메뉴 건너뛰기




Volumn 10, Issue 21, 2004, Pages 2629-2641

Exercise as an anabolic stimulus for bone

Author keywords

Bone density; Bone strength; Desensitization; Nitric oxide; Osteoporosis; Parathyroid hormone; Prostaglandin; Purinergic receptors

Indexed keywords

CALCIUM; CALCIUM CHANNEL L TYPE; ESTROGEN; G PROTEIN COUPLED RECEPTOR; NITRIC OXIDE; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE[1-34]; PROSTAGLANDIN; PROSTAGLANDIN E2; PROSTANOID RECEPTOR; PURINE P2X7 RECEPTOR; PURINE P2Y2 RECEPTOR; SOMATOMEDIN B; SOMATOMEDIN C;

EID: 3242877031     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612043383755     Document Type: Review
Times cited : (91)

References (89)
  • 1
    • 0020619183 scopus 로고
    • Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells
    • Farley JR, Wergedal JE, Baylink DJ. Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells. Science 1983; 222: 330-2.
    • (1983) Science , vol.222 , pp. 330-332
    • Farley, J.R.1    Wergedal, J.E.2    Baylink, D.J.3
  • 3
    • 0344826782 scopus 로고    scopus 로고
    • Bone's mechanostat: A 2003 update
    • Frost HM. Bone's mechanostat: A 2003 update. Anat Rec 2003; 275A: 1081-101.
    • (2003) Anat. Rec. , vol.275 A , pp. 1081-1101
    • Frost, H.M.1
  • 4
    • 0020391814 scopus 로고
    • Limb mechanics as a function of speed and gait: A study of functional strains in the radius and tibia of horse and dog
    • Rubin CT, Lanyon LE. Limb mechanics as a function of speed and gait: a study of functional strains in the radius and tibia of horse and dog. J Exp Biol 1982; 101: 187-211.
    • (1982) J. Exp. Biol. , vol.101 , pp. 187-211
    • Rubin, C.T.1    Lanyon, L.E.2
  • 6
    • 0004127189 scopus 로고    scopus 로고
    • Design in Nature. Learning from Trees
    • Springer, Berlin
    • Mattheck C. Design in Nature. Learning from Trees. Springer, Berlin. 1997.
    • (1997)
    • Mattheck, C.1
  • 7
    • 0035992661 scopus 로고    scopus 로고
    • Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts
    • Robling AG, Hinant FM, Burr DB, Turner CH. Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts. J Bone Miner Res 2002; 17: 1545-1554.
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 1545-1554
    • Robling, A.G.1    Hinant, F.M.2    Burr, D.B.3    Turner, C.H.4
  • 8
    • 0027249345 scopus 로고
    • Physical activity and bone mass: Exercises in futility?
    • Forwood MR, Burr DB. Physical activity and bone mass: exercises in futility? Bone Miner 1993; 21: 89-112.
    • (1993) Bone Miner. , vol.21 , pp. 89-112
    • Forwood, M.R.1    Burr, D.B.2
  • 9
    • 0033941492 scopus 로고    scopus 로고
    • Systematic review of randomized trials of the effect of exercise on bone mass in pre- and postmenopausal women
    • Wallace BA, Cumming RG. Systematic review of randomized trials of the effect of exercise on bone mass in pre- and postmenopausal women. Calcif Tissue Int 2000; 67: 10-18.
    • (2000) Calcif Tissue Int. , vol.67 , pp. 10-18
    • Wallace, B.A.1    Cumming, R.G.2
  • 10
    • 0031655751 scopus 로고    scopus 로고
    • Three rules for bone adaptation to mechanical stimuli
    • Turner CH. Three rules for bone adaptation to mechanical stimuli. Bone 1998; 23: 399-407.
    • (1998) Bone , vol.23 , pp. 399-407
    • Turner, C.H.1
  • 11
    • 0021322767 scopus 로고
    • Regulation of bone formation by applied dynamic loads
    • Rubin CT, Lanyon LE. Regulation of bone formation by applied dynamic loads. J Bone Joint Surg Am 1984; 66: 397-402.
