메뉴 건너뛰기




Volumn 39, Issue 1, 2006, Pages 45-52

Designer zinc finger proteins: Tools for creating artificial DNA-binding functional proteins

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; TRANSCRIPTION FACTOR SP1; ZINC FINGER PROTEIN;

EID: 33344464022     PISSN: 00014842     EISSN: None     Source Type: Journal    
DOI: 10.1021/ar050158u     Document Type: Review
Times cited : (87)

References (58)
  • 2
    • 0034744439 scopus 로고    scopus 로고
    • 2 zinc finger proteins
    • 2 zinc finger proteins. Cell. Mol. Life Sci. 2001, 58, 625-635.
    • (2001) Cell. Mol. Life Sci. , vol.58 , pp. 625-635
    • Iuchi, S.1
  • 3
    • 0035865250 scopus 로고    scopus 로고
    • Expressing the human genome
    • (b) Tupler, R.; Perini, G.; Green, M. R. Expressing the human genome. Nature 2001, 409, 832-833.
    • (2001) Nature , vol.409 , pp. 832-833
    • Tupler, R.1    Perini, G.2    Green, M.R.3
  • 4
    • 0040215628 scopus 로고
    • Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes
    • (a) Miller, J.; McLachlan, A. D.; Klug, A. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J. 1985, 4, 1609-1614.
    • (1985) EMBO J. , vol.4 , pp. 1609-1614
    • Miller, J.1    McLachlan, A.D.2    Klug, A.3
  • 5
    • 0024341072 scopus 로고
    • Three-dimensional solution structure of a single zinc finger DNA-binding domain
    • (b) Lee, M. S.; Gippert, G. L. P.; Soman, K. V.; Case, D. A.; Wright, P. E. Three-dimensional solution structure of a single zinc finger DNA-binding domain. Science 1989, 245, 635-637.
    • (1989) Science , vol.245 , pp. 635-637
    • Lee, M.S.1    Gippert, G.L.P.2    Soman, K.V.3    Case, D.A.4    Wright, P.E.5
  • 6
    • 0025773296 scopus 로고
    • Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2.1 Å
    • (a) Pavletich, N. P.; Pabo, C. O. Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2.1 Å. Science 1991, 252, 809-817.
    • (1991) Science , vol.252 , pp. 809-817
    • Pavletich, N.P.1    Pabo, C.O.2
  • 7
    • 0032539846 scopus 로고    scopus 로고
    • Differing roles for zinc fingers in DNA recognition: Structure of a six-finger transcription factor IIIA complex
    • (b) Nolte, R. T.; Conlin, R. M.; Harrison, S. C.; Brown, R. S. Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 2938-2943.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 2938-2943
    • Nolte, R.T.1    Conlin, R.M.2    Harrison, S.C.3    Brown, R.S.4
  • 8
    • 0030587774 scopus 로고    scopus 로고
    • Zif268 protein-DNA complex refined at 1.6 Å: A model system for understanding zinc finger-DNA interactions
    • (a) Elrod-Erickson, M.; Rould, M. A.; Nekludova, L.; Pabo, C. Zif268 protein-DNA complex refined at 1.6 Å: A model system for understanding zinc finger-DNA interactions. Structure 1996, 4, 1171-1180.
    • (1996) Structure , vol.4 , pp. 1171-1180
    • Elrod-Erickson, M.1    Rould, M.A.2    Nekludova, L.3    Pabo, C.4
  • 9
    • 0029866646 scopus 로고    scopus 로고
    • The galvanization of biology: A growing appreciation for the role of zinc
    • (b) Berg, J. M.; Shi, Y. The galvanization of biology: A growing appreciation for the role of zinc. Science 1996, 271, 1081-1085.
    • (1996) Science , vol.271 , pp. 1081-1085
    • Berg, J.M.1    Shi, Y.2
  • 10
    • 0028328872 scopus 로고
    • Zinc finger phage: Affinity selection of fingers with new DNA-binding specificity
    • (a) Rebar, E. J.; Pabo, C. O. Zinc finger phage: affinity selection of fingers with new DNA-binding specificity. Science 1994, 263, 671-673.
