Unique T cell effector functions elicited by Plasmodium falciparum epitopes in malaria-exposed Africans tested by three T cell assays

Journal of Immunology

Volumn 167, Issue 8, 2001, Pages 4729-4737

  Flanagan, K L ^a   Lee, E A M ^a   Gravenor, M B ^a   Reece, W H H ^a   Urban, B C ^a   Doherty, T ^a   Bojang, K A ^a   Pinder, M ^a   Hill, A V S ^a   Plebanski, M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GAMMA INTERFERON; INTERLEUKIN 4; MALARIA VACCINE;

ADULT; ANTIBODY PRODUCTION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; EFFECTOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GAMBIA; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MALARIA; MALE; MEMORY CELL; MONONUCLEAR CELL; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

EID: 0035887948     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.8.4729     Document Type: Article

References (75)

1. Multi-gene vaccination against malaria: A multistage, multi-immune response approach
2. Development of a malaria vaccine
3. Research towards vaccines against malaria
4. Protective immunity induced by the injection of x-irradiated sporozoites of Plasmodium berghei
5. Immunization of man against sporozoite-induced falciparum malaria
6. Circumsporozoite proteins of malaria parasites
7. The basolateral domain of the hepatocyte plasma membrane bears receptors for the circumsporozoite protein of Plasmodium falciparum sporozoites
8. Malaria circumsporozoite protein binds to heparin sulfate proteoglycans associated with the surface membrane of hepatocytes
9. Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection
10. Efficacy of murine malaria sporozoite vaccines: Implications for human vaccine development
11. Immunity to malaria and naturally acquired antibodies to the circumsporozoite protein of Plasmodium falciparum
12. T cells and antibodies required for immunity to malaria sporzoites
13. Recognition of dominant T cell-stimulating epitopes from the circumsporozoite protein of Plasmodium falciparum and relationship to malaria morbidity in Gambian children
14. Rationale for development of a synthetic vaccine against Plasmodium falciparum malaria
15. Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine
16. Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites
17. Naturally acquired antibodies to sporozoites do not prevent malaria: Vaccine development implications
18. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria
19. Plasmodium berghei: T cell dependence of sporozoite-induced immunity in rodents
20. Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: Immunodominant T-cell domains map to the polymorphic regions of the molecule
21. + T cell clones obtained from Plasmodium falciparum sporozoite-immunized volunteers recognize polymorphic sequences of the circumsporozoite protein
22. Cytotoxic T cells specific for the circumsporozoite protein of Plasmodium falciparum
23. Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria
24. Location of human cytotoxic T cell epitopes within a polymorphic domain of the Plasmodium falciparum circumsporozoite protein
25. Identification of conserved antigenic components for a cytotoxic T lymphocyte-inducing vaccine against malaria
26. Sporozoites of mammalian malaria: Attachment to, interiorization and fate within macrophages
27. The role of the Kupffer cell in the infection of rodents by sporozoites of Plasmodium: Uptake of sporozoites by perfused liver and establishment of infection in vivo
28. An ultrastructural study on the role of Kupffer cells in the process of infection by Plasmodium berghei sporozoites in rats
29. Plasmodium sporozoite interactions with macrophages in vitro: A videomicroscopic analysis
30. The role of Kupffer cells in the clearance of malaria sporozoites from the circulation
31. Plasmodium berghei-specific T cells respond to non-processed sporozoites presented by B cells
32. Plasmodium yoelii: 17-kDa hepatic and erythrocytic stage protein is the target of an inhibitory monoclonal antibody
33. A malaria heat-shock-like determinant expressed on the infected hepatocyte surface is the target of antibody-dependent cell-mediated cytotoxic mechanisms by nonparenchymal liver cells
34. Immunity to sporozoiteinduced malaria infection in mice. I. The effect of immunization of T and B cell-deficient mice
35. Studies on the transfer of protective immunity with lymphoid cells from mice immune to malaria sporozoites
36. Human lymphocyte proliferative response to a sporozoite T cell epitope correlates with resistance to falciparum malaria