    • (1984) J. Bone Joint Surg. Am. , vol.66 , pp. 397-402
    • Rubin, C.T.1    Lanyon, L.E.2
  • 13
    • 0035064222 scopus 로고    scopus 로고
    • Effects of loading frequency on mechanically induced bone formation
    • Hsieh YF, Turner CH. Effects of loading frequency on mechanically induced bone formation. J Bone Miner Res 2001;16: 918-24.
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 918-924
    • Hsieh, Y.F.1    Turner, C.H.2
  • 15
    • 0036785365 scopus 로고    scopus 로고
    • L-type calcium channels mediate mechanically induced bone formation in vivo
    • Li J, Duncan RL, Burr DB, Turner CH. L-type calcium channels mediate mechanically induced bone formation in vivo. J Bone Miner Res 2002; 17: 1795-800.
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 1795-1800
    • Li, J.1    Duncan, R.L.2    Burr, D.B.3    Turner, C.H.4
  • 16
    • 0031046164 scopus 로고    scopus 로고
    • Activation of G proteins mediates flow-induced prostaglandin E2 production in osteoblasts
    • Reich KM, McAllister TN, Gudi S, Frangos JA. Activation of G proteins mediates flow-induced prostaglandin E2 production in osteoblasts. Endocrinology 1997; 138: 1014-8.
    • (1997) Endocrinology , vol.138 , pp. 1014-1018
    • Reich, K.M.1    McAllister, T.N.2    Gudi, S.3    Frangos, J.A.4
  • 17
    • 0035745927 scopus 로고    scopus 로고
    • Recovery periods restore mechanosensitivity to dynamically loaded bone
    • Robling AG, Burr DB, Turner CH. Recovery periods restore mechanosensitivity to dynamically loaded bone. J Exp Biol 2001; 204: 3389-99.
    • (2001) J. Exp. Biol. , vol.204 , pp. 3389-3399
    • Robling, A.G.1    Burr, D.B.2    Turner, C.H.3
  • 19
    • 0036708150 scopus 로고    scopus 로고
    • Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle
    • Srinivasan S, Weimer DA, Agans SC, Bain SD, Gross TS. Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle. J Bone Miner Res 2002; 17: 1613-20.
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 1613-1620
    • Srinivasan, S.1    Weimer, D.A.2    Agans, S.C.3    Bain, S.D.4    Gross, T.S.5
  • 20
    • 0028267333 scopus 로고
    • Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periosteal pressure
    • Torrance AG, Mosley JR, Suswillo RF, Lanyon LE. Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periosteal pressure. Calcif Tissue Int 1994; 54: 241-7.
    • (1994) Calcif Tissue Int. , vol.54 , pp. 241-247
    • Torrance, A.G.1    Mosley, J.R.2    Suswillo, R.F.3    Lanyon, L.E.4
  • 21
    • 0035992661 scopus 로고    scopus 로고
    • Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts
    • Robling AG, Hinant FM, Burr DB, Turner CH. Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts. J Bone Miner Res 2002; 17: 1545-54.
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 1545-1554
    • Robling, A.G.1    Hinant, F.M.2    Burr, D.B.3    Turner, C.H.4
  • 25
    • 3242885681 scopus 로고    scopus 로고
    • Mechanosensitivity of bone decreases after a long period of loading, but may be improved with time off
    • submitted
    • Saxon LK, Robling AG, Turner CH. Mechanosensitivity of bone decreases after a long period of loading, but may be improved with time off. J Bone Miner Res 2003; submitted.
    • (2003) J. Bone Miner. Res.
    • Saxon, L.K.1    Robling, A.G.2    Turner, C.H.3
  • 27
    • 0030948207 scopus 로고    scopus 로고
    • Mechanically regulated expression of a neural glutamate transporter in bone: A role for excitatory amino acids as osteotropic agents?
    • Mason DJ, Suva LJ, Genever PG, Patton AJ, Steuckle S, Hillam RA, Skerry TM. Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents? Bone 1997; 20: 199-205.
    • (1997) Bone , vol.20 , pp. 199-205
    • Mason, D.J.1    Suva, L.J.2    Genever, P.G.3    Patton, A.J.4    Steuckle, S.5    Hillam, R.A.6    Skerry, T.M.7
  • 28
    • 0032101276 scopus 로고    scopus 로고
    • Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone
    • Patton AJ, Genever PG, Birch MA, Suva LJ, Skerry TM. Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone. Bone 1998; 22: 645-9.
