Effect of vaccination with 3 recombinant asexual-stage malaria antigens on initial growth rates of Plasmodium falciparum in non-immune volunteers

Vaccine

Volumn 18, Issue 18, 2000, Pages 1925-1931

  Lawrence, Gregor ^a   Cheng, Qin ^a   Reed, Carol ^a   Taylor, Darrin ^a   Stowers, Anthony ^a   Cloonan, Nicole ^a   Rzepczyk, Christine ^a   Smillie, Anne ^a   Anderson, Karen ^a   Pombo, David ^a   Allworth, Anthony ^b   Eisen, Damon ^a,b   Anders, Robin ^c   Saul, Allan ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^c ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Adjuvant; Human; MSP1; MSP2; Parasite growth rates; Plasmodium falciparum; RESA; Vaccine trial

Indexed keywords

ADJUVANT; AMINO ACID; ANTIBODY; DNA; IMMUNOGLOBULIN G; PARASITE ANTIGEN; VACCINE;

ANTIBODY RESPONSE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; GROWTH RATE; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; MALARIA; PAIN; PHASE 1 CLINICAL TRIAL; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; T LYMPHOCYTE; VACCINATION;

ADULT; ANIMALS; ANTIBODIES, PROTOZOAN; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LYMPHOCYTE ACTIVATION; MALARIA; MALARIA VACCINES; MALE; MIDDLE AGED; PLACEBO EFFECT; PLASMODIUM FALCIPARUM; T-LYMPHOCYTES; VACCINES, DNA;

EID: 0034001440     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00444-2     Document Type: Article

References (6)

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3. Saul A., Lawrence G., Smillie A., et al. Human phase I vaccine trials of 3 recombinant asexual stage malaria antigens with Montanide ISA720 adjuvant. Vaccine. 17:1999;3145-3159.
4. Cheng Q., Lawrence G., Reed C., et al. Measurement of Plasmodium falciparum growth rates in vivo: a test of malaria vaccines. Am. J. Trop. Med. Hyg. 57:1997;495-500.
5. Cheng Q., Cloonan N., Fischer K., et al. stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens. Mol. Biochem. Parasitol. 97:1998;161-176.
6. Saul A. Kinetic constraints on the development of a malaria vaccine. Parasite Immunol. 9:1987;1-9.