    • (1994) Science , vol.263 , pp. 671-673
    • Rebar, E.J.1    Pabo, C.O.2
  • 11
    • 0027994717 scopus 로고
    • Toward a code for the interactions of zinc fingers with DNA: Selection of randomized fingers displayed on phage
    • (b) Choo, Y.; Klug, A. Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 11163-11167.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 11163-11167
    • Choo, Y.1    Klug, A.2
  • 12
    • 0035712253 scopus 로고    scopus 로고
    • Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins
    • (c). Segal, D. J.; Barbas, C. F., III. Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins. Curr. Opin. Biotechnol. 2001, 12, 632-637.
    • (2001) Curr. Opin. Biotechnol. , vol.12 , pp. 632-637
    • Segal, D.J.1    Barbas III, C.F.2
  • 13
    • 1542364377 scopus 로고    scopus 로고
    • The design of functional DNA-binding proteins based on zinc finger domains
    • (d) Jantz, D.; Amann, B. T.; Gatto, G. J., Jr.; Berg, J. M. The design of functional DNA-binding proteins based on zinc finger domains. Chem. Rev. 2004, 104, 789-799.
    • (2004) Chem. Rev. , vol.104 , pp. 789-799
    • Jantz, D.1    Amann, B.T.2    Gatto Jr., G.J.3    Berg, J.M.4
  • 15
    • 9444230573 scopus 로고    scopus 로고
    • Designing transcription factor architectures for drug discovery
    • (b) Blancafort, P.; Segal, D. J.; Barbas C. F., III. Designing transcription factor architectures for drug discovery. Mol. Pharmacol. 2004, 66, 1361-1371.
    • (2004) Mol. Pharmacol. , vol.66 , pp. 1361-1371
    • Blancafort, P.1    Segal, D.J.2    Barbas III, C.F.3
  • 16
    • 14544301097 scopus 로고    scopus 로고
    • Towards therapeutic applications of engineered zinc finger proteins
    • (c) Klug, A. Towards therapeutic applications of engineered zinc finger proteins. FEBS Lett. 2005, 579, 892-894.
    • (2005) FEBS Lett. , vol.579 , pp. 892-894
    • Klug, A.1
  • 17
    • 0023663884 scopus 로고
    • Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain
    • Kadonaga, J. T.; Carner, K. R.; Masiarz, F. R.; Tjian, R. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 1987, 51, 1079-1090.
    • (1987) Cell , vol.51 , pp. 1079-1090
    • Kadonaga, J.T.1    Carner, K.R.2    Masiarz, F.R.3    Tjian, R.4
  • 18
    • 0026754698 scopus 로고
    • Sequence-Specific Recognition of DNA by Zinc-Finger Peptides Derived from the Transcription Factor Sp1
    • Kriwacki, R. W.; Schultz, S. C.; Steitz, T. A.; Caradonna, J. P. Sequence-Specific Recognition of DNA by Zinc-Finger Peptides Derived from the Transcription Factor Sp1. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 9759-9763.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 9759-9763
    • Kriwacki, R.W.1    Schultz, S.C.2    Steitz, T.A.3    Caradonna, J.P.4
  • 19
    • 0026497472 scopus 로고
    • Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sites
    • (a) Berg, J. M. Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sites. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 11109-11110.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 11109-11110
    • Berg, J.M.1
  • 20
    • 0027324409 scopus 로고
    • Binding of transcription factor Sp1 to GC box DNA revealed by footprinting analysis: Different contact of three zinc fingers and sequence recognition mode
    • (b) Kuwahara, J.; Yonezawa, A.; Futamura, M.; Sugiura, Y. Binding of transcription factor Sp1 to GC box DNA revealed by footprinting analysis: different contact of three zinc fingers and sequence recognition mode. Biochemistry 1993, 32, 5994-6001.
