Proteomics: Technologies and applications

Briefings in Functional Genomics and Proteomics

Volumn 1, Issue 1, 2002, Pages 23-39

  Molloy, Mark P ^a   Witzmann, Frank A ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Moss spectometry; Proteomics; Technologies; Toxicology; Two dimensional electrphoresis

Indexed keywords

PROTEIN;

ARTICLE; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; METHODOLOGY; PH; PROTEOMICS; SOLUBILITY; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HYDROGEN-ION CONCENTRATION; MASS SPECTROMETRY; PROTEINS; PROTEOMICS; SOLUBILITY;

EID: 3242885987     PISSN: 14739550     EISSN: 14774062     Source Type: Journal    
DOI: 10.1093/bfgp/1.1.23     Document Type: Article

References (109)

1. International Human Genome Sequencing Consortium (IHGSC) (2001), 'initial sequencing and analysis of the human genome', Nature, Vol. 409, pp. 860-921.
2. Venter, J. C, Adams, M. D., Myers, E. W. et al. (2001), 'The sequence of the human genome', Science, Vol. 291, pp. 1304-1351. (Pubitemid 32173090)
3. Deinen, D., Brancia, F. L. and Oliver, S. G. (2001), 'Towards a truly integrative biology through the functional genomics of yeast', Curr. Opin. Biotechnol, Vol. 12, pp. 87-91. (Pubitemid 32843150)
4. Parinov, S. and Sundaresan, V. (2000), 'Functional genomics in Arabidopsis: large-scale insertional mutagenesis complements the genome sequencing project', Curr. Opin. Biotechnol., Vol. 11, pp. 157-161. (Pubitemid 30182309)
5. Alizadeh, A. A., Eisen, M. B., Davis, R. E. et al. (2000), 'Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling', Nature, Vol. 403, pp. 503-511. (Pubitemid 30082188)
6. Wilkins, M. R., Sanchez, J.-C, Gooley, A. A. et al. (1995), 'Progress with proteome projects: why all proteins expressed by a genome should be identified and how to do it', Biotechnol. Genet. Eng. Rev., Vol. 13, pp-19-50.
7. Anderson, N. L. and Anderson, N.G. (1998), 'Proteome and proteomics: new technologies, new concepts, and new words. Electrophoresis, Vol. 19, pp. 1853-1861. (Pubitemid 28392230)
8. Anderson, L. and Seilhamer, J. (1997), 'A comparison of selected mRNA and protein abundances in human liver', Electrophoresis, Vol. 18, pp. 533-537. (Pubitemid 27174443)
9. Gygi, S. P., Rochon, Y., Franza, B. R. and Aebersold, R. (1999), 'Correlation between proteins and mRNA abundance in yeast', Mol. Cell. Biol., Vol. 19, pp. 1720-1730. (Pubitemid 29098230)
10. Corthals, G. L., Wasinger, V. C, Hochstrasser, D.F. and Sanchez, J.-C. (2000), 'The dynamic range of protein expression: a challenge for proteomic research', Electrophoresis, Vol. 21, pp. 1104-1115. (Pubitemid 30230776)
11. Gygi, S. P., Corthals, G. L., Zhang, Y., Rochon, Y. and Aebersold, R. (2000), 'Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology', Proc. Natl. Acad. Sci. USA, Vol. 97, pp. 9390-9395. (Pubitemid 30650785)
12. VanBogelen, R. A., Schiller, E. E., Thomas, J. D. and Neidhardt, F. C. (1999), 'Diagnosis of cellular states of microbial organisms using proteomics', Electrophoresis, Vol. 20, pp. 2149-2159. (Pubitemid 29413305)
13. Molloy, M. P., Herbert, B. R., Walsh, B. J. and Tyler, M. I. (1998), 'Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis', Electrophoresis, Vol. 19, pp. 837-844. (Pubitemid 28236692)
14. Molloy, M. P., Herbert, B. R., Williams, K. L. and Gooley, A. A. (1999), 'Extraction of Escherichia coli proteins with organic solvents prior to two-dimensional electrophoresis', Electrophoresis, Vol. 20, pp. 701-704. (Pubitemid 29222418)
15. Molloy, M. P., Herbert, B. R., Slade, M. B. et al. (2000), 'Proteomic analysis of the Escherichia coli outer membrane', Eur. J. Biochem., Vol. 267, pp. 2871-2881. (Pubitemid 30321332)
16. Molloy, M. P., Phadke, N. D., Maddock J. R. and Andrews, P. C. (2001), 'Two-dimensional electrophoresis and peptide mass fingerprinting of bacterial outer membrane proteins', Electrophoresis, Vol. 22, pp. 1686-1696.
