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Volumn 304, Issue 5670, 2004, Pages 581-584

The Fine-Scale Structure of Recombination Rate Variation in the Human Genome

Author keywords

[No Author keywords available]

Indexed keywords

GENES; NUCLEIC ACIDS;

EID: 2142773942     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1092500     Document Type: Article
Times cited : (788)

References (44)
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    • note
    • Analysis of 4337 SNPs genotyped in 96 individuals takes ∼3 hours computer processing time on a 2.4 Ghz processor with 1 Gbyte random access memory (RAM).
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    • note
    • er per kilobase) are rescated by the genetic distance across the region as estimated from pedigree data to provide rate estimates in centimorgans per megabase.
  • 25
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    • note
    • If the recombination rate were constant in females, the sex-averaged recombination rate outside hotspots would be at least 1 cM/Mb, much higher than we estimate.
  • 28
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    • unpublished observations
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    • unpublished observations
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    • note
    • Thanks to G. Coop, D. Falush, J. Marchini, M. Przeworski, D. Reich, D. Sherratt, M. Stephens, C. Spencer, and three anonymous reviewers for discussion and comments on the manuscript. The work was supported by the Royal Society, the Nuffield Trust, the Wellcome Trust, NIH, and The SNP Consortium.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.