Cutting edge: A new tool to evaluate human pre-erythrocytic malaria vaccines: Rodent parasites bearing a hybrid Plasmodium falciparum circumsporozoite protein

Journal of Immunology

Volumn 169, Issue 12, 2002, Pages 6681-6685

  Persson, Cathrine ^a,b   Oliveira, Giane A ^a   Sultan, Ali A ^a,c   Bhanot, Purnima ^a   Nussenzweig, Victor ^a   Nardin, Elizabeth ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UMEÅ UNIVERSITY   (Sweden)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; MALARIA VACCINE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; POLYCLONAL ANTIBODY; PROTOZOAL PROTEIN; CIRCUMSPOROZOITE PROTEIN, PROTOZOAN; RECOMBINANT VACCINE;

ANIMAL MODEL; ARTICLE; IMMUNITY; IMMUNIZATION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; INFECTION; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SOUTHERN BLOTTING; SPOROZOITE; AMINO ACID SEQUENCE; ANIMAL; ANOPHELES; C57BL MOUSE; DRUG SCREENING; ERYTHROCYTE; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; IMMUNOLOGY; MALARIA FALCIPARUM; METHODOLOGY; MOLECULAR GENETICS; OOCYST; PARASITOLOGY; PHASE 1 CLINICAL TRIAL; SALIVARY GLAND; SUBCUTANEOUS DRUG ADMINISTRATION;

AMINO ACID SEQUENCE; ANIMALS; ANOPHELES; CLINICAL TRIALS, PHASE I; DRUG EVALUATION, PRECLINICAL; ERYTHROCYTES; HUMANS; INJECTIONS, SUBCUTANEOUS; MALARIA VACCINES; MALARIA, FALCIPARUM; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; OOCYSTS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; SALIVARY GLANDS; VACCINES, SYNTHETIC;

EID: 0037114136     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.12.6681     Document Type: Article

References (22)

1. Nussenzweig, V., and R. S. Nussenzweig. 1989. Rationale for the development of an engineered sporozoite malaria vaccine. Adv. Immunol. 45:283.
2. Richie, T. L., and A. Saul. 2002. Progress and challenges for malaria vaccines. Nature 415:694.
3. Bojang, K. A., P. J. Milligan, M. Pinder, L. Vigneron, A. Alloueche, K. E. Kester, W. R. Ballou, D. J. Conway, W. H. Reece, P. Gothard, et al. 2001. Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in the Gambia: a randomised trial. Lancet 358:1927.
4. Stoute, J. A., K. E. Kester, U. Krzych, B. T. Wellde, T. Hall, K. White, G. Glenn, C. F. Ockenhouse, N. Garcon, R. Schwenk, et al. 1998. Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine. J. Infect. Dis. 178:1139.
5. Stoute, J. A., M. Slaoui, D. G. Heppner, P. Momin, K. E. Kester, P. Desmons, B. T. Wellde, N. Garcon, U. Krzych, and M. Marchand. 1997. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria: RTS,S malaria vaccine evaluation group. N. Engl. J. Med. 336:86.
6. Kester, K. E., D. A. McKinney, N. Tomieporth, C. F. Ockenhouse, D. G. Heppner, T. Hall, U. Krzych, M. Delchambre, G. Voss, M. G. Dowler, et al. 2001. Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria. J. Infect. Dis. 183:640.
7. Thathy, V., H. Fujioka, S. Gantt, R. Nussenzweig, V. Nussenzweig, and R. Menard. 2002. Levels of circumsporozoite protein in the Plasmodium oocyst determine sporozoite morphology. EMBO J. 21:1586.
8. Dame, J. B., J. L. Williams, T. F. McCutchan, J. L. Weber, R. A. Wirtz, W. T. Hockmeyer, W. L. Maloy, J. D. Haynes, I. Schneider, D. Roberts, et al. 1984. Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum. Science 225:593.
9. Menard, R., A. A. Sultan, C. Cortes, R. Altszuler, M. R. van Dijk, C. J. Janse, A. P. Waters, R. S. Nussenzweig, and V. Nussenzweig. 1997. Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes. Nature 385:336.
10. Hollingdale, M. R., E. H. Nardin, S. Tharavanij, A. L. Schwartz, and R. S. Nussenzweig. 1984. Inhibition of entry of Plasmodium falciparum and P. vivax sporozoites into cultured cells: an in vitro assay of protective antibodies. J. Immunol. 132:909.
11. Yoshida, N., R. S. Nussenzweig, P. Potocnjak, V. Nussenzweig, and M. Aikawa. 1980. Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite. Science 207:71.
12. Stewart, M. J., and J. P. Vanderberg. 1988. Malaria sporozoites leave behind trails of circumsporozoite protein during gliding motility. J. Protozool. 35:389.
13. Frevert, U., P. Sinnis, J. D. Esko, and V. Nussenzweig. 1996. Cell surface glycosaminoglycans are not obligatory for Plasmodium berghei sporozoite invasion in vitro. Mol. Biochem. Parasitol. 76:257.
14. Bruna-Romero, O., J. C. Hafalla, G. Gonzalez-Aseguinolaza, G. Sano, M. Tsuji, and F. Zavala. 2001. Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR. Int. J. Parasitol. 31:1499.
15. Nardin, E. H., G. A. Oliveira, J. M. Calvo-Calle, Z. R. Castro. R. S. Nussenzweig, B. Schmeckpeper, B. F. Hall, C. Diggs, S. Bodison, and R. Edelman. 2000. Synthetic peptide malaria vaccine elicits high levels of antibodies in vaccinees of defined HLA genotypes. J. Infect. Dis. 182:1486.
16. Vanderberg, J., R. Nussenzweig, and H. Most. 1969. Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei. V. In vitro effects of immune serum on sporozoites. Mil. Med. 134:1183.
17. Munesinghe, D. Y., P. Clavijo, M. C. Calle, R. S. Nussenzweig, and E. Nardin. 1991. Immunogenicity of multiple antigen peptides (MAP) containing T and B cell epitopes of the repeat region of the P. falciparum circumsporozoite protein. Eur. J. Immunol. 21:3015.
18. Herrington, D., J. Davis, E. Nardin, M. Beier, J. Cortese, H. Eddy, G. Losonsky, M. Hollingdale, M. Sztein, M. Levine, et al. 1991. Successful immunization of humans with irradiated malaria sporozoites: humoral and cellular responses of the protected individuals. Am. J. Trop. Med. Hyg. 45:539.
19. Hoffman, S. L., L. M. Goh, T. C. Luke, I. Schneider, T. P. Le, D. L. Doolan, J. Sacci, P. de la Vega, M. Dowler, C. Paul, et al. 2002. Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. J. Infect. Dis. 185:1155.
20. Nardin, E. H., and R. S. Nussenzweig. 1993. T cell responses to pre-erythrocytic stages of malaria: role in protection and vaccine development. Annu. Rev. Immunol. 11:687.
21. Taneja, V., and C. S. David. 1999. HLA class II transgenic mice as models of human diseases. Immunol. Rev. 169:67.
22. Calvo-Calle, J. M., E. H. Nardin, P. Clavijo, C. Boudin, D. Stuber, B. Takacs, R. S. Nussenzweig, and A. H. Cochrane. 1992. Recognition of different domains of the Plasmodium falciparum CS protein by the sera of naturally infected individuals compared with those of sporozoite-immunized volunteers. J. Immunol. 149:2695.