17. Fialka, I., Pasquali, C, Lottspeich, F., Ahorn, H. and Huber, L. A. (1997), 'Subcellular fractionation of polarized epithelial cells and identification of organelle-specific proteins by two-dimensional gel electrophoresis', Electrophoresis, Vol. 18, pp. 2582-2590. (Pubitemid 28133340)
18. Fialka, I., Steinlein, P., Ahorn, H. et al. (1999), 'Identification of syntenin as a protein of the apical early endocytic compartment in Madin-Darby canine kidney cells', J. Biol. Chem., Vol. 274, pp. 26233-26239.
19. Rabilloud, T., Kieffer, S., Procaccio, V. et al. (1998), 'Two-dimensional electrophoresis of human placental mitochondria and protein identification by mass spectrometry: toward a human mitochondrial proteome', Electrophoresis, Vol. 19, pp. 1006-1014. (Pubitemid 28239970)
20. Jung, E., Hoogland, C, Chiappe, D., Sanchez, J.-C. and Hochstrasser, D. F. (2000), 'The establishment of a human liver nuclei two-dimensional electrophoresis reference map', Electrophoresis, Vol. 21, pp. 3483-3487.
21. Muller, E. C, Schumann, M., Rickers, A., Bommert, K., Wittmann-Liebold, B. and Otto, A. (1999), 'Study of Burkitt lymphoma cell line proteins by high resolution two-dimensional gel electrophoresis and nanoelectrospray mass spectroscopy', Electrophoresis, Vol. 20, pp. 320-330. (Pubitemid 29125019)
22. Jung, E., Heller, M., Sanchez, J.-C. and Hochstrasser, D. F. (2000), 'Proteomics meets cell biology: the establishment of subcellular proteomes', Electrophoresis, Vol. 21, pp. 3369-3377.
23. Bell, A. W., Ward, M. A., Freeman, H. N. et al. (2001), 'Proteomics characterization of abundant Golgi membrane proteins', J. Biol. Chem., Vol. 276, pp. 5152-5165.
24. Zinser, E. and Daum, G. (1995), 'Isolation and biochemical characterization of organelles from the yeast, Saccharomyces cerevisiae', Yeast, Vol. 11, pp. 493-436.
25. Corthals, G. L., Molloy, M. P., Herbert, B. R., Williams, K. L. and Gooley, A. A. (1997), 'Prefractionation of protein samples prior to two-dimensional electrophoresis', Electrophoresis, Vol. 18, pp. 317-323. (Pubitemid 27174414)
26. Righetti, P. G., Bossi, A., Wenisch, E. and Orsini, G. (1997), 'Protein purification in multicompartment electrolyzers with isoelectric membranes', J. Chromatogr. B. Biomed. Sci. Appl., Vol. 699, pp. 105-115. (Pubitemid 27473707)
27. Herbert, B. and Righetti, P. G. (2000), 'A turning point in proteome analysis: sample prefractionation via multicompartment electrolyzers with isoelectric membranes', Electrophoresis, Vol. 21, pp. 3639-3648.
28. Zuo, X. and Speicher, D. W. (2000), 'A method for global analysis of complex proteomes using sample prefractionation by solution isoelectrofocusing prior to two-dimensional electrophoresis', Anal. Biochem., Vol. 284, pp. 266-278.
29. Rabilloud, T. (Ed.) (2000), 'Proteome Research: Two-Dimensional Gel Electrophoresis and Identification Methods', Springer, Berlin.
