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Volumn 6, Issue 1, 2006, Pages 21-32

Pre-erythrocytic malaria vaccines: Towards greater efficacy

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM POTASSIUM SULFATE; ANTIMALARIAL AGENT; BCG VACCINE; CIRCUMSPOROZOITE PROTEIN; DNA VACCINE; EXPORTED PROTEIN 1; FANSIDAR; ICC 1132; IMMUNOLOGICAL ADJUVANT; LIPOPEPTIDE; LIVER ANTIGEN; LIVER STAGE ANTIGEN 1; LIVER STAGE ANTIGEN 3; MALARIA VACCINE; MEROZOITE SURFACE PROTEIN 1; MEROZOITE SURFACE PROTEIN 2; MEROZOITE SURFACE PROTEIN 3; PARASITE ANTIGEN; PHOSPHORYL LIPID A; RING INFECTED ERYTHROCYTE SURFACE ANTIGEN; SPOROZOITE VACCINE; T LYMPHOCYTE ANTIGEN; THROMBOSPONDIN RELATED ADHESION PROTEIN; UNCLASSIFIED DRUG; VIROSOME; WATER OIL CREAM;

EID: 33244471717     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1746     Document Type: Review
Times cited : (132)

References (119)
  • 1
    • 20044384791 scopus 로고    scopus 로고
    • Malaria vaccine proves effective
    • 15 October
    • McNeil, D. J. Jr., Malaria vaccine proves effective. New York Times (15 October 2004).
    • (2004) New York Times
    • McNeil Jr., D.J.1
  • 2
    • 15044338866 scopus 로고    scopus 로고
    • The global distribution of clinical episodes of Plasmodium falciparum malaria
    • Snow, R. W., Guerra, C. A., Noon A. M., Myint, H. Y. & Hay, S. I. The global distribution of clinical episodes of Plasmodium falciparum malaria. Natures 434, 214-217 (2005).
    • (2005) Natures , vol.434 , pp. 214-217
    • Snow, R.W.1    Guerra, C.A.2    Noon, A.M.3    Myint, H.Y.4    Hay, S.I.5
  • 3
    • 20144387467 scopus 로고    scopus 로고
    • Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara
    • Webster, D. P. et al. Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara. Proc. Natl Acad. Sci. USA 102, 4836-4841 (2005). The first report of sterile protection against malaria with vectored vaccines in a sporozoite-challenge study. One volunteer showed sterile protection that was maintained at 20 months after vaccination and was associated with circulating central memory T cells.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 4836-4841
    • Webster, D.P.1
  • 4
    • 17844402000 scopus 로고    scopus 로고
    • Intermittent preventive antimalarial treatment for Tanzanian infants: Follow-up to age 2 years of a randomised, placebo-controlled trial
    • Schellenberg, D. et al. Intermittent preventive antimalarial treatment for Tanzanian infants: follow-up to age 2 years of a randomised, placebo-controlled trial. Lancet 365, 1481-1483 (2005).
    • (2005) Lancet , vol.365 , pp. 1481-1483
    • Schellenberg, D.1
  • 6
    • 5644228594 scopus 로고    scopus 로고
    • Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: Randomised controlled trial
    • Alonso, P. L. et al. Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial. Lancet 364, 1411-1420 (2004). The first report of clear and significant protection against clinical malaria in African children, using the RTS,S/AS02A vaccine. Protection was observed that lasted several months against both clinical disease and parasitaemia.
    • (2004) Lancet , vol.364 , pp. 1411-1420
    • Alonso, P.L.1
  • 7
    • 9144267735 scopus 로고    scopus 로고
    • Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans
    • McShane, H. et al. Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans. Nature Med. 10, 1240-1244 (2004).
    • (2004) Nature Med. , vol.10 , pp. 1240-1244
    • McShane, H.1
  • 8
    • 10744227629 scopus 로고    scopus 로고
    • + T cells producing IFN-γ
    • + T cells producing IFN-γ. J. Immunol. 171, 6961-6967 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 6961-6967
    • Sun, P.1
  • 9
    • 10844264174 scopus 로고    scopus 로고
    • Differential immunogenicity of various heterologous prime-boost vaccine regimens using DNA and viral vectors in healthy volunteers
    • Vuola, J. M. et al. Differential immunogenicity of various heterologous prime-boost vaccine regimens using DNA and viral vectors in healthy volunteers. J. Immunol. 174, 449-455 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 449-455
    • Vuola, J.M.1
  • 10
    • 11144353591 scopus 로고    scopus 로고
    • + T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease
    • + T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease. Nature Med. 10, 406-410 (2004). The first evidence of a peptide-specific strong correlate of protection in a longitudinal field study using a pre-erythrocytic malaria antigen.
    • (2004) Nature Med. , vol.10 , pp. 406-410
    • Reece, W.H.1
  • 11
    • 0037033980 scopus 로고    scopus 로고
    • Progress and challenges for malaria vaccines
    • Richie, T. L. & Saul, A. Progress and challenges for malaria vaccines. Nature 415, 694-701 (2002).
    • (2002) Nature , vol.415 , pp. 694-701
    • Richie, T.L.1    Saul, A.2
  • 12
    • 4344688712 scopus 로고    scopus 로고
    • Update on the clinical development of candidate malaria vaccines
    • Ballou, W. R. et al. Update on the clinical development of candidate malaria vaccines. Am. J. Trop. Med. Hyg. 71, 239-247 (2004).
    • (2004) Am. J. Trop. Med. Hyg. , vol.71 , pp. 239-247
    • Ballou, W.R.1
  • 13
    • 0242658726 scopus 로고    scopus 로고
    • Prime-boost strategies for malaria vaccine development
    • Dunachie, S. J. & Hill, A. V. Prime-boost strategies for malaria vaccine development. J. Exp. Biol. 206, 3771-3779 (2003).
    • (2003) J. Exp. Biol. , vol.206 , pp. 3771-3779
    • Dunachie, S.J.1    Hill, A.V.2
  • 14
    • 0346056892 scopus 로고    scopus 로고
    • Malaria vaccine developments
    • Moorthy, V. S., Good, M. F. & Hill, A. V. Malaria vaccine developments. Lancet 363, 150-156 (2004).
