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Volumn 125, Issue 22, 2003, Pages 6656-6662

Sequence-selective DNA cleavage by a chimeric metallopeptide

Author keywords

[No Author keywords available]

Indexed keywords

METALLOPEPTIDES;

EID: 0038657551     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0210998     Document Type: Article
Times cited : (102)

References (65)
  • 1
    • 0037041438 scopus 로고    scopus 로고
    • Abbot, A. Nature 2002, 416, 470-474.
    • (2002) Nature , vol.416 , pp. 470-474
    • Abbot, A.1
  • 27
    • 0038367449 scopus 로고    scopus 로고
    • note
    • The affinity of P3 was determined by isothermal titration microcalorimetry, as it contains no tryptophan fluorophores.
  • 33
    • 0038367448 scopus 로고    scopus 로고
    • note
    • 222 as described in ref 32, the number of contributing residues is reduced to 16 of 33, or 48%.
  • 42
    • 0038705772 scopus 로고    scopus 로고
    • note
    • "Free metal ions" describe ions not complexed by peptide, although they exist as aquo/hydroxide Tris-stabilized species under these conditions.
  • 43
    • 0038029269 scopus 로고    scopus 로고
    • note
    • 32P- labeled oligonucleotides.
  • 45
    • 0038705797 scopus 로고    scopus 로고
    • note
    • 3 in both directions (paralleling the Ce(IV) results), the data are inconclusive.
  • 46
    • 0037691321 scopus 로고    scopus 로고
    • note
    • No change in background occurs during the course of the reaction, as 0 h and 24 h control lanes look identical.
  • 48
    • 0022693818 scopus 로고
    • Dervan, P. B. Science 1986, 232, 464-471.
    • (1986) Science , vol.232 , pp. 464-471
    • Dervan, P.B.1
  • 50
    • 0037691322 scopus 로고    scopus 로고
    • note
    • The random binding affinity for LnP3W species for DNA has been estimated from plasmid gel shift assays to be ∼15 μM, which is in good agreement with similar studies on EuP3 (ref 8).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.