Cytotoxicity, zinc protection, and stress protein induction in rat proximal tubule cells exposed to cadmium chloride in primary cell culture

Renal Failure

Volumn 18, Issue 6, 1996, Pages 867-882

  Liu, Jenny ^a,d   Squibb, Katherine S ^b,c   Akkerman, Mirriam ^b   Nordberg, Gunnar F ^a   Lipsky, Michael ^c   Fowler, Bruce A ^b,c  

^a UMEÅ UNIVERSITY   (Sweden)

^b UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d Burke Laboratory ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM CHLORIDE; GENE PRODUCT; HEAT SHOCK PROTEIN; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CADMIUM POISONING; CELL ULTRASTRUCTURE; CELL VIABILITY; CONTROLLED STUDY; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MALE; NEPHROTOXICITY; NONHUMAN; POLLUTANT; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT;

EID: 0029908344     PISSN: 0886022X     EISSN: None     Source Type: Journal    
DOI: 10.3109/08860229609047713     Document Type: Article

References (44)

1. Nordberg GF, Goyer RA, Nordberg M: Comparative toxicology of cadmium-metallothionein and cadmium chloride on mouse kidney. Arch Pathol 99:192-197, 1975.
2. Cherian MG, Goyer RA, Delaquerriere-Richardson L: Cadmium metallothionein-induced nephrotoxicity. Toxicol Appl Pharmacol 38:399-408, 1976.
3. Webb M: Toxicology of cadmium-thionein. In Webb M (ed), The Chemistry, Biochemistry and Biology of Cadmium. Elsevier/North Holland, New York, 1979, pp 423-431.
4. Squibb KS, Ridlington JW, Carmichael NJ, Fowler BA: Early cellular effects of circulating cadmium-thionein on kidney proximal tubules. Environ Health Perspect 28:287-296, 1979.
5. Squibb KS, Pritchard JB, Fowler BA: Cadmium metallothionein nephropathy: ultrastructural/biochemical alterations and intracellular cadmium-binding. J Pharmacol Exp Ther 229:311-321, 1984.
6. Cherian MG: Rat kidney epithelial cell culture for metal toxicity studies. In Vitro Cell Dev Biol 21:505-508, 1985.
7. Nordberg GF, Jin T, Nordberg M: Subcellular targets of cadmium nephrotoxicity: cadmium binding to renal membrane proteins in animals with or without protective metallothionein synthesis. Environ Health Perspect 102:191-194, 1994.
8. Cherian MG: Studies on toxicity of metallothionein in rat kidney epithelial cell culture. In Foulkes EC (ed), Biological Roles of Metallothionein. Elsevier/North Holland, New York, 1982, pp 193-202.
9. Jin TY, Nordberg GF, Nordberg M: Influence of cadmium-metallothionein pretreatment on tolerance of rat kidney cortical cells to cadmium toxicity in vitro and in vivo. Pharmacol Toxicol 60:345-349, 1987.
10. 2+ in cadmium-induced renal tubular cell injury. In Nordberg GF, Alessio L, Herber RFM (eds), Cadmium in the Human Environment: Toxicity and Carcinogenicity. IARC, Lyon, 1992, pp 1-7.
11. Levinson W, Oppermann H, Jackson J: Transition series metals and sulfhydryl reagents induce the synthesis of four proteins in eukaryotic cells. Biochim Biophys Acta 606:170-180, 1980.
12. Goering PL, Fisher BR, Kish C: Stress protein synthesis induced in rat liver by cadmium precedes hepatotoxicity. Toxicol Appl Pharmacol 122:139-148, 1993.
13. Goering PL, Fisher BR, Chaudhary PP, Dick CA: Relationship between stress protein induction in rat kidney by mercuric chloride and nephrotoxicity. Toxicol Appl Pharmacol 113:184-191, 1992.
14. Caltabiano MM, Koestler TP, Poste G, Greig RG: Induction of 32- and 34-kDa stress proteins by sodium arsenite, heavy metals, and thiol-reactive agents. J Biol Chem 261:13381-13386, 1986.
15. Bauman JW, Liu J, Klaassen CD: Production of metallothionein and heat-shock proteins in response to metals. Fundam Appl Toxicol 21:15-22, 1993.
16. Riabowol KT, Mizzen AL, Welch WJ. Heat shock is lethal to fibroblasts microinjected with antibodies against hsp 70. Science 242:433-436, 1988.
17. Probst GS, Bousquet WF, Miya TS: Correlation of hepatic metallothionein concentrations with acute cadmium toxicity in the mouse. Toxicol Appl Pharmacol 39:61-69, 1977.
18. Goering PL, Klaassen CD: Zinc-induced tolerance to cadmium hepatotoxicity. Toxicol Appl Pharmacol 74:299-307, 1984.
