Attenuation and vaccine potential of aroQ mutants of Corynebacterium pseudotuberculosis

Infection and Immunity

Volumn 65, Issue 8, 1997, Pages 3048-3056

  Simmons, Cameron P ^a   Hodgson, Adrian L M ^b   Strugnell, Richard A ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b CSIRO   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GAMMA INTERFERON; VACCINE;

ALLELE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORYNEBACTERIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; IMMUNITY; LYMPHADENITIS; MOLECULAR CLONING; MOUSE; MUTANT; NONHUMAN; PLASMID; PRIORITY JOURNAL; SPLEEN CELL; VACCINATION;

EID: 0030807059     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.8.3048-3056.1997     Document Type: Article

References (44)

1. Alexander, J. E., P. W. Andrew, D. Jones, and I. S. Roberts. 1993. Characterization of an aromatic amino acid-dependent Listeria monocytogenes mutant: attenuation, persistence, and ability to induce protective immunity in mice. Infect. Immun. 61:2245-2248.
2. Balasubramanian, V., M. S. Pavelka, Jr., S. S. Bardarov, J. Martin, T. R. Weisbrod, R. A. McAdam, B. R. Bloom, and W. R. Jacobs, Jr. 1996. Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates. J. Bacteriol. 178:273-279.
3. Batey, R. G. 1986. Pathogenesis of caseous lymphadenitis in sheep and goats. Aust. Vet. J. 63:269-272.
4. Bowe, F., P. O'Gaora, D. Maskell, M. Cafferkey, and G. Dougan. 1989. Virulence, persistence, and immunogenicity of Yersinia enterocolitica O:8 aroA mutants. Infect. Immun. 57:3234-3236.
5. Collins, F. M. 1974. Vaccines and cell-mediated immunity. Bacteriol. Rev. 38:371-402.
6. Eisenstein, T. K., and B. M. Sultzer. 1983. Immunity to Salmonella infections. Adv. Exp. Med. Biol. 162:261-296.
7. Garbe, T., S. Servos, A. Hawkins, G. Dimitriadis, D. Young, G. Dougan, and I. Charles. 1901. The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases. Mol. Gen. Genet. 228:385-392.
8. Geever, R. F., L. Huiet, J. A. Baum, B. M. Tyler, V. B. Patel, B. J. Rutledge, M. E. Case, and N. H. Giles. 1989. DNA sequence, organization, and regulation of the qa gene cluster of Neurospora crassa. Microbiol. Rev. 207:15-34.
9. Hard, G. C. 1970. Adoptive transfer of immunity in experimental Coryne- bacterium ovis infection. J. Comp. Pathol. 80:329-334.
10. Hard, G. C. 1975. Comparative toxic effect on the surface lipid of Cornebacterium ovis on peritoneal macrophages. Infect. Immun. 12:1439-1449.
11. Hawkins, A. R., H. K. Lamb, M. Smith, J. K. Keyte, and C. F. Roberts. 1988. Molecular organisation of the quinic acid utilisation (OUT) gene cluster in Aspergillus nidulans. Mol. Gen. Genet. 214:224-231.
12. Hess, J., C. Ladel, D. Miko, and S. H. Kaufmann. 1996. Salmonella typhimurium aroA-infection in gene-targeted immunodeficient mice: major role of CD4+ TCR- alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location. J. Immunol. 156:3321-3326.
13. Hodgson, A. L., J. Krywult, L. A. Corner, J. S. Rothel, and A. J. Radford. 1992. Rational attenuation of Corynebacterium pseudotuberculosis: potential cheesy gland vaccine and live delivery vehicle. Infect. Immun. 60:2900-2905.
14. Hodgson, A. L., M. Tachedjian, L. A. Corner, and A. J. Radford. 1994. Protection of sheep against caseous lymphadenitis by use of a single oral dose of live recombinant Corynebacterium pseudotuberculosis. Infect. Immun. 62:5275-5280.
15. Hodgson, A. L. M., J. Krywult, and A. J. Radford. 1990. Nucleotide sequence of the erythromycin resistance gene from the Corynebacterium plasmid pNG2. Nucleic Acids Res. 18:1891.
16. Hohn, B., and J. Collins. 1975. A small cosmid for efficient cloning of large DNA fragments. Gene 11:291-298.
17. Hoiseth, S. K., and B. A. D. Stocker. 1981. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 291:238- 239.
18. Homchampa, P., R. A. Strugnell, and B. Adler. 1992. Molecular analysis of the aroA gene of Pasteurella multocida and vaccine potential of constructed aroA mutants. Mol. Microbiol. 8:3585-3593.
19. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilcek, R. M. Zinkernagel, and M. Aguet. 1993. Immune response in mice that lack the interferon-gamma receptor. Science 259:1742-1745.
20. Ivins, B. E., S. L. Welkos, G. B. Knudson, and S. F. Little. 1990. Immunization against anthrax with aromatic compound-dependent (AroA ) mutants of Bacillus anthracis and with recombinant strains of Bacillus subtilis that produce anthrax protective antigen. Infect. Immun. 58:303-308.
