; LISTERIA ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ALLOGRAFT; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ANTIGEN PRESENTING CELL; ANTIINFLAMMATORY ACTIVITY; CANDIDA ALBICANS; CANDIDIASIS; CELL STIMULATION; CELL SURFACE; CELL TYPE; CELLULAR IMMUNITY; CRYPTOCOCCOSIS; CYTOKINE RELEASE; EFFECTOR CELL; ENZYME REGULATION; HOST; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; INFECTION PREVENTION; LEISHMANIA; LEISHMANIASIS; MOLECULAR MECHANICS; MYCOBACTERIOSIS; MYCOBACTERIUM AVIUM; NONHUMAN; PATHOGENESIS; PNEUMOCYSTOSIS; PROTEIN PROTEIN INTERACTION; REGULATORY T LYMPHOCYTE; REVIEW;

BACTERIA (MICROORGANISMS); CANDIDA ALBICANS; LISTERIA; MYCOBACTERIUM AVIUM;

EID: 33344472043     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2006.01.003     Document Type: Article

References (58)

1. +T cell response: the alternative approaches Annu. Rev. Immunol. 15 1997 297 322
2. T.R. Mosmann, and S. Sad The expanding universe of T-cell subsets: Th1, Th2 and more Immunol. Today 17 1996 138 146
3. L. Li IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity J. Immunol. 153 1994 3967 3978
4. B. Saha Immunobiological studies on experimental visceral leishmaniasis. III. Cytokine-mediated regulation of parasite replication Scand. J. Immunol. 37 1993 155 158
5. M.F. Krummel, and J.P. Allison CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation J. Exp. Med. 182 1995 459 465
6. T.L. Walunas CTLA-4 ligation blocks CD28-dependent T cell activation J. Exp. Med. 183 1996 2541 2550
7. C.M. Snapper, and W.E. Paul Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production Science 236 1987 944 947
8. M.L. Deschoolmeester Reciprocal effects of interleukin-4 and interferon-gamma on immunoglobulin E-mediated mast cell degranulation: a role for nitric oxide but not peroxynitrite or cyclic guanosine monophosphate Immunology 96 1999 138 144
9. C. van Kooten, and J. Banchereau Functions of CD40 on B cells, dendritic cells and other cells Curr. Opin. Immunol. 9 1997 330 337
10. B.M. Carreno, and M. Collins The B7 family of ligands and its receptors: new pathways for co-stimulation and inhibition of immune responses Annu. Rev. Immunol. 20 2002 29 53
11. T.H. Watts Tnf/Tnfr family members in co-stimulation of T cell responses Annu. Rev. Immunol. 23 2005 23 68
12. I.S. Grewal The CD40-CD154 system in anti-infective host defense Curr. Opin. Immunol. 9 1997 491 497
13. S.A. Mikolajczak The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells J. Exp. Med. 199 2004 1025 1031
14. M. Kamanaka Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity Immunity 4 1996 275 281
15. S.H. Chan Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers J. Exp. Med. 173 1991 869 879
16. P. Scott IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis J. Immunol. 147 1991 3149 3155
17. O. Wurtz IL-4-mediated inhibition of IFN-gamma production by CD4+T cells proceeds by several developmentally regulated mechanisms Int. Immunol. 16 2004 501 508
18. C.A. Akdis, and K. Blaser Mechanisms of interleukin-10-mediated immune suppression Immunology 103 2001 131 136
19. T.A. Wynn IL-13 effector functions Annu. Rev. Immunol. 21 2003 425 456
20. L. Gorelik Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation J. Exp. Med. 195 2002 1499 1505
21. X. Peng Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin-12 for interferon-gamma production Eur. J. Immunol. 26 1996 1621 1627
22. M.H. Blotta Cross-linking of the CD40 ligand on human CD4+T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis J. Immunol. 156 1996 3133 3140
23. M. Cayabyab CD40 preferentially costimulates activation of CD4+T lymphocytes J. Immunol. 152 1994 1523 1531
24. R.J. Armitage CD40 ligand is a T cell growth factor Eur. J. Immunol. 23 1993 2326 2331
25. A. Valle Activation of human B lymphocytes through CD40 and interleukin 4 Eur. J. Immunol. 19 1989 1463 1467
26. T. Yoshimoto Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappa B Eur. J. Immunol. 27 1997 3461 3470
27. P. Mendez-Samperio Interleukin-12 regulates the production of Bacille Calmette-Guerin-induced interferon-gamma from human cells in a CD40-dependent manner Scand. J. Immunol. 50 1999 61 67