    • (1998) Bone , vol.22 , pp. 645-649
    • Patton, A.J.1    Genever, P.G.2    Birch, M.A.3    Suva, L.J.4    Skerry, T.M.5
  • 29
    • 0037318277 scopus 로고    scopus 로고
    • Stochastic resonance in osteogenic response to mechanical loading
    • Tanaka SM, Alam IM, Turner CH. Stochastic resonance in osteogenic response to mechanical loading. FASEB J 2003; 17: 313-4.
    • (2003) FASEB J. , vol.17 , pp. 313-314
    • Tanaka, S.M.1    Alam, I.M.2    Turner, C.H.3
  • 30
    • 0028864773 scopus 로고
    • Noise-induced enhancement of signal transduction across voltage-dependent ion channels
    • Bezrukov SM, Vodyanoy I Noise-induced enhancement of signal transduction across voltage-dependent ion channels. Nature 1995; 378: 362-364.
    • (1995) Nature , vol.378 , pp. 362-364
    • Bezrukov, S.M.1    Vodyanoy, I.2
  • 31
    • 0030273898 scopus 로고    scopus 로고
    • Intracellular Ca2+ stores and extracellular Ca2+ are required in the real-time Ca2+ response of bone cells experiencing fluid flow
    • Hung CT, Allen FD, Pollack SR, Brighton CT. Intracellular Ca2+ stores and extracellular Ca2+ are required in the real-time Ca2+ response of bone cells experiencing fluid flow. J. Biomech 1996; 29: 1411-1417.
    • (1996) J. Biomech. , vol.29 , pp. 1411-1417
    • Hung, C.T.1    Allen, F.D.2    Pollack, S.R.3    Brighton, C.T.4
  • 32
    • 0030463534 scopus 로고    scopus 로고
    • Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain
    • Rawlinson SC, Pitsillides AA, Lanyon LE. Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. Bone 1996; 19: 609-614.
    • (1996) Bone , vol.19 , pp. 609-614
    • Rawlinson, S.C.1    Pitsillides, A.A.2    Lanyon, L.E.3
  • 33
    • 0037387070 scopus 로고    scopus 로고
    • Parathyroid hormone enhances mechanically induced bone formation, possibly involving L-type voltage-sensitive calcium channels
    • Li J, Duncan RL, Burr DB, Gattone VH, Turner CH. Parathyroid hormone enhances mechanically induced bone formation, possibly involving L-type voltage-sensitive calcium channels. Endocrinology 2003; 144: 1226-33.
    • (2003) Endocrinology , vol.144 , pp. 1226-1233
    • Li, J.1    Duncan, R.L.2    Burr, D.B.3    Gattone, V.H.4    Turner, C.H.5
  • 34
    • 0035143357 scopus 로고    scopus 로고
    • Parathyroid hormone enhances fluid shear-induced [Ca2+]i signaling in osteoblastic cells through activation of mechanosensitive and voltage-sensitive Ca2+ channels
    • Ryder KD, Duncan RL. Parathyroid hormone enhances fluid shear-induced [Ca2+]i signaling in osteoblastic cells through activation of mechanosensitive and voltage-sensitive Ca2+ channels. J Bone Miner Res 2001; 16: 240-248.
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 240-248
    • Ryder, K.D.1    Duncan, R.L.2
  • 35
    • 0035918140 scopus 로고    scopus 로고
    • Osteopontin gene regulation by oscillary fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts
    • You J, Reilly GC, Zhen X, Yellowley CE, Chen Q, Donahue HJ, et al. Osteopontin gene regulation by oscillary fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem 2001; 276: 13365-13371.
    • (2001) J. Biol. Chem. , vol.276 , pp. 13365-13371
    • You, J.1    Reilly, G.C.2    Zhen, X.3    Yellowley, C.E.4    Chen, Q.5    Donahue, H.J.6
  • 36
    • 0025734407 scopus 로고
    • Disruption of the actin cytoskeleton after microinjection of proteolytic fragments of alpha-actinin
    • Pavalko FM, Burridge K. Disruption of the actin cytoskeleton after microinjection of proteolytic fragments of alpha-actinin. J Cell Biol 1991; 114: 481-491.