30. Gorg, A., Obermaier, C., Boguth, G. et al. (2000), 'The current state of two-dimensional electrophoresis with immobilized pH gradients', Electrophoresis, Vol. 21, pp. 1037-1053. (Pubitemid 30230771)
31. Adessi, C., Miege, C., Albrieux, C. and Rabilloud, T. (1997), 'Two-dimensional electrophoresis of membrane proteins: a current challenge for immobilized pH gradients', Electrophoresis, Vol. 18, pp. 127-135. (Pubitemid 27073661)
32. Wildgruber, R., Harder, A., Obermaier, C. et al. (2000), 'Towards higher resolution: two-dimensional electrophoresis of Saccharomyces cerevisiae proteins using overlapping narrow immobilized pH gradients', Electrophoresis, Vol. 21, pp. 2610-2616. (Pubitemid 30646295)
33. Hoving, S., Voshol, H. and van Oostrum, J. (2000), 'Towards high performance two-dimensional gel electrophoresis using ultrazoom gels', Electrophoresis, Vol. 21, pp. 2617-2621. (Pubitemid 30646296)
34. Gorg, A., Obermaier, C, Boguth, G., Csordas, A., Diaz, J. J. and Madjar, J. J. (1997), 'Very alkaline immobilized pH gradients for two-dimensional electrophoresis of ribosomal and nuclear proteins', Electrophoresis, Vol. 18, pp. 328-337. (Pubitemid 27174416)
35. Chiari, M., Micheletti, C, Nesi, M., Fazio, M. and Righetti, P. G. (1994), 'Towards new formulations for Polyacrylamide matrices: N-acryloylaminoethoxyethanol, a novel monomer combining high hydrophilicity with extreme hydrolytic stability', Electrophoresis, Vol. 15, pp. 177-186. (Pubitemid 24103898)
36. Molloy, M. P. (2000), 'Two-dimensional electrophoresis of membrane proteins using immobilized pH gradients', Anal. Biochem., Vol. 280, pp. 1-10. (Pubitemid 30210805)
37. Chevallet, M., Santoni, V., Poinas, A. et al. (1998), 'New zwitterionic detergents improve the analysis of membrane proteins by two-dimensional electrophoresis', Electrophoresis, Vol. 19, pp. 1901-1909. (Pubitemid 28392235)
38. Rabilloud, T., Blisnick, T., Heller, M. et al. (1999), 'Analysis of membrane proteins by two-dimensional electrophoresis: comparison of the proteins extracted from normal or Plasmodium falciparum-infected erythrocyte ghosts', Electrophoresis, Vol. 20, pp. 3603-3610. (Pubitemid 30007258)
39. Santoni, V., Molloy, M. and Rabilloud, T. (2000), 'Membrane proteins and proteomics: un amour impossible?' Electrophoresis, Vol. 21, pp. 1054-1070. (Pubitemid 30230772)
40. Shevchenko, A., Wilm, M., Vorm, O. and Mann, M. (1996), 'Mass spectrometric sequencing of proteins silver-stained Polyacrylamide gels', Anal. Chem., Vol. 68, pp. 850-858.
41. Berggren, K., Chernokalskaya, E., Steinberg, T. H. et al. (2000), 'Background-free, high sensitivity staining of proteins in one- and two-dimensional sodium dodecyl sulfate-polyacrylamide gels using a luminescent ruthenium complex', Electrophoresis, Vol. 21, pp. 2509-2521. (Pubitemid 30484941)
42. Smilansky, Z. (2001), 'Automatic registration for images of two-dimensional protein gels', Electrophoresis, Vol. 22, pp. 1616-1626.
43. Link, A. J., Eng, J., Schieltz, D. M. et al. (1999), 'Direct analysis of protein complexes using mass spectrometry', Nat. Biotech., Vol. 17, pp. 676-682. (Pubitemid 29316146)
44. Washburn, M. P., Wolters, D. and Yates, J. R. (2001), 'Large-scale analysis of the yeast proteome by multidimensional protein identification technology', Nat. Biotech., Vol. 19, pp. 242-247. (Pubitemid 32220565)
45. Gygi, S. P., Rist, B., Gerber, S. A., Turecek, F., Gelb, M. H. and Aebersold, R. (1999), 'Quantitative analysis of complex protein mixtures using isotope-coded affinity tags'. Nat. Biotech., Vol. 17, pp. 994-999. (Pubitemid 29474856)