28. A.D. Foey CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways Cytokine 16 2001 131 142
29. H. Groux A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells J. Immunol. 162 1999 1723 1729
30. M. Florido CD40 is required for the optimal induction of protective immunity to Mycobacterium avium Immunology 111 2004 323 327
31. V. Lazarevic CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection Immunity 19 2003 823 835
32. M.S. Rolph, and S.H. Kaufmann CD40 signaling converts a minimally immunogenic antigen into a potent vaccine against the intracellular pathogen Listeria monocytogenes J. Immunol. 166 2001 5115 5121
33. I. Marriott CD40-CD40 ligand interactions augment survival of normal mice, but not CD40 ligand knockout mice, challenged orally with Salmonella dublin Infect. Immun. 67 1999 5253 5257
34. D. Pietrella Disruption of CD40/CD40L interaction influences the course of Cryptococcus neoformans infection FEMS Immunol. Med. Microbiol. 40 2004 63 70
35. J.A. Wiley, and A.G. Harmsen CD40 ligand is required for resolution of Pneumocystis carinii pneumonia in mice J. Immunol. 155 1995 3525 3529
36. M.G. Netea CD40/CD40 ligand interactions in the host defense against disseminated Candida albicans infection: the role of macrophage-derived nitric oxide Eur. J. Immunol. 32 2002 1455 1463
37. D. Chaussabel CD40 ligation prevents Trypanosoma cruzi infection through interleukin-12 upregulation Infect. Immun. 67 1999 1929 1934
38. K.A. Campbell CD40 ligand is required for protective cell-mediated immunity to Leishmania major Immunity 4 1996 283 289
39. L. Soong Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection Immunity 4 1996 263 273
40. A. Awasthi CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response J. Exp. Med. 197 2003 1037 1043
41. R.M. Andrade CD154 activates macrophage antimicrobial activity in the absence of IFN-gamma through a TNF-alpha-dependent mechanism J. Immunol. 171 2003 6750 6756
42. W.I. Khan Disruption of CD40-CD40 ligand pathway inhibits the development of intestinal muscle hypercontractility and protective immunity in nematode infection Am. J. Physiol. Gastrointest. Liver Physiol. 288 2005 G15 G22
43. E. Maggi Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells Science 265 1994 244 248
44. G. Vanham Decreased CD40 ligand induction in CD4 T cells and dysregulated IL-12 production during HIV infection Clin. Exp. Immunol. 117 1999 335 342
45. +T cell memory Science 297 2002 2060 2063
46. R.L. Cotter Regulation of human immunodeficiency virus type 1 infection, beta-chemokine production, and CCR5 expression in CD40L-stimulated macrophages: immune control of viral entry J. Virol. 75 2001 4308 4320
47. A.M. Conge Impairment of B-lymphocyte differentiation induced by dual triggering of the B-cell antigen receptor and CD40 in advanced HIV-1-disease AIDS 12 1998 1437 1449
48. R.K. Mathur Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses Nat. Med. 10 2004 540 544
49. H. Zan CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependent direct S mu→S alpha and sequential S mu→S gamma S gamma→S alpha DNA recombination. J. Immunol. 161 1998 5217 5225
50. K.R. Gantt Activation of TGF-beta by Leishmania chagasi: importance for parasite survival in macrophages J. Immunol. 170 2003 2613 2620
51. +T-reg homeostasis through dendritic cell-produced IL-2 Eur. J. Immunol. 35 2005 557 567
52. P.O. Vidalain CD40 signaling in human dendritic cells is initiated within membrane rafts EMBO J. 19 2000 3304 3313
53. Grassme, H. et al. (2002) Clustering of CD40 ligand is required to form a functional contact with CD40. J. Biol. Chem. 277, 30289-30299. Erratum in 277, 36904
54. A.E. Morris Incorporation of an isoleucine zipper motif enhances the biological activity of soluble CD40L (CD154) J. Biol. Chem. 274 1999 418 423
55. G. Chen, and D.V. Goeddel TNF-R1 signaling: a beautiful pathway Science 296 2002 1634 1635
56. Z.G. Liu Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death Cell 87 1996 565 576
57. O. Schulz CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal Immunity 13 2000 453 462
58. A. Krug Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12 Eur. J. Immunol. 31 2001 3026 3037