    • (1993) Biochemistry , vol.32 , pp. 5994-6001
    • Kuwahara, J.1    Yonezawa, A.2    Futamura, M.3    Sugiura, Y.4
  • 21
    • 0032510823 scopus 로고    scopus 로고
    • Unique DNA binding mode of the N-terminal zinc finger of transcription factor Sp1
    • (a) Yokono, M.; Saegusa, N.; Matsushita, K.; Sugiura, Y. Unique DNA binding mode of the N-terminal zinc finger of transcription factor Sp1. Biochemistry 1998, 37, 6824-6832.
    • (1998) Biochemistry , vol.37 , pp. 6824-6832
    • Yokono, M.1    Saegusa, N.2    Matsushita, K.3    Sugiura, Y.4
  • 23
    • 0021687959 scopus 로고
    • Multiple specific contacts between a mammalian transcription factor and its cognate promoters
    • Gidoni, D.; Dynan, W. S.; Tjian, R. Multiple specific contacts between a mammalian transcription factor and its cognate promoters. Nature 1984, 312, 409-413.
    • (1984) Nature , vol.312 , pp. 409-413
    • Gidoni, D.1    Dynan, W.S.2    Tjian, R.3
  • 24
    • 0026776153 scopus 로고
    • Multiple zinc finger forms resulting from developmentally regulated alternative splicing of a transcription factor gene
    • Hsu, T.; Gogos, J. A.; Kirsh, S. A.; Kafatos, F. C. Multiple zinc finger forms resulting from developmentally regulated alternative splicing of a transcription factor gene. Science 1992, 257, 1946-1950.
    • (1992) Science , vol.257 , pp. 1946-1950
    • Hsu, T.1    Gogos, J.A.2    Kirsh, S.A.3    Kafatos, F.C.4
  • 25
    • 0037067118 scopus 로고    scopus 로고
    • Novel strategy for the design of a new zinc finger: Creation of a zinc finger for the AT-rich sequence by α-helix substitution
    • Nagaoka, M.; Doi, Y.; Kuwahara, J.; Sugiura, Y. Novel strategy for the design of a new zinc finger: Creation of a zinc finger for the AT-rich sequence by α-helix substitution. J. Am. Chem. Soc. 2002, 124, 6526-6527.
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 6526-6527
    • Nagaoka, M.1    Doi, Y.2    Kuwahara, J.3    Sugiura, Y.4
  • 26
    • 0031053362 scopus 로고    scopus 로고
    • A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
    • Greisman, H. A.; Pabo, C. O. A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science 1997, 275, 657-661.
    • (1997) Science , vol.275 , pp. 657-661
    • Greisman, H.A.1    Pabo, C.O.2
  • 27
    • 14044267591 scopus 로고    scopus 로고
    • Swapping of the β-hairpin region between Sp1 and GLI zinc fingers: Significant role of the β-hairpin region in DNA binding properties of C2H2-type zinc finger peptides
    • Shiraishi, Y.; Imanishi, M., Morisaki, T.; Sugiura, Y. Swapping of the β-hairpin region between Sp1 and GLI zinc fingers: Significant role of the β-hairpin region in DNA binding properties of C2H2-type zinc finger peptides. Biochemistry 2005, 44, 2523-2528.
    • (2005) Biochemistry , vol.44 , pp. 2523-2528
    • Shiraishi, Y.1    Imanishi, M.2    Morisaki, T.3    Sugiura, Y.4
  • 28
    • 0027423758 scopus 로고
    • Crystal structure of a five-finger GLI-DNA complex: New perspectives on zinc fingers
    • (a) Pavletich, N. P.; Pabo, C. O. Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. Science 1993, 261, 1701-1707.
    • (1993) Science , vol.261 , pp. 1701-1707
    • Pavletich, N.P.1    Pabo, C.O.2
  • 29
    • 2442711545 scopus 로고    scopus 로고
    • Exchange of histidine spacing between Sp1 and GLI zinc fingers: Distinct effect of histidine spacing-linker region on DNA binding
    • (b) Shiraishi, Y.; Imanishi, M.; Sugiura, Y. Exchange of histidine spacing between Sp1 and GLI zinc fingers: Distinct effect of histidine spacing-linker region on DNA binding. Biochemistry 2004, 43, 6352-6359
    • (2004) Biochemistry , vol.43 , pp. 6352-6359
    • Shiraishi, Y.1    Imanishi, M.2    Sugiura, Y.3
  • 30
    • 0029032723 scopus 로고
    • Zinc Fingers
    • (a) Klug, A.; Schwabe, J. W. Zinc Fingers. FASEB J. 1995, 9, 597-604.