    • (2004) Lancet , vol.363 , pp. 150-156
    • Moorthy, V.S.1    Good, M.F.2    Hill, A.V.3
  • 15
    • 4844219516 scopus 로고    scopus 로고
    • The immunological challenge to developing a vaccine to the blood stages of malaria parasites
    • Good, M. F., Stanisic, D., Xu, H., Elliott, S. & Wykes, M. The immunological challenge to developing a vaccine to the blood stages of malaria parasites. Immunol. Rev. 201, 254-267 (2004).
    • (2004) Immunol. Rev. , vol.201 , pp. 254-267
    • Good, M.F.1    Stanisic, D.2    Xu, H.3    Elliott, S.4    Wykes, M.5
  • 16
    • 20044362219 scopus 로고    scopus 로고
    • Towards an RTS, S-based, multi-stage, multi-antigen vaccine against falciparum malaria: Progress at the Walter Reed Army Institute of Research
    • Heppner, D. G. Jr et al. Towards an RTS, S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research. Vaccine 23, 2243-2250 (2005). A recent account of the longest-running malaria vaccine development programme.
    • (2005) Vaccine , vol.23 , pp. 2243-2250
    • Heppner Jr., D.G.1
  • 18
    • 0027977965 scopus 로고
    • A theoretical framework for the immunoepidemiology of Plasmodium falciparum malaria
    • Gupta, S. & Day, K. P. A theoretical framework for the immunoepidemiology of Plasmodium falciparum malaria. Parasite-Immunol. 16, 361-370 (1994).
    • (1994) Parasite-Immunol. , vol.16 , pp. 361-370
    • Gupta, S.1    Day, K.P.2
  • 19
    • 0014202885 scopus 로고
    • Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei
    • Nussenzweig, R. S., Vanderberg, J., Most, H. & Orton, C. Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei. Nature 216, 160-162 (1967).
    • (1967) Nature , vol.216 , pp. 160-162
    • Nussenzweig, R.S.1    Vanderberg, J.2    Most, H.3    Orton, C.4
  • 20
    • 0015699215 scopus 로고
    • Immunization of man against sporozite-induced falciparum malaria
    • Clyde, D. F., Most, H., McCarthy, V. C. & Vanderberg, J. P. Immunization of man against sporozite-induced falciparum malaria. Am. J. Med. Sci. 266, 169-177 (1973).
    • (1973) Am. J. Med. Sci. , vol.266 , pp. 169-177
    • Clyde, D.F.1    Most, H.2    McCarthy, V.C.3    Vanderberg, J.P.4
  • 21
    • 0031893942 scopus 로고    scopus 로고
    • Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria
    • Bull, P. C. et al. Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria. Nature Med. 4, 358-360 (1998).
    • (1998) Nature Med. , vol.4 , pp. 358-360
    • Bull, P.C.1
  • 22
    • 0035013082 scopus 로고    scopus 로고
    • Antibodies to variant antigens on the surfaces of infected erythrocytes are associated with protection from malaria in Ghanaian children
    • Dodoo, D. et al. Antibodies to variant antigens on the surfaces of infected erythrocytes are associated with protection from malaria in Ghanaian children. Infect Immun. 69, 3713-3718 (2001).
    • (2001) Infect Immun. , vol.69 , pp. 3713-3718
    • Dodoo, D.1
  • 24
    • 0037015614 scopus 로고    scopus 로고
    • Genome sequence of the human malaria parasite Plasmodium falciparum
    • Gardner, M. J. et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419, 498-511 (2002).
    • (2002) Nature , vol.419 , pp. 498-511
    • Gardner, M.J.1
  • 25
    • 0037015602 scopus 로고    scopus 로고
    • A proteomic view of the Plasmodium falciparum life cycle
    • Florens, L. et al. A proteomic view of the Plasmodium falciparum life cycle. Nature 419, 520-526 (2002).
    • (2002) Nature , vol.419 , pp. 520-526
    • Florens, L.1
  • 26
    • 19944429644 scopus 로고    scopus 로고
    • A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses
    • Hall, N. et al. A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science 307, 82-86 (2005).
    • (2005) Science , vol.307 , pp. 82-86
    • Hall, N.1
  • 27
    • 0042191632 scopus 로고    scopus 로고
    • Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data
    • Doolan, D. L. et al. Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data. Proc. Natl Acad. Sci. USA 100, 9952-9957 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9952-9957
    • Doolan, D.L.1
  • 28
    • 14544281079 scopus 로고    scopus 로고
    • Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface
    • Mueller, A. K. et al. Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface. Proc. Natl Acad. Sci. USA 102, 3022-3027 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 3022-3027
    • Mueller, A.K.1
  • 29
    • 12744278200 scopus 로고    scopus 로고
    • Genetically modified Plasmodium parasites as a protective experimental malaria vaccine
    • Mueller, A. K., Labaied, M., Kappe, S. H. & Matuschewski, K. Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Nature 433, 164-167 (2005).
    • (2005) Nature , vol.433 , pp. 164-167
    • Mueller, A.K.1    Labaied, M.2    Kappe, S.H.3    Matuschewski, K.4
  • 30
    • 0037114136 scopus 로고    scopus 로고
    • Cutting edge: A new tool to evaluate human pre-erythrocytic malaria vaccines: rodent parasites bearing a hybrid Plasmodium falciparum circumsporozoite protein
    • Persson, C. et al. Cutting edge: a new tool to evaluate human pre-erythrocytic malaria vaccines: rodent parasites bearing a hybrid Plasmodium falciparum circumsporozoite protein. J. Immunol. 169, 6681-6685 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 6681-6685
    • Persson, C.1
  • 31
    • 0004170486 scopus 로고    scopus 로고
    • A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria
    • Stoute, J. A. et al. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. N. Engl. J. Med. 336, 86-91 (1997). The initial, highly successful, Phase I/IIa trial of the RTS,S vaccine with various adjuvants.