46. Henzel, W. J., Billed, T. M., Stults, J. T., Wong, S. C., Grimley, C. and Watanabe, C. (1993), 'Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases', Proc. Natl. Acad. Sci. USA, Vol. 90, pp. 5011-5015. (Pubitemid 23182965)
47. Tonella, L., Walsh, B. J., Sanchez, J.-C. et al. (1998), '98 Escherichia coli SWISS-2DPAGE database update', Electrophoresis, Vol. 19, pp. 1960-1971. (Pubitemid 28392241)
48. Langen, H., Takacs, B., Evers, S. et al. (2000), 'Two-dimensional map of the proteome of Haemophilus influenzae', Electrophoresis, Vol. 21, pp. 411-429. (Pubitemid 30074736)
49. Perrot, M., Sagliocco, F., Mini, T. et al. (1999), 'Two-dimensional gel protein database of Saccharomyces cerevisiae (update 1999)', Electrophoresis, Vol. 20, pp. 2280-2298. (Pubitemid 29413317)
50. Futcher, B., Latter, G. I., Monardo, P., McLaughlin, C. S. and Garrels, J. I. (1999), 'A sampling of the yeast proteome', Mol. Cell. Biol., Vol. 19, pp. 7357-7368. (Pubitemid 29493399)
51. Mann, M. and Wilm, M. (1994), 'Error-tolerant identification of peptides in sequence databases by peptide sequence tags', Anal. Chem., Vol. 66, pp. 4390-4399. (Pubitemid 124006101)
52. Ducret, A., Van Oostveen, I., Eng, J. K., Yates, J. R. and Aebersold, R. (1998), 'High throughput protein characterization by automated reverse-phase chromatography/ electrospray tandem mass spectrometry', Protein Sci., Vol. 7, pp. 706-719. (Pubitemid 28130893)
53. Yates, J. R., Eng, J. K. and McCormack, A. L. (1995), 'Mining genomes: correlating tandem mass spectra of modified and unmodified peptides to sequences in nucleotide databases', Anal. Chem., Vol. 67, pp. 3202-3210.
54. Oda, Y., Huang, K., Cross, F. R., Cowburn, D. and Chait, B. T. (1999), 'Accurate quantitation of protein expression and site-specific phosphorylation', Proc. Natl. Acad. Sci. USA, Vol. 96, pp. 6591-6596. (Pubitemid 29274927)
55. Gressner, A. M. (1979), 'Two-dimensional electrophoretic analysis of ribosomal proteins from chronically injured liver', J. Clin. Chem. Clin. Biochem., Vol. 17, pp. 541-545. (Pubitemid 9243136)
56. Anderson, N. G. and Anderson, N. L. (1978), 'Analytical techniques for cell fractions. XXL Two-dimensional analysis of serum and tissue proteins: multiple isoelectric focusing', Anal. Biochem., Vol. 85, pp. 331-340. (Pubitemid 9059195)
57. Anderson, N. L. and Anderson, N. G. (1978), 'Analytical techniques for cell fractions. XXII. Two-dimensional analysis of serum and tissue proteins: multiple gradient-slab gel electrophoresis', Anal. Biochem., Vol. 85, pp. 341-354. (Pubitemid 9059196)
58. Garrels, J. I. (1989), 'The QUEST system for quantitative analysis of two-dimensional gels', J. Biol. Chem., Vol. 264, pp. 5269-5282.
59. Anderson, N. L., Esquer-Blasco, R., Hofmann, J. P. and Anderson, N. G. (1991), 'A two-dimensional gel database of rat liver proteins useful in gene regulation and drug effects studies', Electrophoresis, Vol. 12, pp. 907-930.
60. VanBogelen, R. A., Abshire, K. Z., Pertsemlidis, A., Clark, R. L. and Neidhardt, F. C. (1996), 'Gene-Protein Database of Escherichia coli K-12', in Neidhardt, F. C, Ed., 'Escherichia coli and Salmonella: Molecular and Cellular Biology', ASM Press, Washington, DC, pp. 2067-2117.
61. Randic, M., Witzmann, F. A., Vracko, M. and Basak, S. (in press), 'On characterization of proteomic maps and chemically induced changes in proteomes using matrix invariants: applications to peroxisome proliferators', Med. Chem. Res.