    • (1991) J. Cell Biol. , vol.114 , pp. 481-491
    • Pavalko, F.M.1    Burridge, K.2
  • 38
    • 0025359865 scopus 로고
    • Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production
    • Reich KM, Gay CV, Frangos JA. Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production. J Cell Physiol 1990; 143: 100-104.
    • (1990) J. Cell Physiol. , vol.143 , pp. 100-104
    • Reich, K.M.1    Gay, C.V.2    Frangos, J.A.3
  • 39
    • 0031035011 scopus 로고    scopus 로고
    • Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells
    • Klein-Nulend J, Burger EH, Semeins CM, Raisz LG, Pilbeam CC. Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells. J Bone Miner Res 1997; 12: 45-51.
    • (1997) J. Bone Miner. Res. , vol.12 , pp. 45-51
    • Klein-Nulend, J.1    Burger, E.H.2    Semeins, C.M.3    Raisz, L.G.4    Pilbeam, C.C.5
  • 40
    • 0029841159 scopus 로고    scopus 로고
    • Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts
    • Johnson DL, McAllister TN, Frangos JA. Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts. Am J Physic 1996; 271: E205-E208.
    • (1996) Am. J. Physic. , vol.271
    • Johnson, D.L.1    McAllister, T.N.2    Frangos, J.A.3
  • 41
    • 0029564705 scopus 로고
    • Mechanical strain-induced NO production by bone cells: A possible role in adaptive bone (re)modeling?
    • Pitsillides AA, Rawlinson SC, Suswillo RF, Bourrin S, Zaman G, Lanyon LE. Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling? FASEB J 1995;9: 1614-22.
    • (1995) FASEB J. , vol.9 , pp. 1614-1622
    • Pitsillides, A.A.1    Rawlinson, S.C.2    Suswillo, R.F.3    Bourrin, S.4    Zaman, G.5    Lanyon, L.E.6
  • 43
    • 0033933185 scopus 로고    scopus 로고
    • Mechanical strain inhibits expression of osteoclast differentiation factor by murine stromal cells
    • Rubin J, Murphy T, Nanes MS, Fan X. Mechanical strain inhibits expression of osteoclast differentiation factor by murine stromal cells. Am J Physiol 2000; 278: C1126-C1132.
    • (2000) Am. J. Physiol. , vol.278
    • Rubin, J.1    Murphy, T.2    Nanes, M.S.3    Fan, X.4
  • 44
    • 0031779953 scopus 로고    scopus 로고
    • Role of nitric oxide and prostaglandins in mechanically induced bone formation
    • Chow JW, Fox SW, Lean JM, Chambers TJ. Role of nitric oxide and prostaglandins in mechanically induced bone formation. J Bone Miner Res 1999; 13: 1039-1044.
    • (1999) J. Bone Miner. Res. , vol.13 , pp. 1039-1044
    • Chow, J.W.1    Fox, S.W.2    Lean, J.M.3    Chambers, T.J.4
  • 45
    • 0029998565 scopus 로고    scopus 로고
    • Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo
    • Forwood MR. Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo. J Bone Miner Res 1996; 11: 688-1693.
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 688-1693
    • Forwood, M.R.1
  • 46
    • 0036551229 scopus 로고    scopus 로고
    • Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading
    • Li J, Burr DB, Turner CH. Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading. Calcif Tissue Int 2002; 70: 320-329.
    • (2002) Calcif Tissue Int. , vol.70 , pp. 320-329
    • Li, J.1    Burr, D.B.2    Turner, C.H.3
  • 47
    • 0029940159 scopus 로고    scopus 로고
    • Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats
    • Turner CH, Takano Y, Owan I, Murrell GA. Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats. Am J Physiol 1996; 270: E634-E639.
    • (1996) Am. J. Physiol. , vol.270
    • Turner, C.H.1    Takano, Y.2    Owan, I.3    Murrell, G.A.4
  • 48
    • 0016772025 scopus 로고
    • Cyclic AMP and cyclic GMP: Mediators of the mechanical effects on bone remodeling
    • Rodan GA, Bourret LA, Harvey A, Mensi T. Cyclic AMP and cyclic GMP: mediators of the mechanical effects on bone remodeling. Science 1975; 189: 467-9.
    • (1975) Science , vol.189 , pp. 467-469
    • Rodan, G.A.1    Bourret, L.A.2    Harvey, A.3    Mensi, T.4
  • 50
    • 0028294282 scopus 로고
    • Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption
    • Lowik CW, Nibbering PH, van de Ruit M, Papapoulos SE. Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. J Clin Invest 1994, 93: 1465-72.