21. Jacobs, W. R., J. F. Barrett, J. E. Clarke-Curtiss, and R. Curtiss III. 1986. In vivo repackaging of recombinant cosmid molecules for analyses of Salmonella typhimurium. Streptococcus mutans, and mycobacterial genomic libraries. Infect. Immun. 52:101-109.
22. Jolly, R. D. 1965. The pathogenic action of the exotoxin of Corynebacterium ovis. J. Comp. Pathol. 75:417-431.
23. Karem, K. L., S. Chatfield, N. Kuklin, and B. T. Rouse. 1995. Differential induction of carrier antigen-specific immunity by Salmonella typhimurium live-vaccine strains after single mucosal or intravenous immunization of BALB/c mice. Infect. Immun. 63:4557-4563.
24. Kaufmann, S. H. 1993. Immunity to intracellular bacteria. Annu. Rev. Immunol. 11:129-163.
25. Lalonde, G., P. D. O'Hanley, B. A. D. Stocker, and K. T. Denich. 1994. Characterization of a 3-dehydroquinase gene from Actinobacillus pleuropneumoniae with homology to the eukaryotic genes qa-2 and QUTE. Mol. Microbiol. 11:273-280.
26. Levine, M. M., D. Herrington, J. R. Murphy, J. G. Morris, G. Losonsky, B. Tall, A. A. Lindberg, S. Svenson, S. Baqar, M. F. Edwards, and B. Stocker. 1987. Safety, infectivity, immunogenicity and in vivo stability of two attenuated auxotrophic mutant strains of Salmonella typhi, 541Ty and 543Ty, as live oral vaccines in humans. J. Clin. Invest. 79:888-902.
27. Nnalue, N. A., and B. A. D. Stocker. 1987. Tests of the virulence and live-vaccine efficacy of auxotrophic and galE derivatives of Salmonella choleraesuis. Infect. Immun. 55:955-962.
28. O'Callaghan, D., D. Maskell, F. Y. Liew, C. S. F. Easmon, and G. Dougan. 1988. Characterization of aromatic- and purine-dependent Salmonella typhimurium: attenuation, persistence, and ability to induce protective immunity in BALB/c mice. Infect. Immun. 56:419-423.
29. Oyston, P. C. F., P. Russell, E. D. Williamson, and R. W. Titball. 1996. An aroA mutant of Yersinia pestis is attenuated in guinea pigs, but virulent in mice. Microbiology 142:1847-1853.
30. Paton, M. 1993. Control of cheesy gland in sheep. West. Aust. J. Agric. 34:31-37.
31. Paton, M. W., A. R. Mercy, F. C. Wilkinson, J. J. Gardner, S. S. Sutherland, and T. M. Ellis. 1988. The effects of caseous lymphadenitis on wool production and bodyweight in young sheep. Aust. Vet. J. 65:117-119.
32. Pittard, J., and B. J. Wallace. 1966. Distribution and function of genes with aromatic biosynthesis in Escherichia coli. J. Bacteriol. 91:1494-1508.
33. Pogson, C. A., C. P. Simmons, R. A. Strugnell, and A. L. M. Hodgson. 1996. Cloning and manipulation of the Corynebacterium pseudotuberculosis recA gene for live vaccine vector development. FEMS Microbiol. Lett. 142:139- 145.
34. Radford, A. J., and A. L. M. Hodgson. 1991. Construction and characterization of a Mycobacterium-Escherichia coli shuttle vector. Plasmid 25:149-153.
35. Reed, L. J., and H. Muench. 1938. A simple method for estimating fifty percent endpoints. Am. J. Hyg. 27:493-497.
36. Roberts, M., D. Maskell, P. Novotny, and G. Dougan. 1990. Construction and characterization in vivo of Bordetella pertussis aroA mutants. Infect. Immun. 58:732-739.
37. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual. 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbo, N.Y.
38. Schijns, V. E., B. L. Haagmans, E. O. Rijke, S. Huang, M. Aguet, and M. C. Horzinek. 1994. IFN-gamma receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses. J. Immunol. 153:2029-2037.
39. Swihart, K., U. Fruth, N. Messmer, K. Hug, R. Behin, S. Huang, G. Del Giudice, M. Aguet, and J. A. Louis. 1995. Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response. J. Exp. Med. 181:961-971.
40. Szalay, G., C. H. Ladel, and S. H. Kaufmann. 1995. Stimulation of protective CD8+ T lymphocytes by vaccination with nonliving bacteria. Proc. Natl. Acad. Sci. USA 92:12389-12392.
41. Tachedjian, M., J. Krywult, R. J. Moore, and A. L. M. Hodgson. 1995. Caseous lymphadenitis vaccine development: site-specific inactivation of the Corynebacterium pseudotuberculosis phospholipase D gene. Vaccine 13:1785-1792.
42. Vaughn, L. M., P. R. Smith, and T. J. Foster. 1993. An aromatic-dependent mutant of the fish pathogen Aeromonas salmonicida is attenuated in fish and is effective as a live vaccine against the salmonid disease furunculosis. Infect. Immun. 61:2172-2181.
43. Verma, N. K., and A. A. Lindberg. 1991. Construction of aromatic dependent Shigella flexneri 2a live vaccine candidate strains: deletion mutations in the aroA and the aroD genes. Vaccine 9:6-9.
44. Zhang, Y., J. Praszkier, A. Hodgson and A. J. Pittard. 1994. Molecular analysis and characterization of a broad-host-range plasmid, pEP2. J. Bacteriol. 176:5718-5728.