62. Wirth, P. J., Rao, M. S. and Evarts, R. P. (1987), 'Coordinate polypeptide expression during hepatocarcinogenesis in male F-344 rats: comparison of the Solt-Farber and Reddy models', Cancer Res., Vol. 47, pp. 2839-2851. (Pubitemid 17113425)
63. Watanabe, T., Lalwani, N. D. and Reddy, J. K. (1985), 'Specific changes in the protein composition of rat liver in response to the peroxisome proliferators ciprofibrate, Wy-14, 643 and di-(2-ethylhexyl)phthalate', Biochem. J., Vol. 227, pp. 767-775. (Pubitemid 15044652)
64. Giometti, C. S., Tollaksen, S. L., Liang, X. and Cunningham, M. L. (1998), 'A comparison of liver protein changes in mice and hamsters treated with the peroxisome proliferator Wy-14, 643', Electrophoresis, Vol. 19, pp. 2498-2505. (Pubitemid 28483219)
65. Anderson, N. L., Esquer-Blasco, R., Richardson, F., Foxworthy, P. and Eacho, P. (1996), 'The effects of peroxisome proliferators on protein abundances in mouse liver', Toxicol. Appl. Pharmacol., Vol. 137, pp. 75-89. (Pubitemid 26095861)
66. Chevalier, S., Macdonald, N., Tonge, R. et al. (2000), 'Proteomic analysis of differential protein expression in primary hepatocytes induced by EGF, tumour necrosis factor alpha or the peroxisome proliferator nafenopin', Eur. J. Biochem., Vol. 267, pp. 4624-4634. (Pubitemid 30619451)
67. Fountoulakis, M., Berndt, P., Boelsterli, U. A. et al. (2000), 'Two-dimensional database of mouse liver proteins: changes in hepatic protein levels following treatment with acetaminophen or its nontoxic regioisomer 3-acetamidophenol', Electrophoresis, Vol. 21, pp. 2148-2161. (Pubitemid 30435815)
68. Macdonald, N., Barrow, K., Tonge, R., Davison, M., Roberts, R. A. and Chevalier, S. (2000), 'PPARalpha-dependent alteration of GRP94 expression in mouse hepatocytes', Biochem. Biophys. Res. Commun., Vol. 277, pp. 699-704.
69. Tonge, R., Shaw, J. and Middleton, B. (2001), 'Validation and development of fluorescence two-dimensional differential gel electrophoresis proteomics technology', Proteomics, Vol. 1, pp. 377-396. (Pubitemid 33585112)
70. Witzmann, F. A., Fultz, C. D., Grant, R. A., Wright, L. S., Kornguth, S. E. and Siegel, F. L. (1999), 'Regional protein alterations in rat kidneys induced by lead exposure', Electrophoresis, Vol. 20, pp. 943-951. (Pubitemid 29222453)
71. Aicher, L., Wahl, D., Arce, A., Grenet, O. and Steiner, S. (1998), 'New insights into cyclosporine A nephrotoxicity by proteome analysis', Electrophoresis, Vol. 19, pp. 1998-2003. (Pubitemid 28392245)
72. Witzmann, F. A., Bauer, M. D., Fieno, A. M. et al. (2000), 'Proteomic analysis of the renal effects of simulated occupational jet fuel exposure', Electrophoresis, Vol. 21, pp. 976-984. (Pubitemid 30194078)
73. Lame, M. W., Jones, A. D., Wilson, D.W., Dunston, S. K. and Segall, H.J. (2000), 'Protein targets of monocrotaline pyrrole in pulmonary artery endothelial cells', J. Biol. Chem., Vol. 275, pp. 29091-29099.
74. von Bredow, C, Birrer, P. and Griese, M. (2001), 'Surfactant protein A and other bronchoalveolar lavage fluid proteins are altered in cystic fibrosis', Eur. Respir. J., Vol. 17, pp. 716-722. (Pubitemid 32492562)
75. Sabounchi-Schutt, F., Astrom, J., Eklund, A., Grunewald, J. and Bjellqvist, B. (2001), 'Detection and identification of human bronchoalveolar lavage proteins using narrow-range immobilized pH gradient DryStrip and the paper bridge sample application method', Electrophoresis, Vol. 22, pp. 1851-1860.