    • (1997) N. Engl. J. Med. , vol.336 , pp. 86-91
    • Stoute, J.A.1
  • 32
    • 0023254214 scopus 로고
    • Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine
    • Ballou, W. R. et al. Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine. Lancet 1, 1277-1281 (1987).
    • (1987) Lancet , vol.1 , pp. 1277-1281
    • Ballou, W.R.1
  • 33
    • 0023182064 scopus 로고
    • Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites
    • Herrington, D. A. et al. Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites. Nature 328, 257-259 (1987).
    • (1987) Nature , vol.328 , pp. 257-259
    • Herrington, D.A.1
  • 34
    • 0029057169 scopus 로고
    • Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein-hepatitis B surface antigen subunit vaccine
    • Gordon, D. M. et al. Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein-hepatitis B surface antigen subunit vaccine. J. Infect. Dis. 171, 1576-1585 (1995).
    • (1995) J. Infect. Dis. , vol.171 , pp. 1576-1585
    • Gordon, D.M.1
  • 35
    • 0035865867 scopus 로고    scopus 로고
    • Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria
    • Kester, K. E. et al. Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria. J. Infect. Dis. 183, 640-647 (2001).
    • (2001) J. Infect. Dis. , vol.183 , pp. 640-647
    • Kester, K.E.1
  • 36
    • 23844521983 scopus 로고    scopus 로고
    • Malaria vaccines in development
    • Ballou, W. R. Malaria vaccines in development. Expert Opin. Emerg. Drugs 10, 489-503 (2005).
    • (2005) Expert Opin. Emerg. Drugs , vol.10 , pp. 489-503
    • Ballou, W.R.1
  • 37
    • 0035830278 scopus 로고    scopus 로고
    • Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in the Gambia: A randomised trial
    • Bojang, K. A. et al. Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial. Lancet 358, 1927-1934 (2001). Demonstration that the RTS,S vaccine can induce substantial protection against parasitaemia in African adults, but only for 9 weeks.
    • (2001) Lancet , vol.358 , pp. 1927-1934
    • Bojang, K.A.1
  • 38
    • 0037267842 scopus 로고    scopus 로고
    • Protective efficacy of the RTS,S/AS02 Plasmodium falciparum malaria vaccine is not strain specific
    • Alloueche, A. et al. Protective efficacy of the RTS,S/AS02 Plasmodium falciparum malaria vaccine is not strain specific. Am. J. Trop. Med. Hyg. 68, 97-101 (2003).
    • (2003) Am. J. Trop. Med. Hyg. , vol.68 , pp. 97-101
    • Alloueche, A.1
  • 39
    • 0032745349 scopus 로고    scopus 로고
    • H1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine
    • H1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine. J. Infect. Dis. 180, 1656-1664 (1999). Quantitation of the T-cell immunogenicity of the RTS,S vaccine using IFNγ ELISPOT assays.
    • (1999) J. Infect. Dis. , vol.180 , pp. 1656-1664
    • Lalvani, A.1
  • 40
    • 17344368403 scopus 로고    scopus 로고
    • Long-term efficacy and immune responses following immunization with the RTS, S malaria vaccine
    • Stoute, J. A. et al. Long-term efficacy and immune responses following immunization with the RTS, S malaria vaccine. J. Infect. Dis. 178, 1139-1144 (1998).
    • (1998) J. Infect. Dis. , vol.178 , pp. 1139-1144
    • Stoute, J.A.1
  • 41
    • 0036892173 scopus 로고    scopus 로고
    • A modified hepatitis B virus core particle containing multiple epitopes of the Plasmodium falciparum circumsporozoite protein provides a highly immunogenic malaria vaccine in preclinical analyses in rodent and primate hosts
    • Birkett, A. et al. A modified hepatitis B virus core particle containing multiple epitopes of the Plasmodium falciparum circumsporozoite protein provides a highly immunogenic malaria vaccine in preclinical analyses in rodent and primate hosts. Infect. Immun. 70, 6860-6870 (2002).
    • (2002) Infect. Immun. , vol.70 , pp. 6860-6870
    • Birkett, A.1
  • 42
    • 10444286628 scopus 로고    scopus 로고
    • Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720
    • Walther, M. et al. Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720. Vaccine 23, 857-864 (2005).
    • (2005) Vaccine , vol.23 , pp. 857-864
    • Walther, M.1
  • 43
    • 0034938975 scopus 로고    scopus 로고
    • + T lymphocyte immune response in humans. Implications for vaccination strategies
    • + T lymphocyte immune response in humans. Implications for vaccination strategies. Eur. J. Immunol. 31, 1989-1998 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1989-1998
    • Lopez, J.A.1
  • 44
    • 9244234954 scopus 로고    scopus 로고
    • Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs
    • Felnerova, D., Viret, J. F., Gluck, R. & Moser, C. Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs. Curr. Opin. Biotechnol. 15, 518-529 (2004).
    • (2004) Curr. Opin. Biotechnol. , vol.15 , pp. 518-529
    • Felnerova, D.1    Viret, J.F.2    Gluck, R.3    Moser, C.4
  • 45
    • 0037435877 scopus 로고    scopus 로고
    • Immunostimulating reconstituted influenza virosomes
    • Zurbriggen, R. Immunostimulating reconstituted influenza virosomes. Vaccine 21, 921-924 (2003).
    • (2003) Vaccine , vol.21 , pp. 921-924
    • Zurbriggen, R.1
  • 46
    • 0035814134 scopus 로고    scopus 로고
    • Exploiting conformationally constrained peptidomimetics and an efficient human-compatible delivery system in synthetic vaccine design
    • Moreno, R. et al. Exploiting conformationally constrained peptidomimetics and an efficient human-compatible delivery system in synthetic vaccine design. Chembiochem. 2, 838-843 (2001).
    • (2001) Chembiochem. , vol.2 , pp. 838-843
    • Moreno, R.1
  • 47
    • 0042244460 scopus 로고    scopus 로고
    • Induction of parasite growth-inhibitory antibodies by a virosomal formulation of a peptidomimetic of loop I from domain III of Plasmodium falciparum apical membrane antigen 1
    • Mueller, M. S. et al. Induction of parasite growth-inhibitory antibodies by a virosomal formulation of a peptidomimetic of loop I from domain III of Plasmodium falciparum apical membrane antigen 1. Infect. Immun. 71, 4749-4758 (2003).