    • (1995) FASEB J. , vol.9 , pp. 597-604
    • Klug, A.1    Schwabe, J.W.2
  • 32
    • 0037098864 scopus 로고    scopus 로고
    • Contribution of individual zinc ligands to metal binding and peptide folding of zinc finger peptides
    • (a) Nomura, A.; Sugiura, Y. Contribution of individual zinc ligands to metal binding and peptide folding of zinc finger peptides. Inorg. Chem. 2002, 41, 3693-3698
    • (2002) Inorg. Chem. , vol.41 , pp. 3693-3698
    • Nomura, A.1    Sugiura, Y.2
  • 33
    • 1542317534 scopus 로고    scopus 로고
    • Hydrolytic reaction by zinc finger mutant peptides: Successful redesign of structural zinc sites into catalytic zinc sites
    • (b) Nomura, A.; Sugiura, Y. Hydrolytic reaction by zinc finger mutant peptides: Successful redesign of structural zinc sites into catalytic zinc sites. Inorg. Chem. 2004, 43, 1708-1713.
    • (2004) Inorg. Chem. , vol.43 , pp. 1708-1713
    • Nomura, A.1    Sugiura, Y.2
  • 34
    • 0001173153 scopus 로고    scopus 로고
    • Thermodynamic and kinetic studies of zinc(II)-triamine complexes as models of CA and AP
    • Itoh, T.; Fujii, Y.; Tada, T.; Yoshikawa, Y.; Hisada, H. Thermodynamic and kinetic studies of zinc(II)-triamine complexes as models of CA and AP. Bull. Chem. Soc. Jpn. 1996, 69, 1265-1274.
    • (1996) Bull. Chem. Soc. Jpn. , vol.69 , pp. 1265-1274
    • Itoh, T.1    Fujii, Y.2    Tada, T.3    Yoshikawa, Y.4    Hisada, H.5
  • 35
    • 0027975507 scopus 로고
    • Role of Zinc(II) in β-Lactamase II: A Model study with a zinc(II)-macrocyclic tetraamine (1,4,7,10-Tetraazacyclododecane, Cyclen) complex
    • (a) Koike, T.; Takamura, M.; Kimura, E. Role of Zinc(II) in β-Lactamase II: A Model study with a zinc(II)-macrocyclic tetraamine (1,4,7,10-Tetraazacyclododecane, Cyclen) complex. J. Am. Chem. Soc. 1994, 116, 8443-8449.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 8443-8449
    • Koike, T.1    Takamura, M.2    Kimura, E.3
  • 36
    • 0032567195 scopus 로고    scopus 로고
    • Immobile artificial metalloproteinase containing both catalytic and binding groups
    • (b) Jang, B.-B.; Lee, K. P.; Min, D. H.; Suh. J. Immobile artificial metalloproteinase containing both catalytic and binding groups. J. Am. Chem. Soc. 1998, 120, 12008-12016.
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 12008-12016
    • Jang, B.-B.1    Lee, K.P.2    Min, D.H.3    Suh, J.4
  • 37
    • 7644223349 scopus 로고    scopus 로고
    • Sequence selective and hydrolytic cleavage of DNA by zinc finger mutants
    • Nomura, A.; Sugiura, Y. Sequence selective and hydrolytic cleavage of DNA by zinc finger mutants. J. Am. Chem. Soc. 2004, 126, 15374-15375.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 15374-15375
    • Nomura, A.1    Sugiura, Y.2
  • 38
    • 0026469990 scopus 로고
    • Definition of the binding sites of individual zinc fingers in the transcription factor IIIA-5S RNA gene complex
    • Clemens, K. R.; Liao, X.; Wolf, V.; Wright, P. E.; Gottesfeld, J. M. Definition of the binding sites of individual zinc fingers in the transcription factor IIIA-5S RNA gene complex. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 10822-10826.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 10822-10826
    • Clemens, K.R.1    Liao, X.2    Wolf, V.3    Wright, P.E.4    Gottesfeld, J.M.5
  • 39
    • 0035852693 scopus 로고    scopus 로고
    • Design of polyzinc finger peptides with structured linkers
    • Moore, M.; Choo, Y.; Klug, A. Design of polyzinc finger peptides with structured linkers. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 1432-1436.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 1432-1436
    • Moore, M.1    Choo, Y.2    Klug, A.3
  • 40
    • 0038348763 scopus 로고    scopus 로고
    • Custom DNA-binding proteins and artificial transcription factors
    • (a) Lee, D. K.; Seol, W.; Kim, J. S. Custom DNA-binding proteins and artificial transcription factors. Curr. Top. Med. Chem. 2003, 3, 645-657.