    • (1994) J. Clin. Invest. , vol.93 , pp. 1465-1472
    • Lowik, C.W.1    Nibbering, P.H.2    van de Ruit, M.3    Papapoulos, S.E.4
  • 52
    • 0842313070 scopus 로고    scopus 로고
    • Nitric oxide regulates RANKL and OPG expression in bone marrow stromal cells
    • Fan X, Roy E, Zhu L, Murphy TC, Ackert-Bicknell C, Hart CM, et al. Nitric oxide regulates RANKL and OPG expression in bone marrow stromal cells. Endocrinology 2004; 145: 751-9.
    • (2004) Endocrinology , vol.145 , pp. 751-759
    • Fan, X.1    Roy, E.2    Zhu, L.3    Murphy, T.C.4    Ackert-Bicknell, C.5    Hart, C.M.6
  • 54
    • 0034746416 scopus 로고    scopus 로고
    • Systemic prostaglandin E2 increases cancellous bone formation and mass in aging rats and stimulates their bone marrow osteogenic capacity in vivo and in vitro
    • Keila S, Kelner A, Weinreb M. Systemic prostaglandin E2 increases cancellous bone formation and mass in aging rats and stimulates their bone marrow osteogenic capacity in vivo and in vitro. J Endocrin 2001; 168: 131-139.
    • (2001) J. Endocrin. , vol.168 , pp. 131-139
    • Keila, S.1    Kelner, A.2    Weinreb, M.3
  • 55
    • 0025149524 scopus 로고
    • Transient effects of subcutaneously administered prostaglandin E2 on cancellous and cortical bone in young adult dogs
    • 1990
    • Li XJ, Jee WS, Li YL, Patterson-Buckendahl P. (1990) Transient effects of subcutaneously administered prostaglandin E2 on cancellous and cortical bone in young adult dogs. Bone 1990; 11: 353-364.
    • (1990) Bone , vol.11 , pp. 353-364
    • Li, X.J.1    Jee, W.S.2    Li, Y.L.3    Patterson-Buckendahl, P.4
  • 56
    • 0031594125 scopus 로고    scopus 로고
    • Prostaglandin E2 (PGE2) autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells
    • Suda M, Tanaka K, Yasoda A, Natsui K, Sakuma Y, Tanaka I, et al. Prostaglandin E2 (PGE2) autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells. Calcif Tissue Int 1998; 62: 327-331.
    • (1998) Calcif Tissue Int. , vol.62 , pp. 327-331
    • Suda, M.1    Tanaka, K.2    Yasoda, A.3    Natsui, K.4    Sakuma, Y.5    Tanaka, I.6
  • 58
    • 0034922723 scopus 로고    scopus 로고
    • PGE2 is essential for gap junction-mediated intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanical strain
    • Cheng B, Kato Y, Zhao S, Lau J, Sprague E, Bonewald LF, et al. PGE2 is essential for gap junction-mediated intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanical strain. Endocrinology 2001; 142: 3463-3473.
    • (2001) Endocrinology , vol.142 , pp. 3463-3473
    • Cheng, B.1    Kato, Y.2    Zhao, S.3    Lau, J.4    Sprague, E.5    Bonewald, L.F.6
  • 59
    • 11444255760 scopus 로고    scopus 로고
    • Regulation of connexin43 expression and function by prostaglandin E2 (PGE2) and parathyroid hormone (PTH) in osteoblastic cells
    • Civitelli R, Ziambaras K, Warlow PM, Lecanda F, Nelson T, Harley J, et al. Regulation of connexin43 expression and function by prostaglandin E2 (PGE2) and parathyroid hormone (PTH) in osteoblastic cells. J Cell Biochem 1998; 68: 8-21.