    • (2003) Infect. Immun. , vol.71 , pp. 4749-4758
    • Mueller, M.S.1
  • 48
    • 0023483210 scopus 로고
    • + T cells and antibodies required for immunity to malaria sporozoites
    • + T cells and antibodies required for immunity to malaria sporozoites. Nature 330, 664-666 (1987).
    • (1987) Nature , vol.330 , pp. 664-666
    • Schofield, L.1
  • 49
    • 0034254649 scopus 로고    scopus 로고
    • The complexity of protective immunity against liver stage malaria
    • Doolan, D. L. & Hoffman, S. L. The complexity of protective immunity against liver stage malaria. J. Immunol. 165, 1453-1462 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 1453-1462
    • Doolan, D.L.1    Hoffman, S.L.2
  • 50
    • 0024954612 scopus 로고
    • Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria
    • Romero, P. et al. Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria. Nature 341, 323-326 (1989).
    • (1989) Nature , vol.341 , pp. 323-326
    • Romero, P.1
  • 51
    • 0028236416 scopus 로고
    • + cytotoxic T-cell clone recognizing sporozoite surface protein 2
    • + cytotoxic T-cell clone recognizing sporozoite surface protein 2. Infect. Immun. 62, 2979-2983 (1994).
    • (1994) Infect. Immun. , vol.62 , pp. 2979-2983
    • Khusmith, S.1    Sedegah, M.2    Hoffman, S.L.3
  • 52
    • 0026471097 scopus 로고
    • Molecular analysis of the association of HLA-B53 and resistance to severe malaria
    • Hill, A. V. et al. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 360, 434-439 (1992).
    • (1992) Nature , vol.360 , pp. 434-439
    • Hill, A.V.1
  • 53
    • 9444289849 scopus 로고    scopus 로고
    • Comparison of numerous delivery systems for the induction of cytotoxic T lymphocytes by immunization
    • Allsopp, C. E. et al. Comparison of numerous delivery systems for the induction of cytotoxic T lymphocytes by immunization. Eur. J. Immunol. 26, 1951-1959 (1996).
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1951-1959
    • Allsopp, C.E.1
  • 54
    • 0028077102 scopus 로고
    • Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein
    • Sedegah, M., Hedstrom, R., Hobart, P. & Hoffman, S. L. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc. Natl Acad. Sci. USA 91, 9866-9870 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9866-9870
    • Sedegah, M.1    Hedstrom, R.2    Hobart, P.3    Hoffman, S.L.4
  • 55
    • 9244224607 scopus 로고    scopus 로고
    • Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria
    • Lanar, D. E. et al. Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria. Infect. Immun. 64, 1666-1671 (1996).
    • (1996) Infect. Immun. , vol.64 , pp. 1666-1671
    • Lanar, D.E.1
  • 57
    • 0027292880 scopus 로고
    • + T-cell-mediated protective immunity against malaria
    • + T-cell-mediated protective immunity against malaria. Proc. Natl Acad. Sci. USA 90, 5214-5218 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5214-5218
    • Li, S.1
  • 58
    • 0031924077 scopus 로고    scopus 로고
    • + T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara
    • + T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nature Med. 4, 397-402 (1998).
    • (1998) Nature Med. , vol.4 , pp. 397-402
    • Schneider, J.1
  • 59
    • 0032560547 scopus 로고    scopus 로고
    • Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine
    • Sedegah, M. et al. Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine. Proc. Natl Acad. Sci. USA 95, 7648-7653 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7648-7653
    • Sedegah, M.1
  • 60
    • 0037081381 scopus 로고    scopus 로고
    • Enhanced CD8 T cell immunogenicity and protective efficacy in a mouse malaria model using a recombinant adenoviral vaccine in heterologous prime-boost immunisation regimes
    • Gilbert, S. C. et al. Enhanced CD8 T cell immunogenicity and protective efficacy in a mouse malaria model using a recombinant adenoviral vaccine in heterologous prime-boost immunisation regimes. Vaccine 20, 1039-1045 (2002).
    • (2002) Vaccine , vol.20 , pp. 1039-1045
    • Gilbert, S.C.1
  • 61
    • 10744224195 scopus 로고    scopus 로고
    • + T cell immune responses and protection elicited against Plasmodium berghei malaria by prime-boost immunization regimens using a novel attenuated fowlpox virus
    • + T cell immune responses and protection elicited against Plasmodium berghei malaria by prime-boost immunization regimens using a novel attenuated fowlpox virus. J. Immunol. 172, 3094-3100 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 3094-3100
    • Anderson, R.J.1
  • 62
    • 0034860454 scopus 로고    scopus 로고
    • Multistage multiantigen heterologous prime-boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques
    • Rogers, W. O. et al. Multistage multiantigen heterologous prime-boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques. Infect. Immun. 69, 5565-5572 (2001).
    • (2001) Infect. Immun. , vol.69 , pp. 5565-5572
    • Rogers, W.O.1
  • 63
    • 0036073334 scopus 로고    scopus 로고
    • Protection of rhesus macaques against lethal Plasmodium knowlesi malaria by a heterologous DNA priming and poxvirus boosting immunization regimen
    • Rogers, W. O. et al. Protection of rhesus macaques against lethal Plasmodium knowlesi malaria by a heterologous DNA priming and poxvirus boosting immunization regimen. Infect. Immun. 70, 4329-4335 (2002). Demonstration of the protective efficacy of heterologous prime-boost regimes against simian malaria in macaques.
    • (2002) Infect. Immun. , vol.70 , pp. 4329-4335
    • Rogers, W.O.1
  • 64
    • 17344363385 scopus 로고    scopus 로고
    • Phase I/IIa safety, immunogenicity, and efficacy trial of NYVAC-Pf7, a pox-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria
    • Ockenhouse, C. F. et al. Phase I/IIa safety, immunogenicity, and efficacy trial of NYVAC-Pf7, a pox-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria. J. Infect. Dis. 177, 1664-1673 (1998).
    • (1998) J. Infect. Dis. , vol.177 , pp. 1664-1673
    • Ockenhouse, C.F.1
  • 65
    • 0030713343 scopus 로고    scopus 로고
    • A protein particle vaccine containing multiple malaria epitopes
    • Gilbert, S. C. et al. A protein particle vaccine containing multiple malaria epitopes. Nature Biotechnol. 15, 1280-1284 (1997).
    • (1997) Nature Biotechnol. , vol.15 , pp. 1280-1284
    • Gilbert, S.C.1
  • 66
    • 0038714287 scopus 로고    scopus 로고
    • Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans
    • McConkey, S. J. et al. Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans. Nature Med. 9, 729-735 (2003). Demonstration that strong T-cell responses can be generated by heterologous prime-boost immunization with DNA-MVA regimes in humans, and that these T cells can confer some protection in the absence of antibodies.
    • (2003) Nature Med. , vol.9 , pp. 729-735
    • McConkey, S.J.1
  • 67
    • 0032538597 scopus 로고    scopus 로고
    • Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine
    • Wang, R. et al. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science 282, 476-480 (1998). The first report of the immunogenicity of a plasmid DNA prophylactic vaccine in humans.
    • (1998) Science , vol.282 , pp. 476-480
    • Wang, R.1
  • 68
    • 0037449091 scopus 로고    scopus 로고
    • Safety of DNA and modified vaccinia virus Ankara vaccines against liver stage P. falciparum malaria in non-immune volunteers
    • Moorthy, V. S. et al. Safety of DNA and modified vaccinia virus Ankara vaccines against liver stage P. falciparum malaria in non-immune volunteers. Vaccine 21, 1995-2002 (2003).
    • (2003) Vaccine , vol.21 , pp. 1995-2002
    • Moorthy, V.S.1
  • 69
    • 0242364645 scopus 로고    scopus 로고
    • Safety and immunogenicity of DNA/modified vaccinia virus ankara malaria vaccination in African adults
    • Moorthy, V. S. et al. Safety and immunogenicity of DNA/modified vaccinia virus ankara malaria vaccination in African adults. J. Infect. Dis. 188, 1239-1244 (2003).
    • (2003) J. Infect. Dis. , vol.188 , pp. 1239-1244
    • Moorthy, V.S.1
  • 70
    • 2942624113 scopus 로고    scopus 로고
    • Phase 1 evaluation of 3 highly immunogenic prime-boost regimens, including a 12-month reboosting vaccination, for malaria vaccination in Gambian men
    • Moorthy, V. et al. Phase 1 evaluation of 3 highly immunogenic prime-boost regimens, including a 12-month reboosting vaccination, for malaria vaccination in Gambian men. J. Infect. Dis. 189, 2213-2219 (2004).
    • (2004) J. Infect. Dis. , vol.189 , pp. 2213-2219
    • Moorthy, V.1
  • 71
    • 15744387886 scopus 로고    scopus 로고
    • A randomised, double-blind, controlled vaccine efficacy trial of DNA/MVA ME-TRAP against malaria infection in Gambian adults
    • Moorthy, V. S. et al. A randomised, double-blind, controlled vaccine efficacy trial of DNA/MVA ME-TRAP against malaria infection in Gambian adults. PLoS Med. 1, e33 (2004).
    • (2004) PLoS Med. , vol.1
    • Moorthy, V.S.1
  • 72
    • 1342268239 scopus 로고    scopus 로고
    • Comparison of the genome sequence of FP9, an attenuated, tissue culture-adapted European strain of Fowlpox virus, with those of virulent American and European viruses
    • Laidlaw, S. M. & Skinner, M. A. Comparison of the genome sequence of FP9, an attenuated, tissue culture-adapted European strain of Fowlpox virus, with those of virulent American and European viruses. J. Gen. Virol. 85, 305-322 (2004).
    • (2004) J. Gen. Virol. , vol.85 , pp. 305-322
    • Laidlaw, S.M.1    Skinner, M.A.2
  • 73
    • 13444251395 scopus 로고    scopus 로고
    • Calculation of liver-to-blood inocula, parasite growth rates, and preerythrocytic vaccine efficacy, from serial quantitative polymerase chain reaction studies of volunteers challenged with malaria sporozoites
    • Bejon, P. et al. Calculation of liver-to-blood inocula, parasite growth rates, and preerythrocytic vaccine efficacy, from serial quantitative polymerase chain reaction studies of volunteers challenged with malaria sporozoites. J. Infect. Dis. 191, 619-626 (2005).
    • (2005) J. Infect. Dis. , vol.191 , pp. 619-626
    • Bejon, P.1
  • 74
    • 27144489392 scopus 로고    scopus 로고
    • Durable human memory T cells quantifiable by cultured enzyme-linked immunospot assays are induced by heterologous prime-boost immunization and correlate with protection against malaria
    • Keating, S. M. et al. Durable human memory T cells quantifiable by cultured enzyme-linked immunospot assays are induced by heterologous prime-boost immunization and correlate with protection against malaria. J. Immunol. 175, 5675-5680 (2005). This study provides evidence that central memory T cells measured by cultured IFNγELISPOT assays correlate better with protection than effector T cells measured by ex vivo IFNγELISPOT assays.
    • (2005) J. Immunol. , vol.175 , pp. 5675-5680
    • Keating, S.M.1
  • 75
    • 20244380773 scopus 로고    scopus 로고
    • Boosting of DNA vaccine-elicited γ-interferon responses in humans by exposure to malaria parasites
    • Wang, R. et al. Boosting of DNA vaccine-elicited γ-interferon responses in humans by exposure to malaria parasites. Infect. Immun. 73, 2863-2872 (2005).
    • (2005) Infect. Immun. , vol.73 , pp. 2863-2872
    • Wang, R.1
  • 76
    • 11144356341 scopus 로고    scopus 로고
    • + T cell and antibody responses by sequential immunization with malaria DNA and recombinant protein
    • + T cell and antibody responses by sequential immunization with malaria DNA and recombinant protein. J. Immunol. 172, 5561-5569 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 5561-5569
    • Wang, R.1
  • 77
    • 3142764761 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1-specific immune responses in primates upon sequential immunization with adenoviral vaccine carriers of human and simian serotypes
    • Reyes-Sandoval, A. et al. Human immunodeficiency virus type 1-specific immune responses in primates upon sequential immunization with adenoviral vaccine carriers of human and simian serotypes. J. Virol. 78, 7392-7399 (2004).
    • (2004) J. Virol. , vol.78 , pp. 7392-7399
    • Reyes-Sandoval, A.1
  • 78
    • 0035164962 scopus 로고    scopus 로고
    • Replication-defective vector based on a chimpanzee adenovirus
    • Farina, S. F. et al. Replication-defective vector based on a chimpanzee adenovirus. J. Virol. 75, 11603-11613 (2001).
    • (2001) J. Virol. , vol.75 , pp. 11603-11613
    • Farina, S.F.1
  • 79
    • 0023235563 scopus 로고
    • Efficacy of murine malaria sporozoite vaccines: Implications for human vaccine development
    • Egan, J. E. et al. Efficacy of murine malaria sporozoite vaccines: implications for human vaccine development. Science 236, 453-456 (1987).
    • (1987) Science , vol.236 , pp. 453-456
    • Egan, J.E.1
  • 80
    • 0023622196 scopus 로고
    • Synthetic peptide vaccine confers protection against murine malaria
    • Zavala, F. et al. Synthetic peptide vaccine confers protection against murine malaria. J. Exp. Med. 166, 1591-1596 (1987).
    • (1987) J. Exp. Med. , vol.166 , pp. 1591-1596
    • Zavala, F.1
  • 81
    • 0022513753 scopus 로고
    • Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine. Widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine
    • Good, M. F. et al. Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine. Widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine. J. Exp. Med. 164, 655-660 (1986).
    • (1986) J. Exp. Med. , vol.164 , pp. 655-660
    • Good, M.F.1
  • 82
    • 0032726681 scopus 로고    scopus 로고
    • + T-cell- and γ-interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoeiii 17-kilodalton hepatocyte erythrocyte protein
    • + T-cell- and γ-interferon- dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoeiii 17-kilodalton hepatocyte erythrocyte protein. Infect. Immun. 67, 5604-5614 (1999).
    • (1999) Infect. Immun. , vol.67 , pp. 5604-5614
    • Charoenvit, Y.1
  • 83
    • 0029031772 scopus 로고
    • Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites
    • Scheller, L. F. & Azad, A. F. Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites. Proc. Natl Acad. Sci. USA 92, 4066-4068 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4066-4068
    • Scheller, L.F.1    Azad, A.F.2
  • 84
    • 0042123673 scopus 로고    scopus 로고
    • + T cells
    • + T cells. J. Immunol. 171, 2024-2034 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 2024-2034
    • Berenzon, D.1
  • 85
    • 0347624275 scopus 로고    scopus 로고
    • Epidemiology of malaria in a village of Sudanese savannah in Mali (Bancoumana). Anti-TRAP and anti-CS humoral immunity response
    • Dolo, A. et al. Epidemiology of malaria in a village of Sudanese savannah in Mali (Bancoumana). Anti-TRAP and anti-CS humoral immunity response. Bull. Soc. Pathol. Exot. 96, 287-290 (2003).
    • (2003) Bull. Soc. Pathol. Exot. , vol.96 , pp. 287-290
    • Dolo, A.1
  • 86
    • 0027217788 scopus 로고
    • Analysis of the human antibody response to thrombospondin-related anonymous protein of Plasmodium falciparum
    • Scarselli, E. et al. Analysis of the human antibody response to thrombospondin-related anonymous protein of Plasmodium falciparum. Infect. Immun. 61, 3490-3495 (1993).
    • (1993) Infect. Immun. , vol.61 , pp. 3490-3495
    • Scarselli, E.1
  • 87
    • 0033183082 scopus 로고    scopus 로고
    • Thrombospondin related adhesive protein (TRAP), a potential malaria vaccine candidate
    • Dolo, A. et al. Thrombospondin related adhesive protein (TRAP), a potential malaria vaccine candidate. Parassitologia 41, 425-428 (1999).
    • (1999) Parassitologia , vol.41 , pp. 425-428
    • Dolo, A.1
  • 88
    • 0042766473 scopus 로고    scopus 로고
    • Antibodies to the Plasmodium falciparum antigens circumsporozoite protein, thrombospondin-related adhesive protein, and liver stage antigen 1 vary by ages of subjects and by season in a highland area of Kenya
    • John, C. C., Zickafoose, J. S., Sumba, P. O., King, C. L. & Kazura, J. W. Antibodies to the Plasmodium falciparum antigens circumsporozoite protein, thrombospondin-related adhesive protein, and liver stage antigen 1 vary by ages of subjects and by season in a highland area of Kenya. Infect. Immun. 71, 4320-4325 (2003).
    • (2003) Infect. Immun. , vol.71 , pp. 4320-4325
    • John, C.C.1    Zickafoose, J.S.2    Sumba, P.O.3    King, C.L.4    Kazura, J.W.5
  • 89
    • 0024204050 scopus 로고
    • A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules
    • Sinigaglia, F. et al. A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules. Nature 336, 778-780 (1988).
    • (1988) Nature , vol.336 , pp. 778-780
    • Sinigaglia, F.1
  • 90
    • 2142730100 scopus 로고    scopus 로고
    • Central memory and effector memory T cell subsets: Function, generation, and maintenance
    • Sallusto, F., Geginat, J. & Lanzavecchia, A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 22, 745-763 (2004).
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 745-763
    • Sallusto, F.1    Geginat, J.2    Lanzavecchia, A.3
  • 91
    • 0035887948 scopus 로고    scopus 로고
    • Unique T cell effector functions elicited by Plasmodium falciparum epitopes in malaria-exposed Africans tested by three T cell assays
    • Flanagan, K. L. et al. Unique T cell effector functions elicited by Plasmodium falciparum epitopes in malaria-exposed Africans tested by three T cell assays. J. Immunol. 167, 4729-4737 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 4729-4737
    • Flanagan, K.L.1
  • 93
    • 0032948127 scopus 로고    scopus 로고
    • Interferon-γ responses are associated with resistance to reinfection with Plasmodium falciparum in young African children
    • Luty, A. J. et al. Interferon-γ responses are associated with resistance to reinfection with Plasmodium falciparum in young African children. J. Infect. Dis. 179, 980-988 (1999).
    • (1999) J. Infect. Dis. , vol.179 , pp. 980-988
    • Luty, A.J.1
  • 94
    • 4544348363 scopus 로고    scopus 로고
    • γ-Interferon responses to Plasmodium falciparum liver stage antigen 1 and thrombospondin-related adhesive protein and their relationship to age, transmission intensity, and protection against malaria
    • John, C. C. et al. γ-Interferon responses to Plasmodium falciparum liver stage antigen 1 and thrombospondin-related adhesive protein and their relationship to age, transmission intensity, and protection against malaria. Infect. Immun. 72, 5135-5142 (2004).
    • (2004) Infect. Immun. , vol.72 , pp. 5135-5142
    • John, C.C.1
  • 95
    • 0038131816 scopus 로고    scopus 로고
    • Association of interferon-γ responses to pre-erythrocytic stage vaccine candidate antigens of Plasmodium falciparum in young Kenyan children with improved hemoglobin levels: XV. Asembo Bay Cohort Project
    • Ong'echa, J. M. et al. Association of interferon-γ responses to pre-erythrocytic stage vaccine candidate antigens of Plasmodium falciparum in young Kenyan children with improved hemoglobin levels: XV. Asembo Bay Cohort Project. Am. J. Trop. Med. Hyg. 68, 590-597 (2003).
    • (2003) Am. J. Trop. Med. Hyg. , vol.68 , pp. 590-597
    • Ong'echa, J.M.1
  • 96
    • 0042307253 scopus 로고    scopus 로고
    • Ex vivo interferon-γ immune response to thrombospondin-related adhesive protein in coastal Kenyans: Longevity and risk of Plasmodium falciparum infection
    • Flanagan, K. L. et al. Ex vivo interferon-γ immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of Plasmodium falciparum infection. Am. J. Trop. Med. Hyg. 68, 421-430 (2003).
    • (2003) Am. J. Trop. Med. Hyg. , vol.68 , pp. 421-430
    • Flanagan, K.L.1
  • 97
    • 16844369607 scopus 로고    scopus 로고
    • Natural regulatory T cells in infectious disease
    • Belkaid, Y. & Rouse, B. T. Natural regulatory T cells in infectious disease. Nature Immunol. 6, 353-360 (2005).
    • (2005) Nature Immunol. , vol.6 , pp. 353-360
    • Belkaid, Y.1    Rouse, B.T.2
  • 98
    • 1842455770 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. Nature Med. 10, 29-30 (2004).
    • (2004) Nature Med. , vol.10 , pp. 29-30
    • Hisaeda, H.1
  • 99
    • 0242410967 scopus 로고    scopus 로고
    • Differential induction of TGF-β regulates proinflammatory cytokine production and determines the outcome of lethal and nonlethal Plasmodium yoelii infections
    • Orner, F. M., de Souza, J. B. & Riley, E. M. Differential induction of TGF-β regulates proinflammatory cytokine production and determines the outcome of lethal and nonlethal Plasmodium yoelii infections. J. Immunol. 171, 5430-5436 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 5430-5436
    • Orner, F.M.1    De Souza, J.B.2    Riley, E.M.3
  • 100
    • 24944466472 scopus 로고    scopus 로고
    • + regulatory T cells correlates with more rapid parasite growth in human malaria infection
    • + regulatory T cells correlates with more rapid parasite growth in human malaria infection. Immunity 23, 287-296 (2005).
    • (2005) Immunity , vol.23 , pp. 287-296
    • Walther, M.1
  • 102
    • 33244454972 scopus 로고    scopus 로고
    • Anti-CD25 antibody enhancement of vaccine-induced immunogenicity to bacterial, viral and parasitic antigens: Increased durable cellular immunity with reduced immunodominance
    • in the press
    • Moore, A. C., Gallimore, A., Watkins, K. R., Gilbert, S. C. & Hill, A. V. S. Anti-CD25 antibody enhancement of vaccine-induced immunogenicity to bacterial, viral and parasitic antigens: increased durable cellular immunity with reduced immunodominance. J. Immunol. (in the press).
    • J. Immunol.
    • Moore, A.C.1    Gallimore, A.2    Watkins, K.R.3    Gilbert, S.C.4    Hill, A.V.S.5
  • 103
    • 14844367047 scopus 로고    scopus 로고
    • + T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities
    • + T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities. J. Immunol. 174, 3344-3351 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 3344-3351
    • Haeryfar, S.M.1
  • 104
    • 0041626090 scopus 로고    scopus 로고
    • Opsonization by antigen-specific antibodies as a mechanism of protective immunity induced by Plasmodium falciparum circumsporozoite protein-based vaccine
    • Schwenk, R. et al. Opsonization by antigen-specific antibodies as a mechanism of protective immunity induced by Plasmodium falciparum circumsporozoite protein-based vaccine. Parasite Immunol. 25, 17-25 (2003).
    • (2003) Parasite Immunol. , vol.25 , pp. 17-25
    • Schwenk, R.1
  • 105
    • 10744225844 scopus 로고    scopus 로고
    • Cellular immunity induced by the recombinant Plasmodium falciparum malaria vaccine, RTS, S/AS02, in semi-immune adults in the Gambia
    • Pinder, M. et al. Cellular immunity induced by the recombinant Plasmodium falciparum malaria vaccine, RTS, S/AS02, in semi-immune adults in The Gambia. Clin. Exp. Immunol. 135, 286-293 (2004).
    • (2004) Clin. Exp. Immunol. , vol.135 , pp. 286-293
    • Pinder, M.1
  • 106
    • 13444302615 scopus 로고    scopus 로고
    • Malaria vaccine: 3 or 6 months' protection?
    • Smith, P. G. & Milligan, P. J. Malaria vaccine: 3 or 6 months' protection? Lancet 365, 472-473 (2005).
    • (2005) Lancet , vol.365 , pp. 472-473
    • Smith, P.G.1    Milligan, P.J.2
  • 107
    • 23844533200 scopus 로고    scopus 로고
    • eds Levine, M. M., Kaper, J. B., Rappuoli, R., Liu, M. A. & Good, M. F. Marcel Dekker, New York
    • Heppner, D. G. et al. in New Generation Vaccines (eds Levine, M. M., Kaper, J. B., Rappuoli, R., Liu, M. A. & Good, M. F.) 851-860 (Marcel Dekker, New York, 2004).
    • (2004) New Generation Vaccines , pp. 851-860
    • Heppner, D.G.1
  • 108
    • 2942596008 scopus 로고    scopus 로고
    • Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein
    • Skeiky, Y. A. et al. Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein. J. Immunol. 172, 7618-7628 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 7618-7628
    • Skeiky, Y.A.1
  • 109
    • 4444291696 scopus 로고    scopus 로고
    • Pre-clinical evaluation of the malaria vaccine candidate P. falciparum MSP1 (42) formulated with novel adjuvants or with alum
    • Pichyangkul, S. et al. Pre-clinical evaluation of the malaria vaccine candidate P. falciparum MSP1 (42) formulated with novel adjuvants or with alum. Vaccine 22, 3831-3840 (2004).
    • (2004) Vaccine , vol.22 , pp. 3831-3840
    • Pichyangkul, S.1
  • 110
    • 0025899243 scopus 로고
    • The effect of insecticide-treated bed nets on mortality of Gambian children
    • Alonso, P. L. et al. The effect of insecticide-treated bed nets on mortality of Gambian children. Lancet 337, 1499-1502 (1991).
    • (1991) Lancet , vol.337 , pp. 1499-1502
    • Alonso, P.L.1
  • 111
    • 0027166136 scopus 로고
    • A malaria control trial using insecticide-treated bed nets and targeted chemoprophylaxis in a rural area of the Gambia, west Africa. 6. The impact of the interventions on mortality and morbidity from malaria
    • Alonso, P. L. et al. A malaria control trial using insecticide-treated bed nets and targeted chemoprophylaxis in a rural area of The Gambia, west Africa. 6. The impact of the interventions on mortality and morbidity from malaria. Trans. R. Soc. Trop. Med. Hyg. 87 (Suppl. 2), 37-44 (1993).
    • (1993) Trans. R. Soc. Trop. Med. Hyg. , vol.87 , Issue.2 SUPPL. , pp. 37-44
    • Alonso, P.L.1
  • 112
    • 0025913521 scopus 로고
    • Common west African HLA antigens are associated with protection from severe malaria
    • Hill, A. V. et al. Common west African HLA antigens are associated with protection from severe malaria. Nature 352, 595-600 (1991).
    • (1991) Nature , vol.352 , pp. 595-600
    • Hill, A.V.1
  • 113
    • 0029118339 scopus 로고
    • Dynamic interactions in malaria: Host heterogeneity meets parasite polymorphism
    • Gupta, S. & Hill, A. V. Dynamic interactions in malaria: host heterogeneity meets parasite polymorphism. Proc. R. Soc. Lond. B. 261, 271-277 (1995).
    • (1995) Proc. R. Soc. Lond. B. , vol.261 , pp. 271-277
    • Gupta, S.1    Hill, A.V.2
  • 114
    • 0035845527 scopus 로고    scopus 로고
    • + type 1 responses in humans by a malaria DNA vaccine
    • + type 1 responses in humans by a malaria DNA vaccine. Proc. Natl Acad. Sci. USA 98, 10817-10822 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10817-10822
    • Wang, R.1
  • 115
    • 0030850436 scopus 로고    scopus 로고
    • DNA vaccines for malaria: The past, the present & the future
    • Doolan, D. L. et al. DNA vaccines for malaria: the past, the present & the future. Indian. J. Med. Res. 106, 109-119 (1997).
    • (1997) Indian. J. Med. Res. , vol.106 , pp. 109-119
    • Doolan, D.L.1
  • 116
    • 0242658694 scopus 로고    scopus 로고
    • Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine
    • Luke, T. C. & Hoffman, S. L. Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine. J. Exp. Biol. 206, 3803-3808 (2003).
    • (2003) J. Exp. Biol. , vol.206 , pp. 3803-3808
    • Luke, T.C.1    Hoffman, S.L.2
  • 117
    • 0034001440 scopus 로고    scopus 로고
    • Effect of vaccination with 3 recombinant asexual-stage malaria antigens on initial growth rates of Plasmodium falciparum in non-immune volunteers
    • Lawrence, G. et al. Effect of vaccination with 3 recombinant asexual-stage malaria antigens on initial growth rates of Plasmodium falciparum in non-immune volunteers. Vaccine 18, 1925-1931 (2000).
    • (2000) Vaccine , vol.18 , pp. 1925-1931
    • Lawrence, G.1
  • 118
    • 0037086437 scopus 로고    scopus 로고
    • A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a Phase 1-2b trial in Papua New Guinea
    • Genton, B. et al. A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a Phase 1-2b trial in Papua New Guinea. J. Infect. Dis. 185, 820-827 (2002).
    • (2002) J. Infect. Dis. , vol.185 , pp. 820-827
    • Genton, B.1
  • 119
    • 28844483001 scopus 로고    scopus 로고
    • Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: Single-blind extended follow-up of a randomised controlled trial
    • 15 November doi:10.1016/S0140-6736(05)67669-6
    • Alonso, P. L. et al. Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: single-blind extended follow-up of a randomised controlled trial. Lancet 15 November 2005 (doi:10.1016/S0140-6736(05)67669-6).
    • (2005) Lancet
    • Alonso, P.L.1


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