76. Morris, S. M., Pipkin, J. L., Hinson, W. G. et al. (2001), 'Decreased in vitro interaction between p53 and nuclear stress proteins in the p53-deficient mouse', Electrophoresis, Vol. 22, pp. 2092-2097. (Pubitemid 32621939)
77. Gandley, R., Anderson, L. and Silbergeld, E. K. (1999), 'Lead: male-mediated effects on reproduction and development in the rat', Environ. Res., Vol. 80, pp. 355-363. (Pubitemid 29218358)
78. Arnott, D., O'Connell, K. L., King, K. L. and Stults, J. T. (1998), 'An integrated approach to proteome analysis: identification of proteins associated with cardiac hypertrophy', Anal. Biochem., Vol. 258, pp. 1-18. (Pubitemid 28163137)
79. Krapfenbauer, K., Berger, M., Lubec, G. and Fountoulakis, M. (2001), 'Changes in the brain protein levels following administration of kainic acid', Electrophoresis, Vol. 22, pp. 2086-2091. (Pubitemid 32621938)
80. Krapfenbauer, K., Berger, M., Friedlein, A., Lubec, G. and Fountoulakis, M. (2001), 'Changes in the levels of low-abundance brain proteins induced by kainic acid', Eur. J. Biochem., Vol. 268, pp. 3532-3537. (Pubitemid 32862945)
81. Eberini, I., Miller, I., Gemeiner, M. et al. (1999), 'A web site for the rat serum protein study group', Electrophoresis, Vol. 20, pp. 3599-3602. (Pubitemid 30007257)
82. Weinreb, O., Dovrat, A., Dunia, I., Benedetti, E. L. and Bloemendal, H. (2001), 'UV-A-related alterations of young and adult lens water-insoluble alpha-crystallin, plasma membranous and cytoskeletal proteins', Eur. J. Biochem., Vol. 268, pp. 536-543. (Pubitemid 32862611)
83. Prasad, S. C, Soldatenkov, V. A., Kuettel, M. R., Thraves, P. J., Zou, X. and Dritschilo, A. (1999), 'Protein changes associated with ionizing radiation-induced apoptosis in human prostate epithelial tumor cells', Electrophoresis, Vol. 20, pp. 1065-1074. (Pubitemid 29222469)
84. Nakasono, S. and Saiki, H. (2000), 'Effect of ELF magnetic fields on protein synthesis in Escherichia coli K 12', Radiat. Res., Vol. 154, pp. 208-216. (Pubitemid 30612922)
85. Stancato, L. F. and Petricoin, E. F. III (2001), 'Fingerprinting of signal transduction pathways using a combination of anti-phosphotyrosine innnunoprecipitations and two-dimensional Polyacrylamide gel electrophoresis', Electrophoresis, Vol. 22, pp. 2120-2124. (Pubitemid 32621943)
86. Liu, J., Squibb, K. S., Akkerman, M., Nordberg, G. F., Lipsky, M. and Fowler, B. A. (1996), 'Cytotoxicity, zinc protection, and stress protein induction in rat proximal tubule cells exposed to cadmium chloride in primary cell culture', Ren. Fail, Vol. 18, pp. 867-882. (Pubitemid 26399125)
87. Sanders, B. M, Nguyen, J., Martin, L. S., Howe, S. R. and Coventry, S. (1995), 'Induction and subcellular localization of two major stress proteins in response to copper in the fathead minnow Pimephales promelas', Comp. Biochem. Physiol. C Pharmacol Toxicol Endocrinol, Vol. 112, pp. 335-343. (Pubitemid 26038871)
88. Joubert-Caron, R., Feuillard, J., Kohanna, S. et al. (1999), 'A computer-assisted two-dimensional gel electrophoresis approach for studying the variations in protein expression related to an induced functional repression of NFkappaB in lymphoblastoid cell lines', Electrophoresis, Vol. 20, pp. 1017-1026. (Pubitemid 29222463)
89. Mascarell, L., Frey, J. R., Michel, F., Lefkovits, I. and Truffa-Bachi, P. (2000), 'Increased protein synthesis after T cell activation in presence of cyclosporin A', Transplantation, Vol. 70, pp. 340-348. (Pubitemid 30602755)
90. John, N. E., Andersen, H. U., Fey, S. J. et al. (2000), 'Cytokine- or chemically-derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans', Diabetes, Vol. 49, pp. 1819-1829.
91. Parrish, A. R., Zheng, X. H., Turney, K. D., Younis, H. S. and Gandolfi, A.J. (1999), 'Enhanced transcription factor DNA binding and gene expression induced by arsenite or arsenate in renal slices', Toxicol. Sci., Vol. 50, pp. 98-105. (Pubitemid 29344516)
92. Drahushuk, A. T., McGarrigle, B. P., Larsen, K. E., Stegeman, J. J. and Olson, J. R. (1998), 'Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture', Carcinogenesis, Vol. 19, pp. 1361-1368. (Pubitemid 28409832)
93. Witzmann, F. A., Fultz, C. D. and Wyman, J. F. (1997), 'Two-dimensional electrophoresis of precision-cut testis slices: toxicologic application', Electrophoresis, Vol. 18, pp. 642-646. (Pubitemid 27174460)
94. Banks, R. E., Dunn, M.J., Forbes, M. A. et al. (1999), 'The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis - preliminary findings', Electrophoresis, Vol. 20, pp. 689-700. (Pubitemid 29222417)
95. Simone, N. L., Paweletz, C. P., Charboneau, L., Petricoin, E. F. III and Liotta, L. A. (2000), 'Laser capture microdissection: beyond functional genomics to proteomics', Mol. Diagn., Vol. 5, pp. 301-307. (Pubitemid 32622202)
96. Cohen, S. D., Pumford, N. R., Khairallah, E. A. et al. (1997), 'Selective protein covalent binding and target organ toxicity', Toxicol Appl. Pharmacol, Vol. 143, pp. 1-12. (Pubitemid 27130601)
97. Anderson, N. L., Copple, D. C, Bendele, R.A., Probst, G. S. and Richardson, F. C. (1992), 'Covalent protein modifications and gene expression changes in rodent liver following administration of methapyrilene: a study using two-dimensional electrophoresis, Fundam. Appl. Toxicol, Vol. 18, pp. 570-580.