    • (1998) J. Cell Biochem. , vol.68 , pp. 8-21
    • Civitelli, R.1    Ziambaras, K.2    Warlow, P.M.3    Lecanda, F.4    Nelson, T.5    Harley, J.6
  • 60
    • 0037294965 scopus 로고    scopus 로고
    • Fluid shear stress inhibits TNF-alpha-induced apoptosis in osteoblasts: A role for fluid shear stress-induced activation of PI3-kinase and inhibition of caspase 3
    • Pavalko FM, Gerard RL, Ponik SM, Gallagher PJ, Jin Y, Norvell SM. Fluid shear stress inhibits TNF-alpha-induced apoptosis in osteoblasts: a role for fluid shear stress-induced activation of PI3-kinase and inhibition of caspase 3. J Cell Physiol 2003; 194: 194-205.
    • (2003) J. Cell Physiol. , vol.194 , pp. 194-205
    • Pavalko, F.M.1    Gerard, R.L.2    Ponik, S.M.3    Gallagher, P.J.4    Jin, Y.5    Norvell, S.M.6
  • 61
    • 0030776894 scopus 로고    scopus 로고
    • ATP- and gap junction-dependent intercellular calcium signaling in osteoblastic cells
    • Jørgensen NR, Geist ST, Civitelli R, Steinberg TH. ATP- and gap junction-dependent intercellular calcium signaling in osteoblastic cells. J Cell Biol 1997; 139: 497-506.
    • (1997) J. Cell Biol. , vol.139 , pp. 497-506
    • Jørgensen, N.R.1    Geist, S.T.2    Civitelli, R.3    Steinberg, T.H.4
  • 62
    • 2242489133 scopus 로고    scopus 로고
    • P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells
    • You J, Jacobs CR. Steinberg TH, Donahue HJ. P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells. J Biol Chem 2002; 277: 48724-48729.
    • (2002) J. Biol. Chem. , vol.277 , pp. 48724-48729
    • You, J.1    Jacobs, C.R.2    Steinberg, T.H.3    Donahue, H.J.4
  • 63
    • 0037634326 scopus 로고    scopus 로고
    • Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption
    • Ke HZ, Qi H, Weidema AF, Zhang Q, Panupinthu N, Crawford DT, et al. Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol Endocrine 2003; 17: 1356-67.
    • (2003) Mol. Endocrine , vol.17 , pp. 1356-1367
    • Ke, H.Z.1    Qi, H.2    Weidema, A.F.3    Zhang, Q.4    Panupinthu, N.5    Crawford, D.T.6
  • 64
    • 0034603023 scopus 로고    scopus 로고
    • Parathyroid hormone-activated volume-sensitive calcium influx pathways in mechanically loaded osteocytes
    • Miyauchi A, Notoya K, Mikuni-Takagaki Y, Takagi Y, Goto M, Miki Y, et al. Parathyroid hormone-activated volume-sensitive calcium influx pathways in mechanically loaded osteocytes. J Biol Chem 2000; 275: 3335-42.
    • (2000) J. Biol. Chem. , vol.275 , pp. 3335-3342
    • Miyauchi, A.1    Notoya, K.2    Mikuni-Takagaki, Y.3    Takagi, Y.4    Goto, M.5    Miki, Y.6
  • 65
    • 0034975005 scopus 로고    scopus 로고
    • A new view of mechanotransduction and strain amplification in cells with microvilli and cell processes
    • Weinbaum S, Guo P, You L. A new view of mechanotransduction and strain amplification in cells with microvilli and cell processes. Biorheology 2001; 38: 119-142.
    • (2001) Biorheology , vol.38 , pp. 119-142
    • Weinbaum, S.1    Guo, P.2    You, L.3
  • 66
    • 0032970789 scopus 로고    scopus 로고
    • Parathyroid hormone and mechanical usage have a synergistic effect in rat tibial diaphyseal bone
    • Ma Y, Jee WS, Yuan Z, Wei W, Chen H, Pun S, et al. Parathyroid hormone and mechanical usage have a synergistic effect in rat tibial diaphyseal bone. J Bone Miner Res 1999; 14: 439-448.
    • (1999) J. Bone Miner. Res. , vol.14 , pp. 439-448
    • Ma, Y.1    Jee, W.S.2    Yuan, Z.3    Wei, W.4    Chen, H.5    Pun, S.6
  • 67
    • 0031934350 scopus 로고    scopus 로고
    • Role for parathyroid hormone in mechanical responsiveness of rat bone
    • Chow JW, Fox S, Jagger CJ, Chambers TJ. Role for parathyroid hormone in mechanical responsiveness of rat bone. Am J Physiol 1998; 274: E146-E154.