    • (2003) Curr. Top. Med. Chem. , vol.3 , pp. 645-657
    • Lee, D.K.1    Seol, W.2    Kim, J.S.3
  • 41
    • 0037394848 scopus 로고    scopus 로고
    • Zinc fingers and a green thumb: Manipulating gene expression in plants
    • (b) Segal, D. J.; Stege, J. T.; Barbas, C. F., III. Zinc fingers and a green thumb: manipulating gene expression in plants. Curr. Opin. Plant Biol. 2003, 6, 163-168.
    • (2003) Curr. Opin. Plant Biol. , vol.6 , pp. 163-168
    • Segal, D.J.1    Stege, J.T.2    Barbas III, C.F.3
  • 42
    • 0032578492 scopus 로고    scopus 로고
    • Artificial nine zinc-finger peptide with 30 base pair binding sites
    • Kamiuchi, T.; Abe, E.; Imanishi, M.; Kaji, T.; Nagaoka, M.; Sugiura, Y. Artificial nine zinc-finger peptide with 30 base pair binding sites. Biochemistry 1998, 37, 13827-13834.
    • (1998) Biochemistry , vol.37 , pp. 13827-13834
    • Kamiuchi, T.1    Abe, E.2    Imanishi, M.3    Kaji, T.4    Nagaoka, M.5    Sugiura, Y.6
  • 43
    • 0029943268 scopus 로고    scopus 로고
    • Distinct phosphate backbone contacts revealed by some mutant peptides of zinc finger protein Sp1: Effect of protein-induced bending on DNA recognition
    • (a) Nagaoka, M.; Sugiura, Y. Distinct phosphate backbone contacts revealed by some mutant peptides of zinc finger protein Sp1: Effect of protein-induced bending on DNA recognition. Biochemistry 1996, 35, 8761-8768.
    • (1996) Biochemistry , vol.35 , pp. 8761-8768
    • Nagaoka, M.1    Sugiura, Y.2
  • 44
    • 0034681918 scopus 로고    scopus 로고
    • DNA-Bending finger: Artificial design of 6-zinc finger peptides with polyglycine linker and induction of DNA bending
    • (b) Imanishi, M.; Hori, Y.; Nagoaka, M.; Sugiura, Y. DNA-Bending finger: Artificial design of 6-zinc finger peptides with polyglycine linker and induction of DNA bending. Biochemistry 2000, 39, 4383-4390.
    • (2000) Biochemistry , vol.39 , pp. 4383-4390
    • Imanishi, M.1    Hori, Y.2    Nagoaka, M.3    Sugiura, Y.4
  • 45
    • 2442684204 scopus 로고    scopus 로고
    • 2 zinc finger proteins by linker phosphorylation
    • 2 zinc finger proteins by linker phosphorylation. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 7589-7593.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 7589-7593
    • Jantz, D.1    Berg, J.M.2
  • 46
    • 0037192129 scopus 로고    scopus 로고
    • Artificial DNA-bending six-zinc finger peptides with different charged linkers: Distinct kinetic properties of DNA bindings
    • Imanishi, M.; Sugiura, Y. Artificial DNA-bending six-zinc finger peptides with different charged linkers: Distinct kinetic properties of DNA bindings. Biochemistry 2002, 41, 1328-1334.