19. Parizek J: The destructive effect of cadmium on testicular tissue and its prevention by zinc. J Endocrinol 15:56-63, 1957.
20. Stacey NH, Klaassen CD: Interaction of metal ions with cadmium-induced cellular toxicity. J Toxicol Environ Health 7:149-158, 1981.
21. Leber AP, Miya TS: A mechanism for cadmium- and zinc-induced tolerance to cadmium toxicity: involvement of metallothionein. Toxicol Appl Pharmacol 37:403-414, 1976.
22. Piersma AH, Roelen B, Roest P, Kaakmat-Hoesenie AS, Achterberg TA, Mummery CL: Cadmium-induced inhibition of proliferation and differentiation of embryonal carcinoma cells and mechanistic aspects of protection by zinc. Teratology 48:335-341, 1993.
23. Liu XY, Jin TY, Nordberg GF, Rànnar S, Sjöström M, Zhou Y: A multivariate study of protective effects of zinc and copper against nephrotoxicity induced by cadmium metallothionein in rats. Toxicol Appl Pharmacol 114:239-245, 1992.
24. Liu XY, Jin TY, Nordberg GF, Sjöström M, Zhou Y: Influence of zinc and copper administration on metal disposition in rats with cadmium-metallothionein-induced nephrotoxicity. Toxicol Appl Pharmacol 126: 84-90, 1994.
25. Kaji T, Mishima A, Koyanagi E, Yamamoto C, Sakamoto M, Kozuka H: Possible mechanism for zinc protection against cadmium cytotoxicity in cultured vascular endothelial cells. Toxicology 76:257-270, 1992.
26. Hatzinger PB, Stevens JL: Rat kidney proximal tubule cell in defined medium: the roles of cholera toxin, extracellular calcium and serum in cell growth and expression of γ-glutamyltransferase. In Vitro Cell Dev Biol 25:205-212, 1989.
27. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976.
28. McDowell EM: Fixation and processing. In Trump BF, Jones RT (eds), Diagnostic Electron Microscopy. Wiley, New York, 1978, vol 1, pp 113-139.
29. O'Farrell PH: High resolution two dimensional electrophoresis of proteins. J Biol Chem 250:4007-4021, 1975.
30. Page B, Page M, Noel C: A new fluorometric assay for cytotoxicity measurements in vitro. Int J Oncology 3:473-476, 1993.
31. Rutenburg AM, Kim H, Fischbein JW, Hanker JS, Wasserkrug HL, Seligman AM: Histochemical and ultrastructural demonstration of γ-glutamyl transpeptidase activity. J Histochem Cytochem 17:517-526, 1969.
32. Elliget KA, Trump BF: Primary cultures of normal rat kidney proximal tubule epithelial cells for studies of renal cell injury. In Vitro Cell Dev Biol 27A:739-748, 1991.
33. Smith MA, Acosta D: Development of a primary culture system of rat cortical cells to evaluate the nephrotoxicity of xenobiotics. Food Chem Toxicol 24:551-556, 1986
34. 3H]thymidine incorporation assay. J Immun Meth 170:211-224, 1994.
35. Shahan TA, Siegel PD, Sorenson WG, Kuschner WG, Lewis DM: A sensitive new bioassay for tumour necrosis factor. J Immun Meth 175:181-187, 1994.
36. 2+-ionophore-regulated proteins. J Biol Chem 258:7102-7111, 1983.
37. Nishizumi M: Electron microscopic study of cadmium nephrotoxicity in the rat. Arch Environ Health 24:215-225, 1972.
38. Suzuki Y, Morita I, Yamane Y, Sei-itsu: Preventive effect of zinc against cadmium-induced bone resorption. Toxicology 62:27-34, 1990.
39. Fowler BA, Goering PL, Squibb KS: Mechanism of cadmium-metallothionein-induced nephrotoxicity: relationship to altered renal calcium metabolism. Experientia Suppl 52:661-668, 1987.
40. Cherian MG: The synthesis of metallothionein and cellular adaptation to metal toxicity in primary rat kidney epithelial cell cultures. Toxicology 17:225-231, 1980.
41. Waalkes MP, Perantoni A, Bhave M, Rehm S: Strain dependence in mice on resistance and susceptibility to the testicular effects of cadmium: assessment of the role of testicular cadmium-binding proteins. Toxicol Appl Pharmacol 93:47-61, 1988.
42. Welch WJ: The mammalian heat shock (or stress) response: a cellular defense mechanism. Adv Exp Med Biol 225:287-304, 1987.
43. Welch WJ: Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease. Physiol Rev 72:1063-1081, 1992.
44. Lindquist SC: The heat shock response. Annu Rev Biochem 55:1151-1191, 1986.