98. Myers, T. G., Dietz, E. C, Anderson, N.L. Khairallah, E. A., Cohen, S. D. and Nelson, S. D. (1995), 'A comparative study of mouse liver proteins arylated by reactive metabolites of acetaminophen and its nonhepatotoxic regioisomer, 3'-hydroxyacetanilide', Chem. Res. Toxicol, Vol. 8, pp. 403-413.
99. Frey, N., Christen, U., Jeno, P. et al (1995), 'The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis', Chem. Res. Toxicol, Vol. 8, pp. 736-746.
100. Ndikum-Moffor, F. M., Munson, J. W., Bokinkere, N. K., Brown, J. L., Richards, N. and Roberts, S. M. (1998), 'Immunochemical detection of hepatic cocaine-protein adducts in mice', Chem. Res. Toxicol, Vol. 11, pp. 185-192. (Pubitemid 28141745)
101. Conrad, C. C, Choi, J., Malakowsky, C.A. et al. (2001), 'Identification of protein carbonyls after two-dimensional electrophoresis', Proteomics, Vol. 1, pp. 829-834. (Pubitemid 33587408)
102. Witzmann, F. A., Jarnot, B. M., Parker, D. N. and Clack, J. W. (1994), 'Modification of hepatic immunoglobulin heavy chain binding protein (BiP/Grp78) following exposure to structurally diverse peroxisome proliferators', Fundam. Appl Toxicol, Vol. 23, pp. 1-8. (Pubitemid 24247974)
103. Witzmann, F. A., Fultz, C. D., Mangipudy, R. S. and Mehendale, H. M. (1996), 'Two-dimensional electrophoretic analysis of compartment-specific hepatic protein charge modification induced by thioacetamide exposure in rats', Fundam. Appl Toxicol, Vol. 31, pp. 124-132.
104. Nerland, D. E., Cai, J., Pierce, W. M., Jr. and Benz, F. W. (2001), 'Covalent binding of acrylonitrile to specific rat liver glutathione s-transferases in vivo', Chem. Res. Toxicol, Vol. 14, pp. 799-806. (Pubitemid 32661334)
105. Cai, H. and Guengerich, F. P. (2001), 'Reaction of trichloroethylene and trichloroethylene oxide with cytochrome P450 enzymes: inactivation and sites of modification', Chem. Res. Toxicol, Vol. 14, pp. 451-458. (Pubitemid 32367479)
106. Mason, D. E. and Liebler, D. C. (2000), 'Characterization of benzoquinone-peptide adducts by electrospray mass spectrometry', Chem. Res. Toxicol, Vol. 13, pp. 976-982.
107. Anderson, N. G., Matheson, A. and Anderson, N. L. (2001), 'Back to the future: the human protein index (HPI) and the agenda for post-proteomic biology', Proteomics, Vol. 1, pp. 3-12. (Pubitemid 33791868)
108. Burchiel, S. W., Knall, C. M, Davis, J. W. II, Paules, R. S., Boggs, S. E. and Afshari, C. A. (2001), 'Analysis of genetic and epigenetic mechanisms of toxicity: potential roles of toxicogenomics and proteomics in toxicology', Toxicol. Sci., Vol. 59, pp. 193-195. (Pubitemid 32149548)
109. Ideker, T., Thorsson, V., Ranish, J. A. et al. (2001), 'Integrated genomic and proteomic analyses of a systematically perturbed metabolic network', Science, Vol. 292, pp. 929-934. (Pubitemid 32422490)