37. + T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara
38. Inhibition of development of exoerythrocytic forms of malaria parasites by interferon-γ
39. Inhibitory activity of interferons and interleukin 1 on the development of Plasmodium falciparum in human hepatocyte cultures
40. Human T cell recognition of polymorphic epitopes from malaria circumsporozoite protein
41. Major population differences in T cell response to a malaria sporozoite vaccine candidate
42. Precursor frequency analysis of cytotoxic T lymphocytes to pre-erythrocytic antigens of Plasmodium falciparum in West Africa
43. Naturally acquired cellular and humeral immune responses to the major merozoite surface antigen (PfMSP1) of Plasmodium falciparum are associated with reduced malaria morbidity
44. A longitudinal study of naturally acquired cellular and humoral immune responses to a merozoite surface protein (MSP1) of Plasmodium falciparum in an area of seasonal malaria transmission
45. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
46. Functional diversity of T lymphocytes due to secretion of different cytokine patterns
47. Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand
48. Differential ability of T cell subsets to undergo activation-induced cell death
49. Unequal death in T helper cells (Th) 1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas:FasL mediated apoptosis
50. Helper T cell subsets: Phenotype, function and role of lymphokines in regulating their development
51. + memory T cells
52. Protection from Plasmodium berghei infection by priming and boosting T cells to a single class-I-restricted epitope with recombinant carriers suitable for human use
53. The circumsporozoite protein gene from NF54, a Plasmodium falciparum isolate used in malaria vaccine trials
54. High-throughput sequence typing of T-cell epitope polymorphisms in Plasmodium falciparum circumsporozoite protein
55. Broadly distributed T cell reactivity, with no immunodominant loci, to the pre-erythrocytic antigen thrombospondin-related adhesive protein of Plasmodium falciparum in West Africans
56. Production by activated human T cells of interleukin 4 but not interferon-y is associated with elevated levels of serum antibodies to activating malaria antigens
57. Diversity in the immunodominant determinants of the circumsporozoite protein of Plasmodium falciparum parasites from malaria-endemic regions of Papua New Guinea and Brazil
58. Epitopes recognized by human T lymphocytes on malaria circumsporozoite protein
59. A malaria T-cell epitope recognized in association with most mouse and human class II molecules
60. Recombinant human y interferon inhibits simian malaria
61. A systematic molecular analysis of the T cell-stimulating antigens from Mycobacterium leprae with T cell clones of leprosy patients: Identification of a novel M. leprae HSP 70 fragment by M. leprae-specific T cells
62. Analysis of cytokine production by Mycobacterium-reactive T cells: Failure to explain Mycobacterium leprae-specific nonresponsiveness of peripheral blood T cells from lepromatous leprosy patients
63. 1 mice: Implications for autoimmunity and infection
64. The hepatitis B virus core particle and e antigens elicit different Th cell subsets: Antigen structure can affect Th cell phenotype
65. γδ T cells contribute to immunity against the liver stages of malaria in α-β T-cell-deficient mice
66. αβ and γδ T cells in the immune response to the erythrocytic stages of malaria in mice
67. γδ T cells: Their immunobiology and role in malaria infections
68. + T cells in the Plasmodium yoelii model
69. Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine
70. Cell-mediated immune responses to Plasmodium falciparum antigens in adult Gambians
71. T- and B-cell responses of Plasmodium falciparum malaria-immune individuals to synthetic peptides corresponding to epitopes in the conserved repeat regions of the P. falciparum antigen Pf155/RESA
72. Cell-mediated immune responses to soluble Plasmodium falciparum antigens in residents from an area of unstable malaria transmission
73. Common West African HLA antigens are associated with protection from severe malaria
74. The immunologic significance of variation within malaria circumsporozoite protein sequences
75. Neonatal exposure to immunogenic peptides: Differential susceptibility to tolerance induction of helper T cells and B cells reactive to malarial circumsporozoite peptide epitopes