    • (1998) Am. J. Physiol. , vol.274
    • Chow, J.W.1    Fox, S.2    Jagger, C.J.3    Chambers, T.J.4
  • 68
    • 0037288854 scopus 로고    scopus 로고
    • Daily treatment with parathyroid hormone is associated with an increase in vertebral cross-sectional area in postmenopausal women with glucocorticoid-induced osteoporosis
    • Rehman Q, Lang TF, Arnaud CD, Modin GW, Lane NE. Daily treatment with parathyroid hormone is associated with an increase in vertebral cross-sectional area in postmenopausal women with glucocorticoid-induced osteoporosis. Osteoporos Int 2003;14: 77-81.
    • (2003) Osteoporos. Int. , vol.14 , pp. 77-81
    • Rehman, Q.1    Lang, T.F.2    Arnaud, C.D.3    Modin, G.W.4    Lane, N.E.5
  • 69
    • 0034523828 scopus 로고    scopus 로고
    • Three-dimensional modeling of the effects of parathyroid hormone on bone distribution in lumbar vertebrae of ovariectomized cynomolgus macaques
    • Sato M, Westmore M, Clendenon J, Smith S, Hannum B, Zeng GQ, et al. Three-dimensional modeling of the effects of parathyroid hormone on bone distribution in lumbar vertebrae of ovariectomized cynomolgus macaques. Osteoporos Int 2000; 11: 871-80.
    • (2000) Osteoporos. Int. , vol.11 , pp. 871-880
    • Sato, M.1    Westmore, M.2    Clendenon, J.3    Smith, S.4    Hannum, B.5    Zeng, G.Q.6
  • 70
    • 0042967494 scopus 로고    scopus 로고
    • Interactive effects of PTH and mechanical stress on nitric oxide and PGE2 production by primary mouse osteoblastic cells
    • Bakker AD, Joldersma M, Klein-Nulend J, Burger EH. Interactive effects of PTH and mechanical stress on nitric oxide and PGE2 production by primary mouse osteoblastic cells. Am J Physiol Endocrinol Metab 2003; 285: E608-13.
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.285
    • Bakker, A.D.1    Joldersma, M.2    Klein-Nulend, J.3    Burger, E.H.4
  • 71
    • 0033911094 scopus 로고    scopus 로고
    • Mechanical strain activates estrogen response elements in bone cells
    • Zaman G, Cheng MZ, Jessop HL, White R, Lanyon LE. Mechanical strain activates estrogen response elements in bone cells. Bone 2000; 27: 233-239.
    • (2000) Bone , vol.27 , pp. 233-239
    • Zaman, G.1    Cheng, M.Z.2    Jessop, H.L.3    White, R.4    Lanyon, L.E.5
  • 73
  • 74
    • 0142124744 scopus 로고    scopus 로고
    • Estrogen deposits extra mineral into bones of female rats in puberty, but simultaneously seems to suppress the responsiveness of female skeleton to mechanical loading
    • Jarvinen TL, Kannus P, Pajamaki I, Vuohelainen T, Tuukkanen J, Jarvinen M, et al. Estrogen deposits extra mineral into bones of female rats in puberty, but simultaneously seems to suppress the responsiveness of female skeleton to mechanical loading. Bone 2003; 32: 642-51.
    • (2003) Bone , vol.32 , pp. 642-651
    • Jarvinen, T.L.1    Kannus, P.2    Pajamaki, I.3    Vuohelainen, T.4    Tuukkanen, J.5    Jarvinen, M.6
  • 75
    • 0037214288 scopus 로고    scopus 로고
    • The structural and hormonal basis of sex differences in peak appendicular bone strength in rats
    • Kim BT, Mosekilde L, Duan Y, Zhang XZ, Tornvig L, Thomsen JS, et al. The structural and hormonal basis of sex differences in peak appendicular bone strength in rats. J Bone Miner Res 2003; 18: 150-5.
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 150-155
    • Kim, B.T.1    Mosekilde, L.2    Duan, Y.3    Zhang, X.Z.4    Tornvig, L.5    Thomsen, J.S.6
  • 77
    • 0035660587 scopus 로고    scopus 로고
    • Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the OPG/RANKL (osteoprotegerin/receptor activator of NF-kappa B ligand) ratio and serum interleukin-6 in male mice
    • Lindberg MK, Erlandsson M, Alatalo SL, Windahl S, Andersson G, Halleen JM, et al. Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the OPG/RANKL (osteoprotegerin/receptor activator of NF-kappa B ligand) ratio and serum interleukin-6 in male mice. J Endocrinol 2001;171: 425-33.