    • (2002) Biochemistry , vol.41 , pp. 1328-1334
    • Imanishi, M.1    Sugiura, Y.2
  • 47
    • 20444503289 scopus 로고    scopus 로고
    • An artificial six-zinc finger peptide with polyarginine linker: Selective binding to the discontinuous DNA sequences
    • Imanishi, M.; Yan, W.; Morisaki, T.; Sugiura, Y. An artificial six-zinc finger peptide with polyarginine linker: Selective binding to the discontinuous DNA sequences. Biochem. Biophys. Res. Commun. 2005, 167-173.
    • (2005) Biochem. Biophys. Res. Commun. , pp. 167-173
    • Imanishi, M.1    Yan, W.2    Morisaki, T.3    Sugiura, Y.4
  • 48
    • 0038657551 scopus 로고    scopus 로고
    • Sequence-selective DNA cleavage by a chimeric metallopeptide
    • Kovacic, R. T.; Welch, J. T.; Franklin, S. J. Sequence-selective DNA cleavage by a chimeric metallopeptide. J. Am. Chem. Soc. 2003, 125, 6656-6662.
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 6656-6662
    • Kovacic, R.T.1    Welch, J.T.2    Franklin, S.J.3
  • 49
    • 0030032063 scopus 로고    scopus 로고
    • Hybrid restriction enzymes: Zinc finger fusions to Fok I cleavage domain
    • (a) Kim, Y.-G.; Cha, J.; Chandrasegaran, S. Hybrid restriction enzymes: Zinc finger fusions to Fok I cleavage domain. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 1156-1160.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 1156-1160
    • Kim, Y.-G.1    Cha, J.2    Chandrasegaran, S.3
  • 50
    • 0023186275 scopus 로고
    • Chemical conversion of a DNA-binding protein into a site-specific nuclease
    • Chen, C.-H.; Sigman, D. S. Chemical conversion of a DNA-binding protein into a site-specific nuclease. Science 1987, 237, 1197-1201.
    • (1987) Science , vol.237 , pp. 1197-1201
    • Chen, C.-H.1    Sigman, D.S.2
  • 51
    • 0028038669 scopus 로고
    • A novel zinc finger-based DNA cutter: Biosynthetic design and highly selective DNA cleavage
    • Nagaoka, M.; Hagihara, M.; Kuwahara, J.; Sugiura, Y. A novel zinc finger-based DNA cutter: biosynthetic design and highly selective DNA cleavage. J. Am. Chem. Soc. 1994, 116, 4085-4086.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 4085-4086
    • Nagaoka, M.1    Hagihara, M.2    Kuwahara, J.3    Sugiura, Y.4
  • 52
    • 0032709320 scopus 로고    scopus 로고
    • Ni(II) Xaa-Xaa-His metallopeptide DNA/RNA interactions
    • Long, E. C. Ni(II) Xaa-Xaa-His metallopeptide DNA/RNA interactions. Acc. Chem. Res. 1999, 32, 827-836.
    • (1999) Acc. Chem. Res. , vol.32 , pp. 827-836
    • Long, E.C.1
  • 57
    • 2442536906 scopus 로고    scopus 로고
    • Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor
    • (a) Segal, D. J.; Goncalves, J.; Eberhardy, S.; Swan, C. H.; Torbett, B. E.; Li, X.; Barbas, C. F., III. Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. J. Biol. Chem. 2004, 279, 14509-14519.
    • (2004) J. Biol. Chem. , vol.279 , pp. 14509-14519
    • Segal, D.J.1    Goncalves, J.2    Eberhardy, S.3    Swan, C.H.4    Torbett, B.E.5    Li, X.6    Barbas III, C.F.7
  • 58
    • 13444301361 scopus 로고    scopus 로고
    • Inhibition of virus DNA replication by artificial zinc finger proteins
    • (b) Sera, T. Inhibition of virus DNA replication by artificial zinc finger proteins. J. Virol. 2005, 79, 2614-2619.
    • (2005) J. Virol. , vol.79 , pp. 2614-2619
    • Sera, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.