Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine

Journal of Infectious Diseases

Volumn 180, Issue 5, 1999, Pages 1656-1664

  Lalvani, Ajit ^a,d   Moris, Phillipe ^b   Voss, Gerald ^b   Pathan, Ansar A ^a   Kester, Kent E ^c   Brookes, Roger ^a   Lee, Edwin ^a   Koutsoukos, Marguerite ^b   Plebanski, Magdalena ^a   Delchambre, Martine ^b   Flanagan, Katie L ^a   Carton, Cecile ^b   Slaoui, Moncef ^b   Van Hoecke, Christian ^b   Ballou, W Ripley ^c   Hill, Adrian V S ^a   Cohen, Joe ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b GLAXOSMITHKLINE BIOLOGICALS   (Belgium)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; MALARIA VACCINE; PROTOZOAL PROTEIN; PROTOZOON ANTIBODY; RECOMBINANT VACCINE; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMORAL IMMUNITY; IMMUNE RESPONSE; INTRAMUSCULAR DRUG ADMINISTRATION; LYMPHOCYTE PROLIFERATION; MALE; NORMAL HUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; TREATMENT PLANNING;

ADULT; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, PROTOZOAN; CD4-POSITIVE T-LYMPHOCYTES; EPITOPES; HEPATITIS B SURFACE ANTIGENS; HUMANS; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; MALARIA VACCINES; MALARIA, FALCIPARUM; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PEPTIDES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; VACCINATION; VACCINES, SYNTHETIC;

EID: 0032745349     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315074     Document Type: Article

References (27)

1. 1. World Health Organisation. Twelfth programme report of the UNDP/World Bank/WHO special programme for research and training in tropical diseases. Bull World Health Organ 1995; 12:64-76.
2. 2. Nardin EII, Nussenzweig RS. T cell responses to pre-erythrocytic stages of malaria: role in protection and vaccine development against pre-erythrocytic stages. Annu Rev Immunol 1993; 11:687-727.
3. 3. Weiss WR, Sedegah M, Berzofsky JA, Hoffman SL. The role of CD4' T cells in immunity to malaria sporozoites. J Immunol 1993; 151:2690-8.
4. 4. Renia L, Marussig MS, Grillot D, et al. In vitro activity of CD4' and CD8' T lymphocytes from mice immunized with a synthetic malaria peptide. Proc Natl Acad Sci USA 1991; 88:7963-7.
5. 5. Romero P, Maryanski JL, Corradin G, Nussenzweig RS, Nussenzweig V, Zavala F. Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria. Nature 1989; 341:323-6.
6. 6. Lanar DE, Tine JA, de Taisne C, et al. Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria. Infect Immun 1996; 64:1666-71.
7. 7. Schofield L, Villaquiran J, Ferreira A, Schellekens H, Nussenzweig R, Nussenzweig V. Gamma Interferon, CD8' T cells and antibodies required for immunity to malaria sporozoites. Nature 1987; 330:664-6.
8. 8. Herrington D, Davis J, Nardin E, et al. Successful immunization of humans with irradiated malaria sporozoites: humoral and cellular responses of the protected individuals. Am J Trop Med Hyg 1991; 45:539-47.
9. 9. Gordon DM, McGovern TW, Krzych U, et al. Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein hepatitis B surface antigen subunit vaccine. J Infect Dis 1995; 171:1576-85.
10. 10. Stoute JA, Slaoui M, Heppner DG, et al. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. N Engl J Med 1997; 336:86-91.
11. 11. Stoute JA, Kester KE, Krzych U, et al. Long-term efficacy and immune responses following immunization with the RTS.S malaria vaccine. J Infect Dis 1998; 178:1139-44.
12. 12. Lalvani A, Brookes R, Hambleton S. Britton WJ, Hill AVS, McMichael AJ. Rapid effector function in CD8' memory T cells. J Exp Med 1997; 186: 859-65.
13. 13. Lalvani A, Brookes R, Wilkinson RJ, et al. Human cytolytic and interferon gamma-secreting CD8' T lymphocytes specific for Mycobacterium tuberculosis. Proc Natl Acad Sci USA 1998; 95:270-5.
14. 14. Lalvani A, Dong T. Ogg G, et al. Optimization of a peptide-based protocol employing, IL-7 for in vitro restimulation of human cytotoxie T lymphocyte precursors. J Immunol Methods 1997; 210:65-77.
15. 15. Plebanski M, Allsopp CE, Aidoo M, Reyburn H, Hill AVS. Induction of peptide-specific primary cytotoxic T lymphocyte responses from human peripheral blood. Eur J Immunol 1995; 25:1783-7.
16. 16. Hill AVS, Elvin J, Willis AC, et al. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 1992; 360:434-9.
17. 17. Klinman DM. ELISPOT assay to detect cytokine-secreting murine and human cells. Curr Protocols Immunol 1994; 6.19:1-8.
18. 18. Good MF, Pombo D, Quakyi IA, et al. Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule. Proc Natl Acad Sci USA 1988; 85:1199-203.
19. 19. Lockyer MJ, Marsh K, Newbold CI. Wild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein. Mol Biochem Parasitol 1989; 37:275-80.
20. 20. Riley EM, Allen SJ, Bennett S, et al. Recognition of dominant T cell stimulating epitopes from the circumsporozoite protein of Plasmodium falciparum and relationship to malaria morbidity in Gambian children. Trans R Soc Trop Med Hyg 1990; 84:648-57.
21. 21. Doolan DL, Sedegah M, Hedstrom RC, Hobart P, Charoenvit Y, Hoffman SL. Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8' cell , interferon gamma , and nitric oxide-dependent immunity. J Exp Med 1996; 183:1739-46.
22. 22. Bachmann MF, Kundig TM, Hengartner H, Zinkernagel RM. Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without "memory T cells"? Proc Natl Acad Sci USA 1997; 94:640-5.
23. 23. Plehanski M, Gilbert SC, Schneider J, et al. Protection from Plasmodium berghei infection by priming and boosting T cells to a single class I restricted epitope with recombinant carriers suitable for human use. Eur J Immunol 1998; 28:4345-55.
24. 24. Scheller LF, Azad AF. Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites. Proc Natl Acad Sci USA 1995; 92:4066-8.
25. 25. Doolan DL, Hoffman SL, Southwood S, et al. Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles. Immunity 1997; 7:97-112.
26. 26. Aidoo M, Lalvani A, Allsopp CEM, et al. Identification of conserved antigenic components for a cytotoxic T lymphocyte inducing vaccine against malaria. Lancet 1995; 345:1003-7.
27. 27. Schneider J, Gilbert SC, Blanchard TJ, et al. Enhanced immunogenicity for CD8' T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nat Med 1998; 4:397-402.