    • (2001) J. Endocrinol. , vol.171 , pp. 425-433
    • Lindberg, M.K.1    Erlandsson, M.2    Alatalo, S.L.3    Windahl, S.4    Andersson, G.5    Halleen, J.M.6
  • 78
    • 0032748023 scopus 로고    scopus 로고
    • Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice
    • Windahl SH, Vidal O, Andersson G, Gustafsson JA, Ohlsson C. Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice. J Clin Invest 1999:104: 895-901.
    • (1999) J. Clin. Invest. , vol.104 , pp. 895-901
    • Windahl, S.H.1    Vidal, O.2    Andersson, G.3    Gustafsson, J.A.4    Ohlsson, C.5
  • 79
    • 0025125950 scopus 로고
    • Estrogen inhibition of periosteal bone formation in rat long bones: Down-regulation of gene expression for bone matrix proteins
    • Turner RT, Colvard DS, Spelsberg TC. Estrogen inhibition of periosteal bone formation in rat long bones: down-regulation of gene expression for bone matrix proteins. Endocrinology 1990;127: 1346-51.
    • (1990) Endocrinology , vol.127 , pp. 1346-1351
    • Turner, R.T.1    Colvard, D.S.2    Spelsberg, T.C.3
  • 80
    • 0036179760 scopus 로고    scopus 로고
    • Noninvasive loading of the murine tibia: An in vivo model for the study of mechanotransduction
    • Gross TS, Srinivasan S, Liu CC, Clemens TL, Bain SD. Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction. J Bone Miner Res 2002;17: 493-501.
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 493-501
    • Gross, T.S.1    Srinivasan, S.2    Liu, C.C.3    Clemens, T.L.4    Bain, S.D.5
  • 82
    • 0142249280 scopus 로고    scopus 로고
    • Skeletal unloading induces resistance to insulin-like growth factor I on bone formation
    • Sakata T, Halloran BP, Elalieh HZ, Munson SJ, Rudner L, Venton L, et al. Skeletal unloading induces resistance to insulin-like growth factor I on bone formation. Bone 2003;32: 669-80.
    • (2003) Bone , vol.32 , pp. 669-680
    • Sakata, T.1    Halloran, B.P.2    Elalieh, H.Z.3    Munson, S.J.4    Rudner, L.5    Venton, L.6
  • 83
    • 0028929151 scopus 로고
    • Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation
    • Lean JM, Jagger CJ, Chambers TJ, Chow JW. Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation. Am J Physiol 1995;268: E318-27.
    • (1995) Am. J. Physiol. , vol.268
    • Lean, J.M.1    Jagger, C.J.2    Chambers, T.J.3    Chow, J.W.4
  • 85
    • 0242290338 scopus 로고    scopus 로고
    • Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor
    • Cherian PP, Cheng B, Gu S, Sprague E, Bonewald LF, Jiang JX. Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor. J Biol Chem 2003; 278: 43146-56.
    • (2003) J. Biol. Chem. , vol.278 , pp. 43146-43156
    • Cherian, P.P.1    Cheng, B.2    Gu, S.3    Sprague, E.4    Bonewald, L.F.5    Jiang, J.X.6
  • 86
    • 0029661961 scopus 로고    scopus 로고
    • Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist
    • Nishigaki N, Negishi M, Ichikawa A. Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. Mol Pharmacol 1996; 50: 1031-7.
    • (1996) Mol. Pharmacol. , vol.50 , pp. 1031-1037
    • Nishigaki, N.1    Negishi, M.2    Ichikawa, A.3
  • 87
    • 0035992776 scopus 로고    scopus 로고
    • The role of bone density measurements in the evaluation of new treatments for osteoporosis
    • Blake GM, Fogelman I. The role of bone density measurements in the evaluation of new treatments for osteoporosis. Curr Pharm Design 2002; 8(21): 1885-1905.
    • (2002) Curr. Pharm. Design , vol.8 , Issue.21 , pp. 1885-1905
    • Blake, G.M.1    Fogelman, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.