A CD4+ T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease

Nature Medicine

Volumn 10, Issue 4, 2004, Pages 406-410

  Reece, William H H ^a   Pinder, Margaret ^b   Gothard, Philip K ^a   Milligan, Paul ^b   Bojang, Kalifa ^b   Doherty, Tom ^b   Plebanski, Magdalena ^a   Akinwunmi, Peter ^b   Everaere, Simone ^a   Watkins, Katherine R ^a   Voss, Gerald ^c   Tornieporth, Nadia ^c   Alloueche, Ali ^d   Greenwood, Brian M ^d   Kester, Kent E ^e   McAdam, Keith P W J ^b   Cohen, Joe ^c   Hill, Adrian V S ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^c GSK   (Belgium)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIRCUMSPOROZOITE PROTEIN; HLA DR2 ANTIGEN; PEPTIDE DERIVATIVE;

ADULT; AFRICA; AMINO ACID SEQUENCE; ARTICLE; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSPOT ASSAY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MALARIA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTECTION; T LYMPHOCYTE;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CONSERVED SEQUENCE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HUMANS; IMMUNOLOGIC MEMORY; MALARIA, FALCIPARUM; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PROTOZOAN PROTEINS;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 11144353591     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1009     Document Type: Article

References (29)

1. Aidoo, M. & Udhayakumar, V. Field studies of cytotoxic T lymphocytes in malaria infections: implications for malaria vaccine development. Parasitol. Today 16, 50-56 (2000).
2. Sinigaglia, F. et al. A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules. Nature 336, 778-780 (1988).
3. Flanagan, K.L. et al. Unique T cell effector functions elicited by Plasmodium falciparum epitopes in malaria-exposed Africans tested by three T cell assays. J. Immunol. 167, 4729-4737 (2001).
4. Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712 (1999).
5. + T cell- and IFN-γ-dependent elimination of infected hepatocytes. J. Immunol. 157, 4061-4067 (1996).
6. Zavala, F. et al. Synthetic peptide vaccine confers protection against murine malaria. J. Exp. Med. 166, 1591-1596 (1987).
7. Wizel, B. et al. Irradiated sporozoite vaccine induces HLA-B8-restricted cytotoxic T lymphocyte responses against two overlapping epitopes of the Plasmodium falciparum sporozoite surface protein 2. J. Exp. Med. 182, 1435-1445 (1995).
8. Stoute, J.A. et al. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. N. Engl. J. Med. 336, 86-91 (1997).
9. Stoute, J.A. et al. Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine. J. Infect. Dis. 178, 1139-1144 (1998).
10. Sinigaglia, F. et al. Epitopes recognized by human T lymphocytes on malaria circumsporozoite protein. Eur. J. Immunol. 18, 633-636 (1988).
11. Riley, E.M. et al. Recognition of dominant T cell-stimulating epitopes from the circumsporozoite protein of Plasmodium falciparum and relationship to malaria morbidity in Gambian children. Trans. Roy. Soc. Trop. Med. Hyg. 84, 648-657 (1990).
12. Romero, P. et al. Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria. Nature 341, 323-326 (1989).
13. Bojang, K.A. et al. Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciaprum infection in semi-immune adult men in The Gambia: a randomized trial. Lancet 158, 1927-1934 (2001).
14. Pinder, M. et al. Cellular immunity induced by the recombinant Plasmodium falciparum malaria vaccine, RTS,S/AS02, in semi-immune adults in The Gambia. Clin. Exp. Immunol. 135, 286-293 (2004).
15. Lalvani, A. et al. Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine. J. Infect. Dis. 180, 1656-1664 (1999).
16. McConkey, S.J. et al. Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans. Nat. Med. 9, 729-735 (2003).
17. Flanagan, K.F. et al. Ex vivo interferon-γ immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of Plasmodium falciparum infection. Am. J. Trop. Med. Hyg. 68, 421-430 (2003).
18. Kester, K.E. et al. Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria. J. Infect. Dis. 183, 640-647 (2001).
19. Schwenk, R. et al. Opsonization by antigen-specific antibodies as a mechanism of protective immunity induced by Plasmodium falciparum circumsporozoite protein-based vaccine. Parasite Immunol. 25, 17-25 (2003).
20. + T cells producing IFN-γ. J. Immunol. 171, 6961-6967 (2003).
21. Harrell, F.E., Califf, R.M., Pryor, D.B., Lee, K.L. & Rosati, R.A. Evaluating the yield of medical tests. JAMA 247, 2543-2546 (1982).
22. Hoffman, S.L. et al. Human lymphocyte proliferative response to a sporozoite T cell epitope correlates with resistance to falciparum malaria. J. Immunol. 142, 1299-1303 (1989).
23. Alloueche, A. et al. Protective efficacy of the RTS, S/AS02 Plasmodium falciparum malaria vaccine is not strain specific. Am. J. Trop. Med. Hyg. 68, 97-101 (2003).
24. + central and effector memory T cell subsets are largely distinct. Immunity 18, 193-204 (2003).
25. Wherry, E.J. et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 4, 225-234 (2003).
26. H1 cells have differential capacities for memory cell generation in vivo. Nat. Immunol. 3, 852-858 (2002).
27. + T cells after clearance of hepatitis C virus. J. Immunol. 169, 2210-2214 (2002).
28. Bull, P.C. et al. Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria. Nat. Med. 4, 358-360 (1998).
29. Polley, S.D. et al. Repeat sequences in block 2 of Plasmodium falciparum merozoite surface protein 1 are targets of antibodies associated with protection from malaria. Infect. Immun. 71, 1